We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 B.Exoplanet candidates...We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 B.Exoplanet candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium apertures.The analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period targets.TOI-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric data.We measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 B is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).展开更多
During the COVID-19 pandemic,a multitude of narratives saturated the print,audiovisual,and electronic media.Improvised,uninformed,apocalyptic and voluntarist approaches abounded.These notes-written during the pandemic...During the COVID-19 pandemic,a multitude of narratives saturated the print,audiovisual,and electronic media.Improvised,uninformed,apocalyptic and voluntarist approaches abounded.These notes-written during the pandemic and delivered in the conference series-address the proliferation of such discourses,emphasizing a series of issues.First,the widespread ignorance about the history of epidemics.Then,the inability to deal with the uncertainties that reign during pandemic times,as well as the announcements that this extraordinary health/sanitary event would produce a profound watershed in all walks of life and in all corners of the world.Finally,and against the general assertion that“one learns from the past to understand the present,”these notes seek to point out how the present can illuminate the study of the past-or,more personally,what I think I have learned as a historian in the times of the COVID-19 pandemic.展开更多
The globalization of Chinese medicine, forged through successive waves of migration, cultural exchanges, and economic imperatives, constitutes a nuanced and intricate process with historical roots extending over mille...The globalization of Chinese medicine, forged through successive waves of migration, cultural exchanges, and economic imperatives, constitutes a nuanced and intricate process with historical roots extending over millennia. It stands as the culmination of interconnected historical events that reverberated beyond the confines of China, emerging as a phenomenon characterized by the adjustment of Chinese medical theories, clinical practices, and materia medica to indigenous customs and healthcare traditions prevalent in both proximate and distant regions. In these glocalized processes, the global and the local intersect and mix. The frameworks of globalization and glocalization allow a critical interpretation of the many hybridizations that have shaped overseas Chinese medicine's history and present.展开更多
We examine the validity of the ACDM model and probe the dynamics of dark energy with the latest astronomical observations. Using the Ore（z） diagnosis, we find that various kinds of observational data are in tension ...We examine the validity of the ACDM model and probe the dynamics of dark energy with the latest astronomical observations. Using the Ore（z） diagnosis, we find that various kinds of observational data are in tension within the ACDM framework. We then allow for dynamics of dark energy and investigate the constraint on dark energy parameters. We find that for two different kinds of parametri- sations of the equation of state parameter w, a combination of current data mildly favours an evolving w, although the significance is not sufficient for it to be supported by Bayesian evidence. A forecast of the DESI survey shows that the dynamics of dark energy could be detected at the 7σ confidence level and would be decisively supported by Bayesian evidence, if the best-fit model of w derived from current data is the true model.展开更多
We examined historical and ecological factors affecting current primate biodiversity in Southeast Asia.In Africa,Madagascar and South America,but not Southeast Asia,primate species richness is positively associated wi...We examined historical and ecological factors affecting current primate biodiversity in Southeast Asia.In Africa,Madagascar and South America,but not Southeast Asia,primate species richness is positively associated with average rainfall and distance from the equator(latitude).We predicted that Southeast Asia’s non-conformance may be due to the effect of dispersed Pleistocene refuges(locations of constricted tropical forests during glacial maxima which today are at least 305 m in altitude).Based on 45 forested sites(13 on large islands;32 on the mainland)of at least 100 km^(2) to minimize recent human impact,we determined correlations between extant primate species richness and rainfall,latitude and supplementary ecological variables,while controlling for refuges and islands.We found that refuge sites had significantly higher primate species richness than non-refuges(t=-2.76,P<0.05),and distance from the nearest Pleistocene refuge was negatively correlated with species richness for non-refuge sites(r=-0.51,P<0.05).There was no difference in species richness between sites on large islands and the mainland(t=-1.4,P=0.16).The expected positive relationship between rainfall and species richness was not found(r=0.17,P=0.28).As predicted,primate species richness was negatively correlated with latitude(r=-0.39,P<0.05)and positively correlated with mean temperature(r=0.45,P<0.05).General linear models indicated that a site’s latitude(F_(1,38)=6.18,P<0.05)and Pleistocene refuge classification(F_(1,42)=5.96,P<0.05)were the best predictors of species richness.Both ecological and historical factors contribute to present day primate species richness in Southeast Asia,making its biodiversity less of an outlier than previously believed.展开更多
Background:α–synuclein(α–syn)is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease(PD)and certain other neurodegenerative disorders.Recent studies have ...Background:α–synuclein(α–syn)is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease(PD)and certain other neurodegenerative disorders.Recent studies have explored the ability ofα–syn to propagate between or across neighboring neurons and supposedly“infect”them with a prion–like mechanism.However,much of this research has used stereotaxic injections of heterologousα–syn fibrils to induce the spreading of inclusions in the rodent brains.Whetherα–syn is able to transmit from the host cells to their neighboring cells in vivo is unclear.Methods:Using immunestaining,we examined the potential propagation ofα–syn into nigrostriatal dopaminergic(DA)neurons in three lines of transgenic mice that overexpress human wild–typeα–syn(hα–syn)in different neuron populations.Results:After testing for three different routes by which hα–syn propagation might occur,we were unable to find any evidence that hα–syn behaved like a prion and could be transmitted overtime into the DA neurons initially lack of hα–syn expression.Conclusions:In transgenic mice hα–syn does not have the ability to propagate at pathologically significant levels between or across neurons.It must be noted that these observations do not disprove the studies that show its prion–like qualities,but rather that propagation is not detectable in transgenic models that do not use any injections of heterologous proteins or viral vectors to induce a spreading state.展开更多
基金supported by National Natural Science Foundation of China(NSFC,Grant Nos.U1831209 and U2031144)the research fund of Ankara University(BAP)through the project 18A0759001。
文摘We report the confirmation of a sub-Saturn-size exoplanet,TOI-1194 b,with a mass of about 0.456+0.055-0.051M_(J),and a very low mass companion star with a mass of about 96.5±1.5 MJ,TOI-1251 B.Exoplanet candidates provided by the Transiting Exoplanet Survey Satellite(TESS)are suitable for further follow-up observations by ground-based telescopes with small and medium apertures.The analysis is performed based on data from several telescopes worldwide,including telescopes in the Sino-German multiband photometric campaign,which aimed at confirming TESS Objects of Interest(TOIs)using ground-based small-aperture and medium-aperture telescopes,especially for long-period targets.TOI-1194 b is confirmed based on the consistent periodic transit depths from the multiband photometric data.We measure an orbital period of 2.310644±0.000001 days,the radius is 0.767+0.045-0.041RJ and the amplitude of the RV curve is 69.4_(-7.3)^(+7.9)m s^(-1).TOI-1251 B is confirmed based on the multiband photometric and high-resolution spectroscopic data,whose orbital period is 5.963054+0.000002-0.000001days,radius is 0.947+0.035-0.033 R_(J) and amplitude of the RV curve is 9849_(-40)^(+42)ms^(-1).
文摘During the COVID-19 pandemic,a multitude of narratives saturated the print,audiovisual,and electronic media.Improvised,uninformed,apocalyptic and voluntarist approaches abounded.These notes-written during the pandemic and delivered in the conference series-address the proliferation of such discourses,emphasizing a series of issues.First,the widespread ignorance about the history of epidemics.Then,the inability to deal with the uncertainties that reign during pandemic times,as well as the announcements that this extraordinary health/sanitary event would produce a profound watershed in all walks of life and in all corners of the world.Finally,and against the general assertion that“one learns from the past to understand the present,”these notes seek to point out how the present can illuminate the study of the past-or,more personally,what I think I have learned as a historian in the times of the COVID-19 pandemic.
文摘The globalization of Chinese medicine, forged through successive waves of migration, cultural exchanges, and economic imperatives, constitutes a nuanced and intricate process with historical roots extending over millennia. It stands as the culmination of interconnected historical events that reverberated beyond the confines of China, emerging as a phenomenon characterized by the adjustment of Chinese medical theories, clinical practices, and materia medica to indigenous customs and healthcare traditions prevalent in both proximate and distant regions. In these glocalized processes, the global and the local intersect and mix. The frameworks of globalization and glocalization allow a critical interpretation of the many hybridizations that have shaped overseas Chinese medicine's history and present.
基金supported by the National Natural Science Foundation of China(Grant No.11673025)a Key International Collaboration Grant from the Chinese Academy of SciencesGBZ is also supported by a Royal Society Newton Advanced Fellowship
文摘We examine the validity of the ACDM model and probe the dynamics of dark energy with the latest astronomical observations. Using the Ore（z） diagnosis, we find that various kinds of observational data are in tension within the ACDM framework. We then allow for dynamics of dark energy and investigate the constraint on dark energy parameters. We find that for two different kinds of parametri- sations of the equation of state parameter w, a combination of current data mildly favours an evolving w, although the significance is not sufficient for it to be supported by Bayesian evidence. A forecast of the DESI survey shows that the dynamics of dark energy could be detected at the 7σ confidence level and would be decisively supported by Bayesian evidence, if the best-fit model of w derived from current data is the true model.
文摘We examined historical and ecological factors affecting current primate biodiversity in Southeast Asia.In Africa,Madagascar and South America,but not Southeast Asia,primate species richness is positively associated with average rainfall and distance from the equator(latitude).We predicted that Southeast Asia’s non-conformance may be due to the effect of dispersed Pleistocene refuges(locations of constricted tropical forests during glacial maxima which today are at least 305 m in altitude).Based on 45 forested sites(13 on large islands;32 on the mainland)of at least 100 km^(2) to minimize recent human impact,we determined correlations between extant primate species richness and rainfall,latitude and supplementary ecological variables,while controlling for refuges and islands.We found that refuge sites had significantly higher primate species richness than non-refuges(t=-2.76,P<0.05),and distance from the nearest Pleistocene refuge was negatively correlated with species richness for non-refuge sites(r=-0.51,P<0.05).There was no difference in species richness between sites on large islands and the mainland(t=-1.4,P=0.16).The expected positive relationship between rainfall and species richness was not found(r=0.17,P=0.28).As predicted,primate species richness was negatively correlated with latitude(r=-0.39,P<0.05)and positively correlated with mean temperature(r=0.45,P<0.05).General linear models indicated that a site’s latitude(F_(1,38)=6.18,P<0.05)and Pleistocene refuge classification(F_(1,42)=5.96,P<0.05)were the best predictors of species richness.Both ecological and historical factors contribute to present day primate species richness in Southeast Asia,making its biodiversity less of an outlier than previously believed.
基金the intramural research program of National Institute on Aging(HC:AG-000928,929).
文摘Background:α–synuclein(α–syn)is the main component of intracytoplasmic inclusions deposited in the brains of patients with Parkinson’s disease(PD)and certain other neurodegenerative disorders.Recent studies have explored the ability ofα–syn to propagate between or across neighboring neurons and supposedly“infect”them with a prion–like mechanism.However,much of this research has used stereotaxic injections of heterologousα–syn fibrils to induce the spreading of inclusions in the rodent brains.Whetherα–syn is able to transmit from the host cells to their neighboring cells in vivo is unclear.Methods:Using immunestaining,we examined the potential propagation ofα–syn into nigrostriatal dopaminergic(DA)neurons in three lines of transgenic mice that overexpress human wild–typeα–syn(hα–syn)in different neuron populations.Results:After testing for three different routes by which hα–syn propagation might occur,we were unable to find any evidence that hα–syn behaved like a prion and could be transmitted overtime into the DA neurons initially lack of hα–syn expression.Conclusions:In transgenic mice hα–syn does not have the ability to propagate at pathologically significant levels between or across neurons.It must be noted that these observations do not disprove the studies that show its prion–like qualities,but rather that propagation is not detectable in transgenic models that do not use any injections of heterologous proteins or viral vectors to induce a spreading state.
