Prognostic Role of miR-205 in Early-Stage (T1N0) Non-Small Cell Lung Cancer

Background: Published data have shown that microRNAs (miRNAs) could play a potential role as diagnostic and prognostic indicators in cancers. Data for the predictive value of miRNA let-7, miR-21, and miR-205 are inconclusive. The aim of the present analysis was therefore to evaluate the expression and the prognostic role of the above mentioned miRNAs?in early-stage?(T1N0) NSCLC patients. Methods: Quantification of let-7g, miR-21, and miR-205 expression was carried out into 105 early-stage NSCLC by quantitative Real Time-PCR (qRT-PCR).?Results: a significant association between the low miR-205 expression and ADC histotype (p??0.0001) compared to SCC?was found;moreover, survival analysis showed thattumors with a high?miR-205 expression had a significantly shorter mean PFS and OS compared to the patients with a low expression of this miRNA (p = 0.02 and p = 0.03, respectively). No other statistically significant correlations were observed between the analysed miRNAs and the main clinico-pathological characteristics of the NSCLC patients. Conclusion: The results indicated that miR-205 could represent a useful marker in the prognostic management of the early-stage (T1N0) NSCLC patients.

The implication of liquid biopsies to predict chemoresistance in pancreatic cancer

Pancreatic cancer is one of the most aggressive diseases among solid tumors.Most patients are diagnosed with advanced or metastatic disease and are characterized by poor chemosensitivity.Therefore,earlier diagnosis and novel therapeutic possibilities for pancreatic cancer patients are urgently needed.Liquid biopsy is an emerging technology that allows the noninvasive sampling of tumor material.Nowadays,liquid biopsy has shown promising results as diagnostic,prognostic and predictive biomarkers,but it has not yet been universally adopted into regular use by clinicians.In this review,we describe different components of liquid biopsy,especially circulating tumor cells,circulating tumor DNA and exosomes and their potential clinical utility for pancreatic cancer patients.

Fungal mycobiome-mediated immune response:a non-negligible promoter in pancreatic oncogenesis and chemoresistance

Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal cancers in humans due to late diagnosis and poor response to treatments.The tumor microenvironment(TME)of PDAC is characterized by a distinctive,suppressive immune profile,which inhibits the protective functions of anti-tumor immunity and thereby contributes to PDAC progression.Recently,the study of Alam et al.discovered for the first time that the intratumoral fungal mycobiome could contribute to the recruitment and activation of type 2 immune cells in the TME of PDAC via enhancing the secretion of a chemoattractant,interleukin(IL-)33.In this article,we reviewed the important findings of this study.Together with our findings,we synthetically discussed the role of the fungal mycobiome in orchestrating the immune response and thereby modulating tumor progression.