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One fifth of hospitalizations for peptic ulcer-related bleeding are potentially preventable 被引量:8
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作者 Ray Boyapati Sim Ye Ong +6 位作者 Bei Ye Anuk Kruavit Nora Lee Rhys Vaughan Sanjay Nurkar Peter Gibson Mayur Garg 《World Journal of Gastroenterology》 SCIE CAS 2014年第30期10504-10511,共8页
AIM: To calculate the proportion of potentially preventable hospitalizations due to peptic ulcer disease (PUD), erosive gastritis (EG) or duodenitis (ED).
关键词 Peptic ulcer Gastrointestinal hemorrhage PREVENTION Non-steroidal anti-inflammatory drug Proton pump inhibitor GASTROPROTECTION
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Evaluating mechanism and severity of injuries among trauma patients admitted to Sina Hospital,the National Trauma Registry of Iran
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作者 Mina Saeednejad Mohammadreza Zafarghandi +17 位作者 Narjes Khalili Vali Baigi Moein Khormali Zahra Ghodsi Mahdi Sharif-Alhoseini Reilly Gerard M.O’ Khatereh Naghdi Melika Khaleghi-Nekou Seyed mohammad Piri Vafa Rahimi-Movaghar Somayeh Bahrami Marjan Laal Mahdi Mohammadzadeh Esmaeil Fakharian Habibollah Pirnejad Hamid Pahlavanhosseini Payman Salamati Homayoun Sadeghi-Bazargani 《Chinese Journal of Traumatology》 CAS CSCD 2021年第3期153-158,共6页
Purpose:Injuries are one of the leading causes of death and lead to a high social and financial burden.Injury patterns can vary significantly among different age groups and body regions.This study aimed to evaluate th... Purpose:Injuries are one of the leading causes of death and lead to a high social and financial burden.Injury patterns can vary significantly among different age groups and body regions.This study aimed to evaluate the relationship between mechanism of injury,patient comorbidities and severity of injuries.Methods:The study included trauma patients from July 2016 to June 2018,who were admitted to Sina Hospital,Tehran,Iran.The inclusion criteria were all injured patients who had at least one of the following:hospital length of stay more than 24 h,death in hospital,and transfer from the intensive care unit of another hospital.Data collection was performed using the National Trauma Registry of Iran minimum dataset.Results:The most common injury mechanism was road traffic injuries(49.0%),followed by falls(25.5%).The mean age of those who fell was significantly higher in comparison with other mechanisms(p<0.001).Severe extremity injuries occurred more often in the fall group than in the vehicle collision group(69.0%vs.43.5%,p<0.001).Moreover,cases of severe multiple trauma were higher amongst vehicle collisions than injuries caused by falls(27.8%vs.12.9%,p=0.003).Conclusion:Comparing falls with motor vehicle collisions,patients who fell were older and sustained more extremity injuries.Patients injured by motor vehicle collision were more likely to have sustained multiple trauma than those presenting with falls.Recognition of the relationship between mechanisms and consequences of injuries may lead to more effective interventions. 展开更多
关键词 Wounds and injuries Multiple trauma Abbreviated injury scale Injury severity score REGISTRIES
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Venetoclax联合低剂量阿糖胞苷治疗不耐受强化化疗的初治急性髓系白血病患者:一项Ⅲ期随机、安慰剂对照试验中中国队列结果 被引量:9
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作者 胡豫 金洁 +10 位作者 张钰 胡建达 李军民 魏旭东 高素君 Zha Jiuhong Jiang Qi Wu Jun Wellington Mendes Andrew H.Wei 王建祥 《中华血液学杂志》 CAS CSCD 北大核心 2021年第4期288-294,共7页
目的:探讨Venetoclax联合低剂量阿糖胞苷(LDAC)在不能耐受强化诱导化疗的中国急性髓系白血病(AML)患者中的疗效及安全性。方法:一项Ⅲ期随机、双盲安慰剂对照试验(VIALE-C)中中国队列的结果。在本项国际临床试验中,入组了不适合接受强... 目的:探讨Venetoclax联合低剂量阿糖胞苷(LDAC)在不能耐受强化诱导化疗的中国急性髓系白血病(AML)患者中的疗效及安全性。方法:一项Ⅲ期随机、双盲安慰剂对照试验(VIALE-C)中中国队列的结果。在本项国际临床试验中,入组了不适合接受强化化疗、新诊断为AML的18岁或以上的成人患者。在全球范围内,患者(211例)按2∶1的比例随机分配接受Venetoclax+LDAC或安慰剂+LDAC(28 d为1个周期),在第1~10天接受LDAC。主要研究终点为总生存(OS);次要研究终点包括缓解率、无事件生存期及不良事件(AE)。结果:入组15例中国患者(Venetoclax组9例;安慰剂组6例)。中位年龄为72(61~86)岁。与安慰剂组相比,Venetoclax组的死亡风险下降38%(HR=0.62,95%CI 0.12~3.07)。对延长6个月随访进行的计划外分析显示,Venetoclax组的中位OS时间为9.0个月,安慰剂组为4.1个月。完全缓解(CR)率与血细胞计数未完全恢复的CR(CRi)率分别为33%(3/9)和0(0/6)。最常见的非血液学AE(Venetoclax组与安慰剂组)为低钾血症(5/9和4/6)、呕吐(4/9和3/6)、便秘(2/9和4/6)和低白蛋白血症(1/9和4/6)。结论:Venetoclax联合LDAC在中国患者中表现出有意义的疗效和可管理的安全性特征,这与在全球VIALE-C人群中的观察结果一致,使其成为不适合接受强化化疗的新诊断AML患者的一个重要治疗选择。 展开更多
关键词 白血病 髓系 急性 Venetoclax 低剂量阿糖胞苷
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