Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize ...Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize cytokines,such as IL-1 and TNF-α,known to be involved in OA have shown poor clinical efficacy.3 There is an unmet clinical need to find better anti-inflammatory and pain targets for OA therapy and to elucidate the role of other cytokines in OA pathogenesis.Previous studies have shown that IL-22 and its receptor IL-22R play central roles in inflammation and diseases such as psoriasis,ulcerative colitis,graft-versus-host disease,certain infections and tumors,as well as in liver and pancreas damage.4,5 The role of IL-22/IL-22R and the potential for therapeutic targeting of both proteins in OA remain largely unknown,which we sought to investigate.展开更多
A recent article by Grifoni et al.elegantly demonstrated the ability to measure and understand the human CD4+and CD8+T cell responses to SARS-CoV-2 infection.1 These findings highlighted below gave new insights into t...A recent article by Grifoni et al.elegantly demonstrated the ability to measure and understand the human CD4+and CD8+T cell responses to SARS-CoV-2 infection.1 These findings highlighted below gave new insights into the immunopathogenesis of COVID-19,the crossreactivity of the SARS-CoV-2 infections,the potential targets of T cells,and for vaccine design.展开更多
A recent article by Wu et al.1 demonstrated how targeting inflammatory TH17 cells can be achieved by blocking glycolysis pathway genes.These findings could lead to potential drugs to selective target“bad”inflammator...A recent article by Wu et al.1 demonstrated how targeting inflammatory TH17 cells can be achieved by blocking glycolysis pathway genes.These findings could lead to potential drugs to selective target“bad”inflammatory TH17 cells,while not disturbing“good”homeostatic TH17 cells in patients with autoimmune diseases.展开更多
A recent article by Wang et al.elegantly synthesized new nanoparticles consisting of cyclic guanosine monophosphate–adenosine monophosphate(cGAMP),which were administered alongside vaccines,to successfully deliver in...A recent article by Wang et al.elegantly synthesized new nanoparticles consisting of cyclic guanosine monophosphate–adenosine monophosphate(cGAMP),which were administered alongside vaccines,to successfully deliver into the lungs of animals leading to protection against different subtypes of influenza infection without inflammatory side effects.展开更多
Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza...Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza vaccination administration in elderly people to reduce complications,particularly when seasonal influenza infections peak.2 To date,much is known about how influenza infection and host immunity interact during pathogenesis,which has led to a number of vaccines.3,4 However,the impact of influenza vaccines in older people is modest.2 Hence,the underlying pathophysiological mechanisms responsible for the worsening of influenza infection in old age are still elusive.展开更多
基金supported by the Jiangsu Provincial Special Program of Medical Science(grant BL2014005)the Shandong National Science Foundation(ZR2017MC002)the Talent Program of Qingdao Agricultural University.
文摘Osteoarthritis(OA)is characterized by cartilage degradation,pain,and synovitis.1 Joint inflammation driven by cytokines has been demonstrated to cause cartilage degradation and pain.2 However,approaches to neutralize cytokines,such as IL-1 and TNF-α,known to be involved in OA have shown poor clinical efficacy.3 There is an unmet clinical need to find better anti-inflammatory and pain targets for OA therapy and to elucidate the role of other cytokines in OA pathogenesis.Previous studies have shown that IL-22 and its receptor IL-22R play central roles in inflammation and diseases such as psoriasis,ulcerative colitis,graft-versus-host disease,certain infections and tumors,as well as in liver and pancreas damage.4,5 The role of IL-22/IL-22R and the potential for therapeutic targeting of both proteins in OA remain largely unknown,which we sought to investigate.
基金supported by Talent Program of Qingdao Agricultural University and Priority Academic Talent Team Cultivation Program of Shandong Colleges(J.L and J.W)supported by Global Engagement Research Initiation(GERI QMUL)and Medical Charity of Barts Hospital Trustee award to A.S.K.
文摘A recent article by Grifoni et al.elegantly demonstrated the ability to measure and understand the human CD4+and CD8+T cell responses to SARS-CoV-2 infection.1 These findings highlighted below gave new insights into the immunopathogenesis of COVID-19,the crossreactivity of the SARS-CoV-2 infections,the potential targets of T cells,and for vaccine design.
基金supported by Shandong Key Research Program(2019GSF107084)Talent Program of Qingdao Agricultural University.
文摘A recent article by Wu et al.1 demonstrated how targeting inflammatory TH17 cells can be achieved by blocking glycolysis pathway genes.These findings could lead to potential drugs to selective target“bad”inflammatory TH17 cells,while not disturbing“good”homeostatic TH17 cells in patients with autoimmune diseases.
基金supported by the grant BL2014005 from the Jiangsu Provincial Special Program of Medical Science,and by grant ZX2020009 from Nanjing technology development plan for 2020supported by Shandong National Science Foundation(ZR2017MC002)Talent Program of Qingdao Agricultural University.
文摘A recent article by Wang et al.elegantly synthesized new nanoparticles consisting of cyclic guanosine monophosphate–adenosine monophosphate(cGAMP),which were administered alongside vaccines,to successfully deliver into the lungs of animals leading to protection against different subtypes of influenza infection without inflammatory side effects.
文摘Dear Editor,Influenza affects humans of all ages;however,elderly people have increased susceptibility to infections and are especially predisposed to complications.1 A number of global efforts have increased influenza vaccination administration in elderly people to reduce complications,particularly when seasonal influenza infections peak.2 To date,much is known about how influenza infection and host immunity interact during pathogenesis,which has led to a number of vaccines.3,4 However,the impact of influenza vaccines in older people is modest.2 Hence,the underlying pathophysiological mechanisms responsible for the worsening of influenza infection in old age are still elusive.
