Based on a study of Neoproterozoic carbonates in the Jilin-Liaoning-Xuzhou-Huaiyang area, especially its cyclic sequence stratigraphy and Sr isotopes, two maximum sea flooding events (at 820 Ma and 835 Ma) have been i...Based on a study of Neoproterozoic carbonates in the Jilin-Liaoning-Xuzhou-Huaiyang area, especially its cyclic sequence stratigraphy and Sr isotopes, two maximum sea flooding events (at 820 Ma and 835 Ma) have been identified. The resulting isochronous stratigraphic correlation proves that these Precambrian strata were connected between the Qingbaikou and the Nanhuan systems with a time range from 750 Ma to 850 Ma. The disappearance of microsparite carbonate and coming of a glacial stage offer important evidence for worldwide stratigraphic correlation and open a window for further correlation of the stratigraphic successions across the Sino-Korean and Yangtze Plates. A new correlation scheme is therefore provided based on our work.展开更多
We describe the development of a 3D Monte-Carlo model to study hot-electron transport in ionized or partially ionized targets,considering regimes typical of inertial confinement fusion.Electron collisions are modeled ...We describe the development of a 3D Monte-Carlo model to study hot-electron transport in ionized or partially ionized targets,considering regimes typical of inertial confinement fusion.Electron collisions are modeled using a mixed simulation algorithm that considers both soft and hard scattering phenomena.Soft collisions are modeled according to multiple-scattering theories,i.e.,considering the global effects of the scattering centers on the primary particle.Hard collisions are simulated by considering a two-body interaction between an electron and a plasma particle.Appropriate differential cross sections are adopted to correctly model scattering in ionized or partially ionized targets.In particular,an analytical form of the differential cross section that describes a collision between an electron and the nucleus of a partially ionized atom in a plasma is proposed.The loss of energy is treated according to the continuous slowing down approximation in a plasma stopping power theory.Validation against Geant4 is presented.The code will be implemented as a module in 3D hydrodynamic codes,providing a basis for the development of robust shock ignition schemes and allowing more precise interpretations of current experiments in planar or spherical geometries.展开更多
Objectives: The purpose of this study was to characterize the occurrence of phrenic nerve injury(PNI) and its outcome after radiofrequency(RF) ablation of atrial fibrillation(AF). Background: It is recognized that ext...Objectives: The purpose of this study was to characterize the occurrence of phrenic nerve injury(PNI) and its outcome after radiofrequency(RF) ablation of atrial fibrillation(AF). Background: It is recognized that extra-myocardial damage may develop owing to penetration of ablative energy. Methods: Between 1997 and 2004, 3,755 consecutive patients underwent AF ablation at five centers. Among them, 18 patients(0.48%; 9 male, 54±10 years) had PNI(16 right, 2 left). The procedure consisted of pulmonary vein(PV) isolation in 15 patients and anatomic circumferential ablation in 3 patients, with additional left atrial lesions(n=11) and/or superior vena cava(SVC) disconnection(n=4). Results: Right PNI occurred during ablation of right superior PV(n=12) or SVC disconnection(n=3). Left PNI occurred during ablation at the left atrial appendage. Immediate features were dyspnea, cough, hiccup, and/or sudden diaphragmatic elevation in 9, and in the remaining the diagnosis was made after ablation owing to dyspnea(n=7) or on routine radiographic evaluation(n=2). Four patients(22%) were asymptomatic. Complete recovery occurred in 12 patients(66%). Recovery occurred within 24 h in the two patients with left PNI and in one patient with right PNI occurring with SVC disconnection. In the other nine patients, right PNI recovery occurred after 4±5 months(1 to 12 months) with respiratory rehabilitation. After a mean follow-up of 36±33 months, six patients have persistent PNI(three with partial and three with no recovery). Conclusions: In this multicenter experience, PNI was a rare complication(0.48%) of AF ablation. Ablation of the right superior PV, SVC, and left atrial appendage were associated with PNI. Complete(66%) or partial(17%) recovery was observed in the majority.展开更多
We describe two numerical investigations performed using a 3D plasma Monte-Carlo code,developed to study hot-electron transport in the context of inertial confinement fusion.The code simulates the propagation of hot e...We describe two numerical investigations performed using a 3D plasma Monte-Carlo code,developed to study hot-electron transport in the context of inertial confinement fusion.The code simulates the propagation of hot electrons in ionized targets,using appropriate scattering differential cross sections with free plasma electrons and ionized or partially ionized atoms.In this paper,we show that a target in the plasma state stops and diffuses electrons more effectively than a cold target(i.e.,a target under standard conditions in which ionization is absent).This is related to the fact that in a plasma,the nuclear potential of plasma nuclei has a greater range than in the cold case,where the screening distance is determined by the electronic structure of atoms.However,in the ablation zone created by laser interaction,electrons undergo less severe scattering,counterbalancing the enhanced diffusion that occurs in the bulk.We also show that hard collisions,i.e.,collisions with large polar scattering angle,play a primary role in electron beam diffusion and should not be neglected.An application of the plasma MonteCarlo model to typical shock ignition implosions suggests that hot electrons will not give rise to any preheating concerns if their Maxwellian temperature is lower than 25–30 keV,although the presence of populations at higher temperatures must be suppressed.This result does not depend strongly on the initial angular divergence of the electron beam set in the simulations.展开更多
Laser–plasma interaction and hot electrons have been characterized in detail in laser irradiation conditions relevant for direct-drive inertial confinement fusion.The experiment was carried out at the Gekko XII laser...Laser–plasma interaction and hot electrons have been characterized in detail in laser irradiation conditions relevant for direct-drive inertial confinement fusion.The experiment was carried out at the Gekko XII laser facility in multibeam planar target geometry at an intensity of approximately 3×10^(15)W/cm^(2).Experimental data suggest that high-energy electrons,with temperatures of 20–50 keV and conversion efficiencies ofη<1%,were mainly produced by the damping of electron plasma waves driven by two-plasmon decay(TPD).Stimulated Raman scattering(SRS)is observed in a near-threshold growth regime,producing a reflectivity of approximately 0.01%,and is well described by an analytical model accounting for the convective growth in independent speckles.The experiment reveals that both TPD and SRS are collectively driven by multiple beams,resulting in a more vigorous growth than that driven by single-beam laser intensity.展开更多
A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared b...A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA,which then served both as the cargo and as the suspending agent for the SWCNTs.When complexes containing siRNA targeted to hypoxia-inducible factor 1 alpha(HIF-1)were added to cells growing in serum containing culture media,there was strong specific inhibition of cellular HIF-1 activity.The ability to obtain a biological response to SWCNT/siRNA complexes was seen in a wide variety of cancer cell types.Moreover,intratumoral administration of SWCNT-HIF-1 siRNA complexes in mice bearing MiaPaCa-2/HRE tumors signifi cantly inhibited the activity of tumor HIF-1.As elevated levels of HIF-1 are found in many human cancers and are associated with resistance to therapy and decreased patient survival,these results imply that SWCNT/siRNA complexes may have value as therapeutic agents.展开更多
Diatom stable isotope analysis offers considerable potential in palaeoceanography, par-ticularly where carbonate material is scarce or absent. However, extracting pure diatom frustules free of external labile organic ...Diatom stable isotope analysis offers considerable potential in palaeoceanography, par-ticularly where carbonate material is scarce or absent. However, extracting pure diatom frustules free of external labile organic matter from marine sediments is an essential requirement for their applica-tions as paleoenvironmental proxies. Here, based largely on previous work, we developed a method in-cluding physical separation and chemical oxidation steps to concentrate and clean pure large diatoms from laminated diatom mat and diatomaceous clay sediment samples for their stable isotope analysis. Using the physical separation techniques consisting of the removal of carbonate and excess organic matter, sieving, differential settling, and heavy liquid floatation, pure diatoms can be successfully iso-lated from the sediment samples with opal concentration more than 10%. Subsequent time oxidation experiment shows that labile organic matter coating pure diatom valves can be effectively removed with 30% H2O2 at 65 ℃ for 2 h. Measurements of δ13C after every step of physical separation demonstrate that contaminants and lost diatoms can influence the original diatom stable isotope signal, highlighting the importance of a visual check for dominant diatom size in the initial sample and purity in the final sample. Although the protocol described here was only applied to diatom mats or diatom oozes con-taining large diatoms (Ethmodiscus rex), we believe that this method can be adapted to common dia-toms of general marine sediment samples.展开更多
From Newton’s third law,which is known as the principle of actio et reactio1,we expect the forces between interacting particles to be equal and opposite for closed systems.Otherwise,“nonreciprocal”forces can arise....From Newton’s third law,which is known as the principle of actio et reactio1,we expect the forces between interacting particles to be equal and opposite for closed systems.Otherwise,“nonreciprocal”forces can arise.2 This has been shown theoretically in the interaction between dissimilar optically trapped particles that are mediated by an external field.3 As a result,despite the incident external field not having a transverse component of momentum,the particle pair experiences a force in a direction that is transverse to the light propagation direction.3,4 In this letter,we directly measure the net nonreciprocal forces in electrodynamically interacting asymmetric nanoparticle dimers and nanoparticle structures that are illuminated by plane waves and confined to pseudo one-dimensional geometries.We show via electrodynamic theory and simulations that interparticle interactions cause asymmetric scattering from heterodimers.Therefore,the putative nonreciprocal forces are actually a consequence of momentum conservation.Our study demonstrates that asymmetric scatterers exhibit directed motion due to the breakdown of mirror symmetry in their electrodynamic interactions with external fields.展开更多
Three types of BaTiO3 core-amorphous nanoshell composite ceramics were processed from the same core-shell powder by standard sintering,spark-plasma sintering and two-step sintering techniques and characterized by XRD,...Three types of BaTiO3 core-amorphous nanoshell composite ceramics were processed from the same core-shell powder by standard sintering,spark-plasma sintering and two-step sintering techniques and characterized by XRD,HRSEM and broadband dielectric spectroscopy in the frequency range 10^(3)-10^(13)Hz including the THz and IR range.The samples differed by porosity and by the amount of interdiffusion from the cores to shells,in correlation with their increasing porosity.The dielectric spectra were also calculated using suitable models based on effective medium approximation.The measurements revealed a strong dielectric dispersion below the THz range,which cannot be explained by the modeling,and whose strength was in correlation with the degree of interdiffusion.It is assigned to an effect of the interdiffusion layers,giving rise to a strong interfacial polarization.It appears that the high-frequency dielectric spectroscopy is an extremely sensitive tool for detection of any gradient layers and sample inhomogeneities even in dielectric materials with negligible conductivity.展开更多
The present work concerns the numerical approximation of the M_(1) model for radiative transfer.The main purpose is to introduce an accurate finite volume method according to the nonlinear system of conservation laws ...The present work concerns the numerical approximation of the M_(1) model for radiative transfer.The main purpose is to introduce an accurate finite volume method according to the nonlinear system of conservation laws that governs this model.We propose to derive an HLLC method which preserves the stationary contact waves.To supplement this essential property,the method is proved to be robust and to preserve the physical admissible states.Next,a relevant asymptotic preserving correction is proposed in order to obtain a method which is able to deal with all the physical regimes.The relevance of the numerical procedure is exhibited thanks to numerical simulations of physical interest.展开更多
文摘Based on a study of Neoproterozoic carbonates in the Jilin-Liaoning-Xuzhou-Huaiyang area, especially its cyclic sequence stratigraphy and Sr isotopes, two maximum sea flooding events (at 820 Ma and 835 Ma) have been identified. The resulting isochronous stratigraphic correlation proves that these Precambrian strata were connected between the Qingbaikou and the Nanhuan systems with a time range from 750 Ma to 850 Ma. The disappearance of microsparite carbonate and coming of a glacial stage offer important evidence for worldwide stratigraphic correlation and open a window for further correlation of the stratigraphic successions across the Sino-Korean and Yangtze Plates. A new correlation scheme is therefore provided based on our work.
基金This work has been carried out within the framework of the EUROfusion Enabling Research Project No.AWP17-ENR-IFECEA-01“Preparation and Realization of European Shock Ignition Experiments”and has received funding from the Euratom Research and Training Program 2014-2018 under Grant Agreement No.633053The views and opinions expressed herein do not necessarily reflect those of the European Commission.The authors thank Professors Vladimir Tikhonchuk and Stefano Atzeni for many useful discussions.We also thank the anonymous reviewers for their constructive comments.
文摘We describe the development of a 3D Monte-Carlo model to study hot-electron transport in ionized or partially ionized targets,considering regimes typical of inertial confinement fusion.Electron collisions are modeled using a mixed simulation algorithm that considers both soft and hard scattering phenomena.Soft collisions are modeled according to multiple-scattering theories,i.e.,considering the global effects of the scattering centers on the primary particle.Hard collisions are simulated by considering a two-body interaction between an electron and a plasma particle.Appropriate differential cross sections are adopted to correctly model scattering in ionized or partially ionized targets.In particular,an analytical form of the differential cross section that describes a collision between an electron and the nucleus of a partially ionized atom in a plasma is proposed.The loss of energy is treated according to the continuous slowing down approximation in a plasma stopping power theory.Validation against Geant4 is presented.The code will be implemented as a module in 3D hydrodynamic codes,providing a basis for the development of robust shock ignition schemes and allowing more precise interpretations of current experiments in planar or spherical geometries.
文摘Objectives: The purpose of this study was to characterize the occurrence of phrenic nerve injury(PNI) and its outcome after radiofrequency(RF) ablation of atrial fibrillation(AF). Background: It is recognized that extra-myocardial damage may develop owing to penetration of ablative energy. Methods: Between 1997 and 2004, 3,755 consecutive patients underwent AF ablation at five centers. Among them, 18 patients(0.48%; 9 male, 54±10 years) had PNI(16 right, 2 left). The procedure consisted of pulmonary vein(PV) isolation in 15 patients and anatomic circumferential ablation in 3 patients, with additional left atrial lesions(n=11) and/or superior vena cava(SVC) disconnection(n=4). Results: Right PNI occurred during ablation of right superior PV(n=12) or SVC disconnection(n=3). Left PNI occurred during ablation at the left atrial appendage. Immediate features were dyspnea, cough, hiccup, and/or sudden diaphragmatic elevation in 9, and in the remaining the diagnosis was made after ablation owing to dyspnea(n=7) or on routine radiographic evaluation(n=2). Four patients(22%) were asymptomatic. Complete recovery occurred in 12 patients(66%). Recovery occurred within 24 h in the two patients with left PNI and in one patient with right PNI occurring with SVC disconnection. In the other nine patients, right PNI recovery occurred after 4±5 months(1 to 12 months) with respiratory rehabilitation. After a mean follow-up of 36±33 months, six patients have persistent PNI(three with partial and three with no recovery). Conclusions: In this multicenter experience, PNI was a rare complication(0.48%) of AF ablation. Ablation of the right superior PV, SVC, and left atrial appendage were associated with PNI. Complete(66%) or partial(17%) recovery was observed in the majority.
基金This work has been carried out within the framework of the EUROfusion Enabling Research Project No.AWP17-ENR-IFECEA-01“Preparation and Realization of European Shock Ignition Experiments”and has received funding from the Euratom Research and Training Program 2014-2018 under Grant Agreement No.633053.The views and opinions expressed herein do not necessarily reflect those of the European Commission.
文摘We describe two numerical investigations performed using a 3D plasma Monte-Carlo code,developed to study hot-electron transport in the context of inertial confinement fusion.The code simulates the propagation of hot electrons in ionized targets,using appropriate scattering differential cross sections with free plasma electrons and ionized or partially ionized atoms.In this paper,we show that a target in the plasma state stops and diffuses electrons more effectively than a cold target(i.e.,a target under standard conditions in which ionization is absent).This is related to the fact that in a plasma,the nuclear potential of plasma nuclei has a greater range than in the cold case,where the screening distance is determined by the electronic structure of atoms.However,in the ablation zone created by laser interaction,electrons undergo less severe scattering,counterbalancing the enhanced diffusion that occurs in the bulk.We also show that hard collisions,i.e.,collisions with large polar scattering angle,play a primary role in electron beam diffusion and should not be neglected.An application of the plasma MonteCarlo model to typical shock ignition implosions suggests that hot electrons will not give rise to any preheating concerns if their Maxwellian temperature is lower than 25–30 keV,although the presence of populations at higher temperatures must be suppressed.This result does not depend strongly on the initial angular divergence of the electron beam set in the simulations.
基金This work was carried out within the framework of the EUROfusion Consortium,funded by the European Union via the Euratom Research and Training Programme(Grant Agreement No.101052200–EUROfusion)The views and opinions expressed are however those of the author(s)only and do not necessarily reflect those of the European Union or the European Commission.Neither the European Union nor the European Commission can be held responsible for them.The involved teams have operated within the framework of the Enabling Research Project:ENR-IFE.01.CEA‘Advancing shock ignition for direct-drive inertial fusion’This work was also done with the support and under the auspices of the NIFS Collaboration Research program(2021NIFS18KUGK123).
文摘Laser–plasma interaction and hot electrons have been characterized in detail in laser irradiation conditions relevant for direct-drive inertial confinement fusion.The experiment was carried out at the Gekko XII laser facility in multibeam planar target geometry at an intensity of approximately 3×10^(15)W/cm^(2).Experimental data suggest that high-energy electrons,with temperatures of 20–50 keV and conversion efficiencies ofη<1%,were mainly produced by the damping of electron plasma waves driven by two-plasmon decay(TPD).Stimulated Raman scattering(SRS)is observed in a near-threshold growth regime,producing a reflectivity of approximately 0.01%,and is well described by an analytical model accounting for the convective growth in independent speckles.The experiment reveals that both TPD and SRS are collectively driven by multiple beams,resulting in a more vigorous growth than that driven by single-beam laser intensity.
基金the M.D.Anderson Cancer Center from the NIH(CA-77204 and CA-109552)to Rice University from the Welch Foundation(C-0807)+1 种基金the NSF Center for Biological and Environmental Nanotechnology(EEC-0647452)the Alliance for NanoHealth(NASA JSC-NNJ06HC25G).
文摘A new approach is described for delivering small interfering RNA(siRNA)into cancer cells by noncovalently complexing unmodifi ed siRNA with pristine single-walled carbon nanotubes(SWCNTs).The complexes were prepared by simple sonication of pristine SWCNTs in a solution of siRNA,which then served both as the cargo and as the suspending agent for the SWCNTs.When complexes containing siRNA targeted to hypoxia-inducible factor 1 alpha(HIF-1)were added to cells growing in serum containing culture media,there was strong specific inhibition of cellular HIF-1 activity.The ability to obtain a biological response to SWCNT/siRNA complexes was seen in a wide variety of cancer cell types.Moreover,intratumoral administration of SWCNT-HIF-1 siRNA complexes in mice bearing MiaPaCa-2/HRE tumors signifi cantly inhibited the activity of tumor HIF-1.As elevated levels of HIF-1 are found in many human cancers and are associated with resistance to therapy and decreased patient survival,these results imply that SWCNT/siRNA complexes may have value as therapeutic agents.
基金supported by the National Natural Science Foundation of China (No. 40776031)the National Fundamental Research and Development Planning Project (No. 2007CB815903)
文摘Diatom stable isotope analysis offers considerable potential in palaeoceanography, par-ticularly where carbonate material is scarce or absent. However, extracting pure diatom frustules free of external labile organic matter from marine sediments is an essential requirement for their applica-tions as paleoenvironmental proxies. Here, based largely on previous work, we developed a method in-cluding physical separation and chemical oxidation steps to concentrate and clean pure large diatoms from laminated diatom mat and diatomaceous clay sediment samples for their stable isotope analysis. Using the physical separation techniques consisting of the removal of carbonate and excess organic matter, sieving, differential settling, and heavy liquid floatation, pure diatoms can be successfully iso-lated from the sediment samples with opal concentration more than 10%. Subsequent time oxidation experiment shows that labile organic matter coating pure diatom valves can be effectively removed with 30% H2O2 at 65 ℃ for 2 h. Measurements of δ13C after every step of physical separation demonstrate that contaminants and lost diatoms can influence the original diatom stable isotope signal, highlighting the importance of a visual check for dominant diatom size in the initial sample and purity in the final sample. Although the protocol described here was only applied to diatom mats or diatom oozes con-taining large diatoms (Ethmodiscus rex), we believe that this method can be adapted to common dia-toms of general marine sediment samples.
基金support from the Vannevar Bush Faculty Fellowship programsponsored by the Basic Research Office of the Assistant Secretary of Defense for Research and Engineering and funded by the Office of Naval Research through grant N00014-16-1-2502supported by the U.S.Department of Energy,Office of Science,under Contract No.DE-AC02-06CH11357.
文摘From Newton’s third law,which is known as the principle of actio et reactio1,we expect the forces between interacting particles to be equal and opposite for closed systems.Otherwise,“nonreciprocal”forces can arise.2 This has been shown theoretically in the interaction between dissimilar optically trapped particles that are mediated by an external field.3 As a result,despite the incident external field not having a transverse component of momentum,the particle pair experiences a force in a direction that is transverse to the light propagation direction.3,4 In this letter,we directly measure the net nonreciprocal forces in electrodynamically interacting asymmetric nanoparticle dimers and nanoparticle structures that are illuminated by plane waves and confined to pseudo one-dimensional geometries.We show via electrodynamic theory and simulations that interparticle interactions cause asymmetric scattering from heterodimers.Therefore,the putative nonreciprocal forces are actually a consequence of momentum conservation.Our study demonstrates that asymmetric scatterers exhibit directed motion due to the breakdown of mirror symmetry in their electrodynamic interactions with external fields.
基金supported by the Academy of Sci-ences of the Czech Republic(project AVOZ 10100520)the Czech Science Foundation(project 202/09/0430)by COST action MP904.
文摘Three types of BaTiO3 core-amorphous nanoshell composite ceramics were processed from the same core-shell powder by standard sintering,spark-plasma sintering and two-step sintering techniques and characterized by XRD,HRSEM and broadband dielectric spectroscopy in the frequency range 10^(3)-10^(13)Hz including the THz and IR range.The samples differed by porosity and by the amount of interdiffusion from the cores to shells,in correlation with their increasing porosity.The dielectric spectra were also calculated using suitable models based on effective medium approximation.The measurements revealed a strong dielectric dispersion below the THz range,which cannot be explained by the modeling,and whose strength was in correlation with the degree of interdiffusion.It is assigned to an effect of the interdiffusion layers,giving rise to a strong interfacial polarization.It appears that the high-frequency dielectric spectroscopy is an extremely sensitive tool for detection of any gradient layers and sample inhomogeneities even in dielectric materials with negligible conductivity.
文摘The present work concerns the numerical approximation of the M_(1) model for radiative transfer.The main purpose is to introduce an accurate finite volume method according to the nonlinear system of conservation laws that governs this model.We propose to derive an HLLC method which preserves the stationary contact waves.To supplement this essential property,the method is proved to be robust and to preserve the physical admissible states.Next,a relevant asymptotic preserving correction is proposed in order to obtain a method which is able to deal with all the physical regimes.The relevance of the numerical procedure is exhibited thanks to numerical simulations of physical interest.