Multi-functional bismuth-doped bioglasses: combining bioactivity and photothermal response for bone tumor treatment and tissue repair

Treatment of large bone defects derived from bone tumor surgery is typically performed in multiple separate operations,such as hyperthermia to extinguish residual malignant cells or implanting bioactive materials to initiate apatite remineralization for tissue repair;it is very challenging to combine these functions into a material.Herein,we report the first photothermal(PT)effect in bismuth(Bi)-doped glasses.On the basis of this discovery,we have developed a new type of Bi-doped bioactive glass that integrates both functions,thus reducing the number of treatment cycles.We demonstrate that Bi-doped bioglasses(BGs)provide high PT efficiency,potentially facilitating photoinduced hyperthermia and bioactivity to allow bone tissue remineralization.The PT effect of Bi-doped BGs can be effectively controlled by managing radiative and non-radiative processes of the active Bi species by quenching photoluminescence(PL)or depolymerizing glass networks.In vitro studies demonstrate that such glasses are biocompatible to tumor and normal cells and that they can promote osteogenic cell proliferation,differentiation,and mineralization.Upon illumination with near-infrared(NIR)light,the bioglass(BG)can efficiently kill bone tumor cells,as demonstrated via in vitro and in vivo experiments.This indicates excellent potential for the integration of multiple functions within the new materials,which will aid in the development and application of novel biomaterials.

Correction:Multi-functional bismuth-doped bioglasses:combining bioactivity and photothermal response for bone tumor treatment and tissue repair

In this originally published article,we have noticed several mistakes.They should be corrected as follows:1.On page 1,the second affiliation(No.5)of the author“Chuanbin Mao”should be deleted as he does not belong to that affiliation.Namely,he should be only listed with(Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center,University of Oklahoma,Norman,OK 73072,USA).

Bismuth-doped germanate glass fiber fabricated by the rod-in-tube technique

Bismuth （Bi）-doped laser glasses and fiber devices have aroused wide attentions due to their unique potential to work in the new spectral range of 1 to 1.8 μm traditional laser ions, such as rare earth, cannot reach. Current Bi-dopcd silica glass fibers have to be made by modified chemical vapor deposition at a temperature higher than 2000℃. This unavoidably leads to the tremendous loss of Bi by evaporation, since the temperature is several hundred degrees Celsius higher than the Bi boiling temperature, and, therefore, trace Bi （-50 ppm） resides within the final product of silica fiber. So, the gain of such fiber is usually extremely low. One of the solutions is to make the fibers at a temperature much lower than the boiling temperature of Bi. The challenge for this is to find a lower melting point glass, which can stabilize Bi in the near infrared emission center and, meanwhile, does not lose glass transparency during fiber fabrication. None of previously reported Bi-doped multicomponent glasses can meet the prerequisite. Here, we, after hundreds of trials on optimization over glass components, activator content, melting temperature, etc., find a novel Bi-doped gallogermanate glass, which shows good tolerance to thermal impact and can accommodate a higher content of Bi. Consequently, we successfully manu- facture the germanate fiber by a rod-in-tube technique at 850℃. The fiber exhibits similar luminescence to the bulk glass, and it shows saturated absorption at 808 nm rather than 980 nm as the incident power becomes higher than 4 W. Amplified spontaneous emissions are observed upon the pumps of either 980 or 1064 nm from ger- manate fiber.

Lattice Doping of Lanthanide Ions in Cs_(2)AgInCl_(6)Nanocrystals Enabling Tunable Photoluminescence

Lead-free halide double perovskite Cs_(2)AgInCl_(6 )has become the research hotspot in the optoelectronic fields.It is a challenge to utilize the lattice doping by different lanthanide ions with rich and unique photoluminescence(PL)emissions for emerging photonic applications.Here,we successfully incorporated Dy^(3+),Sm^(3+),and Tb3+ions into Cs_(2)AgInCl_(6) nanocrystals(NCs)by the hot-injection method,bringing diverse PL emissions of yellowish,orange,and green light in Cs_(2)AgInCl_(6):Ln^(3+)(Ln^(3+)=Dy^(3+),Sm^(3+),Tb^(3+)).Moreover,benefiting from the energy transfer process,Sm^(3+)and Tb^(3+)ion-codoped Cs_(2)AgInCl_(6) NCs achieved tunable emission from green to yellow orange and a fluorescent pattern from the as-prepared NC-hexane inks by spray coating was made to show its potential application in fluorescent signs and anticounterfeiting technology.This work indicates that lanthanide ions could endow Cs_(2)AgInCl_(6) NCs the unique and tunable PL properties and stimulate the development of lead-free halide perovskite materials for new optoelectronic applications.

镨掺杂的多响应型深紫外荧光粉与杀菌应用

开发能够被不同激发光源激发,并在同一体系中实现多响应发射的多模态发光材料是发光材料领域的一个挑战.本文采用一种异价掺杂策略,在富含缺陷的Li_(2)CaGeO_(4)(LCGO)基质中实现了Pr^(3+)掺杂的多模式深紫外发射.LCGO:Pr^(3+)多响应特性使其能够被常见的光源,包括X射线管、标准紫外灯、蓝光和近红外激光器激发.Pr^(3+)掺杂产生并重建LCGO材料中的缺陷位点,包括阳离子缺陷的产生和氧空位的减少,进而调控了陷阱分布,使得该材料同时表现出余辉发光和光激励发光.基于Pr^(3+)离子的4f离散能级,该材料还表现出上转换发光,入射的可见光可转化为用于杀菌的深紫外发射.基于此,本文设计了一种双模光转换策略用于灭活细菌.这种多响应的深紫外发射体为开发用于杀菌的紫外光源提供了新的思路.在以陷阱为媒介的基质晶格中实施异价掺杂或者取代也为构建多模发光材料提供了可行途径.

内嵌碳点的无铅金属卤化物单晶用于单组分白光发射体

白光发光二极管(WLED)照明光源的发展对于降低能源消耗具有重要意义.然而,常用的基于荧光粉转换技术的WLED器件存在自吸收严重、显色指数低和稀土元素供应风险等多方面的不足.对此,本文通过组装蓝光碳点(CDs)和无铅黄光金属卤化物(Cs_(2)InCl_(5)·H_(2)O:Sb^(3+)),开发了一种新的单组分白光发射材料.采用液-液扩散辅助结晶方法,本工作成功地将CDs嵌入到Cs_(2)InCl_(5)·H_(2)O:Sb^(3+)晶体中,复合材料呈现出白光发射.调节CDs和Cs_(2)InCl_(5)·H_(2)O:Sb^(3+)的比例可实现冷/暖色调可调.使用这种“内嵌CDs的卤化物晶体”复合材料作为转换器,我们成功制造出单一体系WLED,其显色指数(CRI)高达93.6,为下一代室内高品质WLED照明光源提供了一种便捷有效的策略.