Stent placement is an effective palliation therapy for malignant colorectal obstruction.However,recurrent obstruction is a common severe complication caused by tumor ingrowth into the stent lumen.Conventional covered ...Stent placement is an effective palliation therapy for malignant colorectal obstruction.However,recurrent obstruction is a common severe complication caused by tumor ingrowth into the stent lumen.Conventional covered stents play a part in preventing the tumor from growing inward but at the expense of significantly increasing the risk of stent migration.Therefore,there is an urgent demand to develop stents with sustained antitumor and antimigration abilities.Herein,we propose a facile method for fabricating multifunctional bioinspired colorectal stents using 3D printing technology.Inspired by high-adhesion biological structures(gecko feet,tree frog toe pads,and octopus suckers)in nature,different types of bioinspired colorectal stents are designed to reduce migration.After functionalization with graphene oxide(GO),bioinspired colorectal stents show excellent and controllable photothermal performance,which is validated by effective ablation of colon cancer cells in vitro and tumors in vivo.Besides,the bioinspired colorectal stents demonstrate the feasibility of transanal placement and opening of the obstructed colon.More importantly,the facile manufacturing process of multifunctional bioinspired colorectal stents is appealing for mass production,Hence,the developed multifunctional bioinspired colorectal stents exhibit a highly promising potential in clinical applications.展开更多
基金This work was supported by the Heilongjiang Touyan Innovation Team Program.The authors gratefully acknowledge the financial support provided by the National Natural Science Foundation of China(Grant Nos.12072094 and 12172106)This work was also supported by the Fundamental Research Funds for the Central Universities(0-1 Original exploration plan,Nos.IR2021106 and IR2021232).
文摘Stent placement is an effective palliation therapy for malignant colorectal obstruction.However,recurrent obstruction is a common severe complication caused by tumor ingrowth into the stent lumen.Conventional covered stents play a part in preventing the tumor from growing inward but at the expense of significantly increasing the risk of stent migration.Therefore,there is an urgent demand to develop stents with sustained antitumor and antimigration abilities.Herein,we propose a facile method for fabricating multifunctional bioinspired colorectal stents using 3D printing technology.Inspired by high-adhesion biological structures(gecko feet,tree frog toe pads,and octopus suckers)in nature,different types of bioinspired colorectal stents are designed to reduce migration.After functionalization with graphene oxide(GO),bioinspired colorectal stents show excellent and controllable photothermal performance,which is validated by effective ablation of colon cancer cells in vitro and tumors in vivo.Besides,the bioinspired colorectal stents demonstrate the feasibility of transanal placement and opening of the obstructed colon.More importantly,the facile manufacturing process of multifunctional bioinspired colorectal stents is appealing for mass production,Hence,the developed multifunctional bioinspired colorectal stents exhibit a highly promising potential in clinical applications.
