Successful reproduction in mammals requires gamete development,fertilization,and early embryonic development.Defects in any of these processes can lead to infertility,recurrent miscarriages,and congenital defects.The ...Successful reproduction in mammals requires gamete development,fertilization,and early embryonic development.Defects in any of these processes can lead to infertility,recurrent miscarriages,and congenital defects.The clinical recognition of the genetic causes of female reproductive insufficiency using increasingly advanced genetic technologies poses a serious challenge for reproductive medicine in the 21st century.Herein,the current literature on genetic factors involved in reproductive losses was summarized.A literature search was conducted using Web of Science,MEDLINE,and PubMed databases for articles written in English on the genetic causes of women’s reproductive health disorders.Future implementation of whole-exome and wholegenome sequencing is expected to identify numerous genetic factors responsible for oocyte quality.Which will aid in increasing the likelihood of successful female reproductive function,improve the outcomes of assisted reproductive technologies,optimize treatment,and facilitate genetic diagnosis of patients.展开更多
基金supported by Project No.15.BRK.21.008 Multicenter Research Bioresource Collection“Human Reproductive Health”(Agreement No.075-15-2021-1058 dated September 28,2021)funded by the Ministry of Science and Higher Education of the Russian Federation.
文摘Successful reproduction in mammals requires gamete development,fertilization,and early embryonic development.Defects in any of these processes can lead to infertility,recurrent miscarriages,and congenital defects.The clinical recognition of the genetic causes of female reproductive insufficiency using increasingly advanced genetic technologies poses a serious challenge for reproductive medicine in the 21st century.Herein,the current literature on genetic factors involved in reproductive losses was summarized.A literature search was conducted using Web of Science,MEDLINE,and PubMed databases for articles written in English on the genetic causes of women’s reproductive health disorders.Future implementation of whole-exome and wholegenome sequencing is expected to identify numerous genetic factors responsible for oocyte quality.Which will aid in increasing the likelihood of successful female reproductive function,improve the outcomes of assisted reproductive technologies,optimize treatment,and facilitate genetic diagnosis of patients.
