Small GTPases are key molecular switches that bind and hydrolyze GTP in diverse membrane-and cytoskeletonrelated cellular processes.Recently,mounting evidences have highlighted the role of various small GTPases,includ...Small GTPases are key molecular switches that bind and hydrolyze GTP in diverse membrane-and cytoskeletonrelated cellular processes.Recently,mounting evidences have highlighted the role of various small GTPases,including the members in Arf/Arl,Rab,and Ran subfamilies,in cilia formation and function.Once overlooked as an evolutionary vestige,the primary cilium has attracted more and more attention in last decade because of its role in sensing various extracellular signals and the association between cilia dysfunction and a wide spectrum of human diseases,now called ciliopathies.Here we review recent advances about the function of small GTPases in the context of cilia,and the correlation between the functional impairment of small GTPases and ciliopathies.Understanding of these cellular processes is of fundamental importance for broadening our view of cilia development and function in normal and pathological states and for providing valuable insights into the role of various small GTPases in disease processes,and their potential as therapeutic targets.展开更多
Two references were missed on left column of page 16.The original sentence is:Arl3 has been shown to interact with the X-linked retinitis pigmentosa protein(RP2),which is demonstrated to act as the GAP for Arl3(Grayso...Two references were missed on left column of page 16.The original sentence is:Arl3 has been shown to interact with the X-linked retinitis pigmentosa protein(RP2),which is demonstrated to act as the GAP for Arl3(Grayson et al.,2002).The corrected sentence is:Arl3 has been shown to interact with the X-linked retinitis pigmentosa protein(RP2),which is demonstrated to act as the GAP for Arl3(Bartolini et al.,2002;Grayson et al.,2002;Veltel et al.,2008).展开更多
基金the National Institutes of Health grant 1R01DK090038 and the PKD Foundation Young Investigator Award 04YI09a to J.HJ.H.is also supported by FULK Career Development Award,Zell PKD Research Fund,Upjohn PKD Research Fund,and Early Career Development Award from Mayo Clinic.
文摘Small GTPases are key molecular switches that bind and hydrolyze GTP in diverse membrane-and cytoskeletonrelated cellular processes.Recently,mounting evidences have highlighted the role of various small GTPases,including the members in Arf/Arl,Rab,and Ran subfamilies,in cilia formation and function.Once overlooked as an evolutionary vestige,the primary cilium has attracted more and more attention in last decade because of its role in sensing various extracellular signals and the association between cilia dysfunction and a wide spectrum of human diseases,now called ciliopathies.Here we review recent advances about the function of small GTPases in the context of cilia,and the correlation between the functional impairment of small GTPases and ciliopathies.Understanding of these cellular processes is of fundamental importance for broadening our view of cilia development and function in normal and pathological states and for providing valuable insights into the role of various small GTPases in disease processes,and their potential as therapeutic targets.
文摘Two references were missed on left column of page 16.The original sentence is:Arl3 has been shown to interact with the X-linked retinitis pigmentosa protein(RP2),which is demonstrated to act as the GAP for Arl3(Grayson et al.,2002).The corrected sentence is:Arl3 has been shown to interact with the X-linked retinitis pigmentosa protein(RP2),which is demonstrated to act as the GAP for Arl3(Bartolini et al.,2002;Grayson et al.,2002;Veltel et al.,2008).
