Congenital hyposensitivity to pain is a condition with predisposition to injury. In these patients, knowledge regarding anesthetic requirements and complications derives from individual case reports, or small case ser...Congenital hyposensitivity to pain is a condition with predisposition to injury. In these patients, knowledge regarding anesthetic requirements and complications derives from individual case reports, or small case series. Different categories have been described. In patients with hyposensitivity to pain, preventing and treating anxiety as well as insuring immobilization, avoidance of triggering of autonomic reflexes, and sedation are integral aspects for a safe and adequate anesthetic management.展开更多
AIM:To test whether colchicine would be an effective antif ibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-interferon.METHODS:Seventy-four patients(46 males,28 female...AIM:To test whether colchicine would be an effective antif ibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-interferon.METHODS:Seventy-four patients(46 males,28 females) aged 40-66 years(mean 53±13 years) participated in the study.The patients were affected by chronic liver diseases with cirrhosis which was proven histologically(n=58);by chronic active hepatitis C(n=4),chronic active hepatitis B(n=2),and chronic persistent hepatitis C(n=6).In the four patients lacking histology,cirrhosis was diagnosed from anamnesis,serum laboratory tests,esophageal varices and ascites.Patients were assigned to colchicine(1 mg/d) or standard treatment as control in a randomized,double-blind trial,and followed for 4.4 years with clinical and laboratory evaluation.RESULTS:Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group(P=0.001).Serum N-terminal peptide of type Ⅲ procollagen levels fell from 34.0 to 18.3 ng/mL(P=0.0001),and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL(P=0.0001) in the colchicine group,while no signif icant change was seen in controls.Best results were obtained in patients with chronic hepatitis C and in alcoholic cirrhotics.CONCLUSION:Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fi brosis progresses towards cirrhosis.展开更多
Coronary artery bypass grafting (CABG) remains one of the most common procedures worldwide, and remains the gold standard therapy for symptomatic coronary artery disease (CAD) that involves the left main coronary arte...Coronary artery bypass grafting (CABG) remains one of the most common procedures worldwide, and remains the gold standard therapy for symptomatic coronary artery disease (CAD) that involves the left main coronary artery, triple vessel CAD with or without left ventricular dysfunction, and other complex coronary CAD not amenable to percutaneous intervention, especially in diabetic patients or those with chronic total coronary occlusion. The majority of CABG operations are performed utilizing cardiopulmonary bypass, though beating heart or off-pump strategies have gained popularity by some surgeons. This review focuses on current technical strategies, and advances in conduit harvest and utility, and fundamental management components of cardiopulmonary bypass and beating heart principles.展开更多
Confusion continues in figuring out which of the Chinese author＇s name in a publication is the surname, although I have made numerous attempts in suggesting possible solutions to this nasty problem in the past. There...Confusion continues in figuring out which of the Chinese author＇s name in a publication is the surname, although I have made numerous attempts in suggesting possible solutions to this nasty problem in the past. There is a fundamental difference between a Chinese name and a Western name.展开更多
The p21-activated kinase 1(PAK1)belongs to PAKs family,a group of highly evolutionarily conserved protein family of serine/threonine kinases,which acts as a downstream effector of the small GTPases Cdc42 and Rac1,firs...The p21-activated kinase 1(PAK1)belongs to PAKs family,a group of highly evolutionarily conserved protein family of serine/threonine kinases,which acts as a downstream effector of the small GTPases Cdc42 and Rac1,firstly reported in 1994[1].As a serine/threonine kinase,PAK1 plays an important role in many cellular functions including cell morphogenesis,motility,survival,mitosis,angiogenesis,展开更多
文摘Congenital hyposensitivity to pain is a condition with predisposition to injury. In these patients, knowledge regarding anesthetic requirements and complications derives from individual case reports, or small case series. Different categories have been described. In patients with hyposensitivity to pain, preventing and treating anxiety as well as insuring immobilization, avoidance of triggering of autonomic reflexes, and sedation are integral aspects for a safe and adequate anesthetic management.
文摘AIM:To test whether colchicine would be an effective antif ibrotic agent for treatment of chronic liver diseases in patients who could not be treated with α-interferon.METHODS:Seventy-four patients(46 males,28 females) aged 40-66 years(mean 53±13 years) participated in the study.The patients were affected by chronic liver diseases with cirrhosis which was proven histologically(n=58);by chronic active hepatitis C(n=4),chronic active hepatitis B(n=2),and chronic persistent hepatitis C(n=6).In the four patients lacking histology,cirrhosis was diagnosed from anamnesis,serum laboratory tests,esophageal varices and ascites.Patients were assigned to colchicine(1 mg/d) or standard treatment as control in a randomized,double-blind trial,and followed for 4.4 years with clinical and laboratory evaluation.RESULTS:Survival at the end of the study was 94.6% in the colchicine group and 78.4% in the control group(P=0.001).Serum N-terminal peptide of type Ⅲ procollagen levels fell from 34.0 to 18.3 ng/mL(P=0.0001),and pseudocholinesterase levels rose from 4.900 to 5.610 mU/mL(P=0.0001) in the colchicine group,while no signif icant change was seen in controls.Best results were obtained in patients with chronic hepatitis C and in alcoholic cirrhotics.CONCLUSION:Colchicine is an effective and safe antifibrotic drug for long-term treatment of chronic liver disease in which fi brosis progresses towards cirrhosis.
文摘Coronary artery bypass grafting (CABG) remains one of the most common procedures worldwide, and remains the gold standard therapy for symptomatic coronary artery disease (CAD) that involves the left main coronary artery, triple vessel CAD with or without left ventricular dysfunction, and other complex coronary CAD not amenable to percutaneous intervention, especially in diabetic patients or those with chronic total coronary occlusion. The majority of CABG operations are performed utilizing cardiopulmonary bypass, though beating heart or off-pump strategies have gained popularity by some surgeons. This review focuses on current technical strategies, and advances in conduit harvest and utility, and fundamental management components of cardiopulmonary bypass and beating heart principles.
文摘Confusion continues in figuring out which of the Chinese author＇s name in a publication is the surname, although I have made numerous attempts in suggesting possible solutions to this nasty problem in the past. There is a fundamental difference between a Chinese name and a Western name.
文摘The p21-activated kinase 1(PAK1)belongs to PAKs family,a group of highly evolutionarily conserved protein family of serine/threonine kinases,which acts as a downstream effector of the small GTPases Cdc42 and Rac1,firstly reported in 1994[1].As a serine/threonine kinase,PAK1 plays an important role in many cellular functions including cell morphogenesis,motility,survival,mitosis,angiogenesis,
