Research on the Effect of R&D Investment Intensity and Sales Expense on the Performance of Biomedical Enterprises

Objective To explore the influence of new drug R&D investment and sales expense on the performance of biomedical enterprises.Methods The financial statements of 76 listed biomedical enterprises for 5 consecutive years were selected,and the data were modeled to study the effect of R&D investment and sales expense on the performance of biomedical enterprises by using financial indicators as tools and statistical methods of multiple linear regression.Results and Conclusion Under the premise that the weak related factors such as enterprise scale,life cycle and asset-liability ratio are set as unrelated variables,the R&D investment intensity of biomedical enterprises is negatively correlated with the current performance,which also shows that the R&D of biomedical enterprises has the characteristics of high risk.Besides,the influence of early R&D investment is delayed.However,the sales expense of leading biomedical enterprises with large scales have higher proportion.Meanwhile the greater sales expense of the same enterprise in different periods,the better the enterprise performance is.Biomedical enterprises should consider their own development stage to develop more patented drugs.Besides,they must formulate plans for allocating reasonable sales personnel and cost expense to ensure that enterprises can obtain better benefits.

Expression and significance of IL-1β and COX-2 in gingiva tissues in rat periodontitis model with different estrogen levels

Objective:To explore the expressions of IL-1β and COX-2 in the gingiva tissues in rat periodontitis model with different estrogen levels, and the effect of estrogen level on periodontitis.Methods:A total of 40 female Wistar rats were randomized into 4 groups, i.e. normal control group (n=10), periodontitis group (n=10), castraction periodontitis group (n=10), and estrogen therapy group (n=10). RT-PCR was used to detect the expressions of IL-1β and COX-2 in the gingiva tissues in each group.Results:The expression intensity of IL-1β and COX-2 in the estrogen therapy group was significantly lower than that in the castraction periodontitis group (P<0.05).Conclusions:Estrogen can significantly down regulate the expressions of IL-1β and COX-2 in order to alleviate the symptoms of periodontitis.

Synthesis of Red Phosphor CaZrO_(3):Eu^(3+) for White Light-Emitting Diodes

A red-emitting CaZrO_(3):Eu^(3+)phosphor has been prepared by solid state reaction and its luminescent properties are studied.The crystal structure is investigated by the x-ray diffraction.Through energy transitions of^(5)Do→^(7)Fj(J=0,1,2,3)in Eu^(3+)ions,the emission spectrum of the phosphor shows a series of narrow bands under near-ultraviolet light and the strongest peak locates at 613nm.The emission intensity of Cai-xZrO_(3):xEu^(3+)phosphor will reach the maximum as the molar concentration of Eu^(3+)is 5mol%.