Multiple evanescent white dot syndrome relapse following BNT162b2 mRNA COVID-19 vaccination

Dear Editor,We report a case of multiple evanescent white dot syndrome(MEWDS)relapse following mRNA corona virus disease 2019(COVID-19)vaccination.MEWDS is a choroidal inflammatory disease belonging to the group of“white dot syndromes”group,with an excellent prognosis[1].MEWDS is usually idiopathic,but there have been reports of MEWDS following viral infection or vaccination[1-2].

Refractory intraocular hypertension after dexamethasone-implant intravitreal injection treated with Preserflo MicroShunt implantation

Dear Editor,Herein,we report a case of a patient who presented with refractory ocular hypertension(OHT)after a dexamethasone implant(DEX-I)injection.Intraocular pressure(IOP)was finally managed after Preserflo Micro Shunt implantation,allowing the continued use of dexamethasone implant.

Cytoreductive surgery and hyperthermic intraperitonealchemotherapy in gastric cancer

Gastric cancer associated peritoneal carcinomatosis(GCPC) has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in GCPC. Since recurrent gastric cancer remains confined to the abdominal cavity in many patients, regional therapies like aggressive cytoreductive surgery( CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) have been investigated for GCPC. HIPEC has been used for three indications in GC- as an adjuvant therapy after a curative surgery, HIPEC has been shown to improve survival and reduce peritoneal recurrences in many randomised trials in Asian countries; as a definitive treatment in established PC, HIPEC along with CRS is the only therapeutic modality that has resulted in longterm survival in select groups of patients; as a palliative treatment in advanced PC with intractable ascites, HIPEC has been shown to control ascites and reduce the need for frequent paracentesis. While the results of randomised trials of adjuvant HIPEC from western centres are awaited, the role of HIPEC in the treatment of GCPC is still evolving and needs larger studies before it is accepted as a standard of care.

Redox evolution of western Tianshan subduction zone and its effect on deep carbon cycle

Knowing the phase relations of carbon-bearing phases at high-pressure(HP) and high-temperature(HT) condition is essential for understanding the deep carbon cycle in the subduction zones.In particular,the phase relation of carbon-bearing phases is also strongly influenced by redox condition of subduction zones,which is poorly explored.Here we summarized the phase relations of carbon-bearing phases(calcite,aragonite,dolomite,magnesite,graphite,hydrocarbon) in HP metamorphic rocks(marble,metapelite,eclogite) from the Western Tianshan subduction zone and high-pressure experiments.During prograde progress of subduction,carbonates in altered oceanic crust change from Ca-carbonate(calcite) to Ca,Mg-carbonate(dolomite),then finally to Mgcarbonate(magnesite) via Mg-Ca cation exchange reaction between silicate and carbonate,while calcite in sedimentary calcareous ooze on oceanic crust directly transfers to high-pressure aragonite in marble or amorphous CaCO3 in subduction zones.Redox evolution also plays a significant effect on the carbon speciation in the Western Tianshan subduction zone.The prograde oxygen fugacity of the Western Tianshan subduction zone was constrained by mineral assemblage of garnet-omphacite from FMQ-1.9 to FMQ-2.5 at its metamorphic peak(maximum P-T) conditions.In comparison with redox conditions of other subduction zones,Western Tianshan has the lowest oxygen fugacity.Graphite and light hydrocarbon inclusions were ubiqutously identified in Western Tianshan HP metamorphic rocks and speculated to be formed from reduction of Fe-carbonate at low redox condition,which is also confirmed by high-pressure experimental simulation.Based on petrological observation and high-pressure simulation,a polarized redox model of reducing slab but oxidizing mantle wedge in subduction zone is proposed,and its effect on deep carbon cycle in subduction zones is further discussed.

Furongian(upper Cambrian) Guole Konservat-Lagersttte from South China

The Guole biota contains common shelly fossils and some exceptionally well-preserved softbodied fossils. Stratigraphically, it is located in the mudstones and siltstones of the Sandu Formation near Guole Town, Jingxi County, Guangxi, South China. It is the first Furongian （late Cambrian） Burgess Shale-type biota found in the world, thereby filling the gap between middle Cambrian and Lower Ordovician Burgess Shale-type Lagerstaitten. Preliminary studies suggest that the Guole biota includes approximately seven metazoan groups as well as algae. These will provide important new evolutionary and ecological information.

Intra-operative peritoneal lavage for colorectal cancer

Free cancer cells can be detected in peritoneal fluid at the time of colorectal surgery. Peritoneal lavage in colorectal surgery for cancer is not used in routine, and the prognostic significance of intraperitoneal free cancer cells (IPCC) remains unclear. Data concerning the technique of peritoneal lavage to detect IPCC and its timing regarding colorectal resection are scarce. However, positive IPCC might be the first step of peritoneal spread in colorectal cancers, which could lead to early specific treatments. Because of the important heterogeneity of IPCC determination in reported studies, no treatment have been proposed to patients with positive IPCC. Herein, we provide an overview of IPCC detection and its impact on recurrence and survival, and we suggest further multi-institutional studies to evaluate new treatment strategies.

The current role of prostate multiparametric magnetic resonance imaging

Prostate multi-parametric magnetic resonance imaging(mpMRI)has shown excellent sensitivity for Gleason
7 cancers,especially when their volume is
0.5 mL.As a result,performing an mpMRI before prostate biopsy could improve the detection of clinically significant prostate cancer(csPCa)by adding targeted biopsies to systematic biopsies.Currently,there is a consensus that targeted biopsies improve the detection of csPCa in the repeat biopsy setting and at confirmatory biopsy in patients considering active surveillance.Several prospective multicentric controlled trials recently showed that targeted biopsy also improved csPCa detection in biopsy-naǐve patients.The role of mpMRI and targeted biopsy during the follow-up of active surveillance remains unclear.Whether systematic biopsy could be omitted in case of negative mpMRI is also a matter of controversy.mpMRI did show excellent negative predictive values(NPV)in the literature,however,since NPV depends on the prevalence of the disease,negative mpMRI findings should be interpreted in the light of a priori risk for csPCa of the patient.Nomograms combining mpMRI findings and classical risk predictors(age,prostatespecific antigen density,digital rectal examination,etc.)will probably be developed in the future to decide whether a prostate biopsy should be obtained.mpMRI has a good specificity for detecting T3 stage cancers,but its sensitivity is low.It should therefore not be used routinely for staging purposes in low-risk patients.Nomograms combining mpMRI findings and other clinical and biochemical data will also probably be used in the future to better assess the risk of T3 stage disease.

Lorentz force electrical impedance tomography using pulse compression technique

Lorentz force electrical impedance tomography （LFEIT） combines ultrasound stimulation and electromagnetic field detection with the goal of creating a high contrast and high resolution hybrid imaging modality. In this study, pulse compression working together with a linearly frequency modulated ultrasound pulse was investigated in LFEIT. Experiments were done on agar phantoms having the same level of electrical conductivity as soft biological tissues. The results showed that：（i） LFEIT using pulse compression could detect the location of the electrical conductivity variations precisely; （ii） LFEIT using pulse compression could get the same performance of detecting electrical conductivity variations as the traditional LFEIT using high voltage narrow pulse but reduce the peak stimulating power to the transducer by 25.5 dB; （iii） axial resolution of 1 mm could be obtained using modulation frequency bandwidth 2 MHz.

Scaling law of resolved-scale isotropic turbulence and its application in large-eddy simulation

Eddy-damping quasinormal Markovian （EDQNM） theory is employed to calculate the resolved-scale spectrum and transfer spectrum, based on which we investigate the resolved-scale scaling law. Results show that the scaling law of the resolved-scale turbulence, which is affected by several factors, is far from that of the full-scale turbulence and should be corrected. These results are then applied to an existing subgrid model to improve its performance. A series of simulations are performed to verify the necessity of a fixed scaling law in the subgrid modeling.

Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

5-Fluorouracil(5-FU)is an anticancer drug extensively used for different cancers.Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes,DNA and RNA.In this paper,we describe the development of a method based on liquid chromatography coupled with high resolution mass spectrometry suitable for the simultaneous determination of the ten anabolic metabolites(nucleoside,nucleotide and sugar nucleotide)of 5-FU.The chromatographic separationwas optimized on a porous graphitic carbon column allowing the analysis of the metabolites of 5-FU as well as endogenous nucleotides.The detection was performed on an Orbitrap■tandem mass spectrometer.Linearity of the method was verified in intracellular content and in RNA extracts.The limit of detection was equal to 12 pg injected on column for nucleoside metabolites of 5-FU and 150 pg injected on column for mono-and tri-phosphate nucleotide metabolites.Matrix effect was evaluated in cellular contents,DNA and RNA extracts for nucleoside and nucleotides metabolites.The method was successfully applied to i)measure the proportion of each anabolic metabolite of 5-FU in cellular contents,ii)follow the consequence of inhibition of enzymes on the endogenous nucleotide pools,iii)study the incorporation of metabolites of 5-FU into RNA and DNA,and iv)to determine the incorporation rate of 5-FUrd into 18 S and 28 S sub-units of rRNA.

Automatic determination of stellar atmospheric parameters and construction of stellar spectral templates of the Guoshoujing Telescope (LAMOST)

A number of spectroscopic surveys have been carried out or are planned to study the origin of the Milky Way. Their exploitation requires reliable automated methods and softwares to measure the fundamental parameters of the stars. Adopting the ULySS package, we have tested the effect of different resolutions and signal-to- noise ratios （SNR） on the measurement of the stellar atmospheric parameters （effective temperature Teff, surface gravity log g, and metaUicity [Fe/H]）. We show that ULySS is reliable for determining these parameters with medium-resolution spectra （R ～2000）. Then, we applied the method to measure the parameters of 771 stars selected in the commissioning database of the Guoshoujing Telescope （LAMOST）. The results were compared with the SDSS/SEGUE Stellar Parameter Pipeline （SSPP）, and we derived precisions of 167 K, 0.34dex, and 0.16dex for Teff, logg and [Fe/H] respectively. Furthermore, 120 of these stars are selected to construct the primary stellar spectral template library （Version 1.0） of LAMOST, and will be deployed as basic ingredients for the LAMOST automated parametrization pipeline.

Grain crushing in geoscience materials-Key issues on crushing response,measurement and modeling:Review and preface

Grain crushing is commonly encountered in deep foundation engineering,high rockfill dam engineering,railway engineering,mining engineering,coastal engineering,petroleum engineering,and other geoscience application.Grain crushing is affected by fundamental soil characteristics,such as their mineral strength,grain size and distribution,grain shape,density and specimen size,and also by external factors including stress magnitude and path,loading rate and duration,degree of saturation,temperature and geochemical environment.Crushable material becomes a series of different materials with the change in its grading during grain crushing,resulting in a decrease in strength and dilatancy and an increase in compressibility.Effects of grain crushing on strength,dilatancy,deformation and failure mechanisms have been extensively investigated through laboratory testing,discrete element method(DEM)modelling,Weibull statistics,and constitutive modelling within the framework of the extended crushing-dependent critical state theory or the energy-based theory.Eleven papers summarized in this review article for this special issue addressed the above issues in grain crushing through the advanced testing and modelling.

Delayed Ionization and Delayed Detachment in Molecules and Clusters

The evolution of a molecular system excited above its ionization threshold depends on a number of parameters that include the nature of the excited states and their couplings to the various continua. The general nature of the processes governing this evolution depends also essentially on the complexity of the molecule, more precisely on its size, density of states, and strength of the couplings among the various internal degrees of freedom. In this paper we address the question of the transition between autoionization that prevails in small molecules, and delayed ionization occurring in larger molecules or clusters. This transition is illustrated by autoionization of Na2 Rydberg states on one hand, delayed ionization in fullerene C60, and delayed detachment in small cluster anions on the other hand. All processes are studied in the case of nanosecond laser excitation, corresponding to a rather slow deposition of the internal energy.

Effects of particle size on crushing and deformation behaviors of rockfill materials

Strength and deformation behaviors of rockfill materials,key factors for determining the stability of dams,pertain strongly to the grain crushing characteristics.In this study,single-particle crushing tests were carried out on rockfill materials with nominal particle diameters of 2.5 mm,5 mm and 10 mm to investigate the particle size effect on the single-particle strength and the relationship between the characteristic stress and probability of non-failure.Test data were found to be described by the Weibull distribution with the Weibull modulus of 3.24.Assemblies with uniform nominal grains were then subjected to one-dimensional compression tests at eight levels of vertical stress with a maximum of 100 MPa.The yield stress in one-dimensional compression tests increased with decreasing the particle size,which could be estimated from the single-particle crushing tests.The void ratio-vertical stress curve could be predicted by an exponential function.The particle size distribution curve increased obviously with applied stresses less than 16 MPa and gradually reached the ultimate fractal grading.The relative breakage index became constant with stress up to 64 MPa and was obtained from the ultimate grading at the fractal dimension(a?2:7).A hyperbolical function was also found useful for describing the relationship between the relative breakage index and input work during one-dimensional compression tests.

Continuous frequency and phase spectrograms: a study of their 2D and 3D capabilities and application to musical signal analysis

A new lighting and enlargement on phase spectrogram （PS） and frequency spectrogram （FS） is presented in this paper. These representations result from the coupling of power spectrogram and short time Fourier transform （STFT）. The main contribution is the construction of the 3D phase spectrogram （3DPS） and the 3D frequency spectrogram （3DFS）. These new tools allow such specific test signals as small slope linear chirp, phase jump case of musical signal analysis is reported. The main objective is to and small frequency jump to be analyzed. An application detect small frequency and phase variations in order to characterize each type of sound attack without losing the amplitude information given by power spectrogram

Review of the El Soplao Amber Outcrop,Early Cretaceous of Cantabria,Spain

El Soplao outcrop, an Early Cretaceous amber deposit recently discovered in northern Spain （Cantabria）, has been shown to be the largest site of amber with arthropod inclusions that has been found in Spain so far. Relevant data provided herein for biogeochemistry of the amber, palynology, taphonomy and arthropod bioinclusions complement those previously published. This set of data suggests at least two botanical sources for the amber of El Soplao deposit. The first （type A amber） strongly supports a source related to Cheirolepidiaceae, and the second （type B amber） shows non-specific conifer biomarkers. Comparison of molecular composition of type A amber with Frenelopsis leaves （Cheirolepidiaceae） strongly suggests a biochemical affinity and a common botanical origin. A preliminary palynological study indicates a regional high taxonomical diversity, mainly of pteridophyte spores and gymnosperm pollen grains. According to the preliminary palynological data, the region was inhabited by conifer forests adapted to a dry season under a subtropical climate. The abundant charcoalified wood associated with the amber in the same beds is evidence of paleofires that most likely promoted both the resin production and an intensive erosion of the litter, and subsequent great accumulation of amber plus plant cuticles. In addition, for the first time in the fossil record, charcoalified plant fibers as bioinclnsions in amber are reported. Other relevant taphonomic data are the exceptional presence of serpulids and bryozoans on the surfaces of some amber pieces indicating both a long exposure on marine or brackish-water and a mixed assemblage of amber. Lastly, new findings of insect bioiuclusions, some of them uncommon in the fossil record or showing remarkable adaptations, are reported. In conclusion, a documented scenario for the origin of the El Soplao amber outcrop is provided.

Enhancing heat transfer at the micro-scale using elastic turbulence

Small concentrations of a high-molecular-weight polymer have been used to create so-called ＂elastic tur- bulence＂ in a micro-scale serpentine channel geometry. It is known that the interaction of large elastic stresses created by the shearing motion within the fluid flow with streamline curvature of the serpentine geometry leads initially to a purely-elastic instability and then the generation of elastic turbulence. We show that this elastic turbulence enhances the heat transfer at the micro-scale in this geometry by up to 300% under creeping flow conditions in comparison to that achieved by the equivalent Newtonian fluid flow.

Double cholecystectomy in case of accessory gallbladder:Not as easy as two cholecystectomies

To the Editor:Accessory gallbladders(AG)are rare and their management are usually challenging.These variations are related with an abnormal division of the bile ducts precursors between the 5th and the 12th week of pregnancy.Harlaftis et al.[1]proposed an anatomical classification of these variations based on the embryologic abnormalities described.In type 1 both gallbladders are connected to the common bile duct at the same location.In type 2 the AG can reach either the common bile duct(ductular type)or an intrahepatic biliary duct(trabecular type).In type 3,three gallbladders are present.

Secondary relaxation and dynamic heterogeneity in metallic glasses：A brief review

Understanding mechanical relaxation, such as primary（α） and secondary（β） relaxation, is key to unravel the intertwined relation between the atomic dynamics and non-equilibrium thermodynamics in metallic glasses. At a fundamental level, relaxation, plastic deformation, glass transition, and crystallization of metallic glasses are intimately linked to each other, which can be related to atomic packing, inter-atomic diffusion, and cooperative atom movement. Conceptually, βrelaxation is usually associated with structural heterogeneities intrinsic to metallic glasses. However, the details of such structural heterogeneities, being masked by the meta-stable disordered long-range structure, are yet to be understood. In this paper, we briefly review the recent experimental and simulation results that were attempted to elucidate structural heterogeneities in metallic glasses within the framework of β relaxation. In particular, we will discuss the correlation amongβ relaxation, structural heterogeneity, and mechanical properties of metallic glasses.

Field Application of the Mycorrhizal Fungus <i>Rhizophagus irregularis</i>Increases the Yield of Wheat Crop and Affects Soil Microbial Functionalities

The aim of this study was to test the impact of Rhizophagus irregularis, an arbuscular mycorrhizal fungus (AMF), on durum wheat growth and soil microbial functionalities in a field inoculation trial conducted in Morocco. The results showed that i) the R. irregularis inoculum effectively improved wheat growth, ii) wheat growth promotion depended on the soil mycorrhizal infectivity and iii) functional abilities of soil microflora depended on AMF inoculation. This study confirms that field AMF inoculation can be proposed as an effective agronomic practice in wheat production and as a sustainable cultural practice to manage soil biofunctioning. To fully promote inoculation practices, a better knowledge of AMF ecology has to be acquired to better adapt AMF inoculation to environmental conditions, and thus warrant better yields and agricultural sustainability.