Among individuals with known alcohol use disorder(AUD),the prevalence of alcoholic fatty liver disease(AFLD)is present in 25-90%of cases(1).Shroff et al.(1)report that the annual progression to cirrhosis is 3%in the p...Among individuals with known alcohol use disorder(AUD),the prevalence of alcoholic fatty liver disease(AFLD)is present in 25-90%of cases(1).Shroff et al.(1)report that the annual progression to cirrhosis is 3%in the presence of AFLD,10%in case of alcohol-related steatohepatitis(ASH)and 8%with any grade of pre-cirrhotic fibrosis.Alcohol-related liver disease(ALD)is the cause of 36%of cases of cirrhosis in the United States and nearly one half of cirrhosis-related deaths worldwide(1).Ethanol is a recognized carcinogen for several malignancies with the risk starting at low dose(10 gr/1 unit/day)(2).The link between alcohol consumption(AC)and hepatocellular carcinoma(HCC)is well known:various evaluations carried out by both USA and Italian groups indicate that such a correlation is present in 32%to 45%of cases(2).With the reduction of hepatitis C virus(HCV)cases,AC will become the main cause of HCC in Western countries.Furthermore,ALD and metabolic syndrome(MS)are currently the main causes of liver transplantation(LT)(3).展开更多
文摘Among individuals with known alcohol use disorder(AUD),the prevalence of alcoholic fatty liver disease(AFLD)is present in 25-90%of cases(1).Shroff et al.(1)report that the annual progression to cirrhosis is 3%in the presence of AFLD,10%in case of alcohol-related steatohepatitis(ASH)and 8%with any grade of pre-cirrhotic fibrosis.Alcohol-related liver disease(ALD)is the cause of 36%of cases of cirrhosis in the United States and nearly one half of cirrhosis-related deaths worldwide(1).Ethanol is a recognized carcinogen for several malignancies with the risk starting at low dose(10 gr/1 unit/day)(2).The link between alcohol consumption(AC)and hepatocellular carcinoma(HCC)is well known:various evaluations carried out by both USA and Italian groups indicate that such a correlation is present in 32%to 45%of cases(2).With the reduction of hepatitis C virus(HCV)cases,AC will become the main cause of HCC in Western countries.Furthermore,ALD and metabolic syndrome(MS)are currently the main causes of liver transplantation(LT)(3).
