The nanoparticle-based treatment and diagnosis of cancer remain challenging in clinical translation, mainly due to the hurdles that can be associated with the development of targeted delivery, biological side effects,...The nanoparticle-based treatment and diagnosis of cancer remain challenging in clinical translation, mainly due to the hurdles that can be associated with the development of targeted delivery, biological side effects, poor drug loading efficiency (DLE), and instability and so on [1,2].展开更多
Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enh...Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enhance the therapeutic effect. We developed porous hollow palladium nanoparticles （PHPdNPs） to co-deliver ^131I （a radioisotope that is commonly used in radiotherapy） and doxorubicin （DOX; a chemotherapy drug）. Compared with other mesoporous nanocarriers, our PHPdNPs exhibited impressive photothermal conversion efficiency and stability. Drug loading is high and drug release is controllable by repeated laser irradiation and acidic pH in tumor microenvironments. Owing to the specific interaction between palladium and iodine, the PHPdNPs serve as effective ^131I delivery vehicles with excellent radiochemical stability. A single dose of [^131I]PHPdNPs-DOX has superior antitumor efficacy because it enables a combination of chemo-, photothermal-, and radio-therapy. Moreover, the nanocomplex has no obvious side-effects in mice. Therefore, we believe that PHPdNPs are excellent candidates for multimodal imaging-guided therapy.展开更多
Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the...Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.展开更多
Targeted drug delivery to the site of disease is of both fundamental and practical importance in the development of personalized and precision nanomedicine.How to design a drug carrier that can specifically deliver dr...Targeted drug delivery to the site of disease is of both fundamental and practical importance in the development of personalized and precision nanomedicine.How to design a drug carrier that can specifically deliver drugs to tumors and other cell populations has long been a formidable challenge in clinical practice.With the development of nanotechnology,increasing effort has been dedicated to exploring the application of many nanoformulations in biology and medical science,such as nanoparticles,展开更多
基金supported by the National Key Research and Development Program of China (2017YFA0205201 and 2018YFA0107301)the National Natural Science Foundation of China (81422023, U1705281, and U1505221)+1 种基金the Fundamental Research Funds for the Central Universities (20720160065 and 20720150141)the Program for New Century Excellent Talents in University, China (NCET-13-0502)
文摘The nanoparticle-based treatment and diagnosis of cancer remain challenging in clinical translation, mainly due to the hurdles that can be associated with the development of targeted delivery, biological side effects, poor drug loading efficiency (DLE), and instability and so on [1,2].
基金This research was supported in part by the National Key Research and Development Program of China （No. 2016YFA0203600）, National Natural Science Foundation of China （Nos. 81571743, 51502251, and 81571707）, Fundamental Research Funds for Xiamen University （No. 20720160067） and Natural Science Foundation of Fujian Province （Nos. 2015J01519 and 2014Y2004）.
文摘Cancer is one of the major causes of human death. There are many types of cancer treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy. Combining different therapies can synergistically enhance the therapeutic effect. We developed porous hollow palladium nanoparticles （PHPdNPs） to co-deliver ^131I （a radioisotope that is commonly used in radiotherapy） and doxorubicin （DOX; a chemotherapy drug）. Compared with other mesoporous nanocarriers, our PHPdNPs exhibited impressive photothermal conversion efficiency and stability. Drug loading is high and drug release is controllable by repeated laser irradiation and acidic pH in tumor microenvironments. Owing to the specific interaction between palladium and iodine, the PHPdNPs serve as effective ^131I delivery vehicles with excellent radiochemical stability. A single dose of [^131I]PHPdNPs-DOX has superior antitumor efficacy because it enables a combination of chemo-, photothermal-, and radio-therapy. Moreover, the nanocomplex has no obvious side-effects in mice. Therefore, we believe that PHPdNPs are excellent candidates for multimodal imaging-guided therapy.
基金supported by the National Natural Science Foundation of China (11621505, 11435002, 31671016)
文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.
基金supported by the Major State Basic Research Development Program of China(2017YFA0205201,2014CB744503,and 2013CB733802)the National Natural Science Foundation of China(81422023,81371596,81571660,U1705281,and U1505221)
文摘Targeted drug delivery to the site of disease is of both fundamental and practical importance in the development of personalized and precision nanomedicine.How to design a drug carrier that can specifically deliver drugs to tumors and other cell populations has long been a formidable challenge in clinical practice.With the development of nanotechnology,increasing effort has been dedicated to exploring the application of many nanoformulations in biology and medical science,such as nanoparticles,
