Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic ...Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.展开更多
The work aims to study the effect of polycarboxylate type of super plasticizer on the hydration of composite cements.In this paper we have studied the hydration of 20 wt%fly ash(FA)blended Portland cement in the prese...The work aims to study the effect of polycarboxylate type of super plasticizer on the hydration of composite cements.In this paper we have studied the hydration of 20 wt%fly ash(FA)blended Portland cement in the presence of 0.1 wt%super plasticizer(SP).Water consistency,setting times,non-evaporable water contents,compressive strength,water percolation,and air content measurements were carried out.In addition,Xray diffraction studies were carried out to understand the hydration process.The results indicated the increase in compressive strength of the FA blended Portland cement in the presence of SP and with the increase of the hydration time.展开更多
基金the University Grants Commission(UGC),New Delhi,India for the financial support to Mr.Shashi Kant Singh
文摘Objective:To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods:The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the elhanolic extract of stem bark of Mangifera indica.Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin.5-(N-p-chlorophenylamino methyleno) mangiferin,5-(N-2-methyl phenylamino methyleno) mangiferin.5-(N-p-methoxy phenylamino methyleno) mangiferin.5-(N,N-diphenylamino methyleno) mangiferin,5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues.The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 tng/kg.Mangiferin and its analogues were characterized by melting point and R_f value determination and through spectral technique like UV,IR,and NMR spectral analysis.Results:The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie.200 mg/kg which was depicted thmugh a decrease in rectal temperature up to 3 h.Conclusions:The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-αand anti-oxidant activity associated with amelioration of inflammatory actions of cytokines.
文摘The work aims to study the effect of polycarboxylate type of super plasticizer on the hydration of composite cements.In this paper we have studied the hydration of 20 wt%fly ash(FA)blended Portland cement in the presence of 0.1 wt%super plasticizer(SP).Water consistency,setting times,non-evaporable water contents,compressive strength,water percolation,and air content measurements were carried out.In addition,Xray diffraction studies were carried out to understand the hydration process.The results indicated the increase in compressive strength of the FA blended Portland cement in the presence of SP and with the increase of the hydration time.
