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“Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone
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作者 Lei Shen Hongmei Liu +4 位作者 Ming Jin Jinchao Zhang Caixia Yin Shuxiang Wang Yutao Yang 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第10期360-363,共4页
Epilepsy,as a chronic neurological disease of the brain,is closely related to oxidative stress,and the peroxynitrite(ONOO-)significantly rise up in this event.Therefore,ONOO-is considered as a potential biomarker for ... Epilepsy,as a chronic neurological disease of the brain,is closely related to oxidative stress,and the peroxynitrite(ONOO-)significantly rise up in this event.Therefore,ONOO-is considered as a potential biomarker for early prediction of epilepsy.However,some potential diagnostic reagents for epilepsy are hindered by the blood-brain barrier(BBB).Meanwhile,“drug repurposing”is attracting a growing interest.Edaravone(EDA),as a first-line drug in the clinical treatment of cerebral ischemia,plays antioxidant roles in scavenging free radicals,promising potential antiepileptic activity.Thus,it is imperative to develop fluorescent probes for monitoring ONOO-fluctuations in the epileptic brain.Hence,we proposed a novel fluorescent probe with the thiocarbonate as the promising recognition unit for ONOO-and dicyanoisophorone derivative as the fluorophore.Moreover,by the“three-in-one”strategy,the introduction of trifluoromethyl into DCI-ONOO-3 can extend the emission wavelength of the fluorophore,shorten the response and increase lipophilicity.Consequently,DCI-ONOO-3 was used for monitoring ONOO-fluxes in brain of epileptic mice and evaluating the antiepileptic efficacy of EDA.It opens up a new way for the design of BBB permeable fluorescent probes,and provides a convincing new method for the diagnosis and treatment of epilepsy. 展开更多
关键词 Fluorescent probe Blood-brain barrier PEROXYNITRITE EPILEPSY Drug repurposing
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The p38/MAPK pathway as a therapeutic target to prevent therapeutic escape of breast cancer stem cells
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作者 Weixiao Yan Xiaotong Wang +7 位作者 Wenjing Wang Qi Guo Na Huang Hao Chen Xing-Jie Liang Yu Han Dandan Liu Jinchao Zhang 《Science China(Life Sciences)》 SCIE CAS CSCD 2024年第9期1867-1880,共14页
Cancer stem cells(CSCs)play an important role in metastasis development,tumor recurrence,and treatment resistance,and are essential for the eradication of cancer.Currently,therapies fail to eradicate CSCs due to their... Cancer stem cells(CSCs)play an important role in metastasis development,tumor recurrence,and treatment resistance,and are essential for the eradication of cancer.Currently,therapies fail to eradicate CSCs due to their therapeutic stress-induced cellular escape,which leads to enhanced aggressive behaviors compared with CSCs that have never been treated.However,the underlying mechanisms regulating the therapeutic escape remain unknown.To this end,we established a model to isolate the therapeutic escaped CSCs(TSCSCs)from breast CSCs and performed the transcription profile to reveal the mechanism.Mechanistically,we demonstrated that the behavior of therapeutic escape was regulated through the p38/MAPK signaling pathway,resulting in TSCSCs exhibiting enhanced motility and metastasis.Notably,blocking the p38/MAPK signaling pathway effectively reduced motility and metastasis ability both in vitro and in vivo,which were further supported by downregulated motility-related genes and epithelial-mesenchymal transition(EMT)-related proteins vimentin and N-cadherin.The obtained findings reveal the p38/MAPK pathway as a potential therapeutic target for TSCSCs and would provide profound implications for cancer therapy. 展开更多
关键词 therapeutic escape breast cancer stem cells MOTILITY p38/MAPK signaling pathway molecular mechanism
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Z-scheme Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)heterojunctions enable exceptional visible photocatalytic degradation of organic pollutant
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作者 Feng Huang Muhammad Humayun +6 位作者 Gang Li Ting-Ting Fan Wen-Lin Wang Yu-Lin Cao Anton Nikiforov Chun-Dong Wang Jing Wang 《Rare Metals》 SCIE EI CAS CSCD 2024年第7期3161-3172,共12页
One key strategy to enhance photocatalytic performance is to improve the transfer and separation efficiency of photogenerated carriers by building optimized heterojunctions.Herein,novel Bi_(4)O_5Br_(2)/NH_(2)-MIL-125(... One key strategy to enhance photocatalytic performance is to improve the transfer and separation efficiency of photogenerated carriers by building optimized heterojunctions.Herein,novel Bi_(4)O_5Br_(2)/NH_(2)-MIL-125(Ti)Z-scheme heterojunctions are fabricated and used as photocatalysts for organic pollutant photodegradation.The NH_(2)-MIL-125(Ti)nanosheets are exfoliated via a self-developed alkali solution stripping approach and then uniformly decorated on Bi_(4)O_(5)Br_(2).The as-prepared Bi_(4)O_(5)Br_(2)/NH_(2)-MIL-125(Ti)presents more than 90%degradation of various pollutants,outperforming the counterpart individual ones.The various characterization results suggest that the enhanced degradation rate is due to the more intimate face-to-face interfacial contact of the lamellar Z-scheme heterojunction materials,in which the migration path of carriers from the material's interior to the surface can be reduced,in turn enhancing migration efficiency and separation capability significantly.A possible photocatalytic reaction mechanism is proposed based on the photoelectric behaviors,radical trapping experiments and liquid chromatography mass spectrometry analysis.This work promotes the development of new photocatalytic materials for heterojunctions with face-to-face interfacial contacts,as well as the effective purification of wastewater in environmental remediation. 展开更多
关键词 Z-scheme heterojunctions Photocatalysis Alkaline solution stripping Bi_(4)O_(5)Br_(2) NH_(2)-MIL-125(Ti)
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Heterogeneous Catalysis with Metal-Containing Crystalline Porous Materials:Element-and Site-Specific Insights
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作者 Yan Li Andrew G.Walsh +1 位作者 Peng Zhang Tianjun Zhang 《CCS Chemistry》 CSCD 2024年第5期1110-1129,共20页
Metal-containing crystalline porous materials(CPMs)are gaining popularity in heterogeneous catalysis because of their highly crystalline and porous systems,and their excellent chemical tunability.Modification of the m... Metal-containing crystalline porous materials(CPMs)are gaining popularity in heterogeneous catalysis because of their highly crystalline and porous systems,and their excellent chemical tunability.Modification of the metal species and framework structure permits them to have greater activity,selectivity,and stability over other materials.An in-depth understanding of the complex nature of metal active sites in CPMs is essential for revealing the structure-performance relationships and directing the rational design of such catalysts.Compared to conventional characterization techniques,the rapid development of X-ray absorption spectroscopy(XAS)has provided element-and site-specific deep insights into the electronic and structural information of metal species in CPMs.As such,this review begins by summarizing novel XAS techniques and analysis methods in accurately obtaining such data.Next,the combination of XAS with other high-level characterization methods into disclosing the configuration of active sites in metalcontaining CPMs is presented.Then,the utilization of theory-assisted XAS data analysis in examining complex metal-containing CPM catalysts is discussed.Afterwards,advanced in-situ/operando XAS studies into revealing the working sites in metal-containing CPMs under catalytic conditions are highlighted.We conclude by outlining the future challenges and prospects of XAS measurements,data analyses,and in-situ/operando setups in advancing the study of metal-in-CPM catalysts. 展开更多
关键词 X-ray absorption spectroscopy IN-SITU metal species crystalline porous materials heterogeneous catalysis
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ZnGa_(2)S_(4):an infrared nonlinear optical material with large second-harmonic generation response and wide band gap
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作者 Chen-Yang Zhang Xiao-Nan Niu +5 位作者 Yan-Feng Wei Shu-Xing Zhou Da-Qing Yang Ying Wang Jian Wang Bing-Bing Zhang 《Rare Metals》 SCIE EI CAS CSCD 2024年第1期395-401,共7页
High-performance nonlinear optical(NLO)crystals are crucial devices to convert wavelength of solid-state lasers.Chalcogenides play an indispensable role in the research of infrared NLO materials.In this work,ternary c... High-performance nonlinear optical(NLO)crystals are crucial devices to convert wavelength of solid-state lasers.Chalcogenides play an indispensable role in the research of infrared NLO materials.In this work,ternary chalcogenide ZnGa_(2)S_(4) with defect diamond-like structure was screened out and synthesized by chemical vapor transport method. 展开更多
关键词 OPTICAL NONLINEAR HARMONIC
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Tailoring therapeutics via a systematic beneficial elements comparison between photosynthetic bacteria-derived OMVs and extruded nanovesicles
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作者 Tingshan Xiao Yichuan Ma +9 位作者 Ziyang Zhang Yixin Zhang Yu Zhao Xiaohan Zhou Xueyi Wang Kun Ge Junshu Guo Jinchao Zhang Zhenhua Li Huifang Liu 《Bioactive Materials》 SCIE 2024年第6期48-61,共14页
Photosynthetic bacteria(PSB)has shown significant potential as a drug or drug delivery system owing to their photothermal capabilities and antioxidant properties.Nevertheless,the actualization of their potential is im... Photosynthetic bacteria(PSB)has shown significant potential as a drug or drug delivery system owing to their photothermal capabilities and antioxidant properties.Nevertheless,the actualization of their potential is impeded by inherent constraints,including their considerable size,heightened immunogenicity and compromised biosafety.Conquering these obstacles and pursuing more effective solutions remains a top priority.Similar to extracellular vesicles,bacterial outer membrane vesicles(OMVs)have demonstrated a great potential in biomedical applications.OMVs from PSB encapsulate a rich array of bioactive constituents,including proteins,nucleic acids,and lipids inherited from their parent cells.Consequently,they emerge as a promising and practical alternative.Unfortunately,OMVs have suffered from low yield and inconsistent particle sizes.In response,bacteria-derived nanovesicles(BNVs),created through controlled extrusion,adeptly overcome the challenges associated with OMVs.However,the differences,both in composition and subsequent biological effects,between OMVs and BNVs remain enigmatic.In a groundbreaking endeavor,our study meticulously cultivates PSB-derived OMVs and BNVs,dissecting their nuances.Despite minimal differences in morphology and size between PSB-derived OMVs and BNVs,the latter contains a higher concentration of active ingredients and metabolites.Particularly noteworthy is the elevated levels of lysophosphatidylcholine(LPC)found in BNVs,known for its ability to enhance cell proliferation and initiate downstream signaling pathways that promote angiogenesis and epithelialization.Importantly,our results indicate that BNVs can accelerate wound closure more effectively by orchestrating a harmonious balance of cell proliferation and migration within NIH-3T3 cells,while also activating the EGFR/AKT/PI3K pathway.In contrast,OMVs have a pronounced aptitude in anti-cancer efforts,driving macrophages toward the M1 phenotype and promoting the release of inflammatory cytokines.Thus,our findings not only provide a promising methodological framework but also establish a definitive criterion for discerning the optimal application of OMVs and BNVs in addressing a wide range of medical conditions. 展开更多
关键词 Photosynthetic bacteria Outer membrane vesicles Bacteria-derived nanovesicles Antitumor Lysophosphatidylcholine
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Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO_(2) as gatekeeper 被引量:1
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作者 Zhaoyang Wang Zekai Li +1 位作者 Yuehua Shi Leyong Zeng 《Regenerative Biomaterials》 SCIE EI CSCD 2023年第1期1566-1576,共11页
The non-specific leakage of drugs from nanocarriers seriously weakened the safety and efficacy of chemotherapy,and it was very critical of constructing tumor microenvironment(TME)-responsive delivery nanocarriers,achi... The non-specific leakage of drugs from nanocarriers seriously weakened the safety and efficacy of chemotherapy,and it was very critical of constructing tumor microenvironment(TME)-responsive delivery nanocarriers,achieving the modulation release of drugs.Herein,using manganese dioxide(MnO_(2))as gatekeeper,an intelligent nanoplatform based on mesoporous polydopamine(MPDA)was developed to deliver doxorubicin(DOX),by which the DOX release was precisely controlled,and simultaneously the photothermal therapy(PTT)and chemodynamic therapy(CDT)were realized.In normal physiological environment,the stable MnO_(2)shell effectively avoided the leakage of DOX.However,in TME,the overexpressed glutathione(GSH)degraded MnO_(2)shell,which caused the DOX release.Moreover,the photothermal effect of MPDA and the Fenton-like reaction of the generated Mn^(2+)further accelerated the cell death.Thus,the developed MPDA-DOX@MnO_(2)nanoplatform can intelligently modulate the release of DOX,and the combined CDT/PTT/chemotherapy possessed high-safety and high-efficacy against tumors. 展开更多
关键词 mesoporous polydopamine MnO_(2)gatekeeper chemotherapy photothermal therapy chemodynamic therapy
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