Carbon and noble gas isotope analyses are reported for bubbling gas samples from the Tengchong volcanic geothermal area near the Indo-Eurasian suture zone. All samples contain a resolvable component of mantle-derived ...Carbon and noble gas isotope analyses are reported for bubbling gas samples from the Tengchong volcanic geothermal area near the Indo-Eurasian suture zone. All samples contain a resolvable component of mantle-derived 3He. Occurrence of mantle-derived 3He coincides with surface volcanism. However, 3He occurs over a larger geographic areathan do surface volcanics. δ13C values for CO2 and CH4 vary from -33.4‰ to 1.6 ‰ and from -52.8‰ to -2.8‰, respectively. He and C isotope systematics indicate that CO2 and CH4 in the CO2-rich gases originated predominantly from magmatic component mixed with crustal CO2 produced from carbonate. However, breakdown of organic matter and near-surface processes accounts for the CH4 and CO2 in N2-rich gases. 3He/4He ratio distribution pattern suggests that mantle-derived He and heat sources of high-temperature system in central Tengchong originate from a hidden magma reservoir at subsurface. CO2-rich gases with the highest 3He/4He ratio (5.2 Ra) may be representative of the Tengchong magmatic component. Compared with MORB, this relative low 3He/4He ratio could be fully attributed to either deep crustal contamination, or radioactive aging, or past contamination of the local mantle by U- and Th-rich subducted crustal material. However, a combination of low 3He/4He, high radiogenic 4He/40Ar ratio and identical CO2/3He and δ13Cco2 relative to MORB may suggest addition of prior subductedd crsustal material (ca 1 %-2%) to the MORB reservoir around 1.3 Ga ago, which is essentially compatible with the LIL-elements, and Sr-Nd-Pb isotopes of volcanic rocks.展开更多
AIM: To investigate whether vascular endothelial growth factor (VEGF) was over-expressed in hepatocellular carcinoma (HCC) or in surrounding cirrhotic liver tissues.METHODS: Immunohistochemistry was performed to inves...AIM: To investigate whether vascular endothelial growth factor (VEGF) was over-expressed in hepatocellular carcinoma (HCC) or in surrounding cirrhotic liver tissues.METHODS: Immunohistochemistry was performed to investigate the expression of VEGF proteins in HCC tissues from 105 consecutive patients undergoing curative resection for HCC. The immunostaining results and related clinicopathologic materials were analyzed with statistical methods. Kaplan-Meier method was used to calculate survival curves, and Log-rank test was performed to compare differences in survival rates of the patients with positive HCC staining and negative VEGF.RESULTS: VEGF-positive expression was found in 72 of105 HCC patients (68.6%). Capsular infiltration (P= 0.005),vascular invasion (P = 0.035) and intrahepatic metastasis(P=0.008) were observed more frequently in patients with VEGF-positive expression than in those with VEGFnegative expression. Kaplan-Meier curves showed that VEGF-positive expression was associated with a shorter overall survival (P = 0.014). VEGF-positive expression was found in 47 of tissues 68 HCC (69.1%), and VEGF-positive expression was found in 54 of 68 surrounding cirrhotic liver tissues (79.4%). VEGF-positive expression was significantly higher in surrounding cirrhotic liver tissues than in HCC (P= 0.017).CONCLUSION: VEGF may play an important role in the angiogenesis and prognosis of HCC, as well as in the angiogenesis of liver cirrhosis.展开更多
A new modeling approach that couples fundamental metallurgical principles of dynamical recrystallization with the cellular automaton method was developed to simulate the microstructural evolution linking with the plas...A new modeling approach that couples fundamental metallurgical principles of dynamical recrystallization with the cellular automaton method was developed to simulate the microstructural evolution linking with the plastic flow behavior during thermomechanical processing.The driving force for the nucleation and growth of dynamically recrystallized grain is the volume free energy due to the stored dislocation density of a deformation matrix.The growth terminates the impingement.The model is capable of simulating kinetics,microstructure and texture evolution during recrystallization.The predictions of microstructural evolution agree with the experimental results.展开更多
The strength and deformation characteristics of sedimentary soft rock evaluated in relation to several large-scale researc and construction projects in Japan are reviewed.The elastic stiffiness at small non-linearity ...The strength and deformation characteristics of sedimentary soft rock evaluated in relation to several large-scale researc and construction projects in Japan are reviewed.The elastic stiffiness at small non-linearity due to strain and pressure level,and viscous properties are described.The elastic stiffness from triaxial tests using high-quality core samples while measuring stresses and strains accurately is basically the same as the corresponding value from field shear wave velocity.It is necessary to take into account the dependency or stiffness on shear and pressure level,which could be evaluated by relevant laboratory stress-strain tests while referring to results trom relevant field loading tests.Loading rate effects due to the material viscous properties could be simulated by a non-linear three-component model.展开更多
Wing motion of a dragonfly in the maneuvering flight, which was measured by Wang et al. [1]was investigated. Equations of motion for a maneuvering flight of an insect were derived. These equations were applied for an...Wing motion of a dragonfly in the maneuvering flight, which was measured by Wang et al. [1]was investigated. Equations of motion for a maneuvering flight of an insect were derived. These equations were applied for analyzing the maneuvering flight. Inertial forces and moments acting on a body and wings were estimated by using these equations and the measured motions of the body and the wings. The results indicated the following characteristics of this flight: (1)The phase difference in flapping motion between the two fore wings and two hind wings, and the phase difference between the flapping motion and the feathering motion of the four wings are equal to those in a steady forward flight with the maximum efficiency. (2)The camber change and the feathering motion were mainly controlled by muscles at the wing bases.展开更多
Plant architecture is established through the continuous activity of ingenious genetic networks, Although extensive progress has been made towards the elucidation of genetic mechanisms controlling plant development us...Plant architecture is established through the continuous activity of ingenious genetic networks, Although extensive progress has been made towards the elucidation of genetic mechanisms controlling plant development using Arabidopsis,a model plant, little is known about the development of grass species at molecular level,展开更多
Various kinds of data are used in new product design and more accurate datamake the design results more reliable. Even though part of product data can be available directlyfrom the existing similar products, there sti...Various kinds of data are used in new product design and more accurate datamake the design results more reliable. Even though part of product data can be available directlyfrom the existing similar products, there still leaves a great deal of data unavailable. This makesdata prediction a valuable work. A method that can predict data of product under development basedon the existing similar products is proposed. Fuzzy theory is used to deal with the uncertainties indata prediction process. The proposed method can be used in life cycle design, life cycleassessment (LCA) etc. Case study on current refrigerator is used as a demonstration example.展开更多
A persistent interface package Hep MC_Contrib is developed for the C++ Monte Carlo event class library HepMC.HepMC_Contrib package provides an interface to user programs for storing /retrieving HepMC event records to/...A persistent interface package Hep MC_Contrib is developed for the C++ Monte Carlo event class library HepMC.HepMC_Contrib package provides an interface to user programs for storing /retrieving HepMC event records to/from Objectivity database,HepMC_Contrib is designed to utilise the standard features of HepODBMS as much as possible,Two types of implementation of class design were tested to reduce the size of the database,At last,the performance of the package is discussed in terms of the size of database.展开更多
In our country, approximately over 90% of patients with hepatocellular carcinoma were infected by either one of two viruses. Of 205 cases, 11% were infected by HBV and 83% by HCV, indicating practically the most (94%)...In our country, approximately over 90% of patients with hepatocellular carcinoma were infected by either one of two viruses. Of 205 cases, 11% were infected by HBV and 83% by HCV, indicating practically the most (94%) being infected. In order to eradicate HCV in chronic carrier who may eventually progress to hepatocellular carcinoma, interferon treatment was started nationwide in 1992. Approximately 200,000 Japanese patients were treated so far, and among those, HCV was eradicated in 30%. The presence of significant differences in virus amounts and genotypes between responders and noresponders were shown by molecular techniques.展开更多
The infection of H. pylori was conventionally diagnosed by microscope identification and isolation ofthe pathogen by culture. However, these procedures are fairly time consuming and not sensitive enough. We have devel...The infection of H. pylori was conventionally diagnosed by microscope identification and isolation ofthe pathogen by culture. However, these procedures are fairly time consuming and not sensitive enough. We have developed highly sensitive and specific method to detect the infection by PCR based amplification of nucleicacid. Using this procedure, we are studying the molecular aspect of this particular pathogen. The genetic analysis of clarithromycin resistant strain revealed that the appearance of resistant strain is not due to the conversion from sensitive strain to resistant,展开更多
We survey a recent progress on algebraic quantum field theory in connection with subfactor theory. We mainly concentrate on one-dimensional conformal quantum field theory.
SKG mouse,as a model of spontaneous rheumatoid arthritis (RA) bred recent years,is similar to the patients with RA.We analyzed the clonotypes of T cell infiltrating into joints of SKG mice in initial stage and late st...SKG mouse,as a model of spontaneous rheumatoid arthritis (RA) bred recent years,is similar to the patients with RA.We analyzed the clonotypes of T cell infiltrating into joints of SKG mice in initial stage and late stage of RA by using reverse transcriptase-polymerase chain reaction (RT-PCR) and subsequent single-strand conformation polymorphism (SSCP).The results indicated that the percentages of clonotypes TCR Vβ2 and Vβ8.2 of T cell clonotypes increased obviously to 72.3% and 60.2%,respectively.Mice number with identical TCR Vβ2 and Vβ8.2 clonotypes also clearly increased in late stage of disease to 100% and 75%,respectively. These results mean that T cells with TCR Vβ2 and Vβ8.2 clonotypes probably play an important role in RA progression of SKG mouse.Sequencing of the extracted DNA verified that common bands on SSCP gel were derived from the same T cell clones among samples from different joints.The results we obtained implied that RT-PCR/SSCP method was a sensitive and credible method for analyzing T cell clonotypes.When the T cells of SKG mouse were adoptively transferred to a nude mouse,it was verified that the T cells infiltrating into joints were related to morbid formation of RA.Cellular & Molecular Immunology.2004;1(4):300-303.展开更多
文摘Carbon and noble gas isotope analyses are reported for bubbling gas samples from the Tengchong volcanic geothermal area near the Indo-Eurasian suture zone. All samples contain a resolvable component of mantle-derived 3He. Occurrence of mantle-derived 3He coincides with surface volcanism. However, 3He occurs over a larger geographic areathan do surface volcanics. δ13C values for CO2 and CH4 vary from -33.4‰ to 1.6 ‰ and from -52.8‰ to -2.8‰, respectively. He and C isotope systematics indicate that CO2 and CH4 in the CO2-rich gases originated predominantly from magmatic component mixed with crustal CO2 produced from carbonate. However, breakdown of organic matter and near-surface processes accounts for the CH4 and CO2 in N2-rich gases. 3He/4He ratio distribution pattern suggests that mantle-derived He and heat sources of high-temperature system in central Tengchong originate from a hidden magma reservoir at subsurface. CO2-rich gases with the highest 3He/4He ratio (5.2 Ra) may be representative of the Tengchong magmatic component. Compared with MORB, this relative low 3He/4He ratio could be fully attributed to either deep crustal contamination, or radioactive aging, or past contamination of the local mantle by U- and Th-rich subducted crustal material. However, a combination of low 3He/4He, high radiogenic 4He/40Ar ratio and identical CO2/3He and δ13Cco2 relative to MORB may suggest addition of prior subductedd crsustal material (ca 1 %-2%) to the MORB reservoir around 1.3 Ga ago, which is essentially compatible with the LIL-elements, and Sr-Nd-Pb isotopes of volcanic rocks.
基金Supported by the China Scholarship Council, No. 98915009
文摘AIM: To investigate whether vascular endothelial growth factor (VEGF) was over-expressed in hepatocellular carcinoma (HCC) or in surrounding cirrhotic liver tissues.METHODS: Immunohistochemistry was performed to investigate the expression of VEGF proteins in HCC tissues from 105 consecutive patients undergoing curative resection for HCC. The immunostaining results and related clinicopathologic materials were analyzed with statistical methods. Kaplan-Meier method was used to calculate survival curves, and Log-rank test was performed to compare differences in survival rates of the patients with positive HCC staining and negative VEGF.RESULTS: VEGF-positive expression was found in 72 of105 HCC patients (68.6%). Capsular infiltration (P= 0.005),vascular invasion (P = 0.035) and intrahepatic metastasis(P=0.008) were observed more frequently in patients with VEGF-positive expression than in those with VEGFnegative expression. Kaplan-Meier curves showed that VEGF-positive expression was associated with a shorter overall survival (P = 0.014). VEGF-positive expression was found in 47 of tissues 68 HCC (69.1%), and VEGF-positive expression was found in 54 of 68 surrounding cirrhotic liver tissues (79.4%). VEGF-positive expression was significantly higher in surrounding cirrhotic liver tissues than in HCC (P= 0.017).CONCLUSION: VEGF may play an important role in the angiogenesis and prognosis of HCC, as well as in the angiogenesis of liver cirrhosis.
基金Sponsored by National Natural Science Foundation of China(50275130)
文摘A new modeling approach that couples fundamental metallurgical principles of dynamical recrystallization with the cellular automaton method was developed to simulate the microstructural evolution linking with the plastic flow behavior during thermomechanical processing.The driving force for the nucleation and growth of dynamically recrystallized grain is the volume free energy due to the stored dislocation density of a deformation matrix.The growth terminates the impingement.The model is capable of simulating kinetics,microstructure and texture evolution during recrystallization.The predictions of microstructural evolution agree with the experimental results.
文摘The strength and deformation characteristics of sedimentary soft rock evaluated in relation to several large-scale researc and construction projects in Japan are reviewed.The elastic stiffiness at small non-linearity due to strain and pressure level,and viscous properties are described.The elastic stiffness from triaxial tests using high-quality core samples while measuring stresses and strains accurately is basically the same as the corresponding value from field shear wave velocity.It is necessary to take into account the dependency or stiffness on shear and pressure level,which could be evaluated by relevant laboratory stress-strain tests while referring to results trom relevant field loading tests.Loading rate effects due to the material viscous properties could be simulated by a non-linear three-component model.
文摘Wing motion of a dragonfly in the maneuvering flight, which was measured by Wang et al. [1]was investigated. Equations of motion for a maneuvering flight of an insect were derived. These equations were applied for analyzing the maneuvering flight. Inertial forces and moments acting on a body and wings were estimated by using these equations and the measured motions of the body and the wings. The results indicated the following characteristics of this flight: (1)The phase difference in flapping motion between the two fore wings and two hind wings, and the phase difference between the flapping motion and the feathering motion of the four wings are equal to those in a steady forward flight with the maximum efficiency. (2)The camber change and the feathering motion were mainly controlled by muscles at the wing bases.
文摘Plant architecture is established through the continuous activity of ingenious genetic networks, Although extensive progress has been made towards the elucidation of genetic mechanisms controlling plant development using Arabidopsis,a model plant, little is known about the development of grass species at molecular level,
基金This project is supported by Ministry of Education, Culture, Sports, Science and Technology (MONBUSHO), Japan.
文摘Various kinds of data are used in new product design and more accurate datamake the design results more reliable. Even though part of product data can be available directlyfrom the existing similar products, there still leaves a great deal of data unavailable. This makesdata prediction a valuable work. A method that can predict data of product under development basedon the existing similar products is proposed. Fuzzy theory is used to deal with the uncertainties indata prediction process. The proposed method can be used in life cycle design, life cycleassessment (LCA) etc. Case study on current refrigerator is used as a demonstration example.
文摘A persistent interface package Hep MC_Contrib is developed for the C++ Monte Carlo event class library HepMC.HepMC_Contrib package provides an interface to user programs for storing /retrieving HepMC event records to/from Objectivity database,HepMC_Contrib is designed to utilise the standard features of HepODBMS as much as possible,Two types of implementation of class design were tested to reduce the size of the database,At last,the performance of the package is discussed in terms of the size of database.
文摘In our country, approximately over 90% of patients with hepatocellular carcinoma were infected by either one of two viruses. Of 205 cases, 11% were infected by HBV and 83% by HCV, indicating practically the most (94%) being infected. In order to eradicate HCV in chronic carrier who may eventually progress to hepatocellular carcinoma, interferon treatment was started nationwide in 1992. Approximately 200,000 Japanese patients were treated so far, and among those, HCV was eradicated in 30%. The presence of significant differences in virus amounts and genotypes between responders and noresponders were shown by molecular techniques.
文摘The infection of H. pylori was conventionally diagnosed by microscope identification and isolation ofthe pathogen by culture. However, these procedures are fairly time consuming and not sensitive enough. We have developed highly sensitive and specific method to detect the infection by PCR based amplification of nucleicacid. Using this procedure, we are studying the molecular aspect of this particular pathogen. The genetic analysis of clarithromycin resistant strain revealed that the appearance of resistant strain is not due to the conversion from sensitive strain to resistant,
文摘We survey a recent progress on algebraic quantum field theory in connection with subfactor theory. We mainly concentrate on one-dimensional conformal quantum field theory.
文摘SKG mouse,as a model of spontaneous rheumatoid arthritis (RA) bred recent years,is similar to the patients with RA.We analyzed the clonotypes of T cell infiltrating into joints of SKG mice in initial stage and late stage of RA by using reverse transcriptase-polymerase chain reaction (RT-PCR) and subsequent single-strand conformation polymorphism (SSCP).The results indicated that the percentages of clonotypes TCR Vβ2 and Vβ8.2 of T cell clonotypes increased obviously to 72.3% and 60.2%,respectively.Mice number with identical TCR Vβ2 and Vβ8.2 clonotypes also clearly increased in late stage of disease to 100% and 75%,respectively. These results mean that T cells with TCR Vβ2 and Vβ8.2 clonotypes probably play an important role in RA progression of SKG mouse.Sequencing of the extracted DNA verified that common bands on SSCP gel were derived from the same T cell clones among samples from different joints.The results we obtained implied that RT-PCR/SSCP method was a sensitive and credible method for analyzing T cell clonotypes.When the T cells of SKG mouse were adoptively transferred to a nude mouse,it was verified that the T cells infiltrating into joints were related to morbid formation of RA.Cellular & Molecular Immunology.2004;1(4):300-303.
