The rapid development of high-intensity laser-generated particle and photon secondary sources has attracted widespread interest during the last 20 years not only due to fundamental science research but also because of...The rapid development of high-intensity laser-generated particle and photon secondary sources has attracted widespread interest during the last 20 years not only due to fundamental science research but also because of the important applications of this developing technology.For instance,the generation of relativistic particle beams,betatron-type coherent X-ray radiation and high harmonic generation have attracted interest from various fields of science and technology owing to their diverse applications in biomedical,material science,energy,space,and security applications.In the field of biomedical applications in particular,laser-driven particle beams as well as laser-driven X-ray sources are a promising field of study.This article looks at the research being performed at the Institute of Plasma Physics and Lasers(IPPL)of the Hellenic Mediterranean University Research Centre.The recent installation of the ZEUS 45 TW laser system developed at IPPL offers unique opportunities for research in laser-driven particle and X-ray sources.This article provides information about the facility and describes initial experiments performed for establishing the baseline platforms for secondary plasma sources.展开更多
Plasmodium (P.) falciparum is a pathogen that causes severe forms of malaria. Protein interactions have been shown to occur between P. falciparum and human erythrocytes in human blood. The Band 3 Anion Transporter (B3...Plasmodium (P.) falciparum is a pathogen that causes severe forms of malaria. Protein interactions have been shown to occur between P. falciparum and human erythrocytes in human blood. The Band 3 Anion Transporter (B3AT) protein is considered the main invasive pathway for the parasite in erythrocytes that causes clinical symptoms for malaria in humans. The interactions between P. falciparum parasites and erythrocytes along this receptor have previously been explored. Short linear motifs (SLIMs) are short linear mediator sequences that involve several biological processes, acting as mediators of protein interactions identifiable by computational tools such as SLiMFinder. For a given protein, the identification of SLIMs allows predicting its interactors. Using the SLIMs approach, protein-protein interaction network analyses between P. falciparum and its human host, were used to identify a tryptophan-rich protein, A5K5E5_PLAVS as an essential interactor of B3AT. To better understand the interaction mechanism, a guided protein-protein docking approach based on SLIM motifs was performed for human B3AT and A5K5E5_PLAVS. The highlights of this important interaction between P. falciparum and its human host have the potential to pave the way to identify new therapeutic candidates.展开更多
Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-b...Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.展开更多
In this paper,we present a new modification of the newly developed semi-analytical method named the Optimal Auxilary Function Method(OAFM)for fractional-order equations using the Caputo operator,which is named FOAFM.T...In this paper,we present a new modification of the newly developed semi-analytical method named the Optimal Auxilary Function Method(OAFM)for fractional-order equations using the Caputo operator,which is named FOAFM.The mathematical theory of FOAFM is presented and the effectiveness of this method is proven by using it with well-known Fornberg-Whitham Equations(FWE).The FOAFM results are compared with other method results along with their exact solutions with the help of tables and plots to prove the validity of FOAFM.A rapidly convergent series solution is obtained from FOAFMand is validated by comparison with other results.The analysis proves that ourmethod is simply applicable,contains less computationalwork,and is rapidly convergent to the exact solution at the first iteration.A series solution to the problem is obtained with the help of FOAFM.The validity of FOAFM results is validated by comparing its results with the results available in the literature.It is observed that FOAFM is simply applicable,contains less computational work,and is fastly convergent.The convergence and stability are obtained with the help of optimal constants.FOAFM is very easy in applicability and provides excellent results at the first iteration for complex nonlinear initial/boundary value problems.FOAFM contains the optimal auxiliary constants through which we can control the convergence as FOAFM contains the auxiliary functions D_(1),D_(2),D_(3)...in which the optimal constants G_(1),G_(2),...and the control convergence parameters exist to play an important role in getting the convergent solution which is obtained rigorously.The computational work in FOAFM is less when compared to other methods and even a low-specification computer can do the computational work easily.展开更多
As a green environmentally-friendly material,rubberised concrete(Ru C),which has the characteristics of low elastic modulus,large deformation capacity,high damping,good energy dissipation and good crack resistance,has...As a green environmentally-friendly material,rubberised concrete(Ru C),which has the characteristics of low elastic modulus,large deformation capacity,high damping,good energy dissipation and good crack resistance,has attracted extensive attention and research in the civil engineering discipline.However,most of existing studies are based on experimental tests on Ru C material properties,and there has been no numerical study based on meso-scale modelling of Ru C yet.To more comprehensively investigate the Ru C dynamic material properties without conducting intensive experimental tests,this study developed a high-fidelity meso-scale model considering coarse and fine aggregates and rubber crumbs to numerically investigate the mechanical properties of rubberised concrete under different strain rates.The meso-scale model was verified against both quasi-static compressive testing data and Split Hopkinson Pressure Bar(SHPB)dynamic testing data.Using the verified numerical model,the dynamic properties of rubberised concrete with various rubber content(0%-30%)under different strain rates were studied.The numerical results show that the developed meso-scale model can use to predict the static and dynamic properties of rubberised concrete with high accuracy.The dynamic compressive strength of the rubberised concrete increases with the increment of the strain rate,and the strain rate sensitivity increases with the rubber content ranging from 0 to 30%.Based on intensive numerical simulation data,empirical DIFs is used as a function of strain rate and rubber content to predict the dynamic strength of rubberised concrete.展开更多
BACKGROUND Idiopathic pulmonary fibrosis(IPF)is a progressive interstitial lung disease with a high mortality rate.On this basis,exploring potential therapeutic targets to meet the unmet needs of IPF patients is impor...BACKGROUND Idiopathic pulmonary fibrosis(IPF)is a progressive interstitial lung disease with a high mortality rate.On this basis,exploring potential therapeutic targets to meet the unmet needs of IPF patients is important.AIM To explore novel hub genes for IPF therapy.METHODS Here,we used public datasets to identify differentially expressed genes between IPF patients and healthy donors.Potential targets were considered based on multiple bioinformatics analyses,especially the correlation between hub genes and carbon monoxide diffusing capacity of carbon monoxide,forced vital capacity,and patient survival rate.The mRNA levels of the hub genes were determined through quantitative real-time polymerase chain reaction.RESULTS We found that TDO2 was upregulated in IPF patients and predicted poor prognosis.Surprisingly,single-cell RNA sequencing data analysis revealed significant enrichment of TDO2 in alveolar fibroblasts,indicating that TDO2 may participate in the regulation of proliferation and survival.Therefore,we verified the upregulated expression of TDO2 in an experimental mouse model of transforming growth factor-β(TGF-β)-induced pulmonary fibrosis.Furthermore,the results showed that a TDO2 inhibitor effectively suppressed TGF-β-induced fibroblast activation.These findings suggest that TDO2 may be a potential target for IPF treatment.Based on transcription factors-microRNA prediction and scRNA-seq analysis,elevated TDO2 promoted the IPF proliferation of fibroblasts and may be involved in the P53 pathway and aggravate ageing and persistent pulmonary fibrosis.CONCLUSION We provided new target genes prediction and proposed blocking TGF-βproduction as a potential treatment for IPF.展开更多
This paper explains the absorption of an electromagnetic wave within a physical body. We provide a description of how an elementary physical particle absorbs electromagnetic waves within its structure and, after absor...This paper explains the absorption of an electromagnetic wave within a physical body. We provide a description of how an elementary physical particle absorbs electromagnetic waves within its structure and, after absorption, how this particle keeps it in memory and emits it. This absorption is like the eating of cosmological food by physical entities. This paper proposes that the universe is comprised of cosmological, physical, biological, psychological, and intellectual worlds that all follow parallel laws within their referred science. The paper creates a model of the elementary physical particle (EPP) using the parallel logic of the biological DNA model. This model is capable of explaining the emission, absorption, and memorization of physical signals. Several cosmological mysteries, like the interconvertibility of electric and magnetic fields, attraction, repulsion, space fabric, etc., unfold while disclosing the absorption and emission processes. The philosophical correctness of this paper is validated through the unification of multidisciplinary aspects, and its scientific correctness is validated by its logical consistency with the results of well-known experiments. The theory clarifies the “cause” within nature, and by analyzing the “effects”, we can reach new realities of the cosmological world.展开更多
First, we develop a unitary process that can explain all four physical activations: electromagnetic wave, electromagnetic force, repulsion, and attraction. Second, it is clarified that cosmological and physical entiti...First, we develop a unitary process that can explain all four physical activations: electromagnetic wave, electromagnetic force, repulsion, and attraction. Second, it is clarified that cosmological and physical entities relate to different levels of existence in the universe and, hence, cannot be considered under the same paradigm. We know that biological entities use physical substances as executants;analogously, physical entities use cosmological substances as executants. Therefore, we have introduced new terms for the cosmological substances used as executants in physical activities. Third, this study introduces the primary elements of the cosmological world, such as visibility, forcibility, fullness, and hollowness, and defines them according to their attributes. This study explains how different combinations and placements of primary elements create different cosmological fields. These fields are used in all physical activations. Finally, we explain the entity model and how all physical activations occur. This study concludes that all physical activations use primary elements and follow the same universal law. Therefore, this study addresses the untouched subject of the creation of repulsion and attraction (gravitation). Furthermore, it addresses several cosmic mysteries that are yet to be resolved.展开更多
Found in all metazoans, microRNAs or miRNAs are small non-coding RNA of-22 nucleotides in length that completely reshaped our understanding of gene regulation. This new class ofgene regulator is mostly transcribed by ...Found in all metazoans, microRNAs or miRNAs are small non-coding RNA of-22 nucleotides in length that completely reshaped our understanding of gene regulation. This new class ofgene regulator is mostly transcribed by the RNA polymerase II producing a long stem-loop structure, called primary- or pri-miRNA, that will first be processed in the cell nucleus by a multiprotein complex called microprocessor to generate a shorter RNA structure called precursor- or pre-miRNA.展开更多
Chemical and isotopic compositions have been measured for N2-He-rich bubbling gases discharging from hot springs in the Hainan Island, Southern China. Observed 3He/4He ratios （0.1-1.3 RA） indicate the occurrence of ...Chemical and isotopic compositions have been measured for N2-He-rich bubbling gases discharging from hot springs in the Hainan Island, Southern China. Observed 3He/4He ratios （0.1-1.3 RA） indicate the occurrence of a mantle component throughout the island, which has been highly diluted by a crustal radiogenic 4He component. The occurrence of mantle-derived helium is high in the northern island （12%-16% of total He） and gradually decreases towards southern coast （1%-3% of total He）. Such a distribution pattern is most likely controlled by the Pleocene-Quaternary volcanic activities in the northern island and groundwater circulation along the deep major faults. The 4~Ar/36Ar and N2/Ar ratios suggest that N2 and Ar of the hot spring gases are mostly meteoric. Although 13C values of CO2 （-20%0 to -27%0） with low concentrations are consistent with the biogenic origin, the combination of SHe/4He and 51SCco2 suggests a two end-member mixing of mantle and crustal components with CO2/3He ratios of 2x 109 and 8 1011, respectively. However, the low CO2/3He ratios （1- 22106） can not be ascribed in terms of the simple mixing but has to be explained by the addition of radiogenic 4He and loss of CO2 by calcite precipitation in the hydrothermal system, which is most likely controlled by the degree of gas-water-rock interaction.展开更多
Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field defects.It is recognized as a leading cause of irreversible blindness affecting more than ...Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field defects.It is recognized as a leading cause of irreversible blindness affecting more than 70 million people worldwide.Currently,reduction of intraocular pressure,a widely recognized risk factor for glaucoma development,is the only pharmacological strategy for slowing down retinal ganglion cell loss and disease progression.However,retinal ganglion cell death and visual field loss have been observed in normotensive glaucoma,suggesting that the disease process is partially independent of intraocular pressure.Taurine is one of the agents that have attracted attention of researchers recently.Taurine has been shown to be involved in multiple cellular functions,including a central role as a neurotransmitter,as a trophic factor in the central nervous system development,as an osmolyte,as a neuromodulator,and as a neuroprotectant.It also plays a role in the maintenance of the structural integrity of the membranes and in the regulation of calcium transport and homeostasis.Taurine is known to prevent N-methyl-D-aspartic acid-induced excitotoxic injury to retinal ganglion cells.A recently published study clearly demonstrated that taurine prevents retinal neuronal apoptosis both in vivo and in vitro.Protective effect of taurine may be attributed to direct inhibition of apoptosis,an activation of brain derived neurotrophic factor-related neuroprotective mechanisms and reduction of retinal oxidative and nitrosative stresses.Further studies are needed to fully explore the potential of taurine as a neuroprotective agent,so that it can be applied in clinical practice,particularly for the treatment of glaucoma.The objective of current review was to summarize recent evidence on neuroprotective properties of taurine in glaucoma.展开更多
基金support of this work by the project‘ELI-LASERLAB Europe Synergy,Hi PER&IPERIONCH.gr’(MIS 5002735)which is implemented under the Action‘Reinforcement of the Research and Innovation Infrastructure’funded by the Operational Programme‘Competitiveness,Entrepreneurship and Innovation’(NSRF 2014–2020)+2 种基金co-financed by Greece and the European Union(European Regional Development Fund)supported by computational time granted from the Greek Research and Technology Network(GRNET)in the National HPC facility,ARIS,under project ID pr009023-La MIPla S IIIcofinanced by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness,Entrepreneurship,and Innovation,under the call Research–Create–Innovate(project code:T1EDK-04549,project title:Development of a coherent X-ray multispectral microscopy system)。
文摘The rapid development of high-intensity laser-generated particle and photon secondary sources has attracted widespread interest during the last 20 years not only due to fundamental science research but also because of the important applications of this developing technology.For instance,the generation of relativistic particle beams,betatron-type coherent X-ray radiation and high harmonic generation have attracted interest from various fields of science and technology owing to their diverse applications in biomedical,material science,energy,space,and security applications.In the field of biomedical applications in particular,laser-driven particle beams as well as laser-driven X-ray sources are a promising field of study.This article looks at the research being performed at the Institute of Plasma Physics and Lasers(IPPL)of the Hellenic Mediterranean University Research Centre.The recent installation of the ZEUS 45 TW laser system developed at IPPL offers unique opportunities for research in laser-driven particle and X-ray sources.This article provides information about the facility and describes initial experiments performed for establishing the baseline platforms for secondary plasma sources.
文摘Plasmodium (P.) falciparum is a pathogen that causes severe forms of malaria. Protein interactions have been shown to occur between P. falciparum and human erythrocytes in human blood. The Band 3 Anion Transporter (B3AT) protein is considered the main invasive pathway for the parasite in erythrocytes that causes clinical symptoms for malaria in humans. The interactions between P. falciparum parasites and erythrocytes along this receptor have previously been explored. Short linear motifs (SLIMs) are short linear mediator sequences that involve several biological processes, acting as mediators of protein interactions identifiable by computational tools such as SLiMFinder. For a given protein, the identification of SLIMs allows predicting its interactors. Using the SLIMs approach, protein-protein interaction network analyses between P. falciparum and its human host, were used to identify a tryptophan-rich protein, A5K5E5_PLAVS as an essential interactor of B3AT. To better understand the interaction mechanism, a guided protein-protein docking approach based on SLIM motifs was performed for human B3AT and A5K5E5_PLAVS. The highlights of this important interaction between P. falciparum and its human host have the potential to pave the way to identify new therapeutic candidates.
基金supported by the Science Fund of the Republic of Serbia,#Grant No:7748088。
文摘Mushrooms are experiencing a kind of renaissance as a part of the contemporary human diet.These valuable organisms are more than food,they fit in perfectly as a novel market group known as nutra-mycoceuticals.Immune-balancing mushroom dietary fibers and secondary metabolites such as polyphenols are the main focus of the healthcare industry.Wellness and cosmetic companies are increasingly using mushroom extracts rich in these ingredients.This review considers the basic molecular immunomodulatory mechanisms of action of the most commonly used mushroom dietary fibers,β-glucans.The literature data on their bioavailability,metabolic transformations,preclinical and human clinical research,and safety are discussed.Immunomodulatory mechanisms of polyphenol ingredients are also considered.These molecules present great potential in the design of the new immunity balancer formulations according to their widespread structural diversity.Finally,we draw attention to the perspectives of modern trends in mushroom nutraceutical and cosmeceutical formulations to strengthen and balance immunity.
文摘In this paper,we present a new modification of the newly developed semi-analytical method named the Optimal Auxilary Function Method(OAFM)for fractional-order equations using the Caputo operator,which is named FOAFM.The mathematical theory of FOAFM is presented and the effectiveness of this method is proven by using it with well-known Fornberg-Whitham Equations(FWE).The FOAFM results are compared with other method results along with their exact solutions with the help of tables and plots to prove the validity of FOAFM.A rapidly convergent series solution is obtained from FOAFMand is validated by comparison with other results.The analysis proves that ourmethod is simply applicable,contains less computationalwork,and is rapidly convergent to the exact solution at the first iteration.A series solution to the problem is obtained with the help of FOAFM.The validity of FOAFM results is validated by comparing its results with the results available in the literature.It is observed that FOAFM is simply applicable,contains less computational work,and is fastly convergent.The convergence and stability are obtained with the help of optimal constants.FOAFM is very easy in applicability and provides excellent results at the first iteration for complex nonlinear initial/boundary value problems.FOAFM contains the optimal auxiliary constants through which we can control the convergence as FOAFM contains the auxiliary functions D_(1),D_(2),D_(3)...in which the optimal constants G_(1),G_(2),...and the control convergence parameters exist to play an important role in getting the convergent solution which is obtained rigorously.The computational work in FOAFM is less when compared to other methods and even a low-specification computer can do the computational work easily.
文摘As a green environmentally-friendly material,rubberised concrete(Ru C),which has the characteristics of low elastic modulus,large deformation capacity,high damping,good energy dissipation and good crack resistance,has attracted extensive attention and research in the civil engineering discipline.However,most of existing studies are based on experimental tests on Ru C material properties,and there has been no numerical study based on meso-scale modelling of Ru C yet.To more comprehensively investigate the Ru C dynamic material properties without conducting intensive experimental tests,this study developed a high-fidelity meso-scale model considering coarse and fine aggregates and rubber crumbs to numerically investigate the mechanical properties of rubberised concrete under different strain rates.The meso-scale model was verified against both quasi-static compressive testing data and Split Hopkinson Pressure Bar(SHPB)dynamic testing data.Using the verified numerical model,the dynamic properties of rubberised concrete with various rubber content(0%-30%)under different strain rates were studied.The numerical results show that the developed meso-scale model can use to predict the static and dynamic properties of rubberised concrete with high accuracy.The dynamic compressive strength of the rubberised concrete increases with the increment of the strain rate,and the strain rate sensitivity increases with the rubber content ranging from 0 to 30%.Based on intensive numerical simulation data,empirical DIFs is used as a function of strain rate and rubber content to predict the dynamic strength of rubberised concrete.
文摘BACKGROUND Idiopathic pulmonary fibrosis(IPF)is a progressive interstitial lung disease with a high mortality rate.On this basis,exploring potential therapeutic targets to meet the unmet needs of IPF patients is important.AIM To explore novel hub genes for IPF therapy.METHODS Here,we used public datasets to identify differentially expressed genes between IPF patients and healthy donors.Potential targets were considered based on multiple bioinformatics analyses,especially the correlation between hub genes and carbon monoxide diffusing capacity of carbon monoxide,forced vital capacity,and patient survival rate.The mRNA levels of the hub genes were determined through quantitative real-time polymerase chain reaction.RESULTS We found that TDO2 was upregulated in IPF patients and predicted poor prognosis.Surprisingly,single-cell RNA sequencing data analysis revealed significant enrichment of TDO2 in alveolar fibroblasts,indicating that TDO2 may participate in the regulation of proliferation and survival.Therefore,we verified the upregulated expression of TDO2 in an experimental mouse model of transforming growth factor-β(TGF-β)-induced pulmonary fibrosis.Furthermore,the results showed that a TDO2 inhibitor effectively suppressed TGF-β-induced fibroblast activation.These findings suggest that TDO2 may be a potential target for IPF treatment.Based on transcription factors-microRNA prediction and scRNA-seq analysis,elevated TDO2 promoted the IPF proliferation of fibroblasts and may be involved in the P53 pathway and aggravate ageing and persistent pulmonary fibrosis.CONCLUSION We provided new target genes prediction and proposed blocking TGF-βproduction as a potential treatment for IPF.
文摘This paper explains the absorption of an electromagnetic wave within a physical body. We provide a description of how an elementary physical particle absorbs electromagnetic waves within its structure and, after absorption, how this particle keeps it in memory and emits it. This absorption is like the eating of cosmological food by physical entities. This paper proposes that the universe is comprised of cosmological, physical, biological, psychological, and intellectual worlds that all follow parallel laws within their referred science. The paper creates a model of the elementary physical particle (EPP) using the parallel logic of the biological DNA model. This model is capable of explaining the emission, absorption, and memorization of physical signals. Several cosmological mysteries, like the interconvertibility of electric and magnetic fields, attraction, repulsion, space fabric, etc., unfold while disclosing the absorption and emission processes. The philosophical correctness of this paper is validated through the unification of multidisciplinary aspects, and its scientific correctness is validated by its logical consistency with the results of well-known experiments. The theory clarifies the “cause” within nature, and by analyzing the “effects”, we can reach new realities of the cosmological world.
文摘First, we develop a unitary process that can explain all four physical activations: electromagnetic wave, electromagnetic force, repulsion, and attraction. Second, it is clarified that cosmological and physical entities relate to different levels of existence in the universe and, hence, cannot be considered under the same paradigm. We know that biological entities use physical substances as executants;analogously, physical entities use cosmological substances as executants. Therefore, we have introduced new terms for the cosmological substances used as executants in physical activities. Third, this study introduces the primary elements of the cosmological world, such as visibility, forcibility, fullness, and hollowness, and defines them according to their attributes. This study explains how different combinations and placements of primary elements create different cosmological fields. These fields are used in all physical activations. Finally, we explain the entity model and how all physical activations occur. This study concludes that all physical activations use primary elements and follow the same universal law. Therefore, this study addresses the untouched subject of the creation of repulsion and attraction (gravitation). Furthermore, it addresses several cosmic mysteries that are yet to be resolved.
文摘Found in all metazoans, microRNAs or miRNAs are small non-coding RNA of-22 nucleotides in length that completely reshaped our understanding of gene regulation. This new class ofgene regulator is mostly transcribed by the RNA polymerase II producing a long stem-loop structure, called primary- or pri-miRNA, that will first be processed in the cell nucleus by a multiprotein complex called microprocessor to generate a shorter RNA structure called precursor- or pre-miRNA.
基金supported by the China National Key Basic Research and Development Program"973" (No.2009CB219506)
文摘Chemical and isotopic compositions have been measured for N2-He-rich bubbling gases discharging from hot springs in the Hainan Island, Southern China. Observed 3He/4He ratios （0.1-1.3 RA） indicate the occurrence of a mantle component throughout the island, which has been highly diluted by a crustal radiogenic 4He component. The occurrence of mantle-derived helium is high in the northern island （12%-16% of total He） and gradually decreases towards southern coast （1%-3% of total He）. Such a distribution pattern is most likely controlled by the Pleocene-Quaternary volcanic activities in the northern island and groundwater circulation along the deep major faults. The 4~Ar/36Ar and N2/Ar ratios suggest that N2 and Ar of the hot spring gases are mostly meteoric. Although 13C values of CO2 （-20%0 to -27%0） with low concentrations are consistent with the biogenic origin, the combination of SHe/4He and 51SCco2 suggests a two end-member mixing of mantle and crustal components with CO2/3He ratios of 2x 109 and 8 1011, respectively. However, the low CO2/3He ratios （1- 22106） can not be ascribed in terms of the simple mixing but has to be explained by the addition of radiogenic 4He and loss of CO2 by calcite precipitation in the hydrothermal system, which is most likely controlled by the degree of gas-water-rock interaction.
基金This work was financially supported by the Institut Pengurusan Penyelidikan(RMI),Universiti Teknologi MARA,Malaysia,under grants 600-IRMI/MyRA 5/3/BESTARI(004/2017)and 600-IRMI/MyRA 5/3/BESTARI(006/2017).
文摘Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field defects.It is recognized as a leading cause of irreversible blindness affecting more than 70 million people worldwide.Currently,reduction of intraocular pressure,a widely recognized risk factor for glaucoma development,is the only pharmacological strategy for slowing down retinal ganglion cell loss and disease progression.However,retinal ganglion cell death and visual field loss have been observed in normotensive glaucoma,suggesting that the disease process is partially independent of intraocular pressure.Taurine is one of the agents that have attracted attention of researchers recently.Taurine has been shown to be involved in multiple cellular functions,including a central role as a neurotransmitter,as a trophic factor in the central nervous system development,as an osmolyte,as a neuromodulator,and as a neuroprotectant.It also plays a role in the maintenance of the structural integrity of the membranes and in the regulation of calcium transport and homeostasis.Taurine is known to prevent N-methyl-D-aspartic acid-induced excitotoxic injury to retinal ganglion cells.A recently published study clearly demonstrated that taurine prevents retinal neuronal apoptosis both in vivo and in vitro.Protective effect of taurine may be attributed to direct inhibition of apoptosis,an activation of brain derived neurotrophic factor-related neuroprotective mechanisms and reduction of retinal oxidative and nitrosative stresses.Further studies are needed to fully explore the potential of taurine as a neuroprotective agent,so that it can be applied in clinical practice,particularly for the treatment of glaucoma.The objective of current review was to summarize recent evidence on neuroprotective properties of taurine in glaucoma.
