期刊文献+
共找到16篇文章
< 1 >
每页显示 20 50 100
Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease 被引量:11
1
作者 Yun-Dai CHEN Wei-Yi FANG +25 位作者 Ji-Yan CHEN Zhan-Ming FAN Chuan-Yu GAO Jun-Bo GE Zuo-Xiang HE Yong HUO Lang LI Si-Jin LI Xi-Lie LU Bin LV Ju-Ying QIAN Ya-Jun SHI Zhu-Jun SHEN Jing WANG Yi-Ning WANG Lei XU Li YANG Bo YU Mei ZHANG Jun-Jie YANG Shu-Yang ZHANG Xiao-Li ZHANG Shi-Hua ZHAO Yang ZHENG Yu-Chi HAN Guang ZHI 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2018年第1期30-40,共11页
1 Introduction Early detection and diagnosis of stable coronary artery disease (SCAD) is essential for proactive secondary prevention of myocardial infarction (MI), control of disease progress, and reduction of mo... 1 Introduction Early detection and diagnosis of stable coronary artery disease (SCAD) is essential for proactive secondary prevention of myocardial infarction (MI), control of disease progress, and reduction of mortality. Clinical decision-making in modem medicine is increasingly dependent on cardiovascular imaging techniques. 2012 ACCF/AHA/ACP/AATS/ PCNA/SCAI/STS guideline for the diagnosis and management of patients with stable ischemic heart disease has been issued by American Heart Association (AHA). European Society of Cardiology (ESC) has issued 2013 ESC guidelines on the management of stable coronary artery disease. 展开更多
关键词 Expert consensus Clinical pathway Coronary artery disease Non-invasive imaging examination Pre-test probabilities
下载PDF
Analysis on the reproductive health situation of unmarried floating young women in cities
2
作者 张小松 赵更力 +2 位作者 王临虹 吴久玲 Peterb Xenos 《生殖医学杂志》 CAS 2006年第B10期24-27,共4页
Objective: To understand the prevalence of RTIs/STIs, the incidence of sex violence and the KAP of the sex and reproductive health among unmarried floating young women.Methods: During Ocb.2002 to Feb.2003, in the mate... Objective: To understand the prevalence of RTIs/STIs, the incidence of sex violence and the KAP of the sex and reproductive health among unmarried floating young women.Methods: During Ocb.2002 to Feb.2003, in the maternal and child health hospital of Beijing, Shenzhen, Nanning and Zhengzhou, 1,219 unmarried floating young women who wanted termination of pregnancy and was under 24 years old before induced abortion received gynecological and laboratory examination. At the same time, they also answered a self-questionnaire. Results: The mean age of all respondents was (22.0±1.6) years old. The respondents' average age of having first sexual activity was (20.3±1.8) years old. The rate of induced abortion history was 38.7%. 17.5% of young women had never used contraception. The incidence of sex violence was 15.6%. The prevalence of RTIs and STIs was 56.1% and 9.7%, respectively. Young women were lack of the knowledge about reproductive health care. Conclusions: The reproductive health situation of unmarried floating young women was serious, especially on sex violence and RTIs/STIs and higher rate of induced abortion. 展开更多
关键词 生殖健康 女性 保健知识 性生活
下载PDF
Various models of atrial fibrillation induced by acetylcholine and its application in the field of traditional Chinese medicine
3
作者 Qin Zhang Ping Wang Lin Wu 《TMR Modern Herbal Medicine》 2018年第2期72-78,共7页
Atrial fibrillation is of public health importance and profoundly increases morbidity, mortality and health-related expenditures. Morbidities include the increased risks of cardiovascular outcomes such as heart failur... Atrial fibrillation is of public health importance and profoundly increases morbidity, mortality and health-related expenditures. Morbidities include the increased risks of cardiovascular outcomes such as heart failure and stroke, and the deleterious effects on quality of life, functional status and cognition. Our purpose is to understand the molecular mechanism of atrial fibrillation, a model under pathological conditions should be established. Acetylcholine, a neurotransmitter in the vagus nerve, has been established with numerous atrial fibrillation models. We will discuss the established model of atrial fibrillation which induced by acetylcholine, aiming to seek a model which are more close to the clinical condition. The underlying mechanisms will be discussed in order to observe the mechanism of antiarrhythmic drugs. 展开更多
关键词 ACETYLCHOLINE Atrial fibrillation In vivo model In vitro model
下载PDF
The homology analysis of internal transcribed spacer sequence of ribosomal DNA in common dermatophytes
4
作者 QIANG WANG ZHAO HUI JI +6 位作者 HOU MIN LI LI JUAN ZHANG WEI LIU ZHE WAN XIAO HONG WANG DUAN LI WANG RUO YU LI 《Journal of Microbiology and Immunology》 2006年第2期110-116,共7页
In order to analyze the sequences of the internal transcribed spacer (ITS) including the 5.8 S ribosomal DNA (rDNA) of common dermatophytes, so as to obtain a rapid and accurate method to identify the species of d... In order to analyze the sequences of the internal transcribed spacer (ITS) including the 5.8 S ribosomal DNA (rDNA) of common dermatophytes, so as to obtain a rapid and accurate method to identify the species of dermatophytes and to establish the phylogenetic tree of these species to understand their relationship, 16 strains of dermatophytes were collected and preliminarily identified by morphological characteristics. General primers for fungi ITS1 and ITS4 were used to amplify the ITS rDNA of each strains with PCR. The PCR products after purification were sequenced directly and were analyzed through internet. In the results, 11 strains were identified by means of morphological features, among which 5 strains were Trichophyton, 5 strains were Microsporum and 1 was Epidermophytoa, which was consistent with the results by molecular biology. In the 5 unidentifiable strains, 1 strain was proved to be Chrysosporium by molecular biology. These strains studied could be divided into 3 different classes as indicated in the analysis of the phylogenetic tree of the sequences in ITS, which were quite different from those of morphological classification. It is evident from the above observations that the molecular method of analysis on the ITS sequences is a rapid, highly sensitive and accurate approach for the detection of dematophyte species, however, it still exhibits some limitations needing the supplementation with morphological identification. 展开更多
关键词 Dermatophyte Internal transcribed spacer sequence identification Phylogenetic tree
下载PDF
Effects of continuous intermedin infusion on blood pressure and hemodynamic function in spontaneously hypertensive rats 被引量:9
5
作者 Ying Yuan Xi Wang +3 位作者 Qiang Zeng Hong-Mei Wu Yong-Fen Qi Chao-Shu Tang 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2012年第1期17-27,共11页
Objective To examine the effects of exogenously administered intermedin (IMD,adrenomedullin-2) on arterial blood pressure,cardiac function and the cardiovascular IMD receptor system in spontaneously hypertensive ra... Objective To examine the effects of exogenously administered intermedin (IMD,adrenomedullin-2) on arterial blood pressure,cardiac function and the cardiovascular IMD receptor system in spontaneously hypertensive rats (SHRs) as well as to investigate the associated mechanisms.Methods Thirteen week-old male rats were divided in Wistar Kyoto (WKY) group (n =12),SHR group (n =12),IMD group (SHRs infused with IMD 1-47 500 ng/kg per hour,n =12),and ADM group (SHRs infused with adrenomedullin 500 ng/kg per hour,n =12).Results A two-week continuous administration of low dose IMD 1-47 via mini-osmotic pumps markedly reduced blood pressure,the maximal rates of increase and decrease of left-ventricle pressure development (LV ± dp/dtmax),left ventricular systolic pressure and heart rate in SHRs.Furthermore,IMD also inhibited protein over-expression of cardiovascular IMD receptors,myocardial Receptor Activity-Modifying Proteins (RAMP1 and RAMP2),aortic RAMP1,RAMP2,RAMP3,and calcitonin receptor-like receptor (CRLR);suppressed up-regulation of aortic RAMP1,RAMP2,RAMP3 and CRLR gene expression; and markedly elevated the mRNA abundance of myocardial atrial natriuretic peptide (ANP) and myocardial brain natriuretic peptide (BNP).Additionally,IMD 1-47 administration in SHRs increased aortic cAMP concentration and reduced myocardial cAMP concentration.Conclusion These findings support the speculation that IMD,as a cardiovascular active peptide,is involved in blood pressure reduction and cardiac function amelioration during hypertension.The mechanism underlying this effect may involve IMD binding of a receptor complex formed by RAMPs and CRLR,and consequential regulation of cAMP levels and other cardiovascular active factors,such as ANP and BNP. 展开更多
关键词 INTERMEDIN Receptor activity-modifying proteins Calcitonin receptor-like receptor Mini-osmotic pumps Hemodynamicparameters Spontaneously hypertensive rats
下载PDF
Safety and Current Status of the COVID-19 Vaccine among Patients with Breast cancer: A Cross-Sectional Study from China
6
作者 Shaohua Zhang Jianbin Li +22 位作者 Ruonan Xu Qianjun Chen Gang Sun Ying Lin Feng Jin Xinlan Liu Zhimin Fan Yiding Chen Yali Cao Xinzheng Li Jianyun Nie Guiying Xu Xiaojia Wang Yuee Teng Tao Sun Hong Liu Jing Luo Cuizhi Geng Man Li Ting Luo Yinhua Liu Fu-Sheng Wang Zefei Jiang 《Infectious Diseases & Immunity》 CSCD 2023年第3期127-131,共5页
In this study,we aimed to explore the safety and vaccination coverage data of Chinese patients with breast cancer receiving coronavirus disease 2019(COVID-19)vaccination.The patients were recruited from 41 hospitals a... In this study,we aimed to explore the safety and vaccination coverage data of Chinese patients with breast cancer receiving coronavirus disease 2019(COVID-19)vaccination.The patients were recruited from 41 hospitals across 20 Chinese provinces.The vaccination coverage was approximately 22.4%,and the frequency of total adverse events was 13.3%after the first dose and 9.9%after the second dose.The most frequent adverse reaction within 14 days of the first dose was local pain(5.7%).Unvaccinated patients were very likely to reject the vaccine rather than be hesitant in patients with old age(odds ratio[OR],1.238;95%confidence interval[CI],1.101-1.391),chronic disease history(OR,1.189;95%CI,1.057-1.337),and cancer relapse(OR,1.398;95%CI,1.233-1.585).Of the unvaccinated patients with breast cancer,54.1%opted to receive COVID-19 vaccines if more data were available.Considering the safety but low vaccination coverage for breast cancer,increased positive attitudes and acceptance toward COVID-19 vaccines are important. 展开更多
关键词 Breast cancer COVID-19 vaccine SAFETY
原文传递
Preliminary Study on the Lesion Location and Prognosis of Cubital Tunnel Syndrome by Motor Nerve Conduction Studies 被引量:6
7
作者 Zhu Liu Zhi-Rong Jia Ting-Ting Wang Xin Shi Wei Liang 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第9期1165-1170,共6页
Background:To study lesions' location and prognosis of cubital tunnel syndrome (CubTS) by routine motor nerve conduction studies (MNCSs) and short-segment nerve conduction studies (SSNCSs,inching test).Methods... Background:To study lesions' location and prognosis of cubital tunnel syndrome (CubTS) by routine motor nerve conduction studies (MNCSs) and short-segment nerve conduction studies (SSNCSs,inching test).Methods:Thirty healthy subjects were included and 60 ulnar nerves were studied by inching studies for normal values.Sixty-six patients who diagnosed CubTS clinically were performed bilaterally by routine MNCSs and SSNCSs.Follow-up for 1-year,the information of brief complaints,clinical symptoms,and physical examination were collected.Results:Sixty-six patients were included,88 of nerves was abnormal by MNCS,while 105 was abnormal by the inching studies.Medial epicondyle to 2 cm above medial epicondyle is the most common segment to be detected abnormally (59.09%),P < 0.01.Twenty-two patients were followed-up,17 patients' symptoms were improved.Most of the patients were treated with drugs and modification of bad habits.Conclusions:(1) SSNCSs can detect lesions of compressive neuropathy in CubTS more precisely than the routine motor conduction studies.(2) SSNCSs can diagnose CubTS more sensitively than routine motor conduction studies.(3) In this study,we found that medial epicondyle to 2 cm above the medial epicondyle is the most vulnerable place that the ulnar nerve compressed.(4) The patients had a better prognosis who were abnormal in motor nerve conduction time only,but not amplitude in compressed lesions than those who were abnormal both in velocity and amplitude.Our study suggests that SSNCSs is a practical method in detecting ulnar nerve compressed neuropathy,and sensitive in diagnosing CubTS.The compound muscle action potentials by SSNCSs may predict prognosis of CubTS. 展开更多
关键词 Cubital Tunnel Syndrome ELECTROPHYSIOLOGY Short-segment Nerve Conduction Studies Ulnar Nerve
原文传递
Liver microcirculation after hepatic artery embolization with degradable starch microspheres in vivo
8
作者 Jian Wang Satoru Murata Tatsuo Kumazaki 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第26期4214-4218,共5页
AIM: To observe the dynamic changes of liver microcirculation in vivo after arterial embolization with degradable starch microspheres (DSM). METHODS: DSM were injected into the proper hepatic artery through a sila... AIM: To observe the dynamic changes of liver microcirculation in vivo after arterial embolization with degradable starch microspheres (DSM). METHODS: DSM were injected into the proper hepatic artery through a silastic tube inserted retrogradely in gastroduodenal artery (GDA) of SD rats. Fluorescent microscopy was used to evaluate the dynamic changes of blood flow through the terminal portal venules (TPVs), sinusoids and terminal hepatic venules (THVs). The movements of DSM debris were also recorded. Six hours after injection of DSM, percentages of THVs with completely stagnant blood flow were recorded. RESULTS: Two phases of blood flow change were recorded. In phase one: after intra-arterial injection of DSM, slow or stagnant blood flow was immediately recorded in TPVs, sinusoids and THVs. This change was reversible, and blood flow resumed completely. In phase two: after phase one, blood flow in TPVs changed again and three patterns of blood flow were recorded. Six hours after DSM injection, 36.9% ± 9.2% of THVs were found with completely stagnant blood flow. CONCLUSION: DSM can stop the microcirculatory blood flow in some areas of liver parenchyma. Liver parenchyma supplied by arteries with larger A-P shunt is considered at a higher risk of total microcirculatory blood stagnation after injection of DSM through hepatic artery. 展开更多
关键词 Degradable starch microsphere Hepatic microcirculation Hepatic arteries FLUORESCENCE Transartedal chemoembolization
下载PDF
Risk factors for atypical endometrial hyperplasia in infertile women:possible association with polycystic ovary syndrome
9
作者 Lu Qun Shen Huan +2 位作者 Tian Li Zhu Sainan Chen Xi 《现代妇产科进展》 CSCD 北大核心 2008年第2期157-160,共4页
Objective:Endometrial hyperplasia is considered as a precursor of endometrial carcinoma,in which oncogenic potential is low in hyperplasia without atypia,but high in atypical hyperplasia.The objective of this study wa... Objective:Endometrial hyperplasia is considered as a precursor of endometrial carcinoma,in which oncogenic potential is low in hyperplasia without atypia,but high in atypical hyperplasia.The objective of this study was to identify the risk factors for atypical endometrial hyperplasia in infertile women.Methods:Fifty four infertile women with endometrial hyperplasia,which were selected from a large cohort of 2 098 women who desired for the future childbearing in our center,were diagnosed by hysteroscopy with directed biopsies or dilation and curettage (D&C),including 44 with hyperplasia without atypia,10 with atypical hyperplasia.Clinical characteristics were recorded in terms of age,body mass index (BMI),parity,insulin resistance,polycystic ovary syndrome (PCOS).Statistical comparison was made between women with hyperplasia without atypia and atypical hyperplasia.Logistic regression analysis was employed to assess the contribution of PCOS,obesity and insulin resistance to atypical hyperplasia.Results:The incidence of endometrial hyperplasia in infertile women was 2.57% (54/2098),which included 10 women (0.48%) were diagnosed as atypical hyperplasia.PCOS in women with atypical hyperplasia (70%,7/10) was significantly higher than those of hyperplasia without atypia (27.27%,12/44).Stepwise regression analysis showed that PCOS contributed maximally to atypical endometrial hyperplasia in infertile women.Conclusion:PCOS is an independent risk factor for atypical endometrial hyperplasia in women with infertility.The infertile women with PCOS are at an increased risk for atypical endometrial hyperplasia and endometrial cancer. 展开更多
关键词 子宫内膜炎 多囊性卵巢综合症 临床治疗 疗效
下载PDF
TGF-β may be complimentary to PSA in Chinese prostate cancer
10
作者 Yuejing Yang Tao Sun 《The Chinese-German Journal of Clinical Oncology》 CAS 2009年第3期168-171,共4页
Objective: To investigate the value of the plasma transforming growth factor β1 (TGF-β1) level in diagnosis and prognosis of prostate cancer (PCa). Methods: The ELISA kits for human TGF-β1 were used to measur... Objective: To investigate the value of the plasma transforming growth factor β1 (TGF-β1) level in diagnosis and prognosis of prostate cancer (PCa). Methods: The ELISA kits for human TGF-β1 were used to measure the TGF-β1 level in plasmas. A cohort of 295 consecutive PCa patients in recent more than two years in the First Hospital of Peking University of China was enrolled to the study. Furthermore, 55 control subjects were healthy and without evidence of PCa, who were random people that came to the hospital and were identified by prostate biopsy. Results: An age-related frequency chart indicated that 99% confidence interval of the difference with PCa was at the age of 53-85 years. The PCa patients aged 53-85 were classified into three groups according to TNM staging. Group A had Stages TO, T1 and T2. Group B had Stage T3 and Group C had Stage T4. Compared with control group, Group A had the lower level of plasma TGF-β1 (P 〈 0.05), Group B had the higher level of plasma TGF-β1 (P 〈 0.05) and Group C had the even higher level of plasma TGF-β1 (P 〈 0.01). According to TNM staging, Group D had Stages TO, T1 and T2 with the normal level of total PSA (tPSA). Group E with the normal level of tPSA had metastasis after resection. Compared with control group, Group D had the lower plasma level of TGF-β1 (P 〈0.05) and Group E had higher plasma level of TGF-β1 (P 〈 0.01). Conclusion: The plasma TGF-β1 level decreases at early stage of PCa and increases at later stage of PCa, especially at tumor metastasis after the resection. The plasma TGF-β1 level may therefore be complementary to PSA for PCa prognosis. 展开更多
关键词 prostate cancer (PCa) transforming growth factor β (TGF-β) prostate-specific antigen (PSA) age
下载PDF
The Health Status of 50−70 Years Old Women in Some Areas—China,2018
11
作者 Bo Song Gengli Zhao +2 位作者 Jiangli Di Yu Ma Linhong Wang 《China CDC weekly》 2020年第28期525-529,共5页
What is already known about this topic?After menopause,women are prone to chronic diseases such as cardiovascular disease,diabetes and osteoporosis and gynecological diseases such as pelvic floor dysfunction and repro... What is already known about this topic?After menopause,women are prone to chronic diseases such as cardiovascular disease,diabetes and osteoporosis and gynecological diseases such as pelvic floor dysfunction and reproductive tract infection.What is added by this report?The prevalence of hypertension,diabetes,cardiovascular disease and osteoporosis increased with age,while the prevalence of vaginitis and cervicitis decreased with the increase of age.The proportions of women aged 50–70 years old suffering from chronic and gynecological diseases in western and rural areas were significantly higher than those in eastern,central and urban areas.What are the implications for public health practice?It is necessary to take targeted intervention measures in the western region and rural areas,in order to narrow the gap in health of menopausal and older women between different areas of China. 展开更多
关键词 DISEASES CARDIOVASCULAR OSTEOPOROSIS
原文传递
The Utilization of Health Examination by Menopausal and Older Women--6 Provinces,China,2018
12
作者 Bo Song Jiangli Di +2 位作者 Gengli Zhao Yu Ma Linhong Wang 《China CDC weekly》 2020年第37期723-728,共6页
What is already known about this topic?Improving their utilization of health examination is important for improving the health of menopausal and older women.What is added by this report?Only 32.3%and 29.7%of women had... What is already known about this topic?Improving their utilization of health examination is important for improving the health of menopausal and older women.What is added by this report?Only 32.3%and 29.7%of women had been screened for cervical cancer and breast cancer,respectively.The overall utilization rate of health examination for menopausal and older women is low.The health examination services for menopausal and older women were utilized less in the western regions and in rural areas than in the eastern and central regions and in urban areas.What are the implications for public health practice?The imbalance of development is an important factor affecting the utilization of health examination for menopausal and older women.It is necessary to take effective measures to improve the level of service utilization in the western region and rural areas,in order to narrow the gap in health between different regions. 展开更多
关键词 utilized NARROW WOMEN
原文传递
Study on the Relationship between Blood Stasis Syndrome and Clinical Pathology in 227 Patients with Primary Glomerular Disease 被引量:5
13
作者 李深 饶向荣 +4 位作者 王素霞 张改华 李晓玫 戴希文 陈可冀 《Chinese Journal of Integrative Medicine》 SCIE CAS 2009年第3期170-176,共7页
To investigate the relationship between the severity of Chinese medicine(CM) bloodstasis syndrome(BSS) with clinical features and renal lesion indexes of the primary glomerular disease. Methods:An epidemiological surv... To investigate the relationship between the severity of Chinese medicine(CM) bloodstasis syndrome(BSS) with clinical features and renal lesion indexes of the primary glomerular disease. Methods:An epidemiological survey was conducted to collect the data of 227 patients diagnosed as chronic primary glomerular diseases,and their severity of BSS were scored three days before renal biopsies were performed.The following clinical indexes were analyzed:age,course of glomerular diseases,24-h urine protein ration(Up... 展开更多
关键词 primary glomerular diseases blood-stasis syndrome clinical index pathology of the renal biopsy
原文传递
Comparison of postural control between healthy subjects and individuals with nonspecific low back pain during exposure to visual stimulus 被引量:2
14
作者 Li Rui Wang Ninghua +1 位作者 Yan Xiang Wei Kunlin 《Chinese Medical Journal》 SCIE CAS CSCD 2014年第7期1229-1234,共6页
Background Low back pain (LBP) is a common clinical problem.Many researchers have demonstrated that LBP disorders have difference in sensory strategies for postural control.Optokinetic stimulation (OKS) of optic f... Background Low back pain (LBP) is a common clinical problem.Many researchers have demonstrated that LBP disorders have difference in sensory strategies for postural control.Optokinetic stimulation (OKS) of optic flow has been widely applied to study its effect on vision,but has not been applied to LBP.Here we used OKS on different surfaces to investigate the characteristics of chronic nonspecific LBP (CNLBP) posture control,so as to provide new theoretical and experimental data for further recognizing CNLBP and enriching its treatment.Methods Fifteen individuals with CNLBP (age range 25-40 years) and 15 age and gender-matched control subjects were recruited.Each subject,while standing on a stable or soft surface,was exposed to random-dot patterns projected on a large screen,with the dots displaying expansion (+) and contraction (-) and velocities including 80°,40°,and 20° per second.The visual stimulus used a "stimuli-interval" pattern.The peak velocity,different phases' standard deviation (SD) of the anterior-posterior centre of pressure (COP) displacements and the total length of the medial-lateral COP sway (LML) for stable surface and soft surface were recorded by force platform.Results The main effect of surface on all parameters was significant,while the main effect of group and OKS showed no significance with the exception of peak velocity (F(3,95)=3.6,P=0.01) and A2 (F(5,140)=9.34,P <0.01) for which the effect of OKS was significant.The interactions of group by OKS of A2 (F(5,140)=3.65,P <0.01) and group by surface by OKS (F(5,140)=2.83,P=-0.02),and surface by OKS of A1 and A3 (P <0.05) were significant.It was reported that significantly more SD in amplitude in the T2 phase was seen in persons with CNLBP when confronting the + 40 stimuli on the soft surface (P <0.05) compared to healthy individuals.Conclusions There was no significance between persons with CNLBP and healthy people when using the stable surface.Subjects with LBP showed decreased efficiency of postural adjustment when exposed to more complicated tasks and environments,especially OKS in the expansion direction,and displayed a visual-dependent phenomenon.This result suggested that the treatment of abnormal motor patterns in people with LBP should take the properties of task and environment into account. 展开更多
关键词 low back pain postural control optic flow ENVIRONMENT
原文传递
Mutation analysis of potassium channel genes KCNQ1 and KCNH2 in patients with long QT syndrome 被引量:6
15
作者 刘文玲 胡大一 +9 位作者 李翠兰 李萍 李运田 李志明 李蕾 秦绪光 董玮 戚豫 陈胜寒 王擎 《Chinese Medical Journal》 SCIE CAS CSCD 2003年第9期1333-1335,共3页
Objective To determine mutations of two common potassium channel subunit genes KCNQ1, KCNH2 causing long QT syndrome (LQTS) in the Chinese.Methods Thirty-one Chinese LQTS pedigrees were characterized for mutations in ... Objective To determine mutations of two common potassium channel subunit genes KCNQ1, KCNH2 causing long QT syndrome (LQTS) in the Chinese.Methods Thirty-one Chinese LQTS pedigrees were characterized for mutations in the two LQTS genes, KCNQ1 and KCNH2, by sequencing.Results Two novel KCNQ1 mutations, S277L in the S5 domain and G306V in the channel pore, and two novel KCNH2 mutations, L413P in the transmembrane domain S1 and L559H in the transmembrane domain S5 were identified. The triggering factors for cardiac events developed in these mutation carriers included physical exercise and excitation. Mutation L413P in KCNH2 was associated with the notched T wave on ECGs. Mutation L559H in KCNH2 was associated with the typical bifid T wave on ECGs. Mutation S277L in KCNQ1 was associated with a high-amplitude T wave and G306V was associated with a low-amplitude T wave. Two likely polymorphisms, IVS11 +18C >T in KCNQ1 and L520V in KCNH2 were also identified in two LQTS patients.Conclusions The mutation rates for both KCNQ1 (6.4%) and KCNH2 (6.4%) are lower in the Chinese population than those from North America or Europe. 展开更多
关键词 long QT syndrome·mutation·KCNQ1 gene·KCNH2 gene
原文传递
Preparation of sorafenib self-microemulsifying drug delivery system and its relative bioavailability in rats
16
作者 Ya-Ou Liu Jie-Ming Fan +1 位作者 Xue-Qing Wang Qiang Zhang 《Journal of Chinese Pharmaceutical Sciences》 CAS 2011年第2期164-170,共7页
Sorafenib is a novel antitumor drug, which is poorly absorbed in the gastrointestinal tract due to its low solubility in water. To improve the bioavailability of sorafenib, a self-microemulsifying drug delivery system... Sorafenib is a novel antitumor drug, which is poorly absorbed in the gastrointestinal tract due to its low solubility in water. To improve the bioavailability of sorafenib, a self-microemulsifying drug delivery system (SMEDDS) formulation of sorafenib was prepared and its relative bioavailability in rats was evaluated. The blank SMEDDS was prepared from a mixture of ethyl oleate (oil phase, 20%, w/w), Cremophol EL (surfactant, 48%, w/w), PEG-400 (co-surfactant, 16%, w/w) and ethanol (co-surfactant, 16%, w/w). Sorafenib was subsequently dissolved in the blank SMEDDS to obtain a somfenib SMEDDS formulation with a final sorafenib concentration at 20 mg/mL. The particle size of the emulsified sorafenib SMEDDS was about 20-25 nm. Compared with sorafenib suspension, the prepared SMEDDS formulation exhibited no effect on the Tmax, but significantly increased the AUC, Cmax and MRT and decreased the drug clearance. Most importantly, the oral bioavailability based on AUC0-72h increased about 25 times after formulating sorafenib in SMEDDS. We concluded that SMEDDS could be a promising vesicle for the oral delivery of the poorly soluble antitumor drug sorafenib. 展开更多
关键词 SORAFENIB SMEDDS Relative bioavailability
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部