The cross-level and twist irregularities are the most dangerous irregularity types that could cause wheel unloading with the risk of derailments and additional maintenance expenses.However,the mechanism of the irregul...The cross-level and twist irregularities are the most dangerous irregularity types that could cause wheel unloading with the risk of derailments and additional maintenance expenses.However,the mechanism of the irregularities initiation and development is unclear.The motivation of the present study was the previous experimental studies on the application of wide sleepers in the ballasted track.The long-term track geometry measurements with wide sleepers show an enormous reduction of the vertical longitudinal irregularities compared to the conventional track.However,wide sleepers had higher twist and cross-section level irregularities.The present paper aims to explain the phenomenon by discrete element method(DEM)modeling the development process of sleeper inhomogeneous support at cross-level depending on the sleeper form.The DEM simulations show that the maximal settlement intensity is up to 3.5 times lower for a wide sleeper in comparison with the conventional one.Nevertheless,the cross-level differential settlements are almost the same for both sleepers.The particle loading distribution after all loading cycles is concentrated on the smaller area,up to the half sleeper length,with fully unloaded zones under sleeper ends.Ballast flow limitation under the central part of the sleeper could improve the resilience of wide sleepers to the development of cross-level irregularities.The mechanism of initiation of the cross-level irregularity is proposed,which assumes the loss of sleeper support under sleeper ends.The further growth of inhomogeneous settlements along the sleeper is assumed as a result of the interaction of two processes:ballast flow due to dynamic impact during void closing and on the other side high pressure due to the concentration of the pressure under the middle part of the sleeper.The DEM simulation results support the assumption of the mechanism and agree with the experimental studies.展开更多
Information on the physicochemical properties of chemical species is an important prerequisite when performing tasks such as process design and product design.However,the lack of extensive data and high experimental c...Information on the physicochemical properties of chemical species is an important prerequisite when performing tasks such as process design and product design.However,the lack of extensive data and high experimental costs hinder the development of prediction techniques for these properties.Moreover,accuracy and predictive capabilities still limit the scope and applicability of most property estimation methods.This paper proposes a new Gaussian process-based modeling framework that aims to manage a discrete and high-dimensional input space related to molecular structure representation with the group-contribution approach.A warping function is used to map discrete input into a continuous domain in order to adjust the correlation between different compounds.Prior selection techniques,including prior elicitation and prior predictive checking,are also applied during the building procedure to provide the model with more information from previous research findings.The framework is assessed using datasets of varying sizes for 20 pure component properties.For 18 out of the 20 pure component properties,the new models are found to give improved accuracy and predictive power in comparison with other published models,with and without machine learning.展开更多
After the period between 1998 and 2002, sport has again and continuously been considered as a priority strategicsector in Hungary since the year 2010. Hungary has demonstrated remarkable performance in organisinginter...After the period between 1998 and 2002, sport has again and continuously been considered as a priority strategicsector in Hungary since the year 2010. Hungary has demonstrated remarkable performance in organisinginternational sport events. The FINA World Championships and the European Youth Olympic Festival, both heldin 2017, as well as the annual GyulaiIstván Memorial Athletics Hungarian Grand Prix have profound worldwidesignificance. The objective of the study is to give an insight into how the two host cities (Gyor and Székesfehérvár)and their residents perceive these international sport events and their impacts in Hungary.展开更多
The extent to which specific climatic factors influence evapotranspiration under subhumid conditions in Hungary was investigated. The reference evapotranspiration, calculated with the internationally accepted Penman-M...The extent to which specific climatic factors influence evapotranspiration under subhumid conditions in Hungary was investigated. The reference evapotranspiration, calculated with the internationally accepted Penman-Monteith equation proposed by FAO, was considered. The results show that the influence of radiation, which provides energy for evaporation, is the strongest factor and that the influence of global radiation alone is very strong. Taking into account that radiation was measured under rather limited conditions in space and time, global radiation was calculated using the Hargreaves method based on temperature. Accordingly, we have defined a formula based on temperature-based global radiation and verified the data obtained with the Penman-Monteith formula calculated for 14 meteorological stations. The verification gave good results, therefore the method can be used for practical purposes in the subhumid conditions of Hungary based on the data of the nearest meteorological station.展开更多
In the context of the new era of economic globalization,the development of international trade holds immense significance in fostering global economic recovery and advancing the process of global economic integration....In the context of the new era of economic globalization,the development of international trade holds immense significance in fostering global economic recovery and advancing the process of global economic integration.Against this backdrop,aspects such as trade liberalization,digital trade,trade in services,and the influence of multinational companies are becoming increasingly prominent.Concurrently,factors encompassing economic,political,technological,and environmental considerations,as well as regional economic integration,will exert influence on the trajectory of international trade development.This paper aims to comprehensively explore the development trends of international trade and the myriad influencing factors within the framework of the new economic globalization.展开更多
AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,usin...AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 software.The Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal injury.Arthropathy patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were screened.Patients with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the study.During this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d omeprazole.At the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS results.The primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine treatment.RESULTS:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one month.Eight patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS < 135) in five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two patients.Ten patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was performed.When comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-treatment mean total LIS was detected in 7 patients who had moderate-tosevere enteropathy gradings at the inclusion CE (mean LIS:1615 ± 672vs 1064 ± 424,P=0.033).CONCLUSION:According to the small bowel CE evaluation mesalazine granules significantly attenuated mucosal injuries in patients with moderate-to-severe enteropathies induced by naproxen.展开更多
The reference evapotranspiration was calculated using Penman-Monteith method proposed. This method was evaluated on data measured by lysimeter in Szarvas experimental station in Hungary. The results of the two methods...The reference evapotranspiration was calculated using Penman-Monteith method proposed. This method was evaluated on data measured by lysimeter in Szarvas experimental station in Hungary. The results of the two methods were in good agreement. However, this method requires an amount of data which is not available at all sites of meteorological measurement. Therefore it was necessary to investigate which elements influencing evapotranspiration are important and which elements are less important. With the help of investigation was indicated that radiation and vapor pressure deficit play important role in determination of reference evapotranspiration. Taking into account this there was two possibilities to calculate evapotranspiration. One of these is to use Penman-Monteith formula with constant wind speed as advised by Allen. Another one is to neglect wind speed data. Both methods were investigated and the method with constant wind speed was found better in a subhumid climatic condition of Hungary.展开更多
After the 2004 EU accession of Hungary,the evolvement of the cross-border regions has started to emerge there as well,followed by the decrease—and in case of the Schengen Area the complete break off—of the separatio...After the 2004 EU accession of Hungary,the evolvement of the cross-border regions has started to emerge there as well,followed by the decrease—and in case of the Schengen Area the complete break off—of the separation role of the borders as a result of which the citizens of the member states have free movement in the greater part of the European Union.The basic goal of the EU enlargement was the establishment of the free movement of capital,goods,information,and workers.A very strong workforce migration has immediately started and is still ongoing among the EU member states,directing in first row from the less developed economies to the better developed ones.This of course is the same in case of Hungary,where the active population in a rapidly growing number makes the decision to take a job in the well-developed countries of the EU for a shorter or longer period.According to Rechnitzer,people living in the Austrian-Hungarian border region(among whom many were Hungarian citizens)were capable of novation and were active performers in general already before the transition period.The study focuses on the key motivation factors and the possible grouping of the people living in Western-Hungary having decided to work in Austria.展开更多
Expansive soils undergo high volume change due to cyclic swelling and shrinkage behavior during the wet and dry seasons.Thus,such problematic soils should be completely avoided or properly treated when encountered as ...Expansive soils undergo high volume change due to cyclic swelling and shrinkage behavior during the wet and dry seasons.Thus,such problematic soils should be completely avoided or properly treated when encountered as subgrade materials.In the present study,the biomedical waste incinerator ash and lime combination was proposed to stabilize expansive soil.Particle size analysis,Atterberg limits,free-swell,compaction,unconfined compression strength,and California bearing ratio tests were conducted on the natural soil and blended with 3%,5%,7%,9%,and 11%biomedical waste incinerator ash(BWIA).The optimum content of BWIA was determined based on the free-swell test results.To further investigate the relative effectiveness of the stabilizer,2%and 3%lime were also added to the optimum soil-BWIA mixture and UCS and CBR tests were also conducted.In addition,scanning electron microscopy(SEM)tests for representative stabilized samples were also conducted to examine the changes in microfabrics and structural arrangements due to bonding.The addition of BWIA has a promising effect on the index properties and strength of the expansive soil.The strength of the expansive soil significantly increased when it was blended with the optimum content of BWIA amended by 2%and 3%lime.展开更多
文摘The cross-level and twist irregularities are the most dangerous irregularity types that could cause wheel unloading with the risk of derailments and additional maintenance expenses.However,the mechanism of the irregularities initiation and development is unclear.The motivation of the present study was the previous experimental studies on the application of wide sleepers in the ballasted track.The long-term track geometry measurements with wide sleepers show an enormous reduction of the vertical longitudinal irregularities compared to the conventional track.However,wide sleepers had higher twist and cross-section level irregularities.The present paper aims to explain the phenomenon by discrete element method(DEM)modeling the development process of sleeper inhomogeneous support at cross-level depending on the sleeper form.The DEM simulations show that the maximal settlement intensity is up to 3.5 times lower for a wide sleeper in comparison with the conventional one.Nevertheless,the cross-level differential settlements are almost the same for both sleepers.The particle loading distribution after all loading cycles is concentrated on the smaller area,up to the half sleeper length,with fully unloaded zones under sleeper ends.Ballast flow limitation under the central part of the sleeper could improve the resilience of wide sleepers to the development of cross-level irregularities.The mechanism of initiation of the cross-level irregularity is proposed,which assumes the loss of sleeper support under sleeper ends.The further growth of inhomogeneous settlements along the sleeper is assumed as a result of the interaction of two processes:ballast flow due to dynamic impact during void closing and on the other side high pressure due to the concentration of the pressure under the middle part of the sleeper.The DEM simulation results support the assumption of the mechanism and agree with the experimental studies.
基金support from the National Natural Science Foundation of China(22150410338 and 61973268)is gratefully acknowledged.
文摘Information on the physicochemical properties of chemical species is an important prerequisite when performing tasks such as process design and product design.However,the lack of extensive data and high experimental costs hinder the development of prediction techniques for these properties.Moreover,accuracy and predictive capabilities still limit the scope and applicability of most property estimation methods.This paper proposes a new Gaussian process-based modeling framework that aims to manage a discrete and high-dimensional input space related to molecular structure representation with the group-contribution approach.A warping function is used to map discrete input into a continuous domain in order to adjust the correlation between different compounds.Prior selection techniques,including prior elicitation and prior predictive checking,are also applied during the building procedure to provide the model with more information from previous research findings.The framework is assessed using datasets of varying sizes for 20 pure component properties.For 18 out of the 20 pure component properties,the new models are found to give improved accuracy and predictive power in comparison with other published models,with and without machine learning.
文摘After the period between 1998 and 2002, sport has again and continuously been considered as a priority strategicsector in Hungary since the year 2010. Hungary has demonstrated remarkable performance in organisinginternational sport events. The FINA World Championships and the European Youth Olympic Festival, both heldin 2017, as well as the annual GyulaiIstván Memorial Athletics Hungarian Grand Prix have profound worldwidesignificance. The objective of the study is to give an insight into how the two host cities (Gyor and Székesfehérvár)and their residents perceive these international sport events and their impacts in Hungary.
文摘The extent to which specific climatic factors influence evapotranspiration under subhumid conditions in Hungary was investigated. The reference evapotranspiration, calculated with the internationally accepted Penman-Monteith equation proposed by FAO, was considered. The results show that the influence of radiation, which provides energy for evaporation, is the strongest factor and that the influence of global radiation alone is very strong. Taking into account that radiation was measured under rather limited conditions in space and time, global radiation was calculated using the Hargreaves method based on temperature. Accordingly, we have defined a formula based on temperature-based global radiation and verified the data obtained with the Penman-Monteith formula calculated for 14 meteorological stations. The verification gave good results, therefore the method can be used for practical purposes in the subhumid conditions of Hungary based on the data of the nearest meteorological station.
文摘In the context of the new era of economic globalization,the development of international trade holds immense significance in fostering global economic recovery and advancing the process of global economic integration.Against this backdrop,aspects such as trade liberalization,digital trade,trade in services,and the influence of multinational companies are becoming increasingly prominent.Concurrently,factors encompassing economic,political,technological,and environmental considerations,as well as regional economic integration,will exert influence on the trajectory of international trade development.This paper aims to comprehensively explore the development trends of international trade and the myriad influencing factors within the framework of the new economic globalization.
基金Supported by Dr.Falk Pharma GmbH,in part,study code:SAG-43/SBE
文摘AIM:To investigate the effect of mesalazine granules on small intestinal injury induced by naproxen using capsule endoscopy (CE).METHODS:This was a single center,non-randomized,open-label,uncontrolled pilot study,using the PillCam SB CE system with RAPID 5 software.The Lewis Index Score (LIS) for small bowel injury was investigated to evaluate the severity of mucosal injury.Arthropathy patients with at least one month history of daily naproxen use of 1000 mg and proton pump inhibitor co-therapy were screened.Patients with a minimum LIS of 135 were eligible to enter the 4-wk treatment phase of the study.During this treatment period,3 × 1000 mg/d mesalazine granules were added to ongoing therapies of 1000 mg/d naproxen and 20 mg/d omeprazole.At the end of the 4-wk combined treatment period,a second small bowel CE was performed to re-evaluate the enteropathy according to the LIS results.The primary objective of this study was to assess the mucosal changes after 4 wk of mesalazine treatment.RESULTS:A total of 18 patients (16 females),ranging in age from 46 to 78 years (mean age 60.3 years) were screened,all had been taking 1000 mg/d naproxen for at least one month.Eight patients were excluded from the mesalazine therapeutic phase of the study for the following reasons:the screening CE showed normal small bowel mucosa or only insignificant damages (LIS < 135) in five patients,the screening esophagogastroduodenoscopy revealed gastric ulcer in one patient,capsule technical failure and incomplete CE due to poor small bowel cleanliness in two patients.Ten patients (9 female,mean age 56.2 years) whose initial LIS reached mild and moderate-to-severe enteropathy grades (between 135 and 790 and ≥ 790) entered the 4-wk therapeutic phase and a repeat CE was performed.When comparing the change in LIS from baseline to end of treatment in all patients,a marked decrease was seen (mean LIS:1236.4 ± 821.9 vs 925.2 ± 543.4,P=0.271).Moreover,a significant difference between pre-and post-treatment mean total LIS was detected in 7 patients who had moderate-tosevere enteropathy gradings at the inclusion CE (mean LIS:1615 ± 672vs 1064 ± 424,P=0.033).CONCLUSION:According to the small bowel CE evaluation mesalazine granules significantly attenuated mucosal injuries in patients with moderate-to-severe enteropathies induced by naproxen.
文摘The reference evapotranspiration was calculated using Penman-Monteith method proposed. This method was evaluated on data measured by lysimeter in Szarvas experimental station in Hungary. The results of the two methods were in good agreement. However, this method requires an amount of data which is not available at all sites of meteorological measurement. Therefore it was necessary to investigate which elements influencing evapotranspiration are important and which elements are less important. With the help of investigation was indicated that radiation and vapor pressure deficit play important role in determination of reference evapotranspiration. Taking into account this there was two possibilities to calculate evapotranspiration. One of these is to use Penman-Monteith formula with constant wind speed as advised by Allen. Another one is to neglect wind speed data. Both methods were investigated and the method with constant wind speed was found better in a subhumid climatic condition of Hungary.
文摘After the 2004 EU accession of Hungary,the evolvement of the cross-border regions has started to emerge there as well,followed by the decrease—and in case of the Schengen Area the complete break off—of the separation role of the borders as a result of which the citizens of the member states have free movement in the greater part of the European Union.The basic goal of the EU enlargement was the establishment of the free movement of capital,goods,information,and workers.A very strong workforce migration has immediately started and is still ongoing among the EU member states,directing in first row from the less developed economies to the better developed ones.This of course is the same in case of Hungary,where the active population in a rapidly growing number makes the decision to take a job in the well-developed countries of the EU for a shorter or longer period.According to Rechnitzer,people living in the Austrian-Hungarian border region(among whom many were Hungarian citizens)were capable of novation and were active performers in general already before the transition period.The study focuses on the key motivation factors and the possible grouping of the people living in Western-Hungary having decided to work in Austria.
文摘Expansive soils undergo high volume change due to cyclic swelling and shrinkage behavior during the wet and dry seasons.Thus,such problematic soils should be completely avoided or properly treated when encountered as subgrade materials.In the present study,the biomedical waste incinerator ash and lime combination was proposed to stabilize expansive soil.Particle size analysis,Atterberg limits,free-swell,compaction,unconfined compression strength,and California bearing ratio tests were conducted on the natural soil and blended with 3%,5%,7%,9%,and 11%biomedical waste incinerator ash(BWIA).The optimum content of BWIA was determined based on the free-swell test results.To further investigate the relative effectiveness of the stabilizer,2%and 3%lime were also added to the optimum soil-BWIA mixture and UCS and CBR tests were also conducted.In addition,scanning electron microscopy(SEM)tests for representative stabilized samples were also conducted to examine the changes in microfabrics and structural arrangements due to bonding.The addition of BWIA has a promising effect on the index properties and strength of the expansive soil.The strength of the expansive soil significantly increased when it was blended with the optimum content of BWIA amended by 2%and 3%lime.