Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA,which leads to neuronal death.In this way,DNA damage has been implicated in the pathogenesis of...Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA,which leads to neuronal death.In this way,DNA damage has been implicated in the pathogenesis of neurological disorders,cancer,and aging.Lifestyle factors,such as physical exercise,are neuroprotective and increase brain function by improving cognition,learning,and memory,in addition to regulating the cellular redox milieu.Several mechanisms are associated with the effects of exercise in the brain,such as reduced production of oxidants,up-regulation of antioxidant capacity,and a consequent decrease in nuclear DNA damage.Furthermore,physical exercise is a potential strategy for further DNA damage repair.However,the neuroplasticity molecules that respond to different aspects of physical exercise remain unknown.In this review,we discuss the influence of exercise on DNA damage and adjacent mechanisms in the brain.We discuss the results of several studies that focus on the effects of physical exercise on brain DNA damage.展开更多
The properties of mixtures of poly (ethylene oxide) (PEO) and mixed micelles formed from sodium cholate (NaC) and sodium dodecyl sulfate (SDS) in tris/HCl buffered solutions at pH 9.00 were investigated by measuring t...The properties of mixtures of poly (ethylene oxide) (PEO) and mixed micelles formed from sodium cholate (NaC) and sodium dodecyl sulfate (SDS) in tris/HCl buffered solutions at pH 9.00 were investigated by measuring the mean surface tension. The variation in the superficial tension as a function of the time after formation of solutions containing PEO and NaC was characterized by monitoring the time required for the system to reach equilibrium between the micellar and aqueous phases. These results could serve as a reference for the minimum aging time required for solutions before any surface tension measurements can be performed.展开更多
The demand for natural resources, energy and food facing the contemporary perception of sustainability is imposing challenges to the productive sectors in accordance with market guidelines. In this context, the Brazil...The demand for natural resources, energy and food facing the contemporary perception of sustainability is imposing challenges to the productive sectors in accordance with market guidelines. In this context, the Brazilian agribusiness seeks to maintain external competitiveness and to satisfy growing domestic demands. In beef production, this competitiveness pervades traceability, food safety and sustainability. This article aims to identify the sustainability state of the art in agribusiness and characterize it within the Brazilian beef chain. Descriptive methodology, combining a literature review and a documentary data survey were adopted. An outline of the dimensions of agribusiness sustainability, drawn from benchmark practices, indicates that environmental, social and technological demands have become part of the industry's agenda. The data for beef cattle point to a growth in production but demonstrate that expansion has occurred in areas of environmental tension, which creates a demand for sustainability in the beef chain. A table of guidelines for sustainability demonstrates that although perceptions are not yet harmonized among the links in the whole beef chain, many of the technological guidelines for sustainable production may increase the producer's economic efficiency. In the Brazilian case, the increment of initiatives and dissemination of sustainable practices among the beef chain is desirable to provide a coordinated response of production, processing and distribution organizations facing market opportunities for sustainable livestock.展开更多
A wealth of pre-clinical reports and data derived from human subjects and brain autopsies suggest that microbial infections are relevant to Alzheimer’s disease(AD).This has inspired the hypothesis that microbial infe...A wealth of pre-clinical reports and data derived from human subjects and brain autopsies suggest that microbial infections are relevant to Alzheimer’s disease(AD).This has inspired the hypothesis that microbial infections increase the risk or even trigger the onset of AD.Multiple models have been developed to explain the increase in pathogenic microbes in AD patients.Although this hypothesis is well accepted in the field,it is not yet clear whether microbial neuroinvasion is a cause of AD or a consequence of the pathological changes experienced by the demented brain.Along the same line,the gut microbiome has also been proposed as a modulator of AD.In this review,we focus on human-based evidence demonstrating the elevated abundance of microbes and microbe-derived molecules in AD hosts as well as their interactions with AD hallmarks.Further,the direct-purpose and potential off-target effects underpinning the efficacy of anti-microbial treatments in AD are also addressed.展开更多
针对永久散射体PSInSAR(Persistent Scatterer SAR Interferometry)算法流程的局限性,本文立足差分雷达干涉预处理和时序微变反演性能提升,提出了一种基于优化解空间的PSInSAR序贯处理算法。该算法能够实现新SAR影像无缝嵌入,避免时序PS...针对永久散射体PSInSAR(Persistent Scatterer SAR Interferometry)算法流程的局限性,本文立足差分雷达干涉预处理和时序微变反演性能提升,提出了一种基于优化解空间的PSInSAR序贯处理算法。该算法能够实现新SAR影像无缝嵌入,避免时序PSInSAR整体数据处理流程溯源,实现微变参数的准实时更新。研究以南京明城墙文化遗产及其200 m缓冲区赋存环境为示范,基于2015-01—2018-02的32景降轨Cosmo-SkyMed条带影像,开展传统PSInSAR方法与优化解空间PSInSAR序贯方法形变反演与性能对比研究。结果表明,基于解空间优化的PSInSAR序贯方法简化了差分干涉流程,通过解空间搜索机制和结构改进,降低了算法时空复杂度,实现了未知参数求解约10倍效率提升。通过形变场精度交叉验证,发现两种方法形变估计结果吻合(总体误差在0—1 mm),证实了PSInSAR序贯方法的有效性与可靠性,并揭示其在遥感大数据时代文化遗产高精度、准实时微变监测中的应用潜力。展开更多
文摘Cells are constantly subjected to cytotoxic and genotoxic insults resulting in the accumulation of unrepaired damaged DNA,which leads to neuronal death.In this way,DNA damage has been implicated in the pathogenesis of neurological disorders,cancer,and aging.Lifestyle factors,such as physical exercise,are neuroprotective and increase brain function by improving cognition,learning,and memory,in addition to regulating the cellular redox milieu.Several mechanisms are associated with the effects of exercise in the brain,such as reduced production of oxidants,up-regulation of antioxidant capacity,and a consequent decrease in nuclear DNA damage.Furthermore,physical exercise is a potential strategy for further DNA damage repair.However,the neuroplasticity molecules that respond to different aspects of physical exercise remain unknown.In this review,we discuss the influence of exercise on DNA damage and adjacent mechanisms in the brain.We discuss the results of several studies that focus on the effects of physical exercise on brain DNA damage.
文摘The properties of mixtures of poly (ethylene oxide) (PEO) and mixed micelles formed from sodium cholate (NaC) and sodium dodecyl sulfate (SDS) in tris/HCl buffered solutions at pH 9.00 were investigated by measuring the mean surface tension. The variation in the superficial tension as a function of the time after formation of solutions containing PEO and NaC was characterized by monitoring the time required for the system to reach equilibrium between the micellar and aqueous phases. These results could serve as a reference for the minimum aging time required for solutions before any surface tension measurements can be performed.
文摘The demand for natural resources, energy and food facing the contemporary perception of sustainability is imposing challenges to the productive sectors in accordance with market guidelines. In this context, the Brazilian agribusiness seeks to maintain external competitiveness and to satisfy growing domestic demands. In beef production, this competitiveness pervades traceability, food safety and sustainability. This article aims to identify the sustainability state of the art in agribusiness and characterize it within the Brazilian beef chain. Descriptive methodology, combining a literature review and a documentary data survey were adopted. An outline of the dimensions of agribusiness sustainability, drawn from benchmark practices, indicates that environmental, social and technological demands have become part of the industry's agenda. The data for beef cattle point to a growth in production but demonstrate that expansion has occurred in areas of environmental tension, which creates a demand for sustainability in the beef chain. A table of guidelines for sustainability demonstrates that although perceptions are not yet harmonized among the links in the whole beef chain, many of the technological guidelines for sustainable production may increase the producer's economic efficiency. In the Brazilian case, the increment of initiatives and dissemination of sustainable practices among the beef chain is desirable to provide a coordinated response of production, processing and distribution organizations facing market opportunities for sustainable livestock.
基金supported by grants from NIH(RF1AG072491 to RM and TB),the Alzheimer’s Association(AARGD-22-972125 to RM and AARG-D-NTF-19-61645 to TB)the Texas Alzheimer’s Research and Care Consortium(AGT009122 to RM and TB).
文摘A wealth of pre-clinical reports and data derived from human subjects and brain autopsies suggest that microbial infections are relevant to Alzheimer’s disease(AD).This has inspired the hypothesis that microbial infections increase the risk or even trigger the onset of AD.Multiple models have been developed to explain the increase in pathogenic microbes in AD patients.Although this hypothesis is well accepted in the field,it is not yet clear whether microbial neuroinvasion is a cause of AD or a consequence of the pathological changes experienced by the demented brain.Along the same line,the gut microbiome has also been proposed as a modulator of AD.In this review,we focus on human-based evidence demonstrating the elevated abundance of microbes and microbe-derived molecules in AD hosts as well as their interactions with AD hallmarks.Further,the direct-purpose and potential off-target effects underpinning the efficacy of anti-microbial treatments in AD are also addressed.