Simulation study on cosmic ray background at large zenith angle based on GRANDProto35 coincidence array experiment

Neutrino detection in the 100 PeV energy region is the ultimate means of studying the origin of ultra-highenergy cosmic rays,in which the large radio detection array giant radio array for neutrino detection(GRAND)project aims to use to decipher this century-old problem.The GRANDProto35 compact array is a microform of 35 radio prototype detectors for the GRAND experiment,which verifies the reliability of GRAND performance through operation,and data analysis of the prototype detectors.As radio detectors are a novel development in recent years,and their indexes need to be verified by traditional detectors,the GRAND Cooperation Group designed and constructed the GRANDProto35 coincidence array composed of radio detectors and scintillation detectors.This study simulated the changes in detection efficiency,effective area,and event rate of cosmic rays with zenith angle based on this coincidence array.The study found that the 1017 eV energy region is sensitive to GRANDProto35 detection.When the energy exceeded 1017 eV,the array detection efficiency could reach more than 95%and the effective area was up to*29106 m2.A simulation study on cosmic ray events with large zenith angles showed that the event rate detected by the array decreased significantly with increasing zenith angle,and the event rate of cosmic rays was approximately 0.1 per day for a zenith angle of 75.This serves as the background pollution rate for neutrino observation caused by largeangle cosmic-ray events,providing an important reference for further experiments.The study results will be verified after the joint operation of the coincidence array.

Comparative Transcriptomic Analysis of Salt Adaptation in Roots of Contrasting Medicago truncatula Genotypes

Evolutionary diversity can be driven by the interaction of plants with different environments. Molecular bases involved in ecological adaptations to abiotic constraints can be explored using genomic tools. Legumes are major crops worldwide and soil salinity is a main stress affecting yield in these plants. We analyzed in the Medicago truncatula legume the root transcriptome of two genotypes having contrasting responses to salt stress： TN1.11, sampled in a salty Tunisian soil, and the reference Jemalong A17 genotype. TN1.11 plants show increased root growth under salt stress as well as a differential accumulation of sodium ions when compared to A17. Transcriptomic analysis revealed specific gene clusters preferentially regulated by salt in root apices of TN1.11, notably those related to the auxin pathway and to changes in histone variant isoforms. Many genes encoding transcription factors （TFs） were also differentially regulated between the two genotypes in response to salt. Among those selected for functional studies, overexpression in roots of the A17 ge- notype of the bHLH-type TF most differentially regulated between genotypes improved significantly root growth under salt stress. Despite the global complexity of the differential transcriptional responses, we propose that an increase in this bHLH TF expression may be linked to the adaptation of M. truncatula to saline soil environments.

AFF3:a new player in maintaining XIST monoallelic expression

The existence of highly differentiated X and Y chromosomes in mammals raises the issue of X-linked gene dosage compensation between XX females and XY males to avoid what would be similar to a monosomy X in males(Veitia et al.,2015).Inactivation of one copy of the X chromosomes in females provides a dosage-compensation mechanism equalizing the expression of X-linked genes in males and females(Ohno et al.,1959;Lyon,1961).

Linear quadratic optimal control of conditional McKean-Vlasov equation with random coefficients and applications

We consider the optimal control problem for a linear conditional McKeanVlasov equation with quadratic cost functional.The coefficients of the system and the weighting matrices in the cost functional are allowed to be adapted processes with respect to the common noise filtration.Semi closed-loop strategies are introduced,and following the dynamic programming approach in(Pham and Wei,Dynamic programming for optimal control of stochastic McKean-Vlasov dynamics,2016),we solve the problem and characterize time-consistent optimal control by means of a system of decoupled backward stochastic Riccati differential equations.We present several financial applications with explicit solutions,and revisit,in particular,optimal tracking problems with price impact,and the conditional mean-variance portfolio selection in an incomplete market model.

X chromosome inactivation and active X upregulation in therian mammals: facts, questions, and hypotheses

X chromosome inactivation is a mechanism that modulates the expression of X-linked genes in eutherian females(XX).Ohno proposed that to achieve a proper balance between X-linked and autosomal genes,those on the active X should also undergo a 2-fold upregula-tion.Although some support for Ohno's hypothesis has been provided through the years,recent genomic studies testing this hypoth-esis have brought contradictory results and fueled debate.Thus far,there are as many results in favor as against Ohno's hypothesis,depending on the nature of the datasets and the various assumptions and thresholds involved in the analyses.However,they have con-firmed the importance of dosage balance between X-linked and autosomal genes involved in stoichiometric relationships.These facts as well as questions and hypotheses are discussed below.

Search for the doubly charmed baryon ■

A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 TeV.The data correspond to a total integrated luminosity of 9 fb^-1.No significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^2.Upper limits are set at 95%credibility level on the ratio of the ■^+cc production cross-section times the branching fraction to that ofΛ^+c and ■^++cc baryons.The limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.