Schwann cells(SCs)are essential in the development of the peripheral nervous system(PNS),in PNS inj ury,and the aging PNS.SCs comprise greater than 90%of the nucleated cells in peripheral nerves(Campana,2007).Myelinat...Schwann cells(SCs)are essential in the development of the peripheral nervous system(PNS),in PNS inj ury,and the aging PNS.SCs comprise greater than 90%of the nucleated cells in peripheral nerves(Campana,2007).Myelinating SCs insulate large-diameter axons,forming a 1:1relationship and promoting saltatory conduction of axonal action potentials.Non-myelinating SCs ensheathe clusters of smaller diameter axons in Remak bundles.Both types of SCs provide essential metabolic and trophic support to axons,which is essential for maintaining axon integrity in healthy peripheral nerves.展开更多
基金supported by 1101 RX003363 from the Veterans Administration(to WMC)。
文摘Schwann cells(SCs)are essential in the development of the peripheral nervous system(PNS),in PNS inj ury,and the aging PNS.SCs comprise greater than 90%of the nucleated cells in peripheral nerves(Campana,2007).Myelinating SCs insulate large-diameter axons,forming a 1:1relationship and promoting saltatory conduction of axonal action potentials.Non-myelinating SCs ensheathe clusters of smaller diameter axons in Remak bundles.Both types of SCs provide essential metabolic and trophic support to axons,which is essential for maintaining axon integrity in healthy peripheral nerves.
