Adhesive hydrogel interface for enhanced epidermal signal

This paper presents a discussion on the method,mechanism,and application of adhesive hydrogel in enhancing epidermal signal,focusing on the interface between hydrogel and skin.Due to its excellent conductivity and high adaptability to the skin,the hydrogel is exceptionally suitable for detecting human-machine interfaces,particularly epidermal electromyographic signals.However,the detection of the high epidermal signal is hindered by the gap and low adhesion between hydrogel and skin.This paper addresses these challenges by introducing approaches to reduce the interface gap and increase interface adhesion,thereby enabling the development of hydrogel-based epidermal signal detection arrays with enhanced resolution and detection performance.

Clovibactin:一种对病原体展现致死效应且低耐药性的革命性抗生素

The decades spanning from the 1940s to the 1960s are renowned as the heyday of antibiotic discovery.It was during this era that game-changing antibiotics such as streptomycin,vancomycin,and tetracycline were unearthed,fundamentally reshaping the landscape of modern medicine.However,antibiotic discovery faces alarming challenges and traditional screening has not yielded new drugs in many decades.The crisis of antimicrobial resistance(AMR)emerges as a consequence of the unintended disruption of the antibiotic discovery pipeline and the subsequent uncontrolled proliferation of resistant pathogens[1].According to the World Health Organization(WHO),in 2019,approximately1.2 million people worldwide died of bacterial infections exacerbated by AMR,surpassing the number of deaths caused by HIV/AIDS.If this trend continues,by 2050,AMR could potentially result in over 10 million deaths,surpassing the mortality rate attributed to cancer.Thus,we are in dire need of new antibiotics to counter the rising resistance of bacteria to most currently employed clinical antibiotics.

Primary Amebic Meningoencephalitis Caused by Naegleria fowleri in China: A Case Report

Naegleria fowleri is a thermophilic,free-living ameba that is commonly known as the“brain-eating ameba.”This parasite invades the central nervous system and causes an acute fulminant infection,which results in a fatal form of primary amebic meningoencephalitis(PAM).Here,we report a case of PAM by an unexpected transmission route.Regrettably,the patient deteriorated swiftly and passed away subsequent to diagnosis,despite our exhaustive efforts.Here,we compiled a summary of 11 cases of PAM survivors who have all been treated with amphotericin,rifampicin and triazoles.Beside this regimen,miltefosine was also used successfully to treat PAM in an adolescent.More precise understanding of the survival rate and contributing factors can be established with further validation on ad-ditional cases.

3D-printed porous functional composite scaffolds with polydopamine decoration for bone regeneration

Large size bone defects affect human health and remain a worldwide health problem that needs to be solved immediately.3D printing technology has attracted substantial attention for preparing penetrable multifunctional scaffolds to promote bone reconditioning and regeneration.Inspired by the spongy structure of natural bone,novel porous degradable scaffolds have been printed using polymerization of lactide and caprolactone(PLCL)and bioactive glass 45S5(BG),and polydopamine(PDA)was used to decorate the PLCL/BG scaffolds.The physicochemical properties of the PLCL/BG and PLCL/BG/PDA scaffolds were measured,and their osteogenic and angiogenic effects were characterized through a series of experiments both in vitro and in vivo.The results show that the PLCL/BG2/PDA scaffold possessed a good compression modulus and brilliant hydrophilicity.The proliferation,adhesion and osteogenesis of hBMSCs were improved in the PDA coating groups,which exhibited the best performance.The results of the SD rat cranium defect model indicate that PLCL/BG2/PDA obviously promoted osteointegration,which was further confirmed through immunohistochemical staining.Therefore,PDA decoration and the sustained release of bioactive ions(Ca,Si,P)from BG in the 3D-printed PLCL/BG2/PDA scaffold could improve surface bioactivity and promote better osteogenesis and angiogenesis,which may provide a valuable basis for customized implants in extensive bone defect repair applications.