Objective： Cell and platelet attachment on the multiwalled carbon nanotubes （MWCNTs） were studied by ion implantation. Methods： NH2 ion implantation was performed at the energy of 30 keV with the fluence of 1 x 10...Objective： Cell and platelet attachment on the multiwalled carbon nanotubes （MWCNTs） were studied by ion implantation. Methods： NH2 ion implantation was performed at the energy of 30 keV with the fluence of 1 x 1016 ions/era2 at room temperature. Results： The cell attachment tests showed interesting results in that the number of the platclets adhering on the surface of the MWCNTs was reduced significantly after NH2 ion implantation, whereas, mouse fibroblast cells （L929） cultured on NH2 ion implanted MWCNTs displayed higher cell-viability, proliferation, and stretching compared with MWCNTs. Conclusion： No appreciable change in the tensile strength and the optical transmittance of the implanted samples was observed. X-ray photoelectron spectroscopy （XPS） analysis showed that NH2 ion implantation caused the formation of new N-containing groups.展开更多
Targeting androgens via androgen deprivation therapy (ADT) to suppress androgens/androgen receptor (AR) functions remains the standard treatment for prostate cancer. However, most tumors eventually recur
Carbon nitride （CN,） and diamond-like carbon （DLC） coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship ...Carbon nitride （CN,） and diamond-like carbon （DLC） coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of ni- trogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.1〉 the CN0.22 coating showed longer dynamic clotting time （about 42 min）, static clotting time （23.6 min） and recalcification time （45.6 s）, as well as lower platelet adhesion （102 cells μm-2）, aggregation, and activation. The presence of nitrogen in the CNx coatings in- duced their enhanced hemocompatibility compared with DLC.展开更多
基金National Natural Science Foundation of China grant number: 51272176 and 11075116+3 种基金National Basic Research Program of China (973 program) grant number: 2012CB933604The Open Research Fund of the State Key Laboratory of Bioelectronics, Southeast Universitythe Key Laboratory of Beam Technology and Material Modification of the Ministry of Education,Beijing Normal University, China
文摘Objective： Cell and platelet attachment on the multiwalled carbon nanotubes （MWCNTs） were studied by ion implantation. Methods： NH2 ion implantation was performed at the energy of 30 keV with the fluence of 1 x 1016 ions/era2 at room temperature. Results： The cell attachment tests showed interesting results in that the number of the platclets adhering on the surface of the MWCNTs was reduced significantly after NH2 ion implantation, whereas, mouse fibroblast cells （L929） cultured on NH2 ion implanted MWCNTs displayed higher cell-viability, proliferation, and stretching compared with MWCNTs. Conclusion： No appreciable change in the tensile strength and the optical transmittance of the implanted samples was observed. X-ray photoelectron spectroscopy （XPS） analysis showed that NH2 ion implantation caused the formation of new N-containing groups.
文摘Targeting androgens via androgen deprivation therapy (ADT) to suppress androgens/androgen receptor (AR) functions remains the standard treatment for prostate cancer. However, most tumors eventually recur
基金supported by the National Basic Research Program of China (Grant No. 2012CB933604)the National Natural Science Foundation of China (Grant No. 11075116),the National Natural Science Foundation of China "The effect of functionalization induced by ion beam on cell and blood compatibility of graphene" (2013)+1 种基金the Open Research Fund of the State Key Laboratory of Bioelectronics, Southeast Universitythe Key Laboratory of Beam Technology and Material Modification of Ministry of Education, Beijing Normal University, China
文摘Carbon nitride （CN,） and diamond-like carbon （DLC） coatings were prepared by dc magnetron sputtering at room temperature. Different partial pressures of N2 were used to synthesize CNx to evaluate the relationship between the atomic percentage of ni- trogen and hemocompatibility. Auger electron spectroscopy and atomic force microscopy indicated atomic percentages of N of 0.12 and 0.22 and that the CNx coatings were smooth. An in vitro study of the hemocompatibility of the coatings revealed that both CNx coatings had better anticoagulant properties and lower platelet adhesion than DLC. Compared with CN0.1〉 the CN0.22 coating showed longer dynamic clotting time （about 42 min）, static clotting time （23.6 min） and recalcification time （45.6 s）, as well as lower platelet adhesion （102 cells μm-2）, aggregation, and activation. The presence of nitrogen in the CNx coatings in- duced their enhanced hemocompatibility compared with DLC.
