The use of a chiral(NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent.This reaction was applicable to va...The use of a chiral(NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent.This reaction was applicable to various ortho-substituted diaryl keontes,affording benzhydrols in good yields and enantioselectivities.This protocol could be carried out in a gram scale under mild reaction conditions.The utility of the catalytic system was highlighted by the synthesis of the key precursor of(S)-neobenodine.展开更多
基金Financial support from the National Key R&D Program of China(2021YFA1501700,2021YFA1500100)the National Natural Science Foundation of China(22072178,21825109,21821002,21732006)the K.C.Wong Education Foundation,and Ningbo Municipal Bureau of Science and Technology(2019B10096)is gratefully acknowledged.
文摘The use of a chiral(NCP)Ir complex as the precatalyst allowed for the discovery of asymmetric transfer hydrogenation of diaryl ketones with ethanol as the hydrogen source and solvent.This reaction was applicable to various ortho-substituted diaryl keontes,affording benzhydrols in good yields and enantioselectivities.This protocol could be carried out in a gram scale under mild reaction conditions.The utility of the catalytic system was highlighted by the synthesis of the key precursor of(S)-neobenodine.
