Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers ph...Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate that PITPNC1 is a key player in thermogenesis of BAT. While Pitpnc1^(−/−) mice do not differ with wildtype mice in body weight and insulin sensitivity on either chow or high-fat diet, they develop hypothermia when subjected to acute cold exposure at 4℃. The Pitpnc1^(−/−) brown adipocytes exhibit defective β-oxidation and abnormal thermogenesis-related metabolism pathways in mitochondria. The deficiency of lipid mobilization in Pitpnc1^(−/−) brown adipocytes might be the result of excessive accumulation of phosphatidylcholine and a reduction of phosphatidic acid. Our findings have uncovered significant roles of PITPNC1 in mitochondrial phospholipid homeostasis and BAT thermogenesis.展开更多
Exactly one hundred years ago,the world was emerging from the ravages of the Spanish flu pandemic that killed 30 million people.Today,we are also emerging from a similar pandemic caused by coronavirus disease(COVID-19...Exactly one hundred years ago,the world was emerging from the ravages of the Spanish flu pandemic that killed 30 million people.Today,we are also emerging from a similar pandemic caused by coronavirus disease(COVID-19).However,the world that survivors of the flu pandemic inherited was very different from the world that will be left after COVID-19 is finally over.Life,of course,has changed enormously in these last 100 years with the advent of air travel,cars,computers,and the internet.But not only healthy life has changed,but what has also changed is the reasons why we get ill and die.After the flu pandemic,the major killers were still infectious diseases and undernutrition.Nowadays,the main health problems are due to over-nutrition and non-communicable diseases such as obesity,Type 2 diabetes,cardiovascular diseases,cancer,and neurological diseases.展开更多
基金the National Key R&D Program of China(2018YFA0506900)the National Key R&D Program of China(2018YFA0800301)+3 种基金the National Natural Science Foundation of China(91857103)Shanghai Basic Research Field Project“Science and Technology Innovation Action Plan”(21JC1400400)the Lingang Laboratory(LG-QS-202204-06)Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)。
文摘Brown adipose tissue (BAT) plays an essential role in non-shivering thermogenesis. The phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) is identified as a lipid transporter that reciprocally transfers phospholipids between intracellular membrane structures. However, the physiological significance of PITPNC1 and its regulatory mechanism remain unclear. Here, we demonstrate that PITPNC1 is a key player in thermogenesis of BAT. While Pitpnc1^(−/−) mice do not differ with wildtype mice in body weight and insulin sensitivity on either chow or high-fat diet, they develop hypothermia when subjected to acute cold exposure at 4℃. The Pitpnc1^(−/−) brown adipocytes exhibit defective β-oxidation and abnormal thermogenesis-related metabolism pathways in mitochondria. The deficiency of lipid mobilization in Pitpnc1^(−/−) brown adipocytes might be the result of excessive accumulation of phosphatidylcholine and a reduction of phosphatidic acid. Our findings have uncovered significant roles of PITPNC1 in mitochondrial phospholipid homeostasis and BAT thermogenesis.
文摘Exactly one hundred years ago,the world was emerging from the ravages of the Spanish flu pandemic that killed 30 million people.Today,we are also emerging from a similar pandemic caused by coronavirus disease(COVID-19).However,the world that survivors of the flu pandemic inherited was very different from the world that will be left after COVID-19 is finally over.Life,of course,has changed enormously in these last 100 years with the advent of air travel,cars,computers,and the internet.But not only healthy life has changed,but what has also changed is the reasons why we get ill and die.After the flu pandemic,the major killers were still infectious diseases and undernutrition.Nowadays,the main health problems are due to over-nutrition and non-communicable diseases such as obesity,Type 2 diabetes,cardiovascular diseases,cancer,and neurological diseases.
