Objective ：To study curcumin＇s growth inhibitory effects and morphology changes on sarcoma graft＇s of S180 mouse, with further inquiry into the possible mechanisms, Methods： Thirty S180 mouse were randomly assigne...Objective ：To study curcumin＇s growth inhibitory effects and morphology changes on sarcoma graft＇s of S180 mouse, with further inquiry into the possible mechanisms, Methods： Thirty S180 mouse were randomly assigned into 3 groups ： saline group （blank control group）, Cytoxan group （positive control group） and curcumin group. The tumor inhibitory rates, the index of thymus and spleen,the growth of tumor and the change of pathology-morph, the index of apoptosis cells and morphology changes of apoptosis cells in the different groups were observed. Results： （1） Tumor＇s inhibitory rate in curcumin group and cytoxan group was 68, 32% and 70. 43%, respectively. Compared to blank control group, the 2 groups had significant elevated tumor inhibitory rate （P〈0.01）. （2） Thymus index of curcumin group did not have significant decrease compared to blank control group （P〉0.05）, （3） Under electroscope,curcumin group and positive control group had significant decrease in terms of growth of tumor, degree of infiltration of tumor, the number of nucleus fission, and blood vessels number compared to saline group （P〈0.05）, However, the degree of cell necrosis, the number of splenic segments and macrophage are increased significantly compared to negative group, （4） Accumulative score of apoptosis cell in curcumin group was significantly higher than other two groups（P〈0.05）. Conclusion： Internal organ study and ceil morphology observation show curcumin can effectively inhibit the growth and cause the death of sarcoma graft of S180 mouse without interference with thymus.展开更多
This paper presents an efficient and stable algorithm to intra-operative planning for prostate brachytherapy. As a heuristic approach, the algorithm selects one seed at a step and iterates until predefined prostate vo...This paper presents an efficient and stable algorithm to intra-operative planning for prostate brachytherapy. As a heuristic approach, the algorithm selects one seed at a step and iterates until predefined prostate volume is covered by prescribed dose. For each step, potential seeds are evaluated according to the ability to irradiate the target while sparing adjacent organs at risk. And its influence on dose homogeneity is also taken into account. Furthermore, a flexible mechanism is adopted to limit the number of used needles. The mechanism selects acceptable sub-optimal seed in existing needles instead of optimal seed that requires adding a new needle. The efficacy of algorithm is evaluated on five clinical cases. Compared with state-of-the-art methods,this algorithm is efficient and stable without the trial and error process of determining various parameters. These advantages make the algorithm suitable for intra-operative real-time treatment planning.展开更多
文摘Objective ：To study curcumin＇s growth inhibitory effects and morphology changes on sarcoma graft＇s of S180 mouse, with further inquiry into the possible mechanisms, Methods： Thirty S180 mouse were randomly assigned into 3 groups ： saline group （blank control group）, Cytoxan group （positive control group） and curcumin group. The tumor inhibitory rates, the index of thymus and spleen,the growth of tumor and the change of pathology-morph, the index of apoptosis cells and morphology changes of apoptosis cells in the different groups were observed. Results： （1） Tumor＇s inhibitory rate in curcumin group and cytoxan group was 68, 32% and 70. 43%, respectively. Compared to blank control group, the 2 groups had significant elevated tumor inhibitory rate （P〈0.01）. （2） Thymus index of curcumin group did not have significant decrease compared to blank control group （P〉0.05）, （3） Under electroscope,curcumin group and positive control group had significant decrease in terms of growth of tumor, degree of infiltration of tumor, the number of nucleus fission, and blood vessels number compared to saline group （P〈0.05）, However, the degree of cell necrosis, the number of splenic segments and macrophage are increased significantly compared to negative group, （4） Accumulative score of apoptosis cell in curcumin group was significantly higher than other two groups（P〈0.05）. Conclusion： Internal organ study and ceil morphology observation show curcumin can effectively inhibit the growth and cause the death of sarcoma graft of S180 mouse without interference with thymus.
文摘This paper presents an efficient and stable algorithm to intra-operative planning for prostate brachytherapy. As a heuristic approach, the algorithm selects one seed at a step and iterates until predefined prostate volume is covered by prescribed dose. For each step, potential seeds are evaluated according to the ability to irradiate the target while sparing adjacent organs at risk. And its influence on dose homogeneity is also taken into account. Furthermore, a flexible mechanism is adopted to limit the number of used needles. The mechanism selects acceptable sub-optimal seed in existing needles instead of optimal seed that requires adding a new needle. The efficacy of algorithm is evaluated on five clinical cases. Compared with state-of-the-art methods,this algorithm is efficient and stable without the trial and error process of determining various parameters. These advantages make the algorithm suitable for intra-operative real-time treatment planning.
