Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of injury.We aimed to explore how symptom,cognitive,and balance presen...Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of injury.We aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be appropriate.Methods:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive seasons.Players were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,respectively.Symptom,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer vs.shorter).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or improving.Results:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and HIA3.Cognitive and balance performance were not associated with longer return and did not affect median days absence.Conclusion:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP times.This may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.展开更多
Recent years have witnessed a dynamic develop of Peking Union Medical College(PUMC),which was founded in 1921,and Chinese Academy of Medical Sciences(CAMS),which was founded in 1956.In the new era of building a"H...Recent years have witnessed a dynamic develop of Peking Union Medical College(PUMC),which was founded in 1921,and Chinese Academy of Medical Sciences(CAMS),which was founded in 1956.In the new era of building a"Healthy China",General Secretary Xi Jinping has emphasized the importance of a profound understanding of the Chinese civilization to let the world better know and understand China,and urged efforts to combine theories and practices to expound how to better uphold the Chinese path,promote the Chinese spirit,and pool together the Chinese strength[1].As an active response,PUMC organized the first Conference of History of Medicine on May 20-21,2023[2],Based on the rich history of PUMC and with an attempt to explore history,inherit the traditional Chinese culture,and promote the spirit of modern medicine,we issued the following call at the conference。展开更多
The Seventh Annual Meeting of the Chinese Geoscience Union was held in Chongqing Yuelai International Convention Center,from October 18 to 212020,together with the 36th Annual Meeting of Chinese Geophysical Society wh...The Seventh Annual Meeting of the Chinese Geoscience Union was held in Chongqing Yuelai International Convention Center,from October 18 to 212020,together with the 36th Annual Meeting of Chinese Geophysical Society which was held.This annual meeting convened one main venue and 31 academic conference venues,hosting 92 sessions with 51 of them focused on geophysics(including one English session).In addition,there were also six union-wide invited talks,5 presentations on the frontiers of geophysics,and 8 award lectures for the 2020 Fu Chengyi Young Scientist Awardees.The annual meeting received about 3200 abstracts,2150 of which were oral presentations and 950 as posters.In total,there were about 4000 participants from the scientific community and more than 80 exhibitors.展开更多
At present,there are indeed many problems in the training of upgraded talents among e-business students such as unclear training objectives and characteristics,as well as the lack of classified guidance and its corres...At present,there are indeed many problems in the training of upgraded talents among e-business students such as unclear training objectives and characteristics,as well as the lack of classified guidance and its corresponding mechanism.Therefore,there is a need for optimization and upgrading of faculties in which active research should be conducted on these issues.Through various measures to counter the challenges faced in the training of upgraded talents in e-business education based on the student-oriented ideology and advantages of universities,the environment needs to be constantly optimized while improving their levels,designing effective countermeasures,and having finn ideological beliefs.This article strives to educate senior e-business innovative talents in line with the needs of enterprises,continuously promote the integration of industry and education,as well as commit to contributing toward a comprehensive and healthy development of the e-business industry as well as social progress.展开更多
Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union Medical College Hospital and impact factors associated with better decision-ma...Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union Medical College Hospital and impact factors associated with better decision-making.Methods A 21-question anonymous survey was distributed and collected at Peking Union Medical College Hospital,a major teaching hospital in Chinese Academy of Medical Sciences.Data of physicians' educational background,clinical training,patient workload per year and continuing medical education in AGHD were collected.Factors associated with appropriate answers were further analyzed by multivariate regression models.Results One hundred and eighteen internal medicine residents,endocrine fellows,attending physicians and visiting physicians responded to the survey.Among them,44.9% thought that AGHD patients should accept recombinant human growth hormone replacement therapy.Moreover,56.8% selected insulin tolerance test and growth hormone-releasing hormone-arginine test for the diagnosis of AGHD.Logistic regression analysis of physician demographic data,educational background,and work experience found no consistent independent factors associated with better decision-making,other than continued medical education,that were associated with treatment choice.Conclusions The physicians' reported management of AGHD in this major academic healthcare center in Beijing was inconsistent with current evidence.High quality continued medical education is required to improve Chinese physician management of AGHD.展开更多
Objectives To investigate the positive rate of different hepatitis B virus(HBV) serological markers,and the demographic factors related to HBV infection.Methods We enrolled all patients tested for HBV serological mark...Objectives To investigate the positive rate of different hepatitis B virus(HBV) serological markers,and the demographic factors related to HBV infection.Methods We enrolled all patients tested for HBV serological markers,such as HBV surface antigen(HBsAg),HBV surface antibody(HBsAb),hepatitis B e antigen(HBeAg),hepatitis B e antibody(HBeAb),HBV core antibody(HBcAb),and HBV-DNA from July 2008 to July 2009 in Peking Union Medical College Hospital.The positive rate of each HBV serological marker was calculated according to gender,age,and department,respectively.The positive rates of HBV-DNA among patients with positive HBsAg were also analyzed.Results Among 27 409 samples included,2681(9.8%) were HBsAg positive.When patients were divided into 9 age groups,the age-specific positive rate of HBsAg was 1.2%,9.6%,12.3%,10.9%,10.3%,9.7%,8.0%,S.8%,and 4.3%,respectively.The positive rate of HBsAg in non-surgical department,surgical department,and health examination center was 16.2%,5.8%> and 4.7%,respectively.The positive rate of HBsAg of males(13.3%) was higher than that of females(7.3%,P=0.000).Among the 2681 HBsAg(+)patients,1230(45.9%) had HBV-DNA test,of whom 564(45.9%) were positive.Patients with HBsAg(+),HBeAg(+),and HBcAg(+) result usually had high positive rate of HBV-DNA results(71.8%,P=0.000).Conclusions Among this group of patients in our hospital,the positive rate of HBsAg was relatively high.Age group of 20-29,males,and patients in non-surgical departments were factors associated with high positive rate of HBsAg.展开更多
Objective To evaluate the effect of elective repeat cesarean section on the maternal and neonatal outcomes. Methods A retrospective clinicand hospital-based survey was designed for comparing the maternal and neonatal ...Objective To evaluate the effect of elective repeat cesarean section on the maternal and neonatal outcomes. Methods A retrospective clinicand hospital-based survey was designed for comparing the maternal and neonatal outcomes of elective repeat cesarean section [RCS group (one previous cesarean section) and MRCS group (two or more previous cesarean sections)] and primary cesarean section (FCS group) at Peking Union Medical College Hospital from January 1998 to December 2007. Results The incidence of repeat cesarean section increased from 1.26% to 7.32%. The mean gestational age at delivery in RCS group (38.1±1.8 weeks) and MRCS group (37.3±2.5 weeks) were significantly shorter than that in FCS group (38.9±2.1 weeks, all P<0.01). The incidence of complication was 33.8% and 33.3% in RCS group and MRCS group respectively, and was significantly higher than that in FCS group (7.9%, P<0.05). Dense adhesion (13.5% vs. 0.4%, OR=7.156, 95% CI: 1.7-30.7, P<0.01) and uterine rupture (1.0% vs. 0, P<0.05) were commoner in RCS group compared with FCS group. Neonatal morbidity was similar among three groups (P>0.05). Conclusions Repeat cesarean section is associated with more complicated surgery technique and increased frequency of maternal morbidity. However, the incidence of neonatal morbidity is similar to primary cesarean section.展开更多
PM10 was monitored during 2008-2011 period at LUT and BON, two urban tropical stations close to each other at Saint-Pierre city, in Reunion Island (south-western Indian Ocean). During the study period, notable PM10 co...PM10 was monitored during 2008-2011 period at LUT and BON, two urban tropical stations close to each other at Saint-Pierre city, in Reunion Island (south-western Indian Ocean). During the study period, notable PM10 concentrations are observed at BON close to the coasts. At LUT, a more inland site, the daily PM10 concentration range between 13 and 70 μg/m3. Importantly, the limit value for the protection of the human health is systematically exceeded at BON while it is never exceeded at LUT. Also, the quality objective (QO: 30 μg/m3, on annual average) and the limit value for the human health protection (LV: 40 μg/m3, on annual average) are exceeded at BON each year during 2008-2011, while at LUT no regulatory values are exceeded. Nitrogen dioxide, an atmospheric tracer of anthropogenic activities was also monitored at LUT and BON. The mean diurnal NO2 variation is of the same level and order of magnitude and exhibits a similar pattern at both stations suggesting that distinct sources influence the PM10 at LUT and at BON. Chemical analysis was performed on daily filters sampled in September-November 2011 at the two stations to determine the sea salt contribution on PM10 across Saint-Pierre city. It showed that the sea salt contribution to the PM10 is 55% at BON in September 2011. The sea salt particles are therefore the main cause for the exceedances of the regulatory values of PM10 recorded at BON. The results importantly suggest that the notable PM10 concentrations measured at this urban marine site might have some but minor impact on human health.展开更多
Cardiovascular immunology research in Wuhan Union Hospital began in 1991.Anti-heart antibodies in dilated cardiomyopathy and acute viral myocarditis began to be reported from 1993.It was found that a new autoantibody ...Cardiovascular immunology research in Wuhan Union Hospital began in 1991.Anti-heart antibodies in dilated cardiomyopathy and acute viral myocarditis began to be reported from 1993.It was found that a new autoantibody against L-type calcium channel results in ventricular tachycardia and sudden death in patients with dilated cardiomyopathy.Through the Intervention Study of Diltiazem in Dilated Cardiomyopathy,diltiazem was verifi ed to reduce mortality and the chronic heart failure hospitalization rate signifi cantly in patients with dilated cardiomyopathy.The autoantibodies against angiotensin II receptor type 1 andα1-adrenoceptor were associated with the increased recurrence of and death from stroke in hypertensive patients.Through many clinical and experimental studies,the functional imbalance of T-cell subsets was suggested to mediate myocardial injury and chronic heart failure,which provided a new theoretical basis for immunoregulation therapy for heart failure.The first antihypertensive polypeptide vaccine(ATRQβ-001)was invented.In addition to these achievements,there will be more research on cardiovascular immunology in Wuhan Union Hospital in the future.展开更多
Fruitlet Core Rot (FCR) is one of the major postharvest diseases of pineapple (<i><span style="font-family:Verdana;">Ananas comosus</span></i><span style="font-family:Verdana;...Fruitlet Core Rot (FCR) is one of the major postharvest diseases of pineapple (<i><span style="font-family:Verdana;">Ananas comosus</span></i><span style="font-family:Verdana;"> var. </span><i><span style="font-family:Verdana;">comosus</span></i><span style="font-family:Verdana;">), especially on the prone variety Queen Victoria cultivated in Reunion Island. This aggressive disease is generally due to two pathogens: </span><i><span style="font-family:Verdana;">Fusarium ananatum</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Thalaromyces stolii</span></i><span style="font-family:Verdana;">, and needs to be controlled during postharvest. In Reunion Island, </span><i><span style="font-family:Verdana;">F. ananatum</span></i><span style="font-family:Verdana;"> is the principal causal agent impacting fruit exportation. Fruit produced for the export market is generally treated with chemicals. This type of postharvest treatment is not in line with consumer expectations, as consumers prefer fruits treated with nonharmful and natural products. The objective of this work was to study alternative postharvest treatments using the fungitoxic properties of essential oils and their ability to elicit the resistance mechanisms of the fruit. Six EAs were tested </span><i><span style="font-family:Verdana;">in vitro</span></i><span style="font-family:Verdana;"> on mycelial growth of </span><i><span style="font-family:Verdana;">F. ananatum</span></i><span style="font-family:Verdana;">. Whether by volatilization or included in the culture medium, some essential oils such as thymol, eugenol, geraniol and the carvone/menthol mixture have a strong fungistatic effect. But only thymol has a fungitoxic effect. The thymol, a natural molecule synthesized by thyme (</span><i><span style="font-family:Verdana;">Thymus vulgaris</span></i><span style="font-family:Verdana;"> L. </span><i><span style="font-family:Verdana;">thymoliferum</span></i><span style="font-family:Verdana;">) is the more effective </span><i><span style="font-family:Verdana;">in vitro </span></i><span style="font-family:Verdana;">and is the strongest potential to be used in postharvest treatment. Thymol, prepared at 0.025% in a terpene solvent that acts as a penetrating agent, was tested </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> with inoculated fruits. The treatment was effective only on necrosis development from the upper part of the fruits. Pineapple polyphenol biosynthesis appears to have been suppressed by thymol treatment. Results and opportunities for this treatment are discussed. Additional experiments must be carried out in order to decide on the advisability of this type of treatment.</span>展开更多
The coronavirus disease (COVID‑19) has claimed thousands of lives. The patients have been quarantined and treated in special shelter hospitals,and mild illness accounts for the majority of the total number of patients...The coronavirus disease (COVID‑19) has claimed thousands of lives. The patients have been quarantined and treated in special shelter hospitals,and mild illness accounts for the majority of the total number of patients. This article reports one case of the first batches of infected medicalstaff, who got infected with 2019 novel coronavirus and later discharged 2 weeks after receiving treatment and nursing care in Wuhan UnionHospital. Considering all aspects of the patient’s hospitalization, the patient was performed ward environment management, medical nursing,symptomatic treatment, nutrition management, vital signs monitoring, observation and nursing, psychological assessment and support, andinfection protection and management. As the earliest successful case of cure, the patient’s manifestations are classical and common. Moreover,we hope to share it with colleagues to fight against COVID‑19 for reference. The treatment and nursing guidelines can be applied to treat a largenumber of mild cases, thus improving the discharge rate of patients and reducing the pressure of epidemic situation.展开更多
This year marks the 90thanniversary of All-China Federation of Trade Unions(ACFTU),which was founded on May 1st,1925.A review of the Federation’s international exchanges,from which historical experience can be summar...This year marks the 90thanniversary of All-China Federation of Trade Unions(ACFTU),which was founded on May 1st,1925.A review of the Federation’s international exchanges,from which historical experience can be summarized and drawn,is of pragmatic significance for further development of trade unions’foreign affairs with Chinese characteristics.展开更多
BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis an...BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications.展开更多
文摘Background:Return to play(RTP)in elite rugby is managed using a 6-stage graduated RTP protocol,which can result in clearance to play within 1 week of injury.We aimed to explore how symptom,cognitive,and balance presentation and evolution during concussion screens 2 h(head injury assessment(HIA2)and 48 h(HIA3)after injury were associated with time to RTP)to identify whether a more conservative graduated RTP may be appropriate.Methods:A retrospective cohort study was conducted in 380 concussed rugby players from elite men’s rugby over 3 consecutive seasons.Players were classified as shorter or longer returns,depending on whether RTP occurred within 7 days(allowing them to be considered to play the match 1 week after injury)or longer than 8 days,respectively.Symptom,cognitive,and balance performance during screens was assessed relative to baseline(normal or abnormal)and to the preceding screen(improving or worsening).Associations between sub-test abnormalities and RTP time were explored using odds ratios(OR,longer vs.shorter).Median day absence was compared between players with abnormal or worsening results and those whose results were normal or improving.Results:Abnormal symptom results during screens 2 h and 48 h after concussion were associated with longer return time(HIA2:OR=2.21,95%confidence interval(95%CI):1.39-3.50;HIA3:OR=3.30,95%CI:1.89-5.75).Worsening symptom number or severity from the time of injury to 2 h and 48 h post-injury was associated with longer return(HIA2:OR=2.49,95%CI:1.36-4.58;HIA3:OR=3.34,95%CI:1.10-10.15).Median days absence was greater in players with abnormal symptom results at both HIA2 and HIA3.Cognitive and balance performance were not associated with longer return and did not affect median days absence.Conclusion:Symptom presentation and evolution within 48 h of concussion were associated with longer RTP times.This may guide a more conservative approach to RTP,while still adhering to individualized concussion management principles.
文摘Recent years have witnessed a dynamic develop of Peking Union Medical College(PUMC),which was founded in 1921,and Chinese Academy of Medical Sciences(CAMS),which was founded in 1956.In the new era of building a"Healthy China",General Secretary Xi Jinping has emphasized the importance of a profound understanding of the Chinese civilization to let the world better know and understand China,and urged efforts to combine theories and practices to expound how to better uphold the Chinese path,promote the Chinese spirit,and pool together the Chinese strength[1].As an active response,PUMC organized the first Conference of History of Medicine on May 20-21,2023[2],Based on the rich history of PUMC and with an attempt to explore history,inherit the traditional Chinese culture,and promote the spirit of modern medicine,we issued the following call at the conference。
文摘The Seventh Annual Meeting of the Chinese Geoscience Union was held in Chongqing Yuelai International Convention Center,from October 18 to 212020,together with the 36th Annual Meeting of Chinese Geophysical Society which was held.This annual meeting convened one main venue and 31 academic conference venues,hosting 92 sessions with 51 of them focused on geophysics(including one English session).In addition,there were also six union-wide invited talks,5 presentations on the frontiers of geophysics,and 8 award lectures for the 2020 Fu Chengyi Young Scientist Awardees.The annual meeting received about 3200 abstracts,2150 of which were oral presentations and 950 as posters.In total,there were about 4000 participants from the scientific community and more than 80 exhibitors.
基金Supported by Research on the Presence of Online Education under the Mobile Internet Background of Beying Young Teacher Project(Project No.:12205561110-506).
文摘At present,there are indeed many problems in the training of upgraded talents among e-business students such as unclear training objectives and characteristics,as well as the lack of classified guidance and its corresponding mechanism.Therefore,there is a need for optimization and upgrading of faculties in which active research should be conducted on these issues.Through various measures to counter the challenges faced in the training of upgraded talents in e-business education based on the student-oriented ideology and advantages of universities,the environment needs to be constantly optimized while improving their levels,designing effective countermeasures,and having finn ideological beliefs.This article strives to educate senior e-business innovative talents in line with the needs of enterprises,continuously promote the integration of industry and education,as well as commit to contributing toward a comprehensive and healthy development of the e-business industry as well as social progress.
基金Supported by National Natural Science Foundation of China(81400774)PUMC Youth Fund(33320140164 and 3332016128)
文摘Objective To evaluate physicians' attitude and knowledge about the management of adult growth hormone deficiency(AGHD) at Peking Union Medical College Hospital and impact factors associated with better decision-making.Methods A 21-question anonymous survey was distributed and collected at Peking Union Medical College Hospital,a major teaching hospital in Chinese Academy of Medical Sciences.Data of physicians' educational background,clinical training,patient workload per year and continuing medical education in AGHD were collected.Factors associated with appropriate answers were further analyzed by multivariate regression models.Results One hundred and eighteen internal medicine residents,endocrine fellows,attending physicians and visiting physicians responded to the survey.Among them,44.9% thought that AGHD patients should accept recombinant human growth hormone replacement therapy.Moreover,56.8% selected insulin tolerance test and growth hormone-releasing hormone-arginine test for the diagnosis of AGHD.Logistic regression analysis of physician demographic data,educational background,and work experience found no consistent independent factors associated with better decision-making,other than continued medical education,that were associated with treatment choice.Conclusions The physicians' reported management of AGHD in this major academic healthcare center in Beijing was inconsistent with current evidence.High quality continued medical education is required to improve Chinese physician management of AGHD.
基金Supported by the Key Project from Beijing Municipal Science and Technology Commission(D121100003912003)
文摘Objectives To investigate the positive rate of different hepatitis B virus(HBV) serological markers,and the demographic factors related to HBV infection.Methods We enrolled all patients tested for HBV serological markers,such as HBV surface antigen(HBsAg),HBV surface antibody(HBsAb),hepatitis B e antigen(HBeAg),hepatitis B e antibody(HBeAb),HBV core antibody(HBcAb),and HBV-DNA from July 2008 to July 2009 in Peking Union Medical College Hospital.The positive rate of each HBV serological marker was calculated according to gender,age,and department,respectively.The positive rates of HBV-DNA among patients with positive HBsAg were also analyzed.Results Among 27 409 samples included,2681(9.8%) were HBsAg positive.When patients were divided into 9 age groups,the age-specific positive rate of HBsAg was 1.2%,9.6%,12.3%,10.9%,10.3%,9.7%,8.0%,S.8%,and 4.3%,respectively.The positive rate of HBsAg in non-surgical department,surgical department,and health examination center was 16.2%,5.8%> and 4.7%,respectively.The positive rate of HBsAg of males(13.3%) was higher than that of females(7.3%,P=0.000).Among the 2681 HBsAg(+)patients,1230(45.9%) had HBV-DNA test,of whom 564(45.9%) were positive.Patients with HBsAg(+),HBeAg(+),and HBcAg(+) result usually had high positive rate of HBV-DNA results(71.8%,P=0.000).Conclusions Among this group of patients in our hospital,the positive rate of HBsAg was relatively high.Age group of 20-29,males,and patients in non-surgical departments were factors associated with high positive rate of HBsAg.
文摘Protecting the rights and interests of workers and staff members constitutes an important aspect of China’s human rights protection. At the time when
文摘Objective To evaluate the effect of elective repeat cesarean section on the maternal and neonatal outcomes. Methods A retrospective clinicand hospital-based survey was designed for comparing the maternal and neonatal outcomes of elective repeat cesarean section [RCS group (one previous cesarean section) and MRCS group (two or more previous cesarean sections)] and primary cesarean section (FCS group) at Peking Union Medical College Hospital from January 1998 to December 2007. Results The incidence of repeat cesarean section increased from 1.26% to 7.32%. The mean gestational age at delivery in RCS group (38.1±1.8 weeks) and MRCS group (37.3±2.5 weeks) were significantly shorter than that in FCS group (38.9±2.1 weeks, all P<0.01). The incidence of complication was 33.8% and 33.3% in RCS group and MRCS group respectively, and was significantly higher than that in FCS group (7.9%, P<0.05). Dense adhesion (13.5% vs. 0.4%, OR=7.156, 95% CI: 1.7-30.7, P<0.01) and uterine rupture (1.0% vs. 0, P<0.05) were commoner in RCS group compared with FCS group. Neonatal morbidity was similar among three groups (P>0.05). Conclusions Repeat cesarean section is associated with more complicated surgery technique and increased frequency of maternal morbidity. However, the incidence of neonatal morbidity is similar to primary cesarean section.
文摘PM10 was monitored during 2008-2011 period at LUT and BON, two urban tropical stations close to each other at Saint-Pierre city, in Reunion Island (south-western Indian Ocean). During the study period, notable PM10 concentrations are observed at BON close to the coasts. At LUT, a more inland site, the daily PM10 concentration range between 13 and 70 μg/m3. Importantly, the limit value for the protection of the human health is systematically exceeded at BON while it is never exceeded at LUT. Also, the quality objective (QO: 30 μg/m3, on annual average) and the limit value for the human health protection (LV: 40 μg/m3, on annual average) are exceeded at BON each year during 2008-2011, while at LUT no regulatory values are exceeded. Nitrogen dioxide, an atmospheric tracer of anthropogenic activities was also monitored at LUT and BON. The mean diurnal NO2 variation is of the same level and order of magnitude and exhibits a similar pattern at both stations suggesting that distinct sources influence the PM10 at LUT and at BON. Chemical analysis was performed on daily filters sampled in September-November 2011 at the two stations to determine the sea salt contribution on PM10 across Saint-Pierre city. It showed that the sea salt contribution to the PM10 is 55% at BON in September 2011. The sea salt particles are therefore the main cause for the exceedances of the regulatory values of PM10 recorded at BON. The results importantly suggest that the notable PM10 concentrations measured at this urban marine site might have some but minor impact on human health.
文摘Cardiovascular immunology research in Wuhan Union Hospital began in 1991.Anti-heart antibodies in dilated cardiomyopathy and acute viral myocarditis began to be reported from 1993.It was found that a new autoantibody against L-type calcium channel results in ventricular tachycardia and sudden death in patients with dilated cardiomyopathy.Through the Intervention Study of Diltiazem in Dilated Cardiomyopathy,diltiazem was verifi ed to reduce mortality and the chronic heart failure hospitalization rate signifi cantly in patients with dilated cardiomyopathy.The autoantibodies against angiotensin II receptor type 1 andα1-adrenoceptor were associated with the increased recurrence of and death from stroke in hypertensive patients.Through many clinical and experimental studies,the functional imbalance of T-cell subsets was suggested to mediate myocardial injury and chronic heart failure,which provided a new theoretical basis for immunoregulation therapy for heart failure.The first antihypertensive polypeptide vaccine(ATRQβ-001)was invented.In addition to these achievements,there will be more research on cardiovascular immunology in Wuhan Union Hospital in the future.
文摘Fruitlet Core Rot (FCR) is one of the major postharvest diseases of pineapple (<i><span style="font-family:Verdana;">Ananas comosus</span></i><span style="font-family:Verdana;"> var. </span><i><span style="font-family:Verdana;">comosus</span></i><span style="font-family:Verdana;">), especially on the prone variety Queen Victoria cultivated in Reunion Island. This aggressive disease is generally due to two pathogens: </span><i><span style="font-family:Verdana;">Fusarium ananatum</span></i><span style="font-family:Verdana;"> and </span><i><span style="font-family:Verdana;">Thalaromyces stolii</span></i><span style="font-family:Verdana;">, and needs to be controlled during postharvest. In Reunion Island, </span><i><span style="font-family:Verdana;">F. ananatum</span></i><span style="font-family:Verdana;"> is the principal causal agent impacting fruit exportation. Fruit produced for the export market is generally treated with chemicals. This type of postharvest treatment is not in line with consumer expectations, as consumers prefer fruits treated with nonharmful and natural products. The objective of this work was to study alternative postharvest treatments using the fungitoxic properties of essential oils and their ability to elicit the resistance mechanisms of the fruit. Six EAs were tested </span><i><span style="font-family:Verdana;">in vitro</span></i><span style="font-family:Verdana;"> on mycelial growth of </span><i><span style="font-family:Verdana;">F. ananatum</span></i><span style="font-family:Verdana;">. Whether by volatilization or included in the culture medium, some essential oils such as thymol, eugenol, geraniol and the carvone/menthol mixture have a strong fungistatic effect. But only thymol has a fungitoxic effect. The thymol, a natural molecule synthesized by thyme (</span><i><span style="font-family:Verdana;">Thymus vulgaris</span></i><span style="font-family:Verdana;"> L. </span><i><span style="font-family:Verdana;">thymoliferum</span></i><span style="font-family:Verdana;">) is the more effective </span><i><span style="font-family:Verdana;">in vitro </span></i><span style="font-family:Verdana;">and is the strongest potential to be used in postharvest treatment. Thymol, prepared at 0.025% in a terpene solvent that acts as a penetrating agent, was tested </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> with inoculated fruits. The treatment was effective only on necrosis development from the upper part of the fruits. Pineapple polyphenol biosynthesis appears to have been suppressed by thymol treatment. Results and opportunities for this treatment are discussed. Additional experiments must be carried out in order to decide on the advisability of this type of treatment.</span>
文摘The coronavirus disease (COVID‑19) has claimed thousands of lives. The patients have been quarantined and treated in special shelter hospitals,and mild illness accounts for the majority of the total number of patients. This article reports one case of the first batches of infected medicalstaff, who got infected with 2019 novel coronavirus and later discharged 2 weeks after receiving treatment and nursing care in Wuhan UnionHospital. Considering all aspects of the patient’s hospitalization, the patient was performed ward environment management, medical nursing,symptomatic treatment, nutrition management, vital signs monitoring, observation and nursing, psychological assessment and support, andinfection protection and management. As the earliest successful case of cure, the patient’s manifestations are classical and common. Moreover,we hope to share it with colleagues to fight against COVID‑19 for reference. The treatment and nursing guidelines can be applied to treat a largenumber of mild cases, thus improving the discharge rate of patients and reducing the pressure of epidemic situation.
文摘This year marks the 90thanniversary of All-China Federation of Trade Unions(ACFTU),which was founded on May 1st,1925.A review of the Federation’s international exchanges,from which historical experience can be summarized and drawn,is of pragmatic significance for further development of trade unions’foreign affairs with Chinese characteristics.
基金Supported by National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-022 and No.2022-PUMCH-D-002CAMS Innovation Fund for Medical Sciences,No.2021-1-I2M-003+1 种基金Undergraduate Innovation Program,No.2023-zglc-06034National Key Clinical Specialty Construction Project,No.ZK108000。
文摘BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE patients.AIM To improve overall understanding of this disease’s diagnosis and prognosis.METHODS We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic criteria.RESULTS Diarrhea in AIE patients was characterized by secretory diarrhea.The common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and ileum.Villous blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal biopsies.Moreover,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte antibodies.All patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)days.Immunosuppressants were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s lymphoma.The cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,respectively.CONCLUSION Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult AIE.The long-term prognosis is still unsatisfactory despite corticosteroid and immunosuppressant medications,which highlights the need for early diagnosis and novel medications.