During mitosis,the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation,a complex movements orchestrated by mitotic kinases and its effector proteins.Faithful ch...During mitosis,the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation,a complex movements orchestrated by mitotic kinases and its effector proteins.Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell.Defects in these processes can lead to aneuploidy or polyploidy.Aurora/Ipllp family, a class of conserved serine/threonine kinases,plays key roles in chromosome segregation and cytokinesis.This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer.展开更多
Objective To study the role of extracellular signal-regulated kinase (ERK) in cerebral ischemia and the mechanism of protective effects of U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene) on ischem...Objective To study the role of extracellular signal-regulated kinase (ERK) in cerebral ischemia and the mechanism of protective effects of U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene) on ischemic brain. Methods Mice underwent left middle cerebral artery occlusion (MCAO) by introducing a suture in the lumen. U0126 was injected intravenously through the internal jugular vein. The immuno-activity of phosphorylated ERK1/2 (pERK1/2), phos-phorylated mitogen activated protein kinase kinase (pMEK), and phosphorylated Elk-1 (pElk-1) was assessed by Western blot analysis and immunohistochemistry. Interleukin (IL)-1βmRNA level was measured by ribonuclease protection assay. Results Phosphorylated ERK1/2 in 2 hours MCAO mice was down-regulated after intravenous injection of U0126. The inhibition was dose dependent and treatment time related. pMEK and pElk-1 were also reduced in a similar fashion after U0126 treatment. IL-1βmRNA increased after 1 and 2 hours of MCAO. After injection of U0126, it was down-regulated during 1 to 4 hours after MCAO. Conclusion Intravenous administration of the MEK inhibitor U0126 inhibits pMEK, pERK1/2, and pElk-1 up-regulation induced by cerebral ischemia. The protective effect of U0126 against ischemic injury is probably resulted from the reduction of IL-1βmRNA via the inhibition of ERK pathway.展开更多
A nationally representative sample of 1640 Chinese urban adolescents (mean age=14.5 years) and their parents and teachers were surveyed to examine the associations between relationships with teachers and parents and a...A nationally representative sample of 1640 Chinese urban adolescents (mean age=14.5 years) and their parents and teachers were surveyed to examine the associations between relationships with teachers and parents and adolescents' developmental outcomes such as academic performance, psychological well-being, altruistic behaviors, and misconduct. Results showed that the quality of adolescents' relationships with teachers was highly correlated with adolescent outcomes, in most cases more so than for relationships with parents. Furthermore, such associations were the same across both genders and three grade levels. These findings suggest that teachers may play an especially significant role in Chinese adolescent development. This study adds to the small but growing literature on the importance of teachers as well as other non-parental adults in adolescent psychosocial development.展开更多
Microstructures of the localized shear bands generated during explosion with a thick-walled cylinder specimen in Ti-6AI-4V alloy, were characterized by TEM and SEM. The results show that the twinning is a major mode o...Microstructures of the localized shear bands generated during explosion with a thick-walled cylinder specimen in Ti-6AI-4V alloy, were characterized by TEM and SEM. The results show that the twinning is a major mode of deformation, and the distortion-free grains in the bands with the size of 10μm in diameter were proposed to be the re-crystallization during dynamic explosion. The further observations show that the α→α2 phase transformation may occur in the bands, and this kind of transformation could be confirmed by its dark field image and electron diffraction analysis. Analysis shows that there is specified orientation between the α and α2 Phases.展开更多
This paper summarizes recent progress by the authors in developing two solution frameworks for dual control. The first solution framework considers a class of dual control problems where there exists a parameter uncer...This paper summarizes recent progress by the authors in developing two solution frameworks for dual control. The first solution framework considers a class of dual control problems where there exists a parameter uncertainty in the observation equation of the LQG problem. An analytical active dual control law is derived by a variance minimization approach. The issue of how to determine an optimal degree of active learning is then addressed, thus achieving an optimality for this class of dual control problems. The second solution framework considers a general class of discrete-time LQG problems with unknown parameters in both state and observation equations. The best possible (partial) closed-loop feedback control law is derived by exploring the future nominal posterior probabilities, thus taking into account the effect of future learning when constructing the optimal nominal dual control.展开更多
AIM: To study the distribution pattern of transcription factors NF-κB and AP-1 and their relations with the expression of apoptosis associated-proteins Fas/FasL and ICH-1L/S in human hepatocellular carcinoma (HCC).ME...AIM: To study the distribution pattern of transcription factors NF-κB and AP-1 and their relations with the expression of apoptosis associated-proteins Fas/FasL and ICH-1L/S in human hepatocellular carcinoma (HCC).METHODS: We performed in situ hybridization and immunohistochemical techniques for NF-κB, AP-1,Fas/FasL and ICH-1 in 40 cases of human HCC along with corresponding nontumoral tissues and 7 cases of normal liver tissues.RESULTS: Twenty-two (55%) and 25 (62.5%) of 40 cases for NF-κB and AP-1 were presented for nuclear or both nuclear and cytoplastic staining respectively, while less cases were presented for only cytoplastic staining for NF-κB (18%) and AP-1 (10%) in adjacent nontumoral tissues and negative staining in normal liver tissues. There was no statistically significant difference of NF-κB or AP-1activation between well differentiated tumors and poorly differentiated tumors (P＞0.05). NF-κB activity is positively corresponded to AP-1 activation. The expression of ICH-1L/S was associated with the activation of NF-κB and AP-1 (P＜0.05), but no significant relationship was found between Fas/FasL and NF-κB or AP-1(P＞0.05).CONCLUSION: Activation of both NF-κB and AP-1 may be required for ICH-1L/S-induced apoptosis in HCC, but not for Fas/FasL-mediated apoptosis. NF-κB and AP-1may play important roles in the pathogenesis of human HCC.展开更多
This study was undertaken to construct a preliminary spatial analysis method for building an urban-suburban-rural category in the specific sample area of central California and providing distribution characteristics i...This study was undertaken to construct a preliminary spatial analysis method for building an urban-suburban-rural category in the specific sample area of central California and providing distribution characteristics in each category, based on which, some further studies such as regional manners of residential wood burning emission (PM2.5, the term used for a mixture of solid particles and liquid droplets found in the air, refers to particulate matter that is 2.5μm or smaller in size) could be carried out for the project of residential wood combustion. Demographic and infrastructure data with spatial characteristics were processed by integrating both Geographic Information System (GIS) and statistics method (Cluster Analysis), and then output to a category map as the result. It approached the quantitative and multi-variables description on the major characteristics variations among the urban, suburban and rural; and perfected the TIGER’s urban-rural classification scheme by adding suburban category. Based on the free public GIS data, the spatial analysis method provides an easy and ideal tool for geographic researchers, environmental planners, urban/regional planners and administrators to delineate different categories of regional function on the specific locations and dig out spatial distribution information they wanted. Furthermore, it allows for future adjustment on some parameters as the spatial analysis method is implemented in the different regions or various eco-social models.展开更多
Sedimentological, cyclic-stratigraphic, paleomagnetic, and clay-mineralogical studies on the early Oligocene Yaxicuo Group in the Hoh Xil Basin, the largest Cenozoic sedimentary basin in the hinterland of the Tibetan ...Sedimentological, cyclic-stratigraphic, paleomagnetic, and clay-mineralogical studies on the early Oligocene Yaxicuo Group in the Hoh Xil Basin, the largest Cenozoic sedimentary basin in the hinterland of the Tibetan Plateau, provide abundant information of paleoclimate changes. A 350-m thick section in the middle-lower Yaxicuo Group was analyzed to reveal the climatic history that occurred in the Hoh Xil region during the early Oligocene interval 31.30-30.35 Ma, dated with the paleomagnetic chronostratigraphy. The results indicate that arid and cold climate dominated the Hoh Xil region during the early Oligocene in general, being related to the global cooling and drying events that occurred in the earliest Oligocene. Within this period, relatively warm and wet climate accompanied by strong tectonic activity occurred in the 31.05-30.75 Ma interval; while arid and cold climate and relatively inactive tectonics occurred in the 31.30-31.05 and 30.75-30.35 Ma intervals. Furthermore, spectral analyses of high-temporal resolution paleoclimatic records show orbital periods including eccentricity, obliquity, and precession. It is concluded that paleoclimate changes during the early Oligocene in the Hoh Xil region were forced by both tectonic activity and orbital periods.展开更多
文摘During mitosis,the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation,a complex movements orchestrated by mitotic kinases and its effector proteins.Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell.Defects in these processes can lead to aneuploidy or polyploidy.Aurora/Ipllp family, a class of conserved serine/threonine kinases,plays key roles in chromosome segregation and cytokinesis.This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer.
文摘Objective To study the role of extracellular signal-regulated kinase (ERK) in cerebral ischemia and the mechanism of protective effects of U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio] butadiene) on ischemic brain. Methods Mice underwent left middle cerebral artery occlusion (MCAO) by introducing a suture in the lumen. U0126 was injected intravenously through the internal jugular vein. The immuno-activity of phosphorylated ERK1/2 (pERK1/2), phos-phorylated mitogen activated protein kinase kinase (pMEK), and phosphorylated Elk-1 (pElk-1) was assessed by Western blot analysis and immunohistochemistry. Interleukin (IL)-1βmRNA level was measured by ribonuclease protection assay. Results Phosphorylated ERK1/2 in 2 hours MCAO mice was down-regulated after intravenous injection of U0126. The inhibition was dose dependent and treatment time related. pMEK and pElk-1 were also reduced in a similar fashion after U0126 treatment. IL-1βmRNA increased after 1 and 2 hours of MCAO. After injection of U0126, it was down-regulated during 1 to 4 hours after MCAO. Conclusion Intravenous administration of the MEK inhibitor U0126 inhibits pMEK, pERK1/2, and pElk-1 up-regulation induced by cerebral ischemia. The protective effect of U0126 against ischemic injury is probably resulted from the reduction of IL-1βmRNA via the inhibition of ERK pathway.
文摘A nationally representative sample of 1640 Chinese urban adolescents (mean age=14.5 years) and their parents and teachers were surveyed to examine the associations between relationships with teachers and parents and adolescents' developmental outcomes such as academic performance, psychological well-being, altruistic behaviors, and misconduct. Results showed that the quality of adolescents' relationships with teachers was highly correlated with adolescent outcomes, in most cases more so than for relationships with parents. Furthermore, such associations were the same across both genders and three grade levels. These findings suggest that teachers may play an especially significant role in Chinese adolescent development. This study adds to the small but growing literature on the importance of teachers as well as other non-parental adults in adolescent psychosocial development.
基金supported by the National Natural Science Foundation of China(No.50071064 and 19891180-2)the US Army Research Office MURI Program under Contract DAAH04-96-1-0376the Department of Energy Grant DEFG0300SF2202.
文摘Microstructures of the localized shear bands generated during explosion with a thick-walled cylinder specimen in Ti-6AI-4V alloy, were characterized by TEM and SEM. The results show that the twinning is a major mode of deformation, and the distortion-free grains in the bands with the size of 10μm in diameter were proposed to be the re-crystallization during dynamic explosion. The further observations show that the α→α2 phase transformation may occur in the bands, and this kind of transformation could be confirmed by its dark field image and electron diffraction analysis. Analysis shows that there is specified orientation between the α and α2 Phases.
基金the Research Grants Council of Hong Kong, P.R.China under Grant CUHK 4180/03E
文摘This paper summarizes recent progress by the authors in developing two solution frameworks for dual control. The first solution framework considers a class of dual control problems where there exists a parameter uncertainty in the observation equation of the LQG problem. An analytical active dual control law is derived by a variance minimization approach. The issue of how to determine an optimal degree of active learning is then addressed, thus achieving an optimality for this class of dual control problems. The second solution framework considers a general class of discrete-time LQG problems with unknown parameters in both state and observation equations. The best possible (partial) closed-loop feedback control law is derived by exploring the future nominal posterior probabilities, thus taking into account the effect of future learning when constructing the optimal nominal dual control.
文摘AIM: To study the distribution pattern of transcription factors NF-κB and AP-1 and their relations with the expression of apoptosis associated-proteins Fas/FasL and ICH-1L/S in human hepatocellular carcinoma (HCC).METHODS: We performed in situ hybridization and immunohistochemical techniques for NF-κB, AP-1,Fas/FasL and ICH-1 in 40 cases of human HCC along with corresponding nontumoral tissues and 7 cases of normal liver tissues.RESULTS: Twenty-two (55%) and 25 (62.5%) of 40 cases for NF-κB and AP-1 were presented for nuclear or both nuclear and cytoplastic staining respectively, while less cases were presented for only cytoplastic staining for NF-κB (18%) and AP-1 (10%) in adjacent nontumoral tissues and negative staining in normal liver tissues. There was no statistically significant difference of NF-κB or AP-1activation between well differentiated tumors and poorly differentiated tumors (P＞0.05). NF-κB activity is positively corresponded to AP-1 activation. The expression of ICH-1L/S was associated with the activation of NF-κB and AP-1 (P＜0.05), but no significant relationship was found between Fas/FasL and NF-κB or AP-1(P＞0.05).CONCLUSION: Activation of both NF-κB and AP-1 may be required for ICH-1L/S-induced apoptosis in HCC, but not for Fas/FasL-mediated apoptosis. NF-κB and AP-1may play important roles in the pathogenesis of human HCC.
文摘This study was undertaken to construct a preliminary spatial analysis method for building an urban-suburban-rural category in the specific sample area of central California and providing distribution characteristics in each category, based on which, some further studies such as regional manners of residential wood burning emission (PM2.5, the term used for a mixture of solid particles and liquid droplets found in the air, refers to particulate matter that is 2.5μm or smaller in size) could be carried out for the project of residential wood combustion. Demographic and infrastructure data with spatial characteristics were processed by integrating both Geographic Information System (GIS) and statistics method (Cluster Analysis), and then output to a category map as the result. It approached the quantitative and multi-variables description on the major characteristics variations among the urban, suburban and rural; and perfected the TIGER’s urban-rural classification scheme by adding suburban category. Based on the free public GIS data, the spatial analysis method provides an easy and ideal tool for geographic researchers, environmental planners, urban/regional planners and administrators to delineate different categories of regional function on the specific locations and dig out spatial distribution information they wanted. Furthermore, it allows for future adjustment on some parameters as the spatial analysis method is implemented in the different regions or various eco-social models.
文摘Sedimentological, cyclic-stratigraphic, paleomagnetic, and clay-mineralogical studies on the early Oligocene Yaxicuo Group in the Hoh Xil Basin, the largest Cenozoic sedimentary basin in the hinterland of the Tibetan Plateau, provide abundant information of paleoclimate changes. A 350-m thick section in the middle-lower Yaxicuo Group was analyzed to reveal the climatic history that occurred in the Hoh Xil region during the early Oligocene interval 31.30-30.35 Ma, dated with the paleomagnetic chronostratigraphy. The results indicate that arid and cold climate dominated the Hoh Xil region during the early Oligocene in general, being related to the global cooling and drying events that occurred in the earliest Oligocene. Within this period, relatively warm and wet climate accompanied by strong tectonic activity occurred in the 31.05-30.75 Ma interval; while arid and cold climate and relatively inactive tectonics occurred in the 31.30-31.05 and 30.75-30.35 Ma intervals. Furthermore, spectral analyses of high-temporal resolution paleoclimatic records show orbital periods including eccentricity, obliquity, and precession. It is concluded that paleoclimate changes during the early Oligocene in the Hoh Xil region were forced by both tectonic activity and orbital periods.
