Clinical Study of Recombinant Human Endostatin Combined with Iressa in Targeted Treatment of Patients with Lung Adenocarcinoma with Pleural Metastasis

Objective:To evaluate and comprehensively analyze the clinical efficacy of recombinant human endostatin combined with Iressa targeted therapy in patients with pleural metastasis of lung adenocarcinoma.Methods:The interval of the selected study period span was from January 2017 to April 2021.The sample source of the study was 42 patients with lung adenocarcinoma admitted to hospital.The random number table method was used for study grouping,and they were further divided into study groups(n=21,14 cases with pleural metastasis)and control group(n=21,13 cases with pleural metastasis),all patients received systemic chemotherapy with pemetrexed and cisplatin.Patients with pleural metastases in the control group were injected with 60 mg cisplatin into the thoracic cavity.Patients in the study group were treated with Iressa(gefitinib)targeted therapy if genetic testing showed epidermal growth factor receptor(EGRF)mutations,and patients with pleural metastases were treated with pleural metastasis with Endo(recombinant human endostatin YH-16)to control pleural effusion.Two sets of related indicators were compared and analyzed.Results:Comparing the short-term disease control rate,treatment effectiveness and long-term survival rate between the two groups shows that the study group has more advantages(P<0.05).In the comparison between the two groups of serum markers and related indicators,the study group has more advantages(P<0.05),whereas in the comparison between the two groups in the incidence of adverse reactions,there is no significant difference(P>0.05).Based on statistics of the recurrence rate of pleural fluid in the two groups,the study group is significantly lower than the control group(P<0.05).Conclusion:Recombinant human endostatin combined with Iressa targeted therapy for patients with lung adenocarcinoma with pleural metastasis has significant short-term and long-term effects without serious adverse reactions.It can be fully promoted in medical institutions at all levels.

Clinical Application of Point Diji

Diji (SP 8) is a cleft point of the Spleen Channel of Foot-Taiyang. Its indications include abdominal pain, diarrhea, edema, dysmenorrhea and certain other symptoms caused by incoordination between the liver and the spleen. Either taking the point alone or together with some other adjunct points in clinical practice, the author has obtained satisfactory curative effects.

Bevacizumab treatment reduces retinal neovascularization in a mouse model of retinopathy of prematurity

·AIM: To evaluate the effect of different bevacizumab concentrations on retinal neovascularization in a retinopathy of prematurity(ROP) mouse model.·METHODS: A total of 60 of C57BL/6 J mice were exposed to 75% ±2% oxygen from postnatal d7 to postnatal d12. Fifteen nonexposed mice served as negative controls(group A). On d12, 30 mice(group C)were injected with 2.5 μg intravitreal bevacizumab(IVB),30 mice(group D) were injected with 1.25 μg IVB in one eye. The contralateral eyes were injected with balanced salt solution(BSS)(control group =group B). The adenosine diphosphatase(ADPase) histochemical technique was used for retinal flat mount to assess the oxygen-induced changes of retinal vessels.Neovascularization was quantified by counting the endothelial cell proliferation on the vitreal side of the inner limiting membrane of the retina. Histological changes were examined by light microscopy. The mRNA levels of vascular endothelial growth factor(VEGF) were quantified by Real-time PCR. Western-blotting analysis was performed to examine the expression of P-VEGFR.· RESULTS: Comparing with the control group B,regular distributions and reduced tortuosity of vessels were observed in our retinal flat mounts in groups C and D. The endothelial cell count per histological section was lower in groups C(P 【0.0001) and D(P 【0.0001) compared with the control group B. Histological evaluation showed no retinal toxicity in any group. In all oxygen treated groups VEGF mRNA expression was significantly increased as compared to age-matched controls. No significant change in VEGF mRNA expression could be achieved in either of the treatments or the oxygen controls. The results of the Western blot were consistent with that of the Real-time PCR analysis.·CONCLUSION: An intravitreal injection of bevacizumab is able to reduce angioproliferative retinopathy in a mouse model for oxygen-induced retinopathy.

Relationship between sKL, BSP and HD abdominal aortic calcification and prognosis

Objective: To investigate the relationship between the expression levels of sKL and BSP and the calcification and prognosis of abdominal aorta in patients with HD. Methods: 130 patients with HD admitted to our hospital between January 2015 and June 2017 were selected as the research subjects;all patients were treated with Fresenius hemodialysis machine for intervention treatment;the expression levels of sKL and BSP in the patients' blood were monitored, and 30 mmonths were followed up The extent of calcification of the abdominal aorta and the quality of the prognosis of the patients were evaluated and the relationship between the expression levels of sKL and BSP and the calcification and prognosis of the abdominal aorta were analyzed. Results: The levels of sKL and BSP in the blood of patients with different degrees of abdominal aortic calcification were significantly different, and the differences were statistically significant (P <0.05). Among the patients with mild or no calcification, the levels of sKL and BSP were the highest in the blood and those in the death group were the lowest. The sKL level was significantly lower than the survival group, and the BSP level was significantly higher than the survival group, and the differences were statistically significant (P <0.05);the survival rate of patients with high sKL expression was significantly better than that of patients with low sKL expression, and the survival rate of low BSP expression was significantly better High expression in BSP;high sKL and low BSP are independent protective factors affecting abdominal aortic calcification and prognostic quality in HD patients (P <0.05);combined use of sKL and BSP in predicting the prognostic quality of HD patients is sensitive and specific Both are greater than 90%, and AUC> 0.90. Conclusions:High sKL and low BSP in the blood of HD patients are independent protective factors affecting abdominal aortic calcification and prognostic quality. The combined application of sKL and BSP can effectively predict the prognostic quality value of patients.

RELATIONSHIP BETWEEN THE COURSE OF THE DISEASE AND P_300 OF PATIENTS WITH CLOSED CRANIOCEREBRAL TRAUMA

目的:研究闭合性颅脑外伤患者病程与P300之间的关系,并探讨作P300测定的最佳时间。方法:应用Medicid-03E脑诱发电位仪测定518例闭合性颅脑外伤患者的视觉刺激诱发的P300波之潜伏期和波幅。结果:病人组P300波潜伏期较正常对照组明显延长,波幅也明显降低。结论:P300波的变化可作为判断闭合性颅脑外伤患者脑认知功能变化的一项客观指标。

Anterolateral thigh free flap for simultaneous reconstruction of digital extensor tendon and defect of the dorsal hand： A case report

这份报纸与数字伸肌腱损害在手缺点的修理描述一种新技术。有厚大腿骨的扁带的在前面偏一边的大腿拍动在背面的手的合成缺点的重建被使用了，特别腱的缺点。这种技术要求到施主地点的处理和因此原因更少损坏的短时期，但是显示出手功能的更好的恢复。有利药品效果在这个病人被获得了。

不同针灸疗法对化疗后胃动力的调节作用(英文)

目的:观察针灸对化疗后呕吐患者胃动力的调节作用。方法:选取足三里穴,分别采用温针灸、针刺和艾灸3种治疗方法,观察胃电频谱、波形、频率和波幅指标的变化。结果:针刺的即时效应优于温针灸和艾灸,而温针灸的持续效应优于针刺和艾灸。结论:不同的针灸方法,其即时效应和持续效应不尽相同,在临床上可根据患者的具体情况采用适合的针灸疗法。化疗早期介入针灸治疗比在后期使用能更好的调节胃动力。

Clinical Observations on 46 Cases of Globus Hystericus Treated with Modified Banxia Houpu Decoction

Objective:To observe the therapeutic effect and mechanism of modified Banxia Houpu decoction on globus hystericus.Methods:The 95 patients with globus hystericus were randomly divided into a treatment group of 46 cases treated with modified Banxia Houpu decoction and a control group of 49 cases treated with Manyanshuning(Granula for Clearing the Throat).In addition,a normal group of 24 healthy people was set up.SCL-90 scale was adopted to observe the therapeutic effect,evaluate the psychological state of patients and build a database on combination of four diagnoses.Results:The effect of the modified Banxia Houpo decoction was better than that of the control group in relieving depression,anxiety and improving the psychological state(P<0.05 or P<0.01).Conclusion:Modified Banxia Houpu decoction has definite therapeutic effect on globus hystericus.Its mechanism may be related to its function in relieving depression and anxiety and regulating the psychological state.