Role of estrogen in angiogenesis in cardiovascular diseases

The formation of new blood vessels from existing ones is a major process of angiogenesis and it is most effective in the vascular systems。 The physiological process like hypoxia inducible factors involved in the regeneration of damaged tissues varies within the vascular systems in the endothelium and could be limited due to some major angiogenic growth factors like vascular endothelial growth factor, fibroblast growth factors and epidermal growth factor among others which bring about this cellular vascular regrowth。 These physiological processes leading to cellular vascular regrowth could be a major function for the treatment of cardiovascular diseases such as ischemia and atherosclerosis。 Estrogens are one of the known factors within the cellular mechanisms that could initiate repairs to the damaged vascular tissues, since estrogens are known inducers of angiogenesis leading to this cellular regrowth。 Research has also shown that this cellular regrowth is induced by vascular angiogenic growth factors via the estrogen receptors。 In this review we will attempt to summarize the main angiogenic growth factors involved in these physiological processes leading to angiogenesis and possible new mechanisms that could lead to this vascular regrowth。 And also we will try to summarize some reports on the effect of estrogen on these physiological processes leading to angiogenesis in cardiovascular diseases。

Correlation between blood lipids and serum uric acid in the elderly patients with coronary heart disease

Objective:To explore the relationship between blood lipids and serum uric acid(UA)in the elderly patients with coronary heart disease(CHD).Method:Quartered patients according to their uric acid level.Systematic review and compare lipid level among this four groups.Polynary logistic stepwise regression analysis were employed to analyze independent risk factor of coronary heart disease.Results:Serum level of triglycerides(TAG)and very low density lipoprotein cholesterol(VLDL-C)increase significantly(F=7.42,p<0.01;F=5.42,p<0.01 respectively)while high density lipoprotein cholesterol(HDL-C)and Apolipoprotein A1(Apo A1)decrease(F=5.03,p<0.01;F=7.03,p<0.01)upon elevated serum uric acid level among coronary heart disease patients.Gender(OR=0.16,95%CI 0.078~0.315,p=0.001),Ccr(OR=0.95,CI=0.935~0.969,p=0.001),associated hypertension(OR=2.23,CI=1.156~4.285,p=0.017)or DM(OR=2.44,CI=1.154~5.168,p=0.02),TC(OR=1.56,CI=1.119~2.186,p=0.009),HDL-C(OR=0.02,CI=0.004~0.076,p=0.001),UA(OR=1.09,1.086~1.094,p=0.001)are all independent risk factors for coronary heart disease.Conclusion:TAG,VLDL-C were positively related to UA while HDL-C and Apo A1were negatively linked to UA among CHD patients.Gender,Ccr,Hypertension,DM,TC,HDL-C and UA are independent risk factors for CHD while BMI,TAG,LDL-C were not.

Tamoxifen Injection induce transient myocardiac dysfunction in mice

Tamoxifen inducible cre-loxp system has been employed as a very powerful tool for cardiology research in mice. It enables researchers to control their interested gene expression in tight control in terms of tissue specification and time specification. Here, we reported that in the absence of loxp transgenes,tamoxifen injection can lead to myocardiac dysfunction 3 days after drug administration but cardiac function start recover from 2 days later.