One marine natural compound, anhydrofusarubin, was isolated from the endophytic fungus No. B77 from the mangrove tree on the South China Sea coast. It was the first time that such a compound was isolated from marine f...One marine natural compound, anhydrofusarubin, was isolated from the endophytic fungus No. B77 from the mangrove tree on the South China Sea coast. It was the first time that such a compound was isolated from marine fungus. The structure was identified by NMR data and mass spectrometry (MS). In addition, its structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1^- with a = 8.3185(15), b = 12.397(2), c = 13.767(3) A, α = 65.692(3), β = 79.266(3), γ= 75.692(3)°, C15H12O6, Mr= 288.24, V = 1248.0(4) A^3, Z = 4, Dc = 1.534 g/cm^3, F(000) = 600, μ = 0.120 mm^-1, the final R = 0.0459 and wR = 0.1184 for 5360 observed reflections (I 〉 2σ(I)). In the primary bioassay, the title compound shows strong inhibitory activity against Gram-positive bacteria Staphyococcus aureus (ATCC27154) with the MIC value of 12.5 μg/mL.展开更多
The crystal structure of the new title compound 3-(4-chlorophenyl)-8-cyano-2-(di-iso-propylamino)-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidine-4(3H)-one(C22H24ClN5OS,Mr = 441.97)has been determined by sin...The crystal structure of the new title compound 3-(4-chlorophenyl)-8-cyano-2-(di-iso-propylamino)-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidine-4(3H)-one(C22H24ClN5OS,Mr = 441.97)has been determined by single-crystal X-ray diffraction. The crystal is of orthorhombic,space group Pna21 with a = 7.6721(5),b = 18.9370(11),c = 15.6260(9)A,V = 2270.2(2)A^3,Z = 4,Dc = 1.293 g/cm^3,F(000)= 928,μ = 0.283 mm^-1,MoKa radiation(λ = 0.71073 A),R = 0.0494 and wR = 0.1062 for 3278 observed reflections with I 〉 2σ(I). X-ray diffraction analysis reveals that all ring atoms in the py-ridopyrimidinone moiety are almost coplanar. Intramolecular C(20)-H(20)···N(4),C(19)-H(19A)···N(3),C(18)-H(18C)···N(3)and C(16)-H(16B)···O(5)hydrogen bonds together with weak C···π interactions are found in the structure.展开更多
Sulfonylurea(SU) has become one class of the most important herbicides worldwide due to their ultralow application rate and mammalian toxicity. Recently application licenses of 3 classical SU herbicides chlorsulfuro...Sulfonylurea(SU) has become one class of the most important herbicides worldwide due to their ultralow application rate and mammalian toxicity. Recently application licenses of 3 classical SU herbicides chlorsulfuron, metsulfuron-methyl and ethametsulfuron were suspended due to their undesirable long persistence which is incompatible with the particular rotation planting system in China. Our previous study has discovered that electron-donating groups, especially dimethylamino and diethylamino substituents, on the 5 th position of the benzene ring in chlorsulfuron, greatly accelerated its degradation rate in an acidic soil(p H 5.41). Owing to the natural slower degradation of SUs in alkaline soil,dimethylamino and diethylamino substituted chlorsulfuron Ia and Ib were further studied in an alkaline soil(p H 8.46) with chlorsulfuron as a control. The experimental data indicated that the half-life of degradation(DT50) of Ia was 3.36 days while Ib was 6.25 days which amounted to 30 and 15 folds faster than chlorsulfuron(DT5084.53 days), respectively. The research confirmed that our newly-designed structures Ia and Ib can hasten their degradation rate in alkaline soil as well as in acidic soil. This structural modification of the classical SU provided an opportunity to control the degradation rate to reduce their impact on relevant environment and ecology.展开更多
One new sorbicillin derivative, 2-deoxy-sohirnone C(1), one new diketopiperazine alkaloid, 5 S-hydroxynorvalineS-Ile(2), and two naturally occurring diketopiperazines, 3 S-hydroxylcyclo(S-Pro-S-Phe)(3) and cyclo(S-Phe...One new sorbicillin derivative, 2-deoxy-sohirnone C(1), one new diketopiperazine alkaloid, 5 S-hydroxynorvalineS-Ile(2), and two naturally occurring diketopiperazines, 3 S-hydroxylcyclo(S-Pro-S-Phe)(3) and cyclo(S-Phe-S-Gln)(4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 μg·m L^(-1).展开更多
Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene(1), 8,10,13(15)Z,16 E-lobatetraene(2) and 19-...Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene(1), 8,10,13(15)Z,16 E-lobatetraene(2) and 19-hydroxy-lobatetraene(3), and a new natural compound, 17,18-epoxyloba-16-acetoxy-8,10,13(15)-trien(4), co-occurring with a known related diterpenoid, 18-methoxyloba-8,10,13(15),16(17)-tetraene(5), were isolated from the South China Sea soft coral Sinularia polydactyla. The structures of new compounds were determined by extensive spectroscopic analysis and by comparison with those reported in the literature. In bioassay, all the isolates were inactive on antibacterial, PTP1 B inhibitory, and immunological activities. This study increased the chemical diversity of marine diterpenoids.展开更多
Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),w...Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),were isolated from the South China Sea sponge Neopetrosia chaliniformis.展开更多
Pymetrozine is a selective insecticide with a unique chemical structure and mode to control hemipteran and homopteran. While pymetrozine has brought great benefits to crop production by killing insects, its residues i...Pymetrozine is a selective insecticide with a unique chemical structure and mode to control hemipteran and homopteran. While pymetrozine has brought great benefits to crop production by killing insects, its residues in soil may have a detrimental effect on environment. Therefore, it is of great importance to investigate its behaviors in soil. In this study, the sorption and desorption of pymetrozine on six Chinese soils were investigated using a batch equilibrium approach to understand its mobile behavior in the soils. Both sorption and desorption isotherms ofpymetrozine were in good agreement with the Freundlich model. The sorption coefficient KF varied between 3.37 and 58.32 mL. g-1 and the sorption isotherms were nonlinear, with 1/n ranging from 0.57 to 0.91. A regression equation was proposed to predict the solption of pymetrozine on six different soil samples: log KF = 4.3708 - 4.5709 × log (pH in 0.01mol·L-1 CaC12) + 0.4700 × log OC% + 0.0057 × sand (%) + 0.0022 × CEC(clay), with R2 = 0.9982. The organic carbon content of soil positively affected the sorption ofpymetrozine, but soil pH had a negative effect on the sorption. Additionally, effects of CaC12 concentration, soil to solution ratio and pesticide form were investigated. The sorption was promoted with an increase in soil to solution ratio and a decrease in CaC12 concentration. The possible variation of the five formulated products of pymetrozine was also investigated.展开更多
基金the 863 Foundation of China (2003AA624010) Doctoral Startup Fund of Ocean University of China (1404-82421036),and Syngenta limited in UK
文摘One marine natural compound, anhydrofusarubin, was isolated from the endophytic fungus No. B77 from the mangrove tree on the South China Sea coast. It was the first time that such a compound was isolated from marine fungus. The structure was identified by NMR data and mass spectrometry (MS). In addition, its structure was determined by single-crystal X-ray diffraction analysis. It crystallizes in triclinic, space group P1^- with a = 8.3185(15), b = 12.397(2), c = 13.767(3) A, α = 65.692(3), β = 79.266(3), γ= 75.692(3)°, C15H12O6, Mr= 288.24, V = 1248.0(4) A^3, Z = 4, Dc = 1.534 g/cm^3, F(000) = 600, μ = 0.120 mm^-1, the final R = 0.0459 and wR = 0.1184 for 5360 observed reflections (I 〉 2σ(I)). In the primary bioassay, the title compound shows strong inhibitory activity against Gram-positive bacteria Staphyococcus aureus (ATCC27154) with the MIC value of 12.5 μg/mL.
基金supported by the National Natural Science Foundation of China for OutstandingYoung Scientists(No.30525032)Syngenta Postgraduate Fellowship(No.SPF-008)
基金supported by the National Key Project for Basic Research (2010CB126100)National Natural Science Foundation of China (20772042)Syngenta Ltd in UK and supported in part by the PCSIRT (No.IRT0953)
文摘The crystal structure of the new title compound 3-(4-chlorophenyl)-8-cyano-2-(di-iso-propylamino)-5-methyl-7-(methylthio)-pyrido[4,3-d]pyrimidine-4(3H)-one(C22H24ClN5OS,Mr = 441.97)has been determined by single-crystal X-ray diffraction. The crystal is of orthorhombic,space group Pna21 with a = 7.6721(5),b = 18.9370(11),c = 15.6260(9)A,V = 2270.2(2)A^3,Z = 4,Dc = 1.293 g/cm^3,F(000)= 928,μ = 0.283 mm^-1,MoKa radiation(λ = 0.71073 A),R = 0.0494 and wR = 0.1062 for 3278 observed reflections with I 〉 2σ(I). X-ray diffraction analysis reveals that all ring atoms in the py-ridopyrimidinone moiety are almost coplanar. Intramolecular C(20)-H(20)···N(4),C(19)-H(19A)···N(3),C(18)-H(18C)···N(3)and C(16)-H(16B)···O(5)hydrogen bonds together with weak C···π interactions are found in the structure.
基金supported by the National Natural Science Foundation of China (No. 21272129)the State Key Laboratory of Elemento-Organic Chemistry (Nankai University)+1 种基金Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)Syngenta PhD Scholarship
文摘Sulfonylurea(SU) has become one class of the most important herbicides worldwide due to their ultralow application rate and mammalian toxicity. Recently application licenses of 3 classical SU herbicides chlorsulfuron, metsulfuron-methyl and ethametsulfuron were suspended due to their undesirable long persistence which is incompatible with the particular rotation planting system in China. Our previous study has discovered that electron-donating groups, especially dimethylamino and diethylamino substituents, on the 5 th position of the benzene ring in chlorsulfuron, greatly accelerated its degradation rate in an acidic soil(p H 5.41). Owing to the natural slower degradation of SUs in alkaline soil,dimethylamino and diethylamino substituted chlorsulfuron Ia and Ib were further studied in an alkaline soil(p H 8.46) with chlorsulfuron as a control. The experimental data indicated that the half-life of degradation(DT50) of Ia was 3.36 days while Ib was 6.25 days which amounted to 30 and 15 folds faster than chlorsulfuron(DT5084.53 days), respectively. The research confirmed that our newly-designed structures Ia and Ib can hasten their degradation rate in alkaline soil as well as in acidic soil. This structural modification of the classical SU provided an opportunity to control the degradation rate to reduce their impact on relevant environment and ecology.
基金Project supported by the National Natural Science Foundation of China(No.81973460)the Foundation of Science and Technology Department of Sichuan Province(No.2018JY0186)the Xinglin Scholar Research Promotion Project of Chengdu University of Traditional Chinese Medicine(No.BSH2018008)。
基金supported by the Natural Science Foundation of China(No.81520108028)SCTSM Projects(Nos.14431901100 and 15431901000)the SKLDR/SIMM Project(No.SIMM1501ZZ-03)
文摘One new sorbicillin derivative, 2-deoxy-sohirnone C(1), one new diketopiperazine alkaloid, 5 S-hydroxynorvalineS-Ile(2), and two naturally occurring diketopiperazines, 3 S-hydroxylcyclo(S-Pro-S-Phe)(3) and cyclo(S-Phe-S-Gln)(4), together with three known compounds were isolated from the Chinese mangrove endophytic fungus Penicillium sp. GD6. Their structures were determined on the basis of extensive spectroscopic analyses and by comparison with literature data. The absolute configuration of 3-hydroxyl moiety in 3 was determined by Mosher's method, while the absolute stereochemistry of 2 and 4 was established by comparison with the CD spectra of natural and synthesized diketopiperazines. Compound 1 showed moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus with a MIC value of 80 μg·m L^(-1).
基金supported by the National Key Research and Development Program of China (No. 2018YFC-0310903)the Natural Science Foundation of China (Nos. 81991521+6 种基金21672230and 81520108028)the NSFC/CNRS Joint Project (No.81811530284)the SKLDR/SIMM Project (No. SIMM1903ZZ-04)Shanghai Rising-Star Program (No. 20QA1411100)SA-SIBS Scholarship ProgramSyngenta-SIMM-Ph D Studentship Project。
文摘Lobane-type diterpenoids are not frequently discovered from marine soft corals. In this paper, three new lobane type diterpenes, 13-methoxyloba-8,10,15(16),17(18)-tetraene(1), 8,10,13(15)Z,16 E-lobatetraene(2) and 19-hydroxy-lobatetraene(3), and a new natural compound, 17,18-epoxyloba-16-acetoxy-8,10,13(15)-trien(4), co-occurring with a known related diterpenoid, 18-methoxyloba-8,10,13(15),16(17)-tetraene(5), were isolated from the South China Sea soft coral Sinularia polydactyla. The structures of new compounds were determined by extensive spectroscopic analysis and by comparison with those reported in the literature. In bioassay, all the isolates were inactive on antibacterial, PTP1 B inhibitory, and immunological activities. This study increased the chemical diversity of marine diterpenoids.
基金This research work was financially supported by the National Natural Science Foundation of China(Nos.81991521,82022069,42076099,41830535)the Shanghai Rising-Star Program(No.20QA1411100)+1 种基金the National Key Research and Development Program of China(No.2018YFC0310903)the Taishan Scholars Program,China.Bao Chen is thankful for the financial support of Syngenta-OUC-PhD Studentship Project.
文摘Main observation and conclusion Two new bis-quinolizidine alkaloids,neopetrosiasins A(1)and B(2),possessing cis-and trans-quinolizidine nuclei,one known related analogue petrosin(3)and three known xestospongins(4-6),were isolated from the South China Sea sponge Neopetrosia chaliniformis.
文摘Pymetrozine is a selective insecticide with a unique chemical structure and mode to control hemipteran and homopteran. While pymetrozine has brought great benefits to crop production by killing insects, its residues in soil may have a detrimental effect on environment. Therefore, it is of great importance to investigate its behaviors in soil. In this study, the sorption and desorption of pymetrozine on six Chinese soils were investigated using a batch equilibrium approach to understand its mobile behavior in the soils. Both sorption and desorption isotherms ofpymetrozine were in good agreement with the Freundlich model. The sorption coefficient KF varied between 3.37 and 58.32 mL. g-1 and the sorption isotherms were nonlinear, with 1/n ranging from 0.57 to 0.91. A regression equation was proposed to predict the solption of pymetrozine on six different soil samples: log KF = 4.3708 - 4.5709 × log (pH in 0.01mol·L-1 CaC12) + 0.4700 × log OC% + 0.0057 × sand (%) + 0.0022 × CEC(clay), with R2 = 0.9982. The organic carbon content of soil positively affected the sorption ofpymetrozine, but soil pH had a negative effect on the sorption. Additionally, effects of CaC12 concentration, soil to solution ratio and pesticide form were investigated. The sorption was promoted with an increase in soil to solution ratio and a decrease in CaC12 concentration. The possible variation of the five formulated products of pymetrozine was also investigated.