In a study published in Cell,Pozniak et al.explored the spectrum of the phenotypic cell states of human metastatic melanomas in their tumor microenvironment before and early during immune checkpoint inhibitor(ICI)ther...In a study published in Cell,Pozniak et al.explored the spectrum of the phenotypic cell states of human metastatic melanomas in their tumor microenvironment before and early during immune checkpoint inhibitor(ICI)therapy and identified an enrichment of mesenchymal-like(MES)state melanoma cells in non-responders to ICI.1 These findings offer valuable insights into the factors contributing to the refractoriness of certain melanoma patients to ICI,while also unveiling novel molecular targets that hold promise for improving their treatment outcomes.展开更多
We read with great interest the article of Delvecchio et al.published in a recent issue of HPB journal(1).The authors compared short-and long-term outcomes of laparoscopic and open liver resection(OLR)in elderly patie...We read with great interest the article of Delvecchio et al.published in a recent issue of HPB journal(1).The authors compared short-and long-term outcomes of laparoscopic and open liver resection(OLR)in elderly patients with hepatocellular carcinoma(HCC)using 1-1 propensity score matching(PSM).展开更多
文摘In a study published in Cell,Pozniak et al.explored the spectrum of the phenotypic cell states of human metastatic melanomas in their tumor microenvironment before and early during immune checkpoint inhibitor(ICI)therapy and identified an enrichment of mesenchymal-like(MES)state melanoma cells in non-responders to ICI.1 These findings offer valuable insights into the factors contributing to the refractoriness of certain melanoma patients to ICI,while also unveiling novel molecular targets that hold promise for improving their treatment outcomes.
文摘We read with great interest the article of Delvecchio et al.published in a recent issue of HPB journal(1).The authors compared short-and long-term outcomes of laparoscopic and open liver resection(OLR)in elderly patients with hepatocellular carcinoma(HCC)using 1-1 propensity score matching(PSM).
