Activation of the wnt/β-catenin/CYP1B1 pathway alleviates oxidative stress and protects the blood-brain barrier under cerebral ischemia/reperfusion conditions

Accumulating evidence suggests that oxidative stress and the Wnt/β-catenin pathway participate in stroke-induced disruption of the blood-brain barrier.However,the potential links between them following ischemic stroke remain largely unknown.The present study found that cerebral ischemia leads to oxidative stress and repression of the Wnt/β-catenin pathway.Meanwhile,Wnt/β-catenin pathway activation by the pharmacological inhibito r,TWS119,relieved oxidative stress,increased the levels of cytochrome P4501B1(CYP1B1)and tight junction-associated proteins(zonula occludens-1[ZO-1],occludin and claudin-5),as well as brain microvascular density in cerebral ischemia rats.Moreove r,rat brain microvascular endothelial cells that underwent oxygen glucose deprivation/reoxygenation displayed intense oxidative stress,suppression of the Wnt/β-catenin pathway,aggravated cell apoptosis,downregulated CYP1B1and tight junction protein levels,and inhibited cell prolife ration and migration.Overexpression ofβ-catenin or knockdown ofβ-catenin and CYP1B1 genes in rat brain mic rovascular endothelial cells at least partly ameliorated or exacerbated these effects,respectively.In addition,small interfering RNA-mediatedβ-catenin silencing decreased CYP1B1 expression,whereas CYP1B1 knoc kdown did not change the levels of glycogen synthase kinase 3β,Wnt-3a,andβ-catenin proteins in rat brain microvascular endothelial cells after oxygen glucose deprivatio n/reoxygenation.Thus,the data suggest that CYP1B1 can be regulated by Wnt/β-catenin signaling,and activation of the Wnt/β-catenin/CYP1B1 pathway contributes to alleviation of oxidative stress,increased tight junction levels,and protection of the blood-brain barrier against ischemia/hypoxia-induced injury.

In-depth analysis of Bt cotton adoption:farmers'opinions,genetic landscape,and varied perspectives——a case study from Pakistan

Background Bt technology has played significant role in controlling bollworms and increasing cotton yield in earlier days of its introduction,a subsequent decline in yield became apparent over time.This decline may be attributed to various environmental factors,pest dynamics,or combination of both.Therefore,the present biophysical survey and questionnaire were designed to evaluate the impact of Bt cotton on bollworms management and its effect on reducing spray costs,targeting farmers with varied landholdings and educational backgrounds.Additionally,data on farmers'cultivated varieties and the prevalence of bollworms and sucking insects in their fields were recorded.Subsequently,about eleven thousand cotton samples from farmer fields were tested for Cry1Ac,Cry2Ab and Vip3A genes by strip test.Results In this analysis,83% of the farmers planting approved varieties believe that Bt technology control bollworms,while 17% hold contradictory views.Similarly,among farmers cultivating unapproved varieties,77% agree on effectiveness of Bt technology against bollworms,while 23% disagree.On the other hand,67% of farmers planting approved varieties believe that Bt technology does not reduce spray costs,while 33% agree with the effectiveness.Similarly,78% of farmers cultivating unapproved varieties express doubt regarding its role to reduce spray costs,while 22% are in favour of this notion.Differences in opinions on the effectiveness of Bt cotton in controlling bollworms and reducing spray cost between farmers planting unapproved and approved varieties may stem from several factors.One major cause is the heavy infestation of sucking insects,which is probably due to the narrow genetic variation of the cultivated varieties.Additionally,the widespread cultivation of unapproved varieties(21.67%)is also an important factor to cause different opinions on the effectiveness of Bt cotton.Conclusion Based on our findings,we propose that the ineffective control of pests on cotton crop may be attributed to large scale cultivation of unapproved varieties and non-inclusion of double and triple transgene technologies in country's sowing plan.On the basis of our findings,we suggest cotton breeders,regulatory bodies and legislative bodies to discourage the cultivation of unapproved varieties and impure seed.Moreover,the adoption of double and triple Bt genes in cottons with a broad genetic variation could facilitate the revival of the cotton industry,and presenting a promising way forward.

Properties of Bark Particleboard Bonded with Demethylated Lignin Adhesives Derived from Leucaena leucocephala Bark

Lignin extraction from bark can maximize the utilization of biomass waste,offer cost-effectiveness,and promote environmental friendliness when employed as an adhesive material in bark particleboard production.Particles of fine(0.2 to 1.0 mm),medium(1.0 to 2.5 mm),and coarse(2.5 to 12.0 mm)sizes,derived from the bark of Leucaena leucocephala,were hot-pressed using a heating plate at 175℃for 7 min to create single-layer particleboards measuring 320 mm×320 mm×10 mm,targeting a density of 700 kg/m^(3).Subsequently,the samples were trimmed and conditioned at 20℃and 65%relative humidity.In this study,we compared bark particleboard bonded with urea formaldehyde(UF)adhesive to fine-sized particleboard bonded with demethylated lignin adhesive.The results indicated that bark particleboards utilizing demethylated lignin and UF adhesives exhibited similar qualities.Coarse particleboard showed differences in modulus of elasticity(MOE)and modulus of rupture(MOR),while medium-sized particles exhibited significant variations in moisture content(MC)and water absorption(WA).Furthermore,the thickness swelling of coarse and medium-sized particles under wet and oven-dried conditions exhibited notable distinctions.Overall,the demethylated lignin adhesive extracted from L.leucocephala bark demonstrated similar quality to UF adhesive,with particle size correlating inversely to the strength of the bark particleboard.

Growth, yield and fiber quality characteristics of Bt and non-Bt cotton cultivars in response to boron nutrition

Background Boron(B)deficiency is an important factor for poor seed cotton yield and fiber quality.However,it is often missing in the plant nutrition program,particularly in developing countries.The current study investigated B’s effect on growth,yield,and fiber quality of Bt(CIM-663)and non-Bt(Cyto-124)cotton cultivars.The experimental plan consisted of twelve treatments:Control(CK);B at 1 mg·kg^(−1) soil application(SB1);2 mg·kg^(−1) B(SB2);3 mg·kg^(−1) B(SB3);0.2%B foliar spray(FB1);0.4%B foliar spray(FB2);1 mg·kg^(−1) B+0.2%B foliar spray(SB1+FB1);1 mg·kg^(−1) B+0.4%B foliar spray(SB1+FB2);2 mg·kg^(−1) B+0.2%B foliar spray(SB2+FB1);2 mg·kg^(−1) B+0.4%B foliar spray(SB2+FB2);3 mg·kg^(−1) B+0.2%B foliar spray(SB3+FB1);3 mg·kg^(−1) B+0.4%B foliar spray(SB3+FB2).Each treat-ment has three replications,one pot having two plants per replication.Results B nutrition at all levels and methods of application significantly(P≤0.05)affected the growth,physiological,yield,and fiber quality characteristics of both cotton cultivars.However,SB2 either alone or in combination with foliar spray showed superiority over others,particularly in the non-Bt cultivar which responded better to B nutrition.Maxi-mum improvement in monopodial branches(345%),sympodial branches(143%),chlorophyll-a(177%),chlorophyll-b(194%),photosynthesis(169%),and ginning out turn(579%)in the non-Bt cultivar was found with SB2 compared with CK.In Bt cultivar,although no consistent trend was found but integrated use of SB3 with foliar spray performed relatively better for improving cotton growth compared with other treatments.Fiber quality characteristics in both cultivars were improved markedly but variably with different B treatments.Conclusion B nutrition with SB2 either alone or in combination with foliar spray was found optimum for improving cotton’s growth and yield characteristics.

Application of Zinc, Iron and Boron Enhances Productivity and Grain Biofortification of Mungbean

Deficiencies of essential vitamins,iron(Fe),and zinc(Zn)affect over one-half of the world’s population.A significant progress has been made to control micronutrient deficiencies through supplementation,but new approaches are needed,especially to reach the rural poor.Agronomic biofortification of pulses with Zn,Fe,and boron(B)offers a pragmatic solution to combat hidden hunger instead of food fortification and supplementation.Moreover,it also has positive effects on crop production as well.Therefore,we conducted three separate field experiments for two consecutive years to evaluate the impact of soil and foliar application of the aforementioned nutrients on the yield and seed biofortification of mungbean.Soil application of Zn at 0,4.125,8.25,Fe at 0,2.5,5.0 and B at 0,0.55,1.1 kg ha−1 was done in the first,second and third experiment,respectively.Foliar application in these experiments was done at 0.3%Zn,0.2%Fe and 0.1%B respectively one week after flowering initiation.Data revealed that soil-applied Zn,Fe and B at 8.25,5.0 and 1.1 kg ha−1,respectively,enhanced the grain yield of mungbean;however,this increase in yield was statistically similar to that recorded with Zn,Fe and B at 4.125,2.5 and 0.55 kg ha−1,respectively.Foliar application of these nutrients at flower initiation significantly enhanced the Zn contents by 28%and 31%,Fe contents by 80%and 78%,while B contents by 98%and 116%over control during 2019 and 2020,respectively.It was concluded from the results that soil application of Zn,Fe,and B enhanced the yield performance of mungbean;while significant improvements in seed Zn,Fe,and B contents were recorded with foliar application of these nutrients.

Studying the Effect of Polyester Fiber Blend Ratio and Pilling Cycle on Blended Knit Fabrics

Pilling is a severe concern for blended fabrics. The aesthetic look and smoothness are the buyers’ prime requirements. The main focus of the study was to see the pilling behavior from various percentages of polyester fiber blend ratio as well as the different pilling cycles on blended fabrics. The cotton, polyester, and elastane prepared the study fabrics. These fabrics are (90% Cotton/5% Polyester/5% Elastane, 90% Cotton/6% Polyester/4% Elastane, 90% Cotton/7% Polyester/3% Elastane, 90% Cotton/8% Polyester/2% Elastane, and 90% Cotton/9% Polyester/1% Elastane, 85% Cotton/10% Polyester/5% Elastane, 85% Cotton/11% Polyester/4% Elastane, 85% Cotton/12% Polyester/3% Elastane, 85% Cotton/13% Polyester/2% Elastane, and 85% Cotton/ 14% Polyester/1% Elastane, 80% Cotton/15% Polyester/5% Elastane, 80% Cotton/16% Polyester/4% Elastane, 80% Cotton/17% Polyester/3% Elastane, 80% Cotton/18% Polyester/2% Elastane, and 80% Cotton/19% Polyester/1% Elastane). The selected polyester blend ratios were 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18% and 19% respectively. The study used the Martindale pilling tester with 2000, 5000, and 7000 cycles, respectively. The evaluation followed the ISO 12945-2:2000. The study findings are that the polyester fiber blend ratio did not influence the pilling grade on blended fabrics for pilling cycles 2000, and the pilling grade remained constant at 4 - 5. The pilling grade started to deteriorate in pilling cycle 5000 for the fabrics 85%C/10%P/5%E, 85%C/11%P/4%E, 85%C/12%P/3%E, 85%C/ 13%P/2%E, 85%C/14%P/1%E showed the pilling grade 4, and the fabrics made from 80%C/15%P/5%E, 80%C/16%P/4%E, 80%C/17%P/3%E, 80%C/ 18%P/2%E, 80%C/19%P/1%E showed the pilling grade 4, 3, 3, 3, and 3 respectively. For the pilling cycles 7000, the pilling grade further deteriorated for the fabrics 80%C/15%P/5%E, 80%C/16%P/4%E, 80%C/17%P/3%E, 80%C/ 18%P/2%E, 80%C/19%P/1%E showed the pilling grade 3, 3, 2, 2, and 2 respectively. The study finds the dominance of polyester fiber throughout the experiment. The author hopes this study’s outcome will help new researchers, advanced researchers, and the textile industry’s sustainable development research and development team.

Predicting Bursting Strength Behavior of Weft Knitted Fabrics Using Various Percentages of Cotton, Polyester, and Spandex Fibers

The bursting strength is an essential quality parameter of knit fabric. The fabric structure, weight, types of fibers, and fiber blend proportion influence the bursting strength parameter. The tenacity of polyester fiber is better than cotton and spandex. The study focused on predicting knit fabric bursting strength test value using different fibers (cotton, polyester, and spandex) with varying percentages of the blend ratio. This study used fifteen categories of blended fabrics. The Pearson Correlation and the hypothetical ANOVA regression analysis were conducted to do the statistical significance test. The experimental result reveals that the bursting strength test result increased with the increased percentage of polyester and suggested a suitable regression equation. The dominance of the polyester fiber was observed throughout the experiment, i.e., the higher the polyester blend proportion, the higher the bursting strength value. The inclusion of polyester in blends can reduce the cost of fabric. The developed prediction model or equation can help the fabric manufacturer make appropriate decisions regarding getting the expected bursting strength. The researcher hopes that the findings from this study will motivate new researchers, advanced researchers, and the textile manufacturing industry.

Response of Contrasting Rice Genotypes to Zinc Sources under Saline Condition

Abiotic stresses are among the major limiting factors for plant growth and crop productivity.Among these,salinity is one of the major risk factors for plant growth and development in arid to semi-arid regions.Cultivation of salt tolerant crop genotypes is one of the imperative approaches to meet the food demand for increasing population.The current experiment was carried out to access the performance of different rice genotypes under salinity stress and Zinc(Zn)sources.Four rice genotypes were grown in a pot experiment and were exposed to salinity stress(7 dS m^(−1)),and Zn(15 mg kg^(-1)soil)was applied from two sources,ZnSO4 and Zn-EDTA.A control of both salinity and Zn was kept for comparison.Results showed that based on the biomass accumulation and K^(+)/Na^(+)ratio,KSK-133 and BAS-198 emerged as salt tolerant and salt sensitive,respectively.Similarly,based on the Zn concentration,BAS-2000 was reported as Zn-in-efficient while IR-6 was a Zn-efficient genotype.Our results also revealed that plant growth,relative water content(RWC),physiological attributes including chlorophyll contents,ionic concentrations in straw and grains of all rice genotypes were decreased under salinity stress.However,salt tolerant and Zn-in-efficient rice genotypes showed significantly higher shoot K^(+)and Zn concentrations under saline conditions.Zinc application significantly alleviates the harmful effects of salinity by improving morpho-physiological attributes and enhancing antioxidant enzyme activities,and the uptake of K and Zn.The beneficial effect of Zn was more pronounced in salt-tolerant and Zn in-efficient rice genotypes as compared with salt-sensitive and Zn-efficient genotypes.In sum,our results confirmed that Zn application increased overall plant’s performance under saline conditions,particularly in Zn in-efficient and tolerant genotypes as compared with salt-sensitive and Zn efficient rice genotypes.

Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants:The case of Artemisia vulgaris L.substituted for Artemisia annua L.in Western Uganda

Background:Different parts of Artemisia vulgaris L.(A.vulgaris)are ethno-medicinally used as an emmenagogue and for the treatment of ailments such as malaria fever,ulcers,and cancer.However,anecdotal evidence shows that the plant is often substituted for Artemisia annua L.(A.annua)by herbalists in Western Uganda due to similarities in their morphology.Misidentification of medicinal plants and mislabelling of herbal products have been incriminated in toxicity and adverse health outcomes in traditional medicine practise.Because safety continues to be a major issue with the use of herbal remedies,it becomes imperative therefore that medicinal plants should be correctly identified.Methods:This study focused on investigating the macroscopic,microscopic,physicochemical characteristics and phytochemical composition of A.vulgaris leaves compared to A.annua to ease its correct identification.Results:The results showed that there are some colour differences between the leaves of the two species,with a close arrangement of microscopic features but different leaf constants.The leaves of the two Artemisia species had similar tastes,but their shapes and colours(greenish-yellow for A.annua and dark green for A.vulgaris)can be used by the local community to distinguish between them.The artemisinin content was higher in A.vulgaris leaves(1.72%)than in A.annua(1.43%),but the reverse was observed for the total flavonoid content.Conclusion:This observation could justify the change in the use of A.vulgaris by the indigenous community in western Uganda.Further studies should consider the pharmacognostic comparison of A.annua with other species in the genus Artemisia and the use of molecular techniques such as DNA barcoding.

Variability in permeability and integrity of cell membrane and depletion of food reserves in neem(Azadirachta indica) seeds from trees of different age classes

We quantified cell membrane permeability （electrical conduc-tivity-EC, water soluble sugar-WSS, and amino acids-AA） and integrity （phospholipids,α-tocopherol and lipid peroxidation） along with food reserve deterioration （total proteins, total sugar, and total starch） of neem seeds collected from various mother tree age classes and stored for 65 days in airtight plastic containers at ambient room temperature （35±5°C）. Results show that the activities were higher in fresh seeds （EC 267.56-2950.01 μS/g, WSS 19.96-19.48 mg/g and AA 5.40-5.35 mg/g） and declined with increasing duration of storage period （EC 153.37-195.17 μS/g, WSS 3.13-4.17 mg/g and AA 4.29-4.49 mg/g after 35 days and EC 144.02-161.56 μS/g, WSS 2.06-2.40 mg/g and AA 3.98-4.27 mg/g after 65 days of storage）. Phospholipids andα-tocopherol were higher in fresh seed （0.073-0.093 OD at 710 nm and 0.080-0.105 OD, respectively） and declined as storage duration in-creased （0.033-0.042 OD at 710 nm and 00.0010-0.0020 OD, respec-tively）. Dead seeds showed reduced amounts of phospholipids and minimum activity ofα- tocopherol （antioxidants）. The level of MDA was lower in fresh seeds （0.0066-0.0087 OD at 600-535 nm） and increased as storage duration increased （0.0248-0.0268 OD after 65 days of stor-age）. The higher amount of MDA indicated that seeds died due to rancid-ity of the oil inside the seed. Neem seed cake was assessed for deteriora-tion of food reserves （total proteins, total sugar, and total starch）, concen-trations of which were higher in fresh seed and declined as storage dura-tion increased. Germination was higher in fresh seeds and after 65 days, no germination was received perhaps due to deterioration of biochemi-cals in seeds. Patterns of seed deterioration were similar across all seed lots.

BAYESIAN DEMONSTRATION TEST METHOD WITH MIXED BETA DISTRIBUTION

A complex mechatronics system Bayesian plan of demonstration test is studied based on the mixed beta distribution. During product design and improvement various information is appropriately considered by introducing inheritance factor, moreover, the inheritance factor is thought as a random variable, and the Bayesian decision of the qualification test plan is obtained, and the correctness of a Bayesian model presented is verified. The results show that the quantity of the test is too conservative according to classical methods under small binomial samples. Although traditional Bayesian analysis can consider test information of related or similar products, it ignores differences between such products. The method has solved the above problem, furthermore, considering the requirement in many practical projects, the differences among this method, the classical method and Bayesian with beta distribution are compared according to the plan of reliability acceptance test.

Investigation of mechanical behaviour of a quasi-brittle material using Karagozian and Case concrete (KCC) model

The mechanical behaviour of a quasi-brittle material,i.e.Pietra Serena sandstone,was investigated both numerically and experimentally in order to build a reliable numerical modelling system applicable to more complex cases.The Karagozian and Case concrete(KCC)model was exploited as the material constitutive law and a new method to utilise this model for efficient and accurate simulation of quasibrittle materials is discussed.The capability of this model is evaluated by comparing the results of the numerical simulations with the corresponding experimental results,and the method itself is critically assessed.

Experimental study of coal fracture dynamics under the influence of cyclic freezing-thawing using shear elastic waves

Cyclic freezing-thawing can lead to fracture development in coal,affecting its mechanical and consumer properties.To study crack formations in coal,an ultrasonic sounding method using shear polarized waves was proposed.Samples of three coal types(anthracite,lignite and hard coal)were tested.The research results show that,in contrast to the shear wave velocity,the shear wave amplitude is extremely sensitive to the formation of new cracks at the early stages of cyclic freezing-thawing.Tests also show an inverse correlation between coal compressive strength and its tendency to form cracks under temperature impacts;shear wave attenuation increases more sharply in high-rank coals after the first freezing cycle.Spectral analysis of the received signals also confirmed significant crack formation in anthracite after the first freeze-thaw cycle.The initial anisotropy was determined,and its decrease with an increase in the number of freeze-thaw cycles was shown.The data obtained forms an experimental basis for the development of new approaches to preserve coal consumer properties during storage and transportation under severe natural and climatic conditions.

Generalized cubature quadrature Kalman filters:derivations and extensions

A new Gaussian approximation nonlinear filter called generalized cubature quadrature Kalman filter (GCQKF) is introduced for nonlinear dynamic systems. Based on standard GCQKF, two extensions are developed, namely square root generalized cubature quadrature Kalman filter (SR-GCQKF) and iterated generalized cubature quadrature Kalman filter (I-GCQKF). In SR-GCQKF, the QR decomposition is exploited to alter the Cholesky decomposition and both predicted and filtered error covariances have been propagated in square root format to make sure the numerical stability. In I-GCQKF, the measurement update step is executed iteratively to make full use of the latest measurement and a new terminal criterion is adopted to guarantee the increase of likelihood. Detailed numerical experiments demonstrate the superior performance on both tracking stability and estimation accuracy of I-GCQKF and SR-GCQKF compared with GCQKF.

Inhibition of the immunoproteasome LMP_(2) ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Background:Disruption of the blood–brain barrier(BBB)after a stroke can lead to brain injury and neurological impairment.Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass peptide 2(LMP2)in the pathophysiology of ischemia stroke.However,the relationship between the immunoproteasome LMP2 and the BBB remains unclear.Methods:Adult male Sprague–Dawley rats were subjected to transient middle cerebral artery occlusion/reperfusion(MCAO/R).Three days before MCAO,the rats were treated with lentivirus-mediated LMP2 shRNA preparations by stereotactical injection into the ipsilateral hemispheric region.The rat brain microvascular endothelial cell(RBMVEC)line was exposed to oxygen–glucose deprivation/reperfusion(OGD/R)to mimic ischemic conditions in vitro.The RNA interference-mediated knockdown of LMP2 orβ-catenin was analysed in vivo and in vitro.Analysis of the quantity of extravasated Evans blue(EB)and cerebral fluorescent angiography were performed to evaluate the integrity of the BBB.Immunofluorescence and Western blotting were employed to detect the expression of target proteins.Cell migration was evaluated using a scratch migration assay.The results of immunofluorescence,Western blotting and cell migration were quantified using the software ImageJ(Version 1.53).Parametric data from different groups were compared using one-way ANOVA followed by the least significant difference(LSD)test.Results:Cerebral ischemia led to lower levels of structural components of the BBB such as tight junction proteins[occludin,claudin-1 and zonula occludens(ZO-1)]in the MCAO/R group compared with the sham group(P<0.001).However,inhibition of the immunoproteasome LMP2 restored the expression of these proteins,resulting in higher levels of occludin,claudin-1 and ZO-1 in the LMP2-shRNA group compared with the control-shRNA group(P<0.001).In addition,inhibition of the immunoproteasome LMP2 contributed to higher microvascular density and decreased BBB permeability[e.g.,the quantity of extravasated EB:LMP2-shRNA group(58.54±7.37)μg/g vs.control-shRNA group(103.74±4.32)μg/g,P<0.001],and promoted the upregulation of Wnt-3a andβ-catenin proteins in rats following MCAO/R.In vitro experiments,OGD/R induced marked upregulation of LMP2,proapoptotic protein Bax and cleaved caspase-3,and downregulation of occludin,claudin-1,ZO-1 and Bcl-2,as well as inhibition of the Wnt/β-catenin pathway Wnt-3a andβ-catenin proteins in RBMVECs,compared with the control group under normal culture conditions(P<0.001).However,silencing of LMP2 gene expression reversed these protein changes and promoted proliferation and migration of RBMVECs following OGD/R.Silencing ofβ-catenin by transfection of RBMVECs withβ-catenin-si RNA aggravated the downregulation of tight junction proteins,and reduced the proliferation and migration of RBMVECs following OGD/R,compared with the control-siRNA group(P<0.001).LMP2-si RNA andβ-catenin-si RNA co-transfection partly counteracted the beneficial effects of silencing LMP2-siRNA on the levels of tight junction proteins in RBMVECs exposed to OGD/R.Conclusions:This study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia induced BBB injury,and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/β-catenin signalling pathway under ischemic conditions.

Plants Used as Antihypertensive

Hypertension is a critical health problem and worse other cardiovascular diseases.It is mainly of two types:Primary or essential hypertension and Secondary hypertension.Hypertension is the primary possibility feature for coronary heart disease,stroke and renal vascular disease.Herbal medicines have been used for millions of years for the management and treatment of hypertension with minimum side effects.Over aim to write this review is to collect information on the anti-hypertensive effects of natural herbs in animal studies and human involvement as well as to recapitulate the underlying mechanisms,from the bottom of cell culture and ex-vivo tissue data.According to WHO,natural herbs/shrubs are widely used in increasing order to treat almost all the ailments of the human body.Plants are the regular industrial units for the invention of chemical constituents,they used as immunity booster to enhance the natural capacity of the body to fight against different health prob-lems as well as herbal medicines and food products also.Eighty percent population of the world(around 5.6 billion people)consume medicines from natural plants for major health concerns.This review provides a bird’s eye analysis primarily on the traditional utilization,phytochemical constituents and pharmacological values of medicinal herbs used to normalize hypertension i.e.Hibiscus sabdariffa,Allium sativum,Andrographis paniculata,Apium graveolens,Bidenspilosa,Camel-lia sinensis,Coptis chinensis,Coriandrum sativum,Crataegus spp.,Crocus sativus,Cymbopogon citrates,Nigella sativa,Panax ginseng,Salviaemiltiorrhizae,Zingiber officinale,Tribulus terrestris,Rauwolfiaserpentina,Terminalia arjuna etc.

Influence of P-enriched compost application on economics and P use efficiency of a maize–wheat rotation system

Crop phosphorus(P) deficiency and poor utilization of added P is a major agricultural problem due to reduced solubility of soil P and rapid fixation or precipitation of applied P fertilizer in alkaline and calcareous soils. The effects of P-enriched compost and single superphosphate(SSP) fertilization on maize and wheat yields and P use efficiency in a maize–wheat rotation system were studied for three years. On a three-year average, grain yields of maize and wheat after application of P-enriched compost were increased by 18% and 24%, respectively, in comparison with sole addition of a recommended dose of SSP fertilizer. P-enriched compost addition to soil increased maize and wheat yields by 12% and 17%, respectively, compared to P fertilizer plus FYM incorporation. Soil available P concentration and P uptake were affected significantly by the addition of P-enriched compost. On average, increases in P recovery, use efficiency, and agronomic efficiency of 52%, 18%, and 43% were recorded in maize and increases of 50%, 23%, and 49% in wheat. P-enriched compost application yielded 30% and 32%higher economic returns in maize and wheat than SSP fertilization alone.

Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica

Objective:To evaluate the anti-oxidani and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica in in vitro conditions.Methods:In vitro DPPH radical scavenging activity and lipoxygenase（LOX） inhibition assays were used to evaluate the anti-oxidant and anti-inflammatory activities respectively.Methanolic extract（MEMI）,successive water extract （SWMI） and ethyl acetate fraction（EMEMI）,n-butanol fraction（BMEMI） and water soluble fraction （WMEMI） of methanolic extract were evaluated along with respective reference standards. Results:In in ritro DPPH radical scavenging activity,the MEMI,EMEMI and BMEMI have offered significant antioxidant activity with IC50 values of 13.37.3.55 and 14.19μig/mL respectively.Gallic acid,a reference standard showed significant antioxidant activity with IC? value of 1.88 and found to be more potent compared to all the extracts and fractions.In m vitro LOX inhibition assay,the MEMI,EMEMI and BMEMI have showed significant inhibition of LOX enzyme activity with IC50 values of 96.71.63.21 and 107.44μg/mL respectively.While,reference drug Indometlhacin also offered significant inhibtion against LOX enzyme activity with IC50 of 57.75.Furthermore,MEMI was found to more potent than SWMI and among the fractions EMEMI was found to possess more potent antioxidant and anti-inflammatory activity.Conclusions:These findings suggest that the MEMI and F.MEMT possess potent anti-oxidani and anti-inflammatory activities in in vitro conditions.

High-speed broadband data acquisition system based on FPGA

A field-programmable gate array(FPGA)based high-speed broadband data acquisition system is designed.The system has a dual channel simultaneous acquisition function.The maximum sampling rate is 500 MSa/s and bandwidth is200 MHz,which solves the large bandwidth,high-speed signal acquisition and processing problems.At present,the data acquisition system is successfully used in broadband receiver test systems.

Roll angle measurement system based on triaxial magneto-resistive sensor

Aiming at large error when inertial devices measure the roll angle under high overload conditions,the article designs one kind of roll angle measurement system based on magneto-resistive sensor which calculates the roll angle by micro controller STM32.Experiment results of a triaxial turntable show that using magneto-resistive sensor to measure roll angle is feasible and of high accuracy,and it can calculate the roll angle of the conventional projectile with the error in 1°.