A highly selective magnetic sensor with functionalized Fe/Fe_3O_4 nanoparticles for detection of Pb^(2+)

A magnetic sensor for detection of Pb^2＋ has been developed based on Fe/Fe3O4 nanoparticles modified by3-（3,4-dihydroxyphenyl）propionic acid（DHCA）. The carboxyl groups of DHCA have a strong affinity to coordination behavior of Pb^2＋ thus inducing the transformation of Fe/Fe3O4 nanoparticles from a dispersed to an aggregated state with a corresponding decrease, then increase in transverse relaxation time（T2） of the surrounding water protons. Upon addition of the different concentrations of Pb^2＋ to an aq. solution of DHCA functionalized Fe/Fe3O4 nanoparticles（DHCA-Fe/Fe3O4 NPs）（[Fe] = 90 mmol/L）, the change of T2 values display a good linear relationship with the concentration of Pb^2＋ from 40 μmol/L to 100 μmol/L and from 130 μmol/L to 200 μmol/L, respectively. Owing to the especially strong interaction between DHCA and Pb^2＋, DHCA-Fe/Fe3O4 NPs exhibited a high selectivity over other metal ions.

Cytotoxicity of mitochondrial-targeting silica-coated manganese oxide nanoparticles

The mitochondrion is a promising target for diagnosis and therapy. Mitochondrial-targeting silica-coated manganese oxide nanoparticles(Mn O@Si O2-PPh3+ NPs) were successfully synthesized to explore the mitochondrial cytotoxicity of nanoparticles. The mitochondrial targeting property was confirmed by a laser scanning confocal microscopy experiment. Even after incubation for only 4 h, the cytotoxicity of Mn O@Si O2-PPh3+ NPs against cancer cells was obvious; the ATP content was significantly decreased to 40%; and the mitochondrial membrane potential was depleted. All of these results indicated the collapse of mitochondrial function and the start of a cell apoptosis pathway. Our findings suggest that mitochondrial-mediated apoptosis could be strengthened by targeting to the subcellular compartment.

Catalytic reduction of low-concentration CO_2 with water by Pt/Co@NC

The reduction of low-concentration carbon dioxide with water to organic fuels is still a huge challenge. In this study, we successfully designed the partially oxidized cobalt nanoparticles coated by the nitrogendoped carbon layer(Co@NC) of 2-8 nm via a facile method and then interspersed with different amount of Pt nanoparticles. The Co@NC decorated with 1 wt% Pt exhibits the best ability for COreduction to CHand a CHproduction rate of 14.4 μmol·g·his achieved. It is worth noting that the system is carried out under low-concentration CO(400 ppm) circumstance without any sacrificial agent, which could be meaningful to the design of catalysts for atmospheric COreduction.

A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics

As a new family of two-dimensional （2D） nanomaterials, MXenes have recently attracted much attention because of high performance in versatile applications including energy storage and electrochemistry, but their specific application to biomedicine has been rarely reported, especially for theranostic nanomedicine, i.e., concurrent diagnostic imaging and therapy. This study shows for the first time surface engineering and functionalization of 2D Ti3C2 MXene nanosheets by the integration of GdWl0-based polyoxometalates （POMs）. These multifunctional GdWlo@Ti3C2 composite nanosheets provide hypertherrnal treatment with magnetic resonance （MR） and/or computed tomography （CT） imaging guidance toward tumor cells or xenografts. A tumor was effectively eradicated without further reoccurrence during the observation period. GdW10 nanoclusters that were integrated onto the surface of Ti3C2 nanosheets were demonstrated to serve as a contrast agent for contrast-enhanced CT and MR imaging based on their unique composition, thus showing the potential for diagnostic-imaging guidance and monitoring for tumor hyperthermia nanotherapy. The high in vivo biocompatibility of GdW10@TiaC2 composite nanosheets was demonstrated to guarantee their subsequent translation into a medical treatment. This study provides a novel strategy for broadening the biomedical applications of MXenes by surface engineering and multifunctionalization, which is expected to promote further exploration of biomedical applications of MXenes in nanotheranostics.

Two-dimensional Ni（OH）2 nanoplates for flexible on-chip m icrosu pe rcapac itors

有集成电路的在薄片上几何学的在薄片上 microsupercapacitors (MSC ) 兼容机也能在 microelectronic 设备或作为精力存储或精力受体附件单位被用作分开的电源供应。在这个工作，我们报导灵活二维的 Ni 的制造(哦)基于 nanoplates 的 MSC，它在扫描完成了 8.80 F/cm 3 的一个特定的电容 100 mV/s 评估的 2 ，仅仅在 10,000 控告 / 解除以后失去 0.20% 它的原来的价值骑车。而且， MSC 到达了 0.59 mWh/cm 3 的精力密度和电源密度直到比得上传统的基于碳的设备的 1.80 W/cm 3, 。当使遭到了到以各种各样的条件弯曲时，灵活 MSC 展出了好电气化学的稳定性，说明象为便携精力存储的电极的有希望的申请。