Using fluoromctric technique wc tcstcd ED50 ofhistaminc release by LHRH antagonists.There wcrc 9 LHRH antagonists synthesized by us and tested by this method. The range of ED50 is from 0.65±0.08/μg / ml, to 36.8...Using fluoromctric technique wc tcstcd ED50 ofhistaminc release by LHRH antagonists.There wcrc 9 LHRH antagonists synthesized by us and tested by this method. The range of ED50 is from 0.65±0.08/μg / ml, to 36.8±2.8 /μg / ml. We selected a LHRH展开更多
Fourly semen samples were collected from healthy volunteers by masturbation. The samples were then divided into four groups according to the quality and quantity of the sperm. The propranolol (D,L-P) and its isomers i...Fourly semen samples were collected from healthy volunteers by masturbation. The samples were then divided into four groups according to the quality and quantity of the sperm. The propranolol (D,L-P) and its isomers including the Dextko-propranolol (D-P) and LevoAnpropranolol (L-P) solution of various concentrations were tested. SPermicidal e/fect at various intervals was observed by microscopy, and then compared to the Nonoxynol (NP-9) as a reference spermicide.The results showed that the mean values of lowest effective spermicidal concentration of D,L-P, D-P and L-P within twenty seconds were 1.00±0.63,1.10±0.62 and 0.91 ±0.54 (mg/ml) respectively, there was no signijicant difference among them (P>0.05), but they were signilicantly different from that of NP-9 (P<0.001). It is well known that the D- P has no significant beta- adrenoceptor blocking activity, so the D-P might be a new promising vaginal contraceptive drug.展开更多
文摘Using fluoromctric technique wc tcstcd ED50 ofhistaminc release by LHRH antagonists.There wcrc 9 LHRH antagonists synthesized by us and tested by this method. The range of ED50 is from 0.65±0.08/μg / ml, to 36.8±2.8 /μg / ml. We selected a LHRH
文摘Fourly semen samples were collected from healthy volunteers by masturbation. The samples were then divided into four groups according to the quality and quantity of the sperm. The propranolol (D,L-P) and its isomers including the Dextko-propranolol (D-P) and LevoAnpropranolol (L-P) solution of various concentrations were tested. SPermicidal e/fect at various intervals was observed by microscopy, and then compared to the Nonoxynol (NP-9) as a reference spermicide.The results showed that the mean values of lowest effective spermicidal concentration of D,L-P, D-P and L-P within twenty seconds were 1.00±0.63,1.10±0.62 and 0.91 ±0.54 (mg/ml) respectively, there was no signijicant difference among them (P>0.05), but they were signilicantly different from that of NP-9 (P<0.001). It is well known that the D- P has no significant beta- adrenoceptor blocking activity, so the D-P might be a new promising vaginal contraceptive drug.
