Breast cancer is one of the leading causes of cancer-related deaths in women worldwide.It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.Recently,the treatment of breast ca...Breast cancer is one of the leading causes of cancer-related deaths in women worldwide.It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.Recently,the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness,which gives rise to therapeutic resistance.Epidemiological,populationbased,and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast cancer.Diallyl disulfide(DADS)and diallyl trisulfide(DATS)are the main allyl sulfur compounds present in garlic,and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation,tumor metastasis,and angiogenesis.The present review highlights multidrug resistance mechanisms and their signaling pathways in breast cancer.This review discusses the potential anticancer activities of DADS and DATS,with emphasis on drug resistance in triple-negative breast cancer(TNBC).Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC,especially in clinical studies.展开更多
The low ion energy argon plasma was used for surface modification of Poly tetra fluoroethylene (PTFE) polymer. The plasma was generated between two plane metal electrode by using 50 kHz bipolar power supply. The plasm...The low ion energy argon plasma was used for surface modification of Poly tetra fluoroethylene (PTFE) polymer. The plasma was generated between two plane metal electrode by using 50 kHz bipolar power supply. The plasma treated surface was characterized by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The surface free energy (SFE) of plasma treated surface was calculated from contact angle measurement. SFE increases from 33.39 mJ/m2 to 41.40 mJ/m2 with the increase in plasma treatment time and the corresponding contact angle changed from 76? to 60?. XPS study shows that F/C ratio change from 1.8 (untreated) to 1.3 (treated) and O/C ratio changes from 0.094 (untreated) to 0.148 (treated). The XPS analysis shows that both F1s and the C1s spectra for PTFE are marginally modified by plasma treatment. AFM study shows that the average surface roughness (Ra) increased from 8.5 nm to 22.8 nm after plasma treatment. Vicker’s micro hardness of the film increases upon plasma treatment. The increase in SFE after plasma treatment is attributed to the functionalization of the polymer surface with hydrophilic groups as supported from the above observations.展开更多
基金supported by UGC-DAE-CSR,Kolkata(Grant No.:KC/CRS/19/RB-04/1047).
文摘Breast cancer is one of the leading causes of cancer-related deaths in women worldwide.It is a cancer that originates from the mammary ducts and involves mutations in multiple genes.Recently,the treatment of breast cancer has become increasingly challenging owing to the increase in tumor heterogeneity and aggressiveness,which gives rise to therapeutic resistance.Epidemiological,populationbased,and hospital-based case-control studies have demonstrated an association between high intake of certain Allium vegetables and a reduced risk in the development of breast cancer.Diallyl disulfide(DADS)and diallyl trisulfide(DATS)are the main allyl sulfur compounds present in garlic,and are known to exhibit anticancer activity as they interfere with breast cancer cell proliferation,tumor metastasis,and angiogenesis.The present review highlights multidrug resistance mechanisms and their signaling pathways in breast cancer.This review discusses the potential anticancer activities of DADS and DATS,with emphasis on drug resistance in triple-negative breast cancer(TNBC).Understanding the anticancer activities of DADS and DATS provides insights into their potential in targeting drug resistance mechanisms of TNBC,especially in clinical studies.
文摘The low ion energy argon plasma was used for surface modification of Poly tetra fluoroethylene (PTFE) polymer. The plasma was generated between two plane metal electrode by using 50 kHz bipolar power supply. The plasma treated surface was characterized by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The surface free energy (SFE) of plasma treated surface was calculated from contact angle measurement. SFE increases from 33.39 mJ/m2 to 41.40 mJ/m2 with the increase in plasma treatment time and the corresponding contact angle changed from 76? to 60?. XPS study shows that F/C ratio change from 1.8 (untreated) to 1.3 (treated) and O/C ratio changes from 0.094 (untreated) to 0.148 (treated). The XPS analysis shows that both F1s and the C1s spectra for PTFE are marginally modified by plasma treatment. AFM study shows that the average surface roughness (Ra) increased from 8.5 nm to 22.8 nm after plasma treatment. Vicker’s micro hardness of the film increases upon plasma treatment. The increase in SFE after plasma treatment is attributed to the functionalization of the polymer surface with hydrophilic groups as supported from the above observations.
