Biological Activities of Schiff Bases and Their Complexes: A Review of Recent Works

Schiff bases are the most widely used organic compounds. They have been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. This review summarizes the synthesis and biological activities of Schiff bases and their complexes.

Pharmacophore Based Virtual Screening for Identification of Novel CDK₂Inhibitors

CDK2 is one of the most important members of Cyclin-dependent kinases. It is a critical modulator of various oncogenic signaling pathways, and its activity is vital for loss of proliferative control during oncogenesis. This work has focused on developing a pharmacophore model for CDK2 inhibitors by using a dataset of known inhibitors as a pre-filter throughout the virtual screening and docking process. Consequently, the best pharmacophore model was made of one hydrogen bond acceptor, and two aromatic ring features with a high correlation value of 0.906. The validation findings proved out that the selected model can be used as a filter to screen new molecules like Enamine kinase hinge region directed library against CDK2. As a result, 69 hits were subjected to molecular docking studies. Eventually, three compounds (5909, 701 and 8397) scored good interaction energy values and strong molecular interactions. Hence, they were identified as leads for novel CDK2 inhibitors as anticancer drugs.

Preparation and Characterization of Binary and Ternary Blends with Poly(Lactic Acid), Polystyrene, and Acrylonitrile-Butadiene-Styrene

Binary and ternary blends of poly(lactic acid) (PLA), polystyrene (PS) and acrylonitrile-butadiene-styrene (ABS) were prepared using a one-step extrusion process. Rheological and mechanical properties of the prepared blends were determined. Rheological properties were studied using a capillary rheometer, shear rate, shear stress, non-Newtonian index, shear viscosity and flow activation energy were determined. Mechanical properties were studied in term of tensile properties, stress at break, strain at break, and Young’s modulus were determined. The effect of the composition on the rheological and mechanical properties was investigated. The results show that the ternary blend exhibits shear-thinning behavior over the range of the studied shear rates where the true shear viscosity of the blend decreases with increasing true shear rate, also it was found that the true viscosity of the blend decreases with increasing ABS content. The mechanical results showed that, in the most cases, the stress at break and the Young’s modulus improved by the addition of ABS.

Sedimentary Environments, Geometry and Characteristics of the Sand Layers within the Basin of El Ma Labiod （Algero-Tunisian Borders）

The authors＇ work concerns the study of sedimentary environments, the geometry and the characteristics of the silicon-clastic deposits within the basin of EI Ma Labiod at the Algero-Tunisian confines. The sedimentological analysis has proved a Miocene age of the sediments with varied environments： marine, fluvial-deltaic and lake. The geological aspect of the sediment, in particular sandy, is of the movable type or very slightly consolidated. The size of the industrial sand layers can be very diverse, however to feed from the industrial consumers having a certain perenniality, our prospection was directed towards layers with very important reserves. It is about a sedimentary basin with dimensions exceeding very largely the conditions of operating for such projects, which are at least one to two million tons. With the exception of a thin quaternary soil horizon, the basin is almost of an exploitation with open sky. The mineralogical determination has revealed siliceous to extra-siliceous sands, which are absolutely usable in the industry of glass, foundry and also in other functions like the abrasives of sanding and the clothing industry of the sandpapers. Concerning the economic aspect, the materials are very close and this is why the area has known the installation of a glassmaking factory and a cement factory using at the same time the Maastrichtian limestone, the sandy material and the clays of the Western zone of the basin.

The Behavior of Multi-Story Buildings Seismically Isolated System Hybrid Isolation (Friction, Rubber and with the Addition of Rotational Friction Dampers)

Increasing buildings’ resistance to earthquake forces is not always a desirable solution especially for the building contents that are irreplaceable or simply more valuable than the actual primary structure (e.g. museums, data storage Centre’s, etc.). Base isolation and seismic dampers can be employed to minimize inter-story drifts and floor accelerations via specially designed isolation and dampers system at the structural base, or at higher levels of the superstructure. In this research, we’ll examine the response of buildings isolated using isolation system hybrid consisting of Lead-Rubber Bearings (LRB), Flat Sliding Bearings (FSB), with the addition of Rotation Fiction Damper (FD) at the base, then compare the results with buildings that have traditional foundation, in terms of the (period, displacement and distribution shear force and height of the building). It conducts TIME HISTORY seismic analysis for some varying height buildings (eight, twelve, sixteen, and twenty stories), with help of SAP2000 using an earthquake acceleration-time history for (El- Centro). The results show that the use of insulation system Hybrid has had a significant impact on improving the performance of origin in terms of reducing displacements and base shear with in-creasing height of the building, but has had a negative impact on the drift, which leads to an in-crease in drift with the increased flexibility of the building.

聚乳酸/低密度聚乙烯共混聚合物的制备及表征

聚乳酸（PLA）是一种来源于玉米及甜菜根的脂肪类聚合物，可被降解为无毒的化合物。目前，常用的PLA合成方法为直接由乳酸或丙交酯开环聚合制得PLA。首先用乳酸合成低分子量的PLA，随后使其解聚成丙交酯（不稳定的二聚物），最后经催化剂开环聚合成可控的高分子聚合物，其制备过程免溶剂处理。该方法能够以低成本生产高分子量的PLA，故在市场上得到了广泛的应用。

Extra-hepatic manifestations associated with hepatitis E virus infection:a comprehensive review of the literature

Background and aims:Hepatitis E virus(HEV)infection is a significant public health problem that afflicts almost 20 million individuals annually and causes acute liver injury in 3.5 million,with approximately 56000 deaths.As with other viral hepatitides,extra-hepatic manifestations could represent an important aspect of this infection.The spectrum of these manifestations is still emerging.Acute pancreatitis and neurological,musculoskeletal,hematological,renal,and other immune-mediated manifestations have been described.The aim of this article is to comprehensively review the published literature of extra-hepatic manifestations associated with HEV infection.Data sources:We searched the PubMed database using the MeSH term“hepatitis E”and each of the extra-hepaticmanifestations associated with HEV infection.No language or date restrictions were set in these searches.Searches retrieving articles with non-A,non-B hepatitis were excluded.Additional articles were identified through the reference lists of included articles.Results:Several extra-hepatic manifestations associated with HEV infection have been published.The temporal association between some extra-hepatic manifestations and HEV infection and the exclusion of other possible etiologies suggests that HEV infection could have caused some of them.According to the available data,HEV infection appears to be strongly associated with acute pancreatitis,neurological disorders(with primarily dominant peripheral nerve involvement,most commonly manifested as Guillain-Barre´syndrome,followed by neuralgic amyotrophy),hematological diseases(hemolytic anemia due to glucose phosphate dehydrogenase deficiency,and severe thrombocytopenia),glomerulonephritis,and mixed cryoglobulinemia.More data are needed to clarify whether an association exists with musculoskeletal or other immunemediated manifestations.Conclusions:HEV infection should be considered in patients with acute pancreatitis,Guillain-Barre´syndrome,neuralgic amyotrophy,hemolytic anemia due to glucose phosphate dehydrogenase deficiency,severe thrombocytopenia,glomerulonephritis,and mixed cryoglobulinemia.Alternatively,signs and symptoms of these conditions should be sought in patients with acute or chronic HEV infection.More data are needed to confirm the role of HEV in other extra-hepatic disorders.

Colorimetric Determination of Monosodium Glutamate in Food Samples Using Colorimetric Determination of Monosodium Glutamate in Food Samples Using L-glutamate Oxidase-glutamate Oxidase

A rapid, sensitive and simple chromogenic method was developed for quantitative determination of monosodium glutamate(MSG) in food samples. The method incorporated a glutamate oxidase and peroxidase. The librated H 2 O 2 from a glutamate sample as a result of enzymatic action was measured using 4-aminoantipyrine and phenol as a chromogenic reagent at 502 nm. Glutamate calibration curve was linear up to 125 mmol L-1 with a detection limit of 2 mmol L-1. The results of analyzing L-glutamate in various food samples using the approach were compared to those of a standard procedure employing HPLC method. MSG concentration in different samples ranged from 0.93 to 4.9 g/kg. This method is relatively sensitive and specifi c, without the need of pre-treatment for sample. Fig 5, Tab 1, Ref

Progressive liver failure post acute hepatitis A,over a three-month period,resulting in hepatorenal syndrome and death

Hepatitis A is a common viral illness worldwide.It usually results in an acute,self-limiting disease and only rarely leads to fulminant hepatic failure or any other complications.During the period of conflict in Syria,and due to the damages to water infrastructure and poor sanitation,a dramatic increase in hepatitis A virus infection has been documented.Here we report a rare case of a 14-year-old male whose hepatitis A was complicated with hepatorenal syndrome and subacute liver failure.The war condition in Syria impeded transportation of the patient to a nearby country for liver transplantation,contributing to his unfortunate death.