Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐resolution.However,obtained information of these con-volutional neural networks cannot completely exp...Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐resolution.However,obtained information of these con-volutional neural networks cannot completely express predicted high‐quality images for complex scenes.A dynamic network for image super‐resolution(DSRNet)is presented,which contains a residual enhancement block,wide enhancement block,feature refine-ment block and construction block.The residual enhancement block is composed of a residual enhanced architecture to facilitate hierarchical features for image super‐resolution.To enhance robustness of obtained super‐resolution model for complex scenes,a wide enhancement block achieves a dynamic architecture to learn more robust information to enhance applicability of an obtained super‐resolution model for varying scenes.To prevent interference of components in a wide enhancement block,a refine-ment block utilises a stacked architecture to accurately learn obtained features.Also,a residual learning operation is embedded in the refinement block to prevent long‐term dependency problem.Finally,a construction block is responsible for reconstructing high‐quality images.Designed heterogeneous architecture can not only facilitate richer structural information,but also be lightweight,which is suitable for mobile digital devices.Experimental results show that our method is more competitive in terms of performance,recovering time of image super‐resolution and complexity.The code of DSRNet can be obtained at https://github.com/hellloxiaotian/DSRNet.展开更多
Humans can perceive our complex world through multi-sensory fusion.Under limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and rapidly.However,replicating this uniq...Humans can perceive our complex world through multi-sensory fusion.Under limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and rapidly.However,replicating this unique capability in robots remains a significant challenge.Here,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object recognition.The sensor exhibits human-like pressure(0.04–100 kPa)and temperature(21.5–66.2℃)detection,millisecond response times(11 ms),a pressure sensitivity of 92.22 kPa^(−1)and triboelectric durability of over 6000 cycles.The devised algorithm has universality and can accommodate a range of application scenarios.The tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%accuracy.This sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.展开更多
Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration...Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration technique is proposed.For the implementation of different electromagnetic methods of physical optics(PO),shooting and bouncing ray(SBR),and physical theory of diffraction(PTD),a parallel computing scheme based on the CPU-GPU parallel computing scheme is realized to balance computing tasks.Finally,a multi-GPU framework is further proposed to solve the computational difficulty caused by the massive number of ray tubes in the ray tracing process.By using the established simulation platform,signals of ships at different seas are simulated and their images are achieved as well.It is shown that the higher sea states degrade the averaged peak signal-to-noise ratio(PSNR)of radar image.展开更多
Various strategies,including controls of morphology,oxidation state,defect,and doping,have been developed to improve the performance of Cu-based catalysts for CO_(2) reduction reaction(CO_(2)RR),generating a large amo...Various strategies,including controls of morphology,oxidation state,defect,and doping,have been developed to improve the performance of Cu-based catalysts for CO_(2) reduction reaction(CO_(2)RR),generating a large amount of data.However,a unified understanding of underlying mechanism for further optimization is still lacking.In this work,combining first-principles calculations and machine learning(ML)techniques,we elucidate critical factors influencing the catalytic properties,taking Cu-based single atom alloys(SAAs)as examples.Our method relies on high-throughput calculations of 2669 CO adsorption configurations on 43 types of Cu-based SAAs with various surfaces.Extensive ML analyses reveal that low generalized coordination numbers and valence electron number are key features to determine catalytic performance.Applying our ML model with cross-group learning scheme,we demonstrate the model generalizes well between Cu-based SAAs with different alloying elements.Further,electronic structure calculations suggest surface negative center could enhance CO adsorption by back donating electrons to antibonding orbitals of CO.Finally,several SAAs,including PCu,AgCu,GaCu,ZnCu,SnCu,GeCu,InCu,and SiCu,are identified as promising CO_(2)RR catalysts.Our work provides a paradigm for the rational design and fast screening of SAAs for various electrocatalytic reactions.展开更多
Few-shot learning is becoming more and more popular in many fields,especially in the computer vision field.This inspires us to introduce few-shot learning to the genomic field,which faces a typical few-shot problem be...Few-shot learning is becoming more and more popular in many fields,especially in the computer vision field.This inspires us to introduce few-shot learning to the genomic field,which faces a typical few-shot problem because some tasks only have a limited number of samples with high-dimensions.The goal of this study was to investigate the few-shot disease sub-type prediction problem and identify patient subgroups through training on small data.Accurate disease subtype classification allows clinicians to efficiently deliver investigations and interventions in clinical practice.We propose the SW-Net,which simulates the clinical process of extracting the shared knowledge from a range of interrelated tasks and generalizes it to unseen data.Our model is built upon a simple baseline,and we modified it for genomic data.Supportbased initialization for the classifier and transductive fine-tuning techniques were applied in our model to improve prediction accuracy,and an Entropy regularization term on the query set was appended to reduce over-fitting.Moreover,to address the high dimension and high noise issue,we future extended a feature selection module to adaptively select important features and a sample weighting module to prioritize high-confidence samples.Experiments on simulated data and The Cancer Genome Atlas meta-dataset show that our new baseline model gets higher prediction accuracy compared to other competing algorithms.展开更多
Background:Women with uterine leiomyomas may suffer severe symptoms.To avoid risks of side effects,it is necessary to develop an optimal agent to shrink leiomyomas with fewer side effects and a lower recurrence rate.C...Background:Women with uterine leiomyomas may suffer severe symptoms.To avoid risks of side effects,it is necessary to develop an optimal agent to shrink leiomyomas with fewer side effects and a lower recurrence rate.Curcumin may have a lower side effect in uterine leiomyoma treatment.Methods:We established the estrogen-and-progesterone-induced murine model of uterine leiomyoma.Next,we determined the expression of related genes of the β-catenin/Wnt signaling pathway by western blot,reverse transcription-polymerase chain reaction,and immunohistochemistry.We also noticed the morphological changes in uterine tissues by hematoxylin-eosin staining.Results:Curcumin plays an important role in Wnt/β-catenin signaling pathway-related expression including β-catenin,adenomatous polyposis coli,glycogen synthase kinase-3β,Wnt-11,and serum hormone concentrations.Conclusions:Curcumin could the down-regulation of serum hormone concentrations and inhibition of the β-catenin/Wnt signaling pathway in the treatment of uterine leiomyoma.展开更多
We report the discovery of PSR J1909+0122 by the Five-hundred-meter Aperture Spherical Radio Telescope(FAST)as part of the Commensal Radio Astronomy FAST Survey.PSR J1909+0122 has a spin period of 1.257 s and a disper...We report the discovery of PSR J1909+0122 by the Five-hundred-meter Aperture Spherical Radio Telescope(FAST)as part of the Commensal Radio Astronomy FAST Survey.PSR J1909+0122 has a spin period of 1.257 s and a dispersion measure of 186.2 pc cm^(-3).The averaged pulse profile shows two distinct components.We performed a single-pulse study based on a one-hour observation at 1.25 GHz on 2021 August 23.We used a threshold of 5σ_(ep) to measure the nulling fraction(NF)as 63%±1.5%.The longitude-resolved fluctuation spectra and fast Fourier transform spectra of the binary sequences revealed the quasi-periodicity of nulling with a period of 30 rotation periods.We examined the reliability of the periodicity by comparing it to random noise injection.The NF,E,and modulation periodicity P_(M) of PSR J1909+0122 were compared with other periodic nulling pulsars,showing that the source of J1909+0122 has the second largest NF in the population.Long-term timing observations over six months were used to derive the phase-connected ephemeris of this pulsar.The measured P and P values disfavor dipolar geometry for polar gap models,and the prediction for a space-charge-limited flow model in the case of inverse Compton scattering is only just above the death line.In this work,PSR J1909+0122 has revealed possible correlations between nulling behavior and pulsar properties,which will help to shed light on the pulsar emission mechanism and its temporal evolution in future observations.展开更多
We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polar...We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polarization profile of this millisecond pulsar(MSP) using the Five-hundred-meter Aperture Spherical radio Telescope(FAST), the Green Bank Telescope(GBT), and the Parkes Telescope. For the first time from such a system, an oscillatory polarization angle change was observed from a particular eclipse egress with partial depolarization, indicating 10-milliGauss-level reciprocating magnetic fields oscillating in a length scale of 5 ×10^(3)km(assuming an orbital inclination angle of 90°) outside the companion's magnetosphere. The dispersion measure variation observed during the ingresses and egresses shows the rapid raising of the electron density in the shock boundary between the companion's magnetosphere and the surrounding pulsar wind. We suggest that the observed oscillatory magnetic fields originate from the pulsar wind outside the companion's magnetosphere.展开更多
In this paper,we summarize recent progresses made in deep learning based acoustic models and the motivation and insights behind the surveyed techniques.We first discuss models such as recurrent neural networks(RNNs) a...In this paper,we summarize recent progresses made in deep learning based acoustic models and the motivation and insights behind the surveyed techniques.We first discuss models such as recurrent neural networks(RNNs) and convolutional neural networks(CNNs) that can effectively exploit variablelength contextual information,and their various combination with other models.We then describe models that are optimized end-to-end and emphasize on feature representations learned jointly with the rest of the system,the connectionist temporal classification(CTC) criterion,and the attention-based sequenceto-sequence translation model.We further illustrate robustness issues in speech recognition systems,and discuss acoustic model adaptation,speech enhancement and separation,and robust training strategies.We also cover modeling techniques that lead to more efficient decoding and discuss possible future directions in acoustic model research.展开更多
Flexible strain sensors play an important role in electronic skins,wearable medical devices,and advanced robots.Herein,a highly sensitive and fast response optical strain sensor with two evanescently coupled optical m...Flexible strain sensors play an important role in electronic skins,wearable medical devices,and advanced robots.Herein,a highly sensitive and fast response optical strain sensor with two evanescently coupled optical micro/nanofibers(MNFs)embedded in a polydimethylsiloxane(PDMS)film is proposed.The strain sensor exhibits a gauge factor as high as 64.5 for strain≤0.5%and a strain resolution of 0.0012%which corresponds to elongation of 120 nm on a 1 cm long device.As a proof-of-concept,highly sensitive fingertip pulse measurement is realized.The properties of fast temporal frequency response up to 30 kHz and a pressure sensitivity of 102 kPa^(−1) enable the sensor for sound detection.Such versatile sensor could be of great use in physiological signal monitoring,voice recognition and micro-displacement detection.展开更多
随着多媒体数据的爆发式增长,云端数据呈现出大规模多模态混合并存的特性.服务于数据分析的传统存储系统因为缺乏数据的语义管理而面临读取延时超长的挑战.针对图像和文本2种模态数据,在传统存储系统之上提出一种跨模态图文数据内容筛...随着多媒体数据的爆发式增长,云端数据呈现出大规模多模态混合并存的特性.服务于数据分析的传统存储系统因为缺乏数据的语义管理而面临读取延时超长的挑战.针对图像和文本2种模态数据,在传统存储系统之上提出一种跨模态图文数据内容筛选存储机制(cross-modal image and text content sifting storage,CITCSS),用于提供大规模在线相似性内容筛选服务,从存储系统层面缓解数据分析时必须从存储中读出所有数据的读带宽压力.机制分为离线与在线2个阶段.离线阶段中,引入基于自监督的生成对抗式Hash方法,系统利用这种方法生成语义元数据.然后,将元数据注入独立的元数据空间.最后,根据相似性Hash码间汉明距离能够度量语义距离的特点,利用Neo4j图数据库构建Hash元数据图谱,并在语义图谱中建立Hash码与存储路径之间的映射.在线阶段中,用户发送与分析相关的图像或文本,存储系统首先转化数据为Hash码.然后,在筛选半径内通过Hash元数据图谱寻找相似节点,进而找到相似文件的底层存储路径返回筛选数据.实验结果表明,与传统语义存储系统相比,CITCSS在召回率超过98%的性能下,读取延迟相对降低了99.07%~99.77%.展开更多
In the present study,the over-constrained hybrid manipulator R(2RPR)R/SP+RR is considered as the research objective.In this paper,kinematics of the hybrid manipulator,including the forward and inverse position,are ana...In the present study,the over-constrained hybrid manipulator R(2RPR)R/SP+RR is considered as the research objective.In this paper,kinematics of the hybrid manipulator,including the forward and inverse position,are analyzed.Then,the workspace is checked based on the inverse position solution to evaluate whether the workspace of the hybrid manipulator meets the requirements,and the actual workspace of the hybrid robot is analyzed.After that,the force analysis of the over-constrained parallel mechanism is carried out,and an ADAMS-ANSYS rigid-flexible hybrid body model is established to verify the simulation.Based on the obtained results from the force analysis,the manipulator structure is designed.Then,the structure optimization is carried out to improve the robot stiffness.Finally,calibration and workspace verification experiments are performed on the prototype,cutting experiment of an S-shaped aluminum alloy workpiece is completed,and the experiment verifies the machining ability of the prototype.This work conducts kinematics,workspace,force analyses,structural optimization design and experiments on the over-constrained hybrid manipulator R(2RPR)R/SP+RR,providing design basis and technical support for the development of the novel hybrid manipulator in practical engineering.展开更多
Behind the prevalence of multimedia technology,digital copyright disputes are becoming increasingly serious.The digital watermarking prevention technique against the copyright infringement needs to be improved urgentl...Behind the prevalence of multimedia technology,digital copyright disputes are becoming increasingly serious.The digital watermarking prevention technique against the copyright infringement needs to be improved urgently.Among the proposed technologies,zero-watermarking has been favored recently.In order to improve the robustness of the zero-watermarking,a novel robust audio zerowatermarking method based on sparse representation is proposed.The proposed scheme is mainly based on the K-singular value decomposition(K-SVD)algorithm to construct an optimal over complete dictionary from the background audio signal.After that,the orthogonal matching pursuit(OMP)algorithm is used to calculate the sparse coefficient of the segmented test audio and generate the corresponding sparse coefficient matrix.Then,the mean value of absolute sparse coefficients in the sparse matrix of segmented speech is calculated and selected,and then comparing the mean absolute coefficient of segmented speech with the average value of the selected coefficients to realize the embedding of zero-watermarking.Experimental results show that the proposed audio zerowatermarking algorithm based on sparse representation performs effectively in resisting various common attacks.Compared with the baseline works,the proposed method has better robustness.展开更多
BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-bas...BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-based computer-assisted detection(CADe)techniques were established from small single-center datasets,and unrepresentative learning materials might confine their application and generalization in wide practice.Although CADes have been reported to identify polyps in colonoscopic images and videos in real time,their diagnostic performance deserves to be further validated in clinical practice.AIM To train and test a CADe based on multicenter high-quality images of polyps and preliminarily validate it in clinical colonoscopies.METHODS With high-quality screening and labeling from 55 qualified colonoscopists,a dataset consisting of over 71000 images from 20 centers was used to train and test a deep learning-based CADe.In addition,the real-time diagnostic performance of CADe was tested frame by frame in 47 unaltered full-ranged videos that contained 86 histologically confirmed polyps.Finally,we conducted a selfcontrolled observational study to validate the diagnostic performance of CADe in real-world colonoscopy with the main outcome measure of polyps per colonoscopy in Changhai Hospital.RESULTS The CADe was able to identify polyps in the test dataset with 95.0%sensitivity and 99.1%specificity.For colonoscopy videos,all 86 polyps were detected with 92.2%sensitivity and 93.6%specificity in frame-by-frame analysis.In the prospective validation,the sensitivity of CAD in identifying polyps was 98.4%(185/188).Folds,reflections of light and fecal fluid were the main causes of false positives in both the test dataset and clinical colonoscopies.Colonoscopists can detect more polyps(0.90 vs 0.82,P<0.001)and adenomas(0.32 vs 0.30,P=0.045)with the aid of CADe,particularly polyps<5 mm and flat polyps(0.65 vs 0.57,P<0.001;0.74 vs 0.67,P=0.001,respectively).However,high efficacy is not realized in colonoscopies with inadequate bowel preparation and withdrawal time(P=0.32;P=0.16,respectively).CONCLUSION CADe is feasible in the clinical setting and might help endoscopists detect more polyps and adenomas,and further confirmation is warranted.展开更多
The artistic style transfer of images aims to synthesise novel images by combining the content of one image with the style of another,which is a long-standing research topic and already has been widely applied in real...The artistic style transfer of images aims to synthesise novel images by combining the content of one image with the style of another,which is a long-standing research topic and already has been widely applied in real world.However,defining the aesthetic perception from the human visual system is a challenging problem.In this study,the authors propose a novel method for automatic visual perception style transfer.First,they render a novel saliency detection algorithm to automatically perceive the visual attention of an image.Then,different from conventional style transfer algorithm in which style transferring is applied uniformly across all image regions,the authors apply a saliency algorithm to guide the style transferring process,enabling different types of style transferring to occur in different regions.Extensive experiments show that the proposed saliency detection algorithm and the style transfer algorithm are superior in performance and efficiency。展开更多
基金the TCL Science and Technology Innovation Fundthe Youth Science and Technology Talent Promotion Project of Jiangsu Association for Science and Technology,Grant/Award Number:JSTJ‐2023‐017+4 种基金Shenzhen Municipal Science and Technology Innovation Council,Grant/Award Number:JSGG20220831105002004National Natural Science Foundation of China,Grant/Award Number:62201468Postdoctoral Research Foundation of China,Grant/Award Number:2022M722599the Fundamental Research Funds for the Central Universities,Grant/Award Number:D5000210966the Guangdong Basic and Applied Basic Research Foundation,Grant/Award Number:2021A1515110079。
文摘Convolutional neural networks depend on deep network architectures to extract accurate information for image super‐resolution.However,obtained information of these con-volutional neural networks cannot completely express predicted high‐quality images for complex scenes.A dynamic network for image super‐resolution(DSRNet)is presented,which contains a residual enhancement block,wide enhancement block,feature refine-ment block and construction block.The residual enhancement block is composed of a residual enhanced architecture to facilitate hierarchical features for image super‐resolution.To enhance robustness of obtained super‐resolution model for complex scenes,a wide enhancement block achieves a dynamic architecture to learn more robust information to enhance applicability of an obtained super‐resolution model for varying scenes.To prevent interference of components in a wide enhancement block,a refine-ment block utilises a stacked architecture to accurately learn obtained features.Also,a residual learning operation is embedded in the refinement block to prevent long‐term dependency problem.Finally,a construction block is responsible for reconstructing high‐quality images.Designed heterogeneous architecture can not only facilitate richer structural information,but also be lightweight,which is suitable for mobile digital devices.Experimental results show that our method is more competitive in terms of performance,recovering time of image super‐resolution and complexity.The code of DSRNet can be obtained at https://github.com/hellloxiaotian/DSRNet.
基金the National Natural Science Foundation of China(Grant No.52072041)the Beijing Natural Science Foundation(Grant No.JQ21007)+2 种基金the University of Chinese Academy of Sciences(Grant No.Y8540XX2D2)the Robotics Rhino-Bird Focused Research Project(No.2020-01-002)the Tencent Robotics X Laboratory.
文摘Humans can perceive our complex world through multi-sensory fusion.Under limited visual conditions,people can sense a variety of tactile signals to identify objects accurately and rapidly.However,replicating this unique capability in robots remains a significant challenge.Here,we present a new form of ultralight multifunctional tactile nano-layered carbon aerogel sensor that provides pressure,temperature,material recognition and 3D location capabilities,which is combined with multimodal supervised learning algorithms for object recognition.The sensor exhibits human-like pressure(0.04–100 kPa)and temperature(21.5–66.2℃)detection,millisecond response times(11 ms),a pressure sensitivity of 92.22 kPa^(−1)and triboelectric durability of over 6000 cycles.The devised algorithm has universality and can accommodate a range of application scenarios.The tactile system can identify common foods in a kitchen scene with 94.63%accuracy and explore the topographic and geomorphic features of a Mars scene with 100%accuracy.This sensing approach empowers robots with versatile tactile perception to advance future society toward heightened sensing,recognition and intelligence.
基金supported by the Opening Foundation of the Agile and Intelligence Computing Key Laboratory of Sichuan Province under Grant No.H23004the Chengdu Municipal Science and Technology Bureau Technological Innovation R&D Project(Key Project)under Grant No.2024-YF08-00106-GX.
文摘Aiming to solve the bottleneck problem of electromagnetic scattering simulation in the scenes of extremely large-scale seas and ships,a high-frequency method by using graphics processing unit(GPU)parallel acceleration technique is proposed.For the implementation of different electromagnetic methods of physical optics(PO),shooting and bouncing ray(SBR),and physical theory of diffraction(PTD),a parallel computing scheme based on the CPU-GPU parallel computing scheme is realized to balance computing tasks.Finally,a multi-GPU framework is further proposed to solve the computational difficulty caused by the massive number of ray tubes in the ray tracing process.By using the established simulation platform,signals of ships at different seas are simulated and their images are achieved as well.It is shown that the higher sea states degrade the averaged peak signal-to-noise ratio(PSNR)of radar image.
基金supported by the National Natural Science Foundation of China (Grant Nos.62006219 and 62001266)Guangdong Innovative and Entrepre-neurial Research Team Program (grant No.2017ZT07C341)+2 种基金the Bureau of Industry and Information Technology of Shenzhen for the 2017 Graphene Manufacturing Innovation Center Project (No.201901171523)the China Postdoctoral Science Foundation (No.2020M680506)Guangdong Basic and Applied Basic Research Foundation (No.2020A1515110338).
文摘Various strategies,including controls of morphology,oxidation state,defect,and doping,have been developed to improve the performance of Cu-based catalysts for CO_(2) reduction reaction(CO_(2)RR),generating a large amount of data.However,a unified understanding of underlying mechanism for further optimization is still lacking.In this work,combining first-principles calculations and machine learning(ML)techniques,we elucidate critical factors influencing the catalytic properties,taking Cu-based single atom alloys(SAAs)as examples.Our method relies on high-throughput calculations of 2669 CO adsorption configurations on 43 types of Cu-based SAAs with various surfaces.Extensive ML analyses reveal that low generalized coordination numbers and valence electron number are key features to determine catalytic performance.Applying our ML model with cross-group learning scheme,we demonstrate the model generalizes well between Cu-based SAAs with different alloying elements.Further,electronic structure calculations suggest surface negative center could enhance CO adsorption by back donating electrons to antibonding orbitals of CO.Finally,several SAAs,including PCu,AgCu,GaCu,ZnCu,SnCu,GeCu,InCu,and SiCu,are identified as promising CO_(2)RR catalysts.Our work provides a paradigm for the rational design and fast screening of SAAs for various electrocatalytic reactions.
基金supported by the Macao Science and Technology Development Funds Grands No.0158/2019/A3 from the Macao Special Administrative Region of the People’s Republic of China.
文摘Few-shot learning is becoming more and more popular in many fields,especially in the computer vision field.This inspires us to introduce few-shot learning to the genomic field,which faces a typical few-shot problem because some tasks only have a limited number of samples with high-dimensions.The goal of this study was to investigate the few-shot disease sub-type prediction problem and identify patient subgroups through training on small data.Accurate disease subtype classification allows clinicians to efficiently deliver investigations and interventions in clinical practice.We propose the SW-Net,which simulates the clinical process of extracting the shared knowledge from a range of interrelated tasks and generalizes it to unseen data.Our model is built upon a simple baseline,and we modified it for genomic data.Supportbased initialization for the classifier and transductive fine-tuning techniques were applied in our model to improve prediction accuracy,and an Entropy regularization term on the query set was appended to reduce over-fitting.Moreover,to address the high dimension and high noise issue,we future extended a feature selection module to adaptively select important features and a sample weighting module to prioritize high-confidence samples.Experiments on simulated data and The Cancer Genome Atlas meta-dataset show that our new baseline model gets higher prediction accuracy compared to other competing algorithms.
文摘Background:Women with uterine leiomyomas may suffer severe symptoms.To avoid risks of side effects,it is necessary to develop an optimal agent to shrink leiomyomas with fewer side effects and a lower recurrence rate.Curcumin may have a lower side effect in uterine leiomyoma treatment.Methods:We established the estrogen-and-progesterone-induced murine model of uterine leiomyoma.Next,we determined the expression of related genes of the β-catenin/Wnt signaling pathway by western blot,reverse transcription-polymerase chain reaction,and immunohistochemistry.We also noticed the morphological changes in uterine tissues by hematoxylin-eosin staining.Results:Curcumin plays an important role in Wnt/β-catenin signaling pathway-related expression including β-catenin,adenomatous polyposis coli,glycogen synthase kinase-3β,Wnt-11,and serum hormone concentrations.Conclusions:Curcumin could the down-regulation of serum hormone concentrations and inhibition of the β-catenin/Wnt signaling pathway in the treatment of uterine leiomyoma.
基金supported by the National Natural Science Foundation of China(NSFC)Grant Nos.11988101,1172531312041303,12041304,12203045,12203070,12103013,T2241020the National SKA Program of China(Nos.2020SKA0120200,2022SKA0130100,2022SKA0130104)+5 种基金the Foundation of Science and Technology of Guizhou Province(No.(2021)023)the Foundation of Guizhou Provincial Education Department(Nos.KY(2021)303,KY(2020)003)support from the National Natural Science Foundation of China under grant U2031117the Youth Innovation Promotion Association CAS(id.2021055)CAS Project for Young Scientists in Basic Research(grant YSBR006)the Cultivation Project for FAST Scientific Payoff and Research Achievement of CAMS-CAS。
文摘We report the discovery of PSR J1909+0122 by the Five-hundred-meter Aperture Spherical Radio Telescope(FAST)as part of the Commensal Radio Astronomy FAST Survey.PSR J1909+0122 has a spin period of 1.257 s and a dispersion measure of 186.2 pc cm^(-3).The averaged pulse profile shows two distinct components.We performed a single-pulse study based on a one-hour observation at 1.25 GHz on 2021 August 23.We used a threshold of 5σ_(ep) to measure the nulling fraction(NF)as 63%±1.5%.The longitude-resolved fluctuation spectra and fast Fourier transform spectra of the binary sequences revealed the quasi-periodicity of nulling with a period of 30 rotation periods.We examined the reliability of the periodicity by comparing it to random noise injection.The NF,E,and modulation periodicity P_(M) of PSR J1909+0122 were compared with other periodic nulling pulsars,showing that the source of J1909+0122 has the second largest NF in the population.Long-term timing observations over six months were used to derive the phase-connected ephemeris of this pulsar.The measured P and P values disfavor dipolar geometry for polar gap models,and the prediction for a space-charge-limited flow model in the case of inverse Compton scattering is only just above the death line.In this work,PSR J1909+0122 has revealed possible correlations between nulling behavior and pulsar properties,which will help to shed light on the pulsar emission mechanism and its temporal evolution in future observations.
基金The Parkes Radio Telescope (Murriyang) is part of the Australia Telescope National Facility, which is funded by the Australian Government for operation as a National Facility managed by CSIROsupported by the National Natural Science Foundation of China (NSFC) grant Nos. 12041303, 12041304, 11873067, 12133004, 12203045, 12203070, 12203072, 12103013, U2031117 and T2241020+11 种基金the CAS-MPG LEGACY project and the National SKA Program of China No. 2020SKA0120200the Foundation of Science and Technology of Guizhou Province No. ((2021)023)the Foundation of Guizhou Provincial Education Department (No.KY(2021)303)the National Key Research and Development Program of China Nos. 2022YFC2205202 and 2022YFC2205203the Major Science and Technology Program of Xinjiang Uygur Autonomous Region Nos. 2022A03013-1, 2022A03013-3 and 2022A03013-4the National Key Research and Development Program of China No. 2022YFC2205203the 2021 project Xinjiang Uygur autonomous region of China for Tianshan elites and the Youth Innovation Promotion Association of CAS under No. 2023069support from the Youth Innovation Promotion Association CAS (id. 2021055)CAS Project for Young Scientists in Basic Research (grant YSBR-006)the Cultivation Project for FAST Scientific Payoff and Research Achievement of CAMS-CASsupport from Zhejiang Provincial Natural Science Foundation of China under grant No. LY23A030001supported by the NSF Physics Frontiers Center award number 2020265。
文摘We report the radio observations of the eclipsing black widow pulsar J1720-0534, a 3.26 ms pulsar in orbit with a low mass companion of mass 0.029 to 0.034 M⊙. We obtain the phase-connected timing ephemeris and polarization profile of this millisecond pulsar(MSP) using the Five-hundred-meter Aperture Spherical radio Telescope(FAST), the Green Bank Telescope(GBT), and the Parkes Telescope. For the first time from such a system, an oscillatory polarization angle change was observed from a particular eclipse egress with partial depolarization, indicating 10-milliGauss-level reciprocating magnetic fields oscillating in a length scale of 5 ×10^(3)km(assuming an orbital inclination angle of 90°) outside the companion's magnetosphere. The dispersion measure variation observed during the ingresses and egresses shows the rapid raising of the electron density in the shock boundary between the companion's magnetosphere and the surrounding pulsar wind. We suggest that the observed oscillatory magnetic fields originate from the pulsar wind outside the companion's magnetosphere.
文摘In this paper,we summarize recent progresses made in deep learning based acoustic models and the motivation and insights behind the surveyed techniques.We first discuss models such as recurrent neural networks(RNNs) and convolutional neural networks(CNNs) that can effectively exploit variablelength contextual information,and their various combination with other models.We then describe models that are optimized end-to-end and emphasize on feature representations learned jointly with the rest of the system,the connectionist temporal classification(CTC) criterion,and the attention-based sequenceto-sequence translation model.We further illustrate robustness issues in speech recognition systems,and discuss acoustic model adaptation,speech enhancement and separation,and robust training strategies.We also cover modeling techniques that lead to more efficient decoding and discuss possible future directions in acoustic model research.
基金We are grateful for financial supports from the National Natural Science Foundation of China(No.61975173)the National Key Research and Development Program of China(No.SQ2019YFC170311)+3 种基金the Major Scientific Research Project of Zhejiang Lab(No.2019MC0AD01)the Key Research and Development Project of Zhejiang Province(No.2021C05003)the Quantum Joint Funds of the Natural Foundation of Shandong Province(No.ZR2020LLZ007)the CIE-Tencent Robotics X Rhino-Bird Focused Research Program(No.2020-01-006).
文摘Flexible strain sensors play an important role in electronic skins,wearable medical devices,and advanced robots.Herein,a highly sensitive and fast response optical strain sensor with two evanescently coupled optical micro/nanofibers(MNFs)embedded in a polydimethylsiloxane(PDMS)film is proposed.The strain sensor exhibits a gauge factor as high as 64.5 for strain≤0.5%and a strain resolution of 0.0012%which corresponds to elongation of 120 nm on a 1 cm long device.As a proof-of-concept,highly sensitive fingertip pulse measurement is realized.The properties of fast temporal frequency response up to 30 kHz and a pressure sensitivity of 102 kPa^(−1) enable the sensor for sound detection.Such versatile sensor could be of great use in physiological signal monitoring,voice recognition and micro-displacement detection.
文摘随着多媒体数据的爆发式增长,云端数据呈现出大规模多模态混合并存的特性.服务于数据分析的传统存储系统因为缺乏数据的语义管理而面临读取延时超长的挑战.针对图像和文本2种模态数据,在传统存储系统之上提出一种跨模态图文数据内容筛选存储机制(cross-modal image and text content sifting storage,CITCSS),用于提供大规模在线相似性内容筛选服务,从存储系统层面缓解数据分析时必须从存储中读出所有数据的读带宽压力.机制分为离线与在线2个阶段.离线阶段中,引入基于自监督的生成对抗式Hash方法,系统利用这种方法生成语义元数据.然后,将元数据注入独立的元数据空间.最后,根据相似性Hash码间汉明距离能够度量语义距离的特点,利用Neo4j图数据库构建Hash元数据图谱,并在语义图谱中建立Hash码与存储路径之间的映射.在线阶段中,用户发送与分析相关的图像或文本,存储系统首先转化数据为Hash码.然后,在筛选半径内通过Hash元数据图谱寻找相似节点,进而找到相似文件的底层存储路径返回筛选数据.实验结果表明,与传统语义存储系统相比,CITCSS在召回率超过98%的性能下,读取延迟相对降低了99.07%~99.77%.
基金National Natural Science Foundation of China(Grant No.51875495)National Key R&D Program of China(Grant No.2017YFB1301901)Hebei Provincial Science and Technology Project of China(Grant No.206Z1805G).
文摘In the present study,the over-constrained hybrid manipulator R(2RPR)R/SP+RR is considered as the research objective.In this paper,kinematics of the hybrid manipulator,including the forward and inverse position,are analyzed.Then,the workspace is checked based on the inverse position solution to evaluate whether the workspace of the hybrid manipulator meets the requirements,and the actual workspace of the hybrid robot is analyzed.After that,the force analysis of the over-constrained parallel mechanism is carried out,and an ADAMS-ANSYS rigid-flexible hybrid body model is established to verify the simulation.Based on the obtained results from the force analysis,the manipulator structure is designed.Then,the structure optimization is carried out to improve the robot stiffness.Finally,calibration and workspace verification experiments are performed on the prototype,cutting experiment of an S-shaped aluminum alloy workpiece is completed,and the experiment verifies the machining ability of the prototype.This work conducts kinematics,workspace,force analyses,structural optimization design and experiments on the over-constrained hybrid manipulator R(2RPR)R/SP+RR,providing design basis and technical support for the development of the novel hybrid manipulator in practical engineering.
基金the National Natural Science Foundation of China(No.62001100)the Fundamental Research Funds for the Central Universities(No.2232019D3-52)Shanghai Sailing Program.(No.19YF1402000).
文摘Behind the prevalence of multimedia technology,digital copyright disputes are becoming increasingly serious.The digital watermarking prevention technique against the copyright infringement needs to be improved urgently.Among the proposed technologies,zero-watermarking has been favored recently.In order to improve the robustness of the zero-watermarking,a novel robust audio zerowatermarking method based on sparse representation is proposed.The proposed scheme is mainly based on the K-singular value decomposition(K-SVD)algorithm to construct an optimal over complete dictionary from the background audio signal.After that,the orthogonal matching pursuit(OMP)algorithm is used to calculate the sparse coefficient of the segmented test audio and generate the corresponding sparse coefficient matrix.Then,the mean value of absolute sparse coefficients in the sparse matrix of segmented speech is calculated and selected,and then comparing the mean absolute coefficient of segmented speech with the average value of the selected coefficients to realize the embedding of zero-watermarking.Experimental results show that the proposed audio zerowatermarking algorithm based on sparse representation performs effectively in resisting various common attacks.Compared with the baseline works,the proposed method has better robustness.
基金the National Key R&D Program of China,No.2018YFC1313103the National Natural Science Foundation of China,No.81670473 and No.81873546+1 种基金the“Shu Guang”Project of Shanghai Municipal Education Commission and Shanghai Education Development Foundation,No.19SG30the Key Area Research and Development Program of Guangdong Province,China,No.2018B010111001.
文摘BACKGROUND Artificial intelligence in colonoscopy is an emerging field,and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas.Several deep learning-based computer-assisted detection(CADe)techniques were established from small single-center datasets,and unrepresentative learning materials might confine their application and generalization in wide practice.Although CADes have been reported to identify polyps in colonoscopic images and videos in real time,their diagnostic performance deserves to be further validated in clinical practice.AIM To train and test a CADe based on multicenter high-quality images of polyps and preliminarily validate it in clinical colonoscopies.METHODS With high-quality screening and labeling from 55 qualified colonoscopists,a dataset consisting of over 71000 images from 20 centers was used to train and test a deep learning-based CADe.In addition,the real-time diagnostic performance of CADe was tested frame by frame in 47 unaltered full-ranged videos that contained 86 histologically confirmed polyps.Finally,we conducted a selfcontrolled observational study to validate the diagnostic performance of CADe in real-world colonoscopy with the main outcome measure of polyps per colonoscopy in Changhai Hospital.RESULTS The CADe was able to identify polyps in the test dataset with 95.0%sensitivity and 99.1%specificity.For colonoscopy videos,all 86 polyps were detected with 92.2%sensitivity and 93.6%specificity in frame-by-frame analysis.In the prospective validation,the sensitivity of CAD in identifying polyps was 98.4%(185/188).Folds,reflections of light and fecal fluid were the main causes of false positives in both the test dataset and clinical colonoscopies.Colonoscopists can detect more polyps(0.90 vs 0.82,P<0.001)and adenomas(0.32 vs 0.30,P=0.045)with the aid of CADe,particularly polyps<5 mm and flat polyps(0.65 vs 0.57,P<0.001;0.74 vs 0.67,P=0.001,respectively).However,high efficacy is not realized in colonoscopies with inadequate bowel preparation and withdrawal time(P=0.32;P=0.16,respectively).CONCLUSION CADe is feasible in the clinical setting and might help endoscopists detect more polyps and adenomas,and further confirmation is warranted.
文摘The artistic style transfer of images aims to synthesise novel images by combining the content of one image with the style of another,which is a long-standing research topic and already has been widely applied in real world.However,defining the aesthetic perception from the human visual system is a challenging problem.In this study,the authors propose a novel method for automatic visual perception style transfer.First,they render a novel saliency detection algorithm to automatically perceive the visual attention of an image.Then,different from conventional style transfer algorithm in which style transferring is applied uniformly across all image regions,the authors apply a saliency algorithm to guide the style transferring process,enabling different types of style transferring to occur in different regions.Extensive experiments show that the proposed saliency detection algorithm and the style transfer algorithm are superior in performance and efficiency。