Role of copper chelating agents: between old applications and new perspectives in neuroscience

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

Decoding of Factorial Experimental Design Models Implemented in Production Process

The paper deals with factorial experimental design models decoding.For the ease of calculation of the experimental mathematical models,it is convenient first to code the independent variables.When selecting independent variables,it is necessary to take into account the range covered by each.A wide range of choices of different variables is presented in this paper.After calculating the regression model,its variables must be returned to their original values for the model to be easy recognized and represented.In the paper,the procedures of simple first order models,with interactions and with second order models,are presented,which could be a very complicated process.Models without and with the mutual influence of independent variables differ.The encoding and decoding procedure on a model with two independent first-order parameters is presented in details.Also,the procedure of model decoding is presented in the experimental surface roughness parameters models’determination,in the face milling machining process,using the first and second order model central compositional experimental design.The simple calculation procedure is recommended in the case study.Also,a large number of examples using mathematical models obtained on the basis of the presented methodology are presented throughout the paper.

Applied Ethics and Modem Enterprises One Viewpoint

Business ethics has been growing from a philosophy discipline to an applied science. That explains its significance for more efficient functioning of various systems in business world. For that reason, organized societies with developed economies invest in empiric, theoretic, and theoretic-empiric investigations of various sectors and applied dimensions of business ethics. Its epistemological sense reflects to increasing productivity, more successful establishing of the system of hierarchy within an enterprise, appropriate formulating the strategy of management, improving the market reputation, increasing profitability, and strengthening social responsibility. The complexity of modem and successful business is based on a series of social factors which spread in the arch from anthropological, socially-psychological, and cultural characteristics of a human being, to quality characteristics of the global society. That is why the scientific information available to business ethics is synthesized from various scientific perspectives. This paradigm is a starting point of this project which is about the above subject. Its cognitive aim is presented through the description, classification, and explanation of the influence of business ethics to successful functioning of every kind of business institution. As a theoretic investigation which grows from verified scientific information and their critical analysis, it relies on standard, general scientific, basic special and general methods which are characteristic to the applied scientific disciplines. Business ethics has clearly established two key cognitive bases of its investigations： 1） personal value attitude; and 2） interests of a company, groups, and individuals in them. This project is only a small contribution to explaining elementary functions of this applied ethics in business world.

Influence of Tooth Loss and Unmet Treatment Needs on the Social Aspects of Quality of Life and Self-esteem in Adolescents

Adolescence represents specific period of life and development,when young person is going through physical,emotional and mental changes,risking poor general and oral health outcome that might affect quality of life.Negative effects of poor oral health are various:difficulties with speaking and eating,pain and malfunction.This might cause emotional and mental problems,leading to avoidance of speaking,smiling and socializing with friends.Cross-sectional study included 234 participants(15-16 years old).The research instruments used in the study were questionnaire and clinical examination.Questionnaire referred to socio-demographic characteristics of participants,their oral and general health related habits,self-evaluation of confidence and successfulness and effect of oral impacts on daily performances.Clinical examination was used to determine dental status in terms of tooth loss,need for prosthodontic rehabilitation and presence of dental malocclusion.Results:24.6%(58)of adolescents had at least one tooth missing.Significant difference between the genders was obtained,as 32.5%girls had at least one tooth extracted compared to 8.1%of boys.Normative need for prosthodontic rehabilitation was present in 22.0%of subjects.Dental problems negatively affected their sleep and emotions(14.4%and 10.2%few times in period of one month).Data analyses pointed one correlation between extracted teeth and psychosocial aspect of participants'life(difficulties and embarrassment when smiling,talking and spending time with friends,emotional problems).Unmet normative need for prosthodonic or orthodontic treatment affected participants'ability to sleep and relax.Percentage of adolescents with extracted teeth was high,as well as normative treatment need for prosthodontic rehabilitation.Poor dental status affected quality of life of adolescents,especially emotional and mental well-being.Dental service should provide sufficient information to adolescents about prevention of tooth loss and consequences of teeth extraction,not only within masticatory function but also concerning oral health related quality of life.