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免疫疗法联合立体定向放疗治疗非小细胞肺癌脑转移:一项AIRO多中心回顾性研究
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作者 Silvia SCOCCIANTI Emanuela OLMETTO +28 位作者 Valentina PINZI Mattia Falchetto OSTI Rossella Di FRANCO Saverio CAINI Paola ANSELMO Paolo MATTEUCCI Davide FRANCESCHINI Cristina MANTOVANI Giancarlo BELTRAMO Francesco PASQUALETTI Alessio BRUNI Paolo TINI Emilia GIUDICE Patrizia CIAMMELLA Anna MERLOTTI Sara PEDRETTI Marianna TRIGNANI Marco KRENGLI NiccolòGIAJ-LEVRA Isacco DESIDERI Guido PECCHIOLI Paolo MUTO Ernesto MARANZANO Laura FARISELLI Pierina NAVARRIA Umberto RICARDI Vieri SCOTTI Lorenzo LIVI 王绿化(翻译/校对) 《中国肺癌杂志》 CAS CSCD 北大核心 2022年第4期I0007-I0022,共16页
背景与目的 通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放... 背景与目的 通过意大利放射治疗和临床肿瘤学学会(Italian Association of Radiotherapy and Clinical Oncology, AIRO)的一项多中心回顾性研究,明确免疫疗法(immunotherapy, IT)和立体定向放疗(stereotactic radiotherapy,SRT)包括放射外科治疗(radiosurgery, RS)或大分割立体定向放疗(hypofractionated stereotactic radiotherapy, HFSRT)治疗非小细胞肺癌(non-small cell lung cancer, NSCLC)脑转移的疗效和毒性。方法 对来自19个意大利中心接受SRT+IT的NSCLC伴脑转移患者进行分析,并与单独接受SRT的对照组患者进行比较。结果 共纳入SRT+IT组100例和单独SRT组50例。接受SRT+IT的患者有更长的颅内局部无进展生存期(intracranial local progression-free survival, i LPFS)(经倾向性评分调整后,P=0.007)。在诊断为脑转移时接受IT合并有颅外进展的患者中(n=24),接受SRT后再进行IT与较好的总生存期(overall survival, OS)相关(P=0.037)。多因素分析显示组织学类型为非腺癌、卡氏体能状态(Karnofsky performance status,KPS)评分=70分以及接受HFSRT与显著减少的生存期相关(P值分别为0.019、0.017和0.007)。与SRT和IT治疗间隔>7天(n=10)相比,治疗间隔≤7天(n=90)与更长的OS相关(经倾向性评分调整后,P=0.008)。联合治疗耐受性良好。在放射性坏死方面,接受SRT+IT的患者与单独SRT的患者无显著差异。SRT和IT的治疗间隔对毒性发生率无影响。结论 SRT+IT是一种安全的联合治疗方法,与单独SRT相比,具有更长的i LPFS。 展开更多
关键词 立体定向放疗 回顾性研究 脑转移 倾向性评分 临床肿瘤学 免疫疗法 放射治疗
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A Family of Relaxation Schemes for Nonlinear Convection Diffusion Problems
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作者 Fausto Cavalli Giovanni Naldi +1 位作者 Gabriella Puppo Matteo Semplice 《Communications in Computational Physics》 SCIE 2009年第2期532-545,共14页
In this work we present a family of relaxation schemes for nonlinear convection diffusion problems,which can tackle also the cases of degenerate diffusion and of convection dominated regimes.The schemes proposed can a... In this work we present a family of relaxation schemes for nonlinear convection diffusion problems,which can tackle also the cases of degenerate diffusion and of convection dominated regimes.The schemes proposed can achieve any order of accuracy,give non-oscillatory solutions even in the presence of singularities and their structure depends only weakly on the particular PDE being integrated.One and two dimensional results are shown,and a nonlinear stability estimate is given. 展开更多
关键词 CONVECTION-DIFFUSION relaxation schemes degenerate parabolic problems
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The Role of a Vanishing Interfacial Layer in Perfect Elasto-Plasticity
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作者 Gilles A.FRANCFORT Alessandro GIACOMINI 《Chinese Annals of Mathematics,Series B》 SCIE CSCD 2015年第5期813-828,共16页
A two-phase elasto-plastic material is investigated. It is shown that, if the interface is modeled as the limit of a vanishing layer of a third material, then the resulting two-phase material will exhibit a smaller in... A two-phase elasto-plastic material is investigated. It is shown that, if the interface is modeled as the limit of a vanishing layer of a third material, then the resulting two-phase material will exhibit a smaller interfacial dissipation than that of a pure twophase model. 展开更多
关键词 界面层 理想弹塑性 弹塑性材料 两相材料 损耗比
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