Exploration of The Construction Path of Sports Injury and First Aid Course Systems for College Students

By the requirements of the Ministry of Education on life safety education, colleges, and universities have set up a course on Sports Injury and First Aid to organize relevant knowledge and increase the student’s awareness of first aid knowledge so that they can use reasonable methods to address sport-related injuries. At the same time, they can cope with first-aid situations and assist rescuers in completing resuscitation activities. This paper is based on the study of three colleges in Chongqing. This paper selected students from 3 universities in Chongqing and evaluated the mastery of first aid knowledge of college students, pointing out the value of implementing the “Sports Injury and First Aid” course in colleges and universities. This can provide opportunities to improve the theoretical content of the discipline, actively carry out practical activities, reasonably set the assessment method, and provide basic protection to ensure that the “Sports Injury and First Aid” course can be carried out normally to improve the mastery level of students’ first aid knowledge.

Treatment of cancer cachexia with exercise

Cancer cachexia is a multifactorial syndrome characterized by the irreversible loss of body weight,fat,and muscle.Its main characteristics include nutrient intake and absorption disorders,systemic inflammation,mitochondrial dysfunction,immune imbalance,and protein and fat consumption,which ultimately lead to patient death.So far,there has been no effective method identified to combat the malignant progression of cancer cachexia.The effects of a single nutritional supplement or drug intervention strategy are insufficient.Exercise training is considered a potential treatment for cancer cachexia.Both clinical studies and animal experiments suggest that exercise training can help improve the intake and absorption of nutrients,inhibit inflammatory signaling pathways,regulate immunity andmetabolism,alleviate insulin resistance,promote protein synthesis,maintain muscle mass,and so on.The use of multimodal methods that combine nutritional support and/or other treatments with exercise provides a potential prospect for the treatment of cancer cachexia.However,the optimal prescription of exercise for the treatment of cancer cachexia is still unclear.The main purpose of this review is to summarize the growing body of research on the impact of exercise on cancer cachexia and to provide evidence supporting the use of exercise as an intervention for cancer cachexia in the clinical setting.

YB-1 downregulation attenuates UQCRC1 protein expression level in H9C2 cells and decreases the mitochondrial membrane potential

UQCRC1 is one of the 10 mitochondrial complex III subunits,this protein has a role in energy metabolism,myocardial protection,and neurological diseases.The upstream mechanism of the UQCRC1 protective effect on cardiomyocytes is currently unavailable.In order to explore the upstream molecules of UQCRC1 and elucidate the protective mechanism of UQCRC1 on cardiomyocytes in more detail,we focused on the nuclease-sensitive elementbinding protein 1(YB-1).We hypothesized YB-1 acts as an upstream regulatory molecule of UQCRC1.This study found that YB-1 RNAi significantly reduces the expression of the UQCRC1 protein level(p<0.05)and obviously decreases the mitochondrial membrane potential(p<0.05),and that YB-1 interacts with UQCRC1 protein in vivo,but YB-1 RNAi has little effect on the UQCRC1 gene transcription.

Discussion on the mechanism of Salvia miltiorrhiza in treating pathological scars based on network pharmacology

In the present study, we aimed to explore the mechanism of Salvia miltiorrhiza in the treatment of pathological scars(PS) by network pharmacology. The active ingredients and drug targets of Salvia miltiorrhiza were screened out through TCMSP database, the disease targets of PS in Gene Cards database were obtained, and Venn diagram analysis on drug targets and disease targets was performed, and the intersection was used as the target of Salvia miltiorrhiza for the treatment of PS. Cytoscape software was used to construct a drug-ingredient-target-disease network diagram. A protein-protein interaction network was constructed through String website, its key protein modules and hub genes were screened with Cytoscape software, and GO and KEGG enrichment analyses were performed in DAVID database. Fifty-nine active ingredients, 138 drug targets, and 90 targets of Salvia miltiorrhiza for the treatment of PS were screened out. Core ingredients, such as luteolin and tanshinone IIA, were obtained. The hub genes, such as VEGFA, TP53, JUN, STAT3, AKT1, MAPK1, and PTGS2, and signaling pathways, such as HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT, were screened out. Salvia miltiorrhiza might improve PS hypoxia, inflammation, and balance of proliferation and apoptosis of fibroblasts by regulating HIF-1, TNF, MAPK, PI3 K-Akt, and Jak-STAT signaling pathways. Moreover, it had the characteristics of multiple centers, multiple targets, and multiple pathways.