The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progressIn this work based on 78 gastritis patients an...The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progressIn this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrenee and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis.展开更多
Traditional Chinese medicine(TCM)has been applied in treating various complex diseases for thousands of years,and has been widely known for its distinguished holistic therapeutic strategy.How to ensure the safety and ...Traditional Chinese medicine(TCM)has been applied in treating various complex diseases for thousands of years,and has been widely known for its distinguished holistic therapeutic strategy.How to ensure the safety and lower the risk of toxic effects of TCM herbal formulae are of critical importance during the process of the modernization of TCM industry.Due to the complex composition of TCM herbal formulae and its sophisticated interaction between the biomolecules inside the body.展开更多
As one of the most important complementary and alternative therapies in clinical practice,traditional Chinese medicine(TCM)holds great potential in treating various complex diseases,especially in the area of chronic a...As one of the most important complementary and alternative therapies in clinical practice,traditional Chinese medicine(TCM)holds great potential in treating various complex diseases,especially in the area of chronic and non-communicable diseases.However,in terms of the complexity of chemical and biological profiles in TCM,a traditional reductionist cannot adequately explain the scientific nature of TCM.展开更多
基金National Natural Science Foundation of China (Grant Nos. 81630103, 91729301, 91229201 and 81225025)the Project of Tsinghua-Fuzhou Insititute for Data Technology (TFIDT2018001)to S. Li and grants 61673231 and 61721003 to X. Zhang.
文摘The development of gastritis is associated with an increased risk of gastric cancer. Current invasive gastritis diagnostic methods are not suitable for monitoring progressIn this work based on 78 gastritis patients and 50 healthy individuals, we observed that the variation of tongue-coating microbiota was associated with the occurrenee and development of gastritis. Twenty-one microbial species were identified for differentiating tongue-coating microbiomes of gastritis and healthy individuals. Pathways such as microbial metabolism in diverse environments, biosynthesis of antibiotics and bacterial chemotaxis were up-regulated in gastritis patients. The abundance of Campylobacter concisus was found associated with the gastric precancerous cascade. Furthermore, Campylobacter concisus could be detected in tongue coating and gastric fluid in a validation cohort containing 38 gastritis patients. These observations provided biological evidence of tongue diagnosis in traditional Chinese medicine, and indicated that tongue-coating microbiome could be a potential non-invasive biomarker, which might be suitable for long-term monitoring of gastritis.
文摘Traditional Chinese medicine(TCM)has been applied in treating various complex diseases for thousands of years,and has been widely known for its distinguished holistic therapeutic strategy.How to ensure the safety and lower the risk of toxic effects of TCM herbal formulae are of critical importance during the process of the modernization of TCM industry.Due to the complex composition of TCM herbal formulae and its sophisticated interaction between the biomolecules inside the body.
文摘As one of the most important complementary and alternative therapies in clinical practice,traditional Chinese medicine(TCM)holds great potential in treating various complex diseases,especially in the area of chronic and non-communicable diseases.However,in terms of the complexity of chemical and biological profiles in TCM,a traditional reductionist cannot adequately explain the scientific nature of TCM.
