Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depth...Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions.展开更多
基金supported by the National Key Technologies Research and Development Program of China(2017YFA0205903,2017YFA0701100)the National Natural Science Foundation of China(61634006,62071447)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences Pilot Project(XDB32030102,XDB32040203,XDA16021305)the Key Research Programs of Frontier Sciences,CAS(QYZDY-SSW-JSC004).
文摘Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various patterns.It is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording demands.This study proposed a strategy for reducing the microelectrode volume with integrated packaging.An implantation system was developed specifically for semiautomatic distributed implantation.The feasibility and convenience of the fMEA and implantation platform were verified in rodents.The acute and chronic recording results provied the effectiveness of the packaging and implantation methods.These methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions.
