Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today,most neuroendocrine tumors (NETs) of ...Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today,most neuroendocrine tumors (NETs) of the duodenum are detected "incidentally" and therefore recognized at an early stage. Duodenal NETs which are well differentiated,not larger than 10 mm and limited to the mucosa/submucosa can be endoscopically resected. The management of duodenal NETs ranging between 10 and 20 mm needs an interdisciplinary discussion. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. Surgery is recommended for well-differentiated duodenal NET tumors greater than 20 mm,for localized sporadic gastrinomas (of any size) and for localized poorly differentiated NE cancers. Surgery is recommended for any ileal NET. Advanced ileal NETs with a carcinoid syndrome are treated with longacting somatostatin analogs. This treatment significantly improves (progression-free) survival in patients with metastatic NETs of the ileum. For optimal NET management,tumor biology,type,localization and stage of the neoplasm,as well as the patient's individual circumstances have to be taken into account.展开更多
We study the origin of baryon resonances which are dynamically generated in the chiral unitary approach. We propose a natural renormalization scheme for the dynamical generation of resonances using the low energy chir...We study the origin of baryon resonances which are dynamically generated in the chiral unitary approach. We propose a natural renormalization scheme for the dynamical generation of resonances using the low energy chiral interaction and a general feature of the scattering theory. A deviation of a phenomenological scattering amplitude from the natural one is interpreted by an effective pole term interaction of genuine nature which can not be described by the meson-baryon dynamics,reminiscent of the CDD pole. Applying the present method to physical meson-baryon scatterings,we find that the Λ(1405) resonance is dominated by a meson-baryon component forming a KN-πΣ molecular-like structure,while the N(1535) resonance requires some pole contribution.展开更多
文摘Neuroendocrine tumors of the small bowel are on the rise. In the US they have increased by 300%-500% in the last 35 years. At the same time their prognosis is much improved. Today,most neuroendocrine tumors (NETs) of the duodenum are detected "incidentally" and therefore recognized at an early stage. Duodenal NETs which are well differentiated,not larger than 10 mm and limited to the mucosa/submucosa can be endoscopically resected. The management of duodenal NETs ranging between 10 and 20 mm needs an interdisciplinary discussion. Endoscopic ultrasound is the method of choice to determine tumor size and depth of infiltration. Surgery is recommended for well-differentiated duodenal NET tumors greater than 20 mm,for localized sporadic gastrinomas (of any size) and for localized poorly differentiated NE cancers. Surgery is recommended for any ileal NET. Advanced ileal NETs with a carcinoid syndrome are treated with longacting somatostatin analogs. This treatment significantly improves (progression-free) survival in patients with metastatic NETs of the ileum. For optimal NET management,tumor biology,type,localization and stage of the neoplasm,as well as the patient's individual circumstances have to be taken into account.
基金Ministry of Education, Culture,Sports,Science and Technology,Japan(19540297,19853800,20028004)
文摘We study the origin of baryon resonances which are dynamically generated in the chiral unitary approach. We propose a natural renormalization scheme for the dynamical generation of resonances using the low energy chiral interaction and a general feature of the scattering theory. A deviation of a phenomenological scattering amplitude from the natural one is interpreted by an effective pole term interaction of genuine nature which can not be described by the meson-baryon dynamics,reminiscent of the CDD pole. Applying the present method to physical meson-baryon scatterings,we find that the Λ(1405) resonance is dominated by a meson-baryon component forming a KN-πΣ molecular-like structure,while the N(1535) resonance requires some pole contribution.
