The research roots of 19fluorine （19F） magnetic resonance imaging （MRI） date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imagi...The research roots of 19fluorine （19F） magnetic resonance imaging （MRI） date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, ~gF/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of ~gF into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.展开更多
基金supported in whole or part by grants from the National Institutes of Health (CA154737, CA199092, HL122471, HL112518, HL113392, and HHSN26820140042C for Gregory M.Lanza AR067491, DK102691, and HL073646 for Samuel A.Wickline)We appreciate the further support provided the Barnes-Jewish Research Foundation
文摘The research roots of 19fluorine （19F） magnetic resonance imaging （MRI） date back over 35 years. Over that time span, 1H imaging flourished and was adopted worldwide with an endless array of applications and imaging approaches, making magnetic resonance an indispensable pillar of biomedical diagnostic imaging. For many years during this timeframe, 19F imaging research continued at a slow pace as the various attributes of the technique were explored. However, over the last decade and particularly the last several years, the pace and clinical relevance of 19F imaging has exploded. In part, this is due to advances in MRI instrumentation, ~gF/1H coil designs, and ultrafast pulse sequence development for both preclinical and clinical scanners. These achievements, coupled with interest in the molecular imaging of anatomy and physiology, and combined with a cadre of innovative agents, have brought the concept of ~gF into early clinical evaluation. In this review, we attempt to provide a slice of this rich history of research and development, with a particular focus on liquid perfluorocarbon compound-based agents.
