Pediatric central nervous system tumors are the most common tumors in children,it constitute 15%–20%of all malignancies in children and are the leading cause of cancer related deaths in children.Proteogenomics is an ...Pediatric central nervous system tumors are the most common tumors in children,it constitute 15%–20%of all malignancies in children and are the leading cause of cancer related deaths in children.Proteogenomics is an emerging field of biological research that utilizes a combination of proteomics,genomics,and transcriptomics to aid in the discovery and identification of biomarkers for diagnosis and therapeutic purposes.Integrative proteogenomics analysis of pediatric tumors identified underlying biological processes and potential treatments as well as the functional effects of somatic mutations and copy number variation driving tumorigenesis.展开更多
基金the National Institutes of Health,USA(NIH,P30 DK063491).
文摘Pediatric central nervous system tumors are the most common tumors in children,it constitute 15%–20%of all malignancies in children and are the leading cause of cancer related deaths in children.Proteogenomics is an emerging field of biological research that utilizes a combination of proteomics,genomics,and transcriptomics to aid in the discovery and identification of biomarkers for diagnosis and therapeutic purposes.Integrative proteogenomics analysis of pediatric tumors identified underlying biological processes and potential treatments as well as the functional effects of somatic mutations and copy number variation driving tumorigenesis.
