To feed the increasing world population, more food needs to be produced from agricultural land systems. Solutions to produce more food with fewer resources while minimizing adverse environmental and ecological consequ...To feed the increasing world population, more food needs to be produced from agricultural land systems. Solutions to produce more food with fewer resources while minimizing adverse environmental and ecological consequences require sustainable agricultural land use practices as supplementary to advanced biotechnology and agronomy. This review paper, from a land system perspective, systematically proposed and analyzed three interactive strategies that could possibly raise future food production under global change. By reviewing the current literatures, we suggest that cropland expansion is less possible amid iferce land competition, and it is likely to do less in increasing food production. Moreover, properly allocating crops in space and time is a practical way to ensure food production. Climate change, dietary shifts, and other socio-economic drivers, which would shape the demand and supply side of food systems, should be taken into consideration during the decision-making on rational land management in respect of sustainable crop choice and allocation. And ifnally, crop-speciifc agricultural intensiifcation would play a bigger role in raising future food production either by increasing the yield per unit area of individual crops or by increasing the number of crops sown on a particular area of land. Yet, only when it is done sustainably is this a much more effective strategy to maximize food production by closing yield and harvest gaps.展开更多
Rice is one of the most important grain crops in Northeast China （NEC） and its cultivation is sensitive to climate change. This study aimed to explore the spatio-temporal changes in the NEC rice planting area over t...Rice is one of the most important grain crops in Northeast China （NEC） and its cultivation is sensitive to climate change. This study aimed to explore the spatio-temporal changes in the NEC rice planting area over the period of 1980-2010 and to analyze their relationship to climate change. To do so, the CLUE-S （conversion of land use and its effects at small region extent） model was ifrst updated and used to simulate dynamic changes in the rice planting area in NEC to understand spatio-temporal change trends during three periods： 1980-1990, 1990-2000 and 2000-2010. The changing results in individual periods were then linked to climatic variables to investigate the climatic drivers of these changes. Results showed that the NEC rice planting area expanded quickly and increased by nearly 4.5 times during 1980-2010. The concentration of newly planted rice areas in NEC constantly moved northward and the changes were strongly dependent on latitude. This conifrmed that climate change, increases in temperature in particular, greatly inlfuenced the shift in the rice planting area. The shift in the north limit of the NEC rice planting area generally followed a 1＆#176;C isoline migration pattern, but with an obvious time-lag effect. These ifndings can help policy makers and crop producers take proper adaptation measures even when exposed to the global warming situation in NEC.展开更多
Although climate change impacts and agricultural adaptations have been studied extensively, how smallholder farmers perceive climate change and adapt their agricultural activities is poorly understood. Survey-based da...Although climate change impacts and agricultural adaptations have been studied extensively, how smallholder farmers perceive climate change and adapt their agricultural activities is poorly understood. Survey-based data （presents farmers＇ personal perceptions and adaptations to climate change） associated with external biophysical-socioeconomic data （presents real-world climate change） were used to develop a farmer-centered framework to explore climate change impacts and agricultural adaptations at a local level. A case study at Bin County （1980s-2010s）, Northeast China, suggested that increased annual average temperature （0.6＆#176;C per decade） and decreased annual precipitation （46 mm per decade, both from meteorological datasets） were correctly perceived by 76 and 66.9%, respectively, of farmers from the survey, and that a longer growing season was conifrmed by 70%of them. These reasonably correct perceptions enabled local farmers to make appropriate adaptations to cope with climate change：Longer season alternative varieties were found for maize and rice, which led to a signiifcant yield increase for both crops. The longer season also affected crop choice：More farmers selected maize instead of soybean, as implicated from survey results by a large increase in the maize growing area. Comparing warming-related factors, we found that precipitation and agricultural disasters were the least likely causes for farmers＇ agricultural decisions. As a result, crop and variety selection, rather than disaster prevention and infrastructure improvement, was the most common ways for farmers to adapt to the notable warming trend in the study region.展开更多
Two amphiboles and a syn-metamorphic quartz vein from the Yuka terrane,North Qaidam,western China,have been analyzed by joint40Ar/39Ar crushing in vacuo and stepwise heating techniques.The crushing in vacuo results pr...Two amphiboles and a syn-metamorphic quartz vein from the Yuka terrane,North Qaidam,western China,have been analyzed by joint40Ar/39Ar crushing in vacuo and stepwise heating techniques.The crushing in vacuo results provide information to directly constrain the timing of fluid activity and the age of amphibolite-facies retrogression.The stepwise heating results could further be used to decipher the thermal history of the UHP rocks.Amphiboles from amphibolites and quartz vein within garnetamphibolite lens analyzed by in vacuo crushing yield similarly shaped age spectra and exhibit relatively flat age plateaus for the last several steps.The characteristics of gas release patterns and geochronological data testify to the presence of significant excess40Ar within the fluid inclusions.The age plateaux with weighted mean ages（WMA） ranges from 488 to 476 Ma for amphiboles and 403 Ma for quartz（2σ）.These data points constitute amphibole WMA yielding excellent isochrons with isochron ages of 469 and 463 Ma with initial40Ar/36Ar ratios of 520 and 334,respectively.The isochron ages are interpreted to represent initial amphibolite-facies retrogression.The data points constituting the quartz age plateaux give an isochron age of 405 Ma with initial40Ar/36Ar ratio of 295,recording a significant aqueous fluid flow episode during the early Devonian.Age spectra obtained by stepwise heating of amphibole residues remaining after crushing experiments are characterized by younger and relatively complex age spectra,which are probably influenced by the combined effects of resetting argon and/or mineral inclusions.Nevertheless,we note that the spectra shapes have features in common:excluding the last two steps,minimum apparent ages are found at temperatures of around 500 ℃,corresponding to319 and 249 Ma,perhaps representing the time of isotopic resetting or resulting from release gas from mineral inclusions of,e.g.,biotite or feldspar.Maximum apparent ages are obtained at temperatures of around 800℃,corresponding to 418 and 413 Ma,which probably reflect mixed ages of radiogenic resetting and original amphibole.These results indicate that the Yuka eclogites and their retrogressed equivalents were overprinted by multiple thermal events in the Silurian and possibly as young as the Triassic.展开更多
The Huang Shui River, a main tributary of the Yellow River, crosses a series of tectonically subsided and uplifted areas that show different patterns of terrace formation. The distribution of fluvial terrace of the Hu...The Huang Shui River, a main tributary of the Yellow River, crosses a series of tectonically subsided and uplifted areas that show different patterns of terrace formation. The distribution of fluvial terrace of the Huang Shui River is studied through topographic and sedimentologic terrace mapping. Three terraces in the Haiyan Basin, four terraces in the Huangyuan Basin, 19 terraces in the Xi＇ning Basin （the four high terraces may belong to another river）, nine terraces in the Ping＇an Basin, five terraces in the Ledu Basin and 12 terraces in the Minhe Basin are recognized. Sedimentology research shows that the geomorphologic and sedimentological pattern of the Huang Shui River, which is located at the margin of Tibet, are different from that of the rivers at other regions. The formation process of the terrace is more complicated at the Huang Shui catchment： both accumulation terrace and erosion terrace were formed in each basin and accumulation terraces were developed in some basins when erosion terraces were formed in other basins, indicating fluvial aggradation may occur in some basins simultaneously with river incision in other basins. A conceptual model of the formation process of these two kinds of fluvial terraces at Huang Shui catchment is brought forward in this paper. First, the equilibrium state of the river is broken because of climatic change and/or tectonic movement, and the river incises in all basins in the whole catchment until reaching a new equilibrium state. Then, the downstream basin subsides quickly and the equilibrium state is broken again, and the river incises at upstream basins while the river accumulates at the subsidence basin quickly until approaching a new equilibrium state again. Finally, the river incises in the whole catchment because of climatic change and/or tectonic movement and the accumulation terrace is formed at the subsidence basin while the erosion terrace is formed at other basins. The existence of the accumulation terrace implied the tectonic subsidence in the sub-basins in Huang Shui catchment. These tectonic subsidence movements gradually developed from the downstream Minhe Basin to the upstream Huangyuan Basin. Dating the terrace sequence has potential to uncover the relationship between the subsidence in the catchment and the regional tectonic at the northeastern Tibetan Plateau.展开更多
Injury of the periodontium followed by inflammatory response often leads to mot resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact ...Injury of the periodontium followed by inflammatory response often leads to mot resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts. Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin （IL）- 1β hereupon. Extracted teeth from healthy volunteers were subjected to sequential digestion by type I collagenase and trypsin. The effect of enzymatic digestion on the presence of cells on the root surface was analyzed by histology. Gene expression of primary human cementoblasts （pHCB） was compared with a human cementoblast cell line （HCEM）. The pHCBs were analyzed for their expression of IL-1 receptors as well as of receptor activator of nuclear factor kappa-B ligand （RANKL） and osteoprotegerin （OPG）. In a co-culture system consisting of osteoclast precursors （blood monocytes） and pHCBs, the formation of osteoclasts and their resorptive activity was assessed by osteo-assay and ivory slices. The cells obtained after a 120 min enzyme digestion expressed the highest level of bone sialoprotein, similar to that of HCEM. This fraction of isolated cells also shared a similar expression pattern of IL-1 receptors （ILl-R1 and ILl-R2）. Treatment with IL-11~ potently upregulated RANKL expression but not of OPG. pHCBs were shown to induce the formation of functional osteoclasts. This capacity was significantly stimulated by pretreating the pHCBs with IL-1β prior to their co-culture with human blood monocytes. Our study demonstrated that cementoblasts have the capacity to induce osteoclastogenesis, a capacity strongly promoted by IL-1β. These results may explain why osteoclasts can be formed next to the root of teeth.展开更多
The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of dev...The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology.展开更多
Background:Despite the well-established health benefits of physical activity(PA)for young people(aged 419 years),most do not meet PA guidelines.Policies that support PA in schools may be promising,but their impact on ...Background:Despite the well-established health benefits of physical activity(PA)for young people(aged 419 years),most do not meet PA guidelines.Policies that support PA in schools may be promising,but their impact on PA behavior is poorly understood.The aim of this systematic review was to ascertain the level and type of evidence reported in the international scientific literature for policies within the school setting that contribute directly or indirectly to increasing PA.Methods:This systematic review is compliant with Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines.Six databases were searched using key concepts of policy,school,evaluation,and PA.Following title and abstract screening of 2323 studies,25 progressed to data synthesis.Methodological quality was assessed using standardized tools,and the strength of the evidence of policy impact was described based on pre-determined codes:positive,negative,inconclusive,or untested statistically.Results:Evidence emerged for 9 policy areas that had a direct or indirect effect on PA within the school setting.These were whole school PA policy,physical education,sport/extracurricular PA,classroom-based PA,active breaks/recess,physical environment,shared use agreements,active school transport,and surveillance.The bulk of the evidence was significantly positive(54%),27%was inconclusive,9%was significantly negative,and 11%was untested(due to rounding,some numbers add to 99%or 101%).Frequency of evidence was highest in the primary setting(41%),34%in the secondary setting,and 24%in primary/secondary combined school settings.By policy area,frequency of evidence was highest for sport/extracurricular PA(35%),17%for physical education,and 12%for whole school PA policy,with evidence for shared use agreements between schools and local communities rarely reported(2%).Comparing relative strength of evidence,the evidence for shared use agreements,though sparse,was 100%positive,while 60%of the evidence for whole school PA policy,59%of the evidence for sport/extracurricular PA,57%of the evidence for physical education,50%of the evidence for PA in classroom,and 50%of the evidence for active breaks/recess were positive.Conclusion:The current evidence base supports the effectiveness of PA policy actions within the school setting but cautions against a“one-sizefits-all”approach and emphasizes the need to examine policy implementation to maximize translation into practice.Greater clarity regarding terminology,measurement,and methods for evaluation of policy interventions is needed.展开更多
BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal tract.Current therapeutic options are translated nowadays from treatment s...BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal tract.Current therapeutic options are translated nowadays from treatment strategies for patients with colorectal cancer due to histopathological similarities.AIM To retrospectively investigate the clinical outcome of patients with DA and it-PVA.METHODS All patients with DA and it-PVA diagnosed between 2000 and 2017 were included at two academic centers in the Netherlands.All patients with histopathologically-confirmed DA or it-PVA were eligible for inclusion.Clinical outcome was compared between DA and it-PVA per disease stage.In the subgroup of stage IV disease,survival after local treatment of oligometastases was compared with systemic therapy or supportive care.RESULTS In total,155 patients with DA and it-PVA were included.Patients with it-PVA more often presented with stage I disease,while DA was more often diagnosed at stage IV(P<0.001).Of all patients,79%were treated with curative intent.The median survival was 39 mo,and no difference in survival was found for patients with DA and it-PVA after stratification for disease stage.Seven(23%)of 31 patients with synchronous stage IV disease underwent resection of the primary tumor,combined with local treatment of oligometastases.Local treatment of metastases was associated with an overall survival of 37 mo,compared to 14 and 6 mo for systemic therapy and supportive care,respectively.CONCLUSION Survival of patients with DA and it-PVA is comparable per disease stage.These results suggest a potential benefit for local treatment strategies in selected patients with oligometastases,although additional prospective studies are needed.展开更多
Sea asparagus is a newly emerging seawater-irrigated vegetable. Firstly, the economic value of sea asparagus was introduced, and then, someexploiting approaches of sea asparagus werefully reviewed. The exploiting appr...Sea asparagus is a newly emerging seawater-irrigated vegetable. Firstly, the economic value of sea asparagus was introduced, and then, someexploiting approaches of sea asparagus werefully reviewed. The exploiting approaches mainly include fresh vegetable, pickle, bio-salt, health-care products, animal feed, vegetable oil, bio-diesel and skin-care products.展开更多
There are high expectations for Mobile Health to transform health into a sustainable and prevention-based system. Unfortunately it has not reached its scale of adoption many had hoped for, due to the existence of adop...There are high expectations for Mobile Health to transform health into a sustainable and prevention-based system. Unfortunately it has not reached its scale of adoption many had hoped for, due to the existence of adoption barriers. More insight into these barriers fosters adoption of mHealth and the innovation it can bring to worldwide healthcare. This study investigates the main barriers in the adoption of mHealth, their underlying causes and their breakthrough possibilities. All the data are gathered from an international and multi-stakeholder point of view. First of all we tried to identify the main barriers by doing an international literature study. Second of all we asked Dutch mHealth Key Opinion Leaders (KOLs) to rank the barriers to importance. These KOLs were from different stakeholder groups;policy-makers, users and developers. At last we asked the KOLs in interviews for underlying causes and breakthrough opportunities of the barriers. Eventually twelve main adoption barriers emerged. According to literature and to the KOLs the most important barriers are “Integration and interoperability” and “Business case”. An underlying cause for the barrier “Integration and interoperability” might be the active closed power system of technology suppliers, which exists in the Netherlands. Furthermore there seems to be a difference in the importance of the barriers “Privacy and security” and “Conservative culture” when perceptions of Dutch KOLS and international literature are compared. Within the stakeholders-groups, the KOLs think differently about the importance of the barriers “Visionless development” and “Competing payment mechanism”. The Dutch healthcare insurers could take a more leading role in the fragmented landscape of mHealth in the Netherlands, by strategically funding new initiatives that use open standards and deliver better value for end-users. Other chances might lie in the international cooperation between countries to overcome certain barriers.展开更多
基金supported and financed by the National Basic Research Program of China(973 Program,2010CB951504)the National Natural Science Foundation of China(41271112)the National Non-Profit Institute Research Grant of Chinese Academy of Agricultural Sciences,China(IARRP-2014-2)
文摘To feed the increasing world population, more food needs to be produced from agricultural land systems. Solutions to produce more food with fewer resources while minimizing adverse environmental and ecological consequences require sustainable agricultural land use practices as supplementary to advanced biotechnology and agronomy. This review paper, from a land system perspective, systematically proposed and analyzed three interactive strategies that could possibly raise future food production under global change. By reviewing the current literatures, we suggest that cropland expansion is less possible amid iferce land competition, and it is likely to do less in increasing food production. Moreover, properly allocating crops in space and time is a practical way to ensure food production. Climate change, dietary shifts, and other socio-economic drivers, which would shape the demand and supply side of food systems, should be taken into consideration during the decision-making on rational land management in respect of sustainable crop choice and allocation. And ifnally, crop-speciifc agricultural intensiifcation would play a bigger role in raising future food production either by increasing the yield per unit area of individual crops or by increasing the number of crops sown on a particular area of land. Yet, only when it is done sustainably is this a much more effective strategy to maximize food production by closing yield and harvest gaps.
基金supported and financed by the National Basic Research Program of China(973 Program,2010CB951504)the National Natural Science Foundation of China(41201089 and 41271112)
文摘Rice is one of the most important grain crops in Northeast China （NEC） and its cultivation is sensitive to climate change. This study aimed to explore the spatio-temporal changes in the NEC rice planting area over the period of 1980-2010 and to analyze their relationship to climate change. To do so, the CLUE-S （conversion of land use and its effects at small region extent） model was ifrst updated and used to simulate dynamic changes in the rice planting area in NEC to understand spatio-temporal change trends during three periods： 1980-1990, 1990-2000 and 2000-2010. The changing results in individual periods were then linked to climatic variables to investigate the climatic drivers of these changes. Results showed that the NEC rice planting area expanded quickly and increased by nearly 4.5 times during 1980-2010. The concentration of newly planted rice areas in NEC constantly moved northward and the changes were strongly dependent on latitude. This conifrmed that climate change, increases in temperature in particular, greatly inlfuenced the shift in the rice planting area. The shift in the north limit of the NEC rice planting area generally followed a 1＆#176;C isoline migration pattern, but with an obvious time-lag effect. These ifndings can help policy makers and crop producers take proper adaptation measures even when exposed to the global warming situation in NEC.
基金financed by the National Basic Research Program of China(2010CB951504)the National Natural Science Foundation of China(41271112 and 40930101)the National Nonprofit Institute Research Grant of CAAS(IARRP-2014-16)
文摘Although climate change impacts and agricultural adaptations have been studied extensively, how smallholder farmers perceive climate change and adapt their agricultural activities is poorly understood. Survey-based data （presents farmers＇ personal perceptions and adaptations to climate change） associated with external biophysical-socioeconomic data （presents real-world climate change） were used to develop a farmer-centered framework to explore climate change impacts and agricultural adaptations at a local level. A case study at Bin County （1980s-2010s）, Northeast China, suggested that increased annual average temperature （0.6＆#176;C per decade） and decreased annual precipitation （46 mm per decade, both from meteorological datasets） were correctly perceived by 76 and 66.9%, respectively, of farmers from the survey, and that a longer growing season was conifrmed by 70%of them. These reasonably correct perceptions enabled local farmers to make appropriate adaptations to cope with climate change：Longer season alternative varieties were found for maize and rice, which led to a signiifcant yield increase for both crops. The longer season also affected crop choice：More farmers selected maize instead of soybean, as implicated from survey results by a large increase in the maize growing area. Comparing warming-related factors, we found that precipitation and agricultural disasters were the least likely causes for farmers＇ agricultural decisions. As a result, crop and variety selection, rather than disaster prevention and infrastructure improvement, was the most common ways for farmers to adapt to the notable warming trend in the study region.
基金funded by the Chinese Academy Sciences-Royal Netherlands Academy of Arts and Sciences(CAS-KNAW)Joint PhD Training Programme(ISK/3523/PhD)the joint research project between the CAS and the De Koninklijke Nederlandse Akademie van Wetenschappen(06CDP002)
文摘Two amphiboles and a syn-metamorphic quartz vein from the Yuka terrane,North Qaidam,western China,have been analyzed by joint40Ar/39Ar crushing in vacuo and stepwise heating techniques.The crushing in vacuo results provide information to directly constrain the timing of fluid activity and the age of amphibolite-facies retrogression.The stepwise heating results could further be used to decipher the thermal history of the UHP rocks.Amphiboles from amphibolites and quartz vein within garnetamphibolite lens analyzed by in vacuo crushing yield similarly shaped age spectra and exhibit relatively flat age plateaus for the last several steps.The characteristics of gas release patterns and geochronological data testify to the presence of significant excess40Ar within the fluid inclusions.The age plateaux with weighted mean ages（WMA） ranges from 488 to 476 Ma for amphiboles and 403 Ma for quartz（2σ）.These data points constitute amphibole WMA yielding excellent isochrons with isochron ages of 469 and 463 Ma with initial40Ar/36Ar ratios of 520 and 334,respectively.The isochron ages are interpreted to represent initial amphibolite-facies retrogression.The data points constituting the quartz age plateaux give an isochron age of 405 Ma with initial40Ar/36Ar ratio of 295,recording a significant aqueous fluid flow episode during the early Devonian.Age spectra obtained by stepwise heating of amphibole residues remaining after crushing experiments are characterized by younger and relatively complex age spectra,which are probably influenced by the combined effects of resetting argon and/or mineral inclusions.Nevertheless,we note that the spectra shapes have features in common:excluding the last two steps,minimum apparent ages are found at temperatures of around 500 ℃,corresponding to319 and 249 Ma,perhaps representing the time of isotopic resetting or resulting from release gas from mineral inclusions of,e.g.,biotite or feldspar.Maximum apparent ages are obtained at temperatures of around 800℃,corresponding to 418 and 413 Ma,which probably reflect mixed ages of radiogenic resetting and original amphibole.These results indicate that the Yuka eclogites and their retrogressed equivalents were overprinted by multiple thermal events in the Silurian and possibly as young as the Triassic.
基金supported by the National Natural Science Foundation of China(Grant no.40901002 and 40325007)the 985 project to Nanjing University and the CAS-KNAW PhD project(05-PhD-10)
文摘The Huang Shui River, a main tributary of the Yellow River, crosses a series of tectonically subsided and uplifted areas that show different patterns of terrace formation. The distribution of fluvial terrace of the Huang Shui River is studied through topographic and sedimentologic terrace mapping. Three terraces in the Haiyan Basin, four terraces in the Huangyuan Basin, 19 terraces in the Xi＇ning Basin （the four high terraces may belong to another river）, nine terraces in the Ping＇an Basin, five terraces in the Ledu Basin and 12 terraces in the Minhe Basin are recognized. Sedimentology research shows that the geomorphologic and sedimentological pattern of the Huang Shui River, which is located at the margin of Tibet, are different from that of the rivers at other regions. The formation process of the terrace is more complicated at the Huang Shui catchment： both accumulation terrace and erosion terrace were formed in each basin and accumulation terraces were developed in some basins when erosion terraces were formed in other basins, indicating fluvial aggradation may occur in some basins simultaneously with river incision in other basins. A conceptual model of the formation process of these two kinds of fluvial terraces at Huang Shui catchment is brought forward in this paper. First, the equilibrium state of the river is broken because of climatic change and/or tectonic movement, and the river incises in all basins in the whole catchment until reaching a new equilibrium state. Then, the downstream basin subsides quickly and the equilibrium state is broken again, and the river incises at upstream basins while the river accumulates at the subsidence basin quickly until approaching a new equilibrium state again. Finally, the river incises in the whole catchment because of climatic change and/or tectonic movement and the accumulation terrace is formed at the subsidence basin while the erosion terrace is formed at other basins. The existence of the accumulation terrace implied the tectonic subsidence in the sub-basins in Huang Shui catchment. These tectonic subsidence movements gradually developed from the downstream Minhe Basin to the upstream Huangyuan Basin. Dating the terrace sequence has potential to uncover the relationship between the subsidence in the catchment and the regional tectonic at the northeastern Tibetan Plateau.
基金Ratchadaphiseksomphot Endowment Fund Chulalongkorn University(R/F_2557_021_03_32)Integrated-Innovation Academic Center’Chulalongkorn University Centenary Academic Development Project+1 种基金The 2012 Research Chair GrantThailand National Science and Technology Development Agency(NSTDA)
文摘Injury of the periodontium followed by inflammatory response often leads to mot resorption. Resorption is accomplished by osteoclasts and their generation may depend on an interaction with the cells in direct contact with the root, the cementoblasts. Our study aimed to investigate the role of human cementoblasts in the formation of osteoclasts and the effect of interleukin （IL）- 1β hereupon. Extracted teeth from healthy volunteers were subjected to sequential digestion by type I collagenase and trypsin. The effect of enzymatic digestion on the presence of cells on the root surface was analyzed by histology. Gene expression of primary human cementoblasts （pHCB） was compared with a human cementoblast cell line （HCEM）. The pHCBs were analyzed for their expression of IL-1 receptors as well as of receptor activator of nuclear factor kappa-B ligand （RANKL） and osteoprotegerin （OPG）. In a co-culture system consisting of osteoclast precursors （blood monocytes） and pHCBs, the formation of osteoclasts and their resorptive activity was assessed by osteo-assay and ivory slices. The cells obtained after a 120 min enzyme digestion expressed the highest level of bone sialoprotein, similar to that of HCEM. This fraction of isolated cells also shared a similar expression pattern of IL-1 receptors （ILl-R1 and ILl-R2）. Treatment with IL-11~ potently upregulated RANKL expression but not of OPG. pHCBs were shown to induce the formation of functional osteoclasts. This capacity was significantly stimulated by pretreating the pHCBs with IL-1β prior to their co-culture with human blood monocytes. Our study demonstrated that cementoblasts have the capacity to induce osteoclastogenesis, a capacity strongly promoted by IL-1β. These results may explain why osteoclasts can be formed next to the root of teeth.
基金supported by grants from the Italian Ministry of University and Research(MIUR)(SYSBIONET-Italian ROADMAP ESFRI Infrastructures to LA,AMC and MP IVASCOMAR-National Cluster to AMC)+5 种基金Netherlands Organization for Scientific Research(NWO)in the integrated program of WOTRO [W01.65.324.00/project 4] Science for Global DevelopmentSynpol:EU-FP7 [KBBE.2012.3.4-02#311815]Corbel:EU-H2020 [NFRADEV-4-2014-2015#654248]Epipredict:EU-H2020 MSCA-ITN-2014-ETN:Marie Sk?odowska-Curie Innovative Training Networks(ITN-ETN)[#642691]BBSRC China [BB/J020060/1] to HVWCorbel:EU-H2020 [PID 2354] to HVW and AMC
文摘The recognition that neurogenesis does not stop with adolescence has spun off research towards the reduction of brain disorders by enhancing brain regeneration. Adult neurogenesis is one of the tougher problems of developmental biology as it requires the generation of complex intracellular and pericellular anatomies, amidst the danger of neuroinflammation. We here review how a multitude of regulatory pathways optimized for early neurogenesis has to be revamped into a new choreography of time dependencies. Distinct pathways need to be regulated, ranging from neural growth factor induced differentiation to mitochondrial bioenergetics, reactive oxygen metabolism, and apoptosis. Requiring much Gibbs energy consumption, brain depends on aerobic energy metabolism, hence on mitochondrial activity. Mitochondrial fission and fusion, movement and perhaps even mitoptosis, thereby come into play. All these network processes are interlinked and involve a plethora of molecules. We recommend a deep thinking approach to adult neurobiology.
文摘Background:Despite the well-established health benefits of physical activity(PA)for young people(aged 419 years),most do not meet PA guidelines.Policies that support PA in schools may be promising,but their impact on PA behavior is poorly understood.The aim of this systematic review was to ascertain the level and type of evidence reported in the international scientific literature for policies within the school setting that contribute directly or indirectly to increasing PA.Methods:This systematic review is compliant with Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines.Six databases were searched using key concepts of policy,school,evaluation,and PA.Following title and abstract screening of 2323 studies,25 progressed to data synthesis.Methodological quality was assessed using standardized tools,and the strength of the evidence of policy impact was described based on pre-determined codes:positive,negative,inconclusive,or untested statistically.Results:Evidence emerged for 9 policy areas that had a direct or indirect effect on PA within the school setting.These were whole school PA policy,physical education,sport/extracurricular PA,classroom-based PA,active breaks/recess,physical environment,shared use agreements,active school transport,and surveillance.The bulk of the evidence was significantly positive(54%),27%was inconclusive,9%was significantly negative,and 11%was untested(due to rounding,some numbers add to 99%or 101%).Frequency of evidence was highest in the primary setting(41%),34%in the secondary setting,and 24%in primary/secondary combined school settings.By policy area,frequency of evidence was highest for sport/extracurricular PA(35%),17%for physical education,and 12%for whole school PA policy,with evidence for shared use agreements between schools and local communities rarely reported(2%).Comparing relative strength of evidence,the evidence for shared use agreements,though sparse,was 100%positive,while 60%of the evidence for whole school PA policy,59%of the evidence for sport/extracurricular PA,57%of the evidence for physical education,50%of the evidence for PA in classroom,and 50%of the evidence for active breaks/recess were positive.Conclusion:The current evidence base supports the effectiveness of PA policy actions within the school setting but cautions against a“one-sizefits-all”approach and emphasizes the need to examine policy implementation to maximize translation into practice.Greater clarity regarding terminology,measurement,and methods for evaluation of policy interventions is needed.
基金Supported by the Bennink Foundation,No.2002262the Cancer Center Amsterdam Foundation
文摘BACKGROUND Duodenal adenocarcinoma(DA)and intestinal-type papilla of Vater adenocarcinoma(it-PVA)are rare malignancies of the gastrointestinal tract.Current therapeutic options are translated nowadays from treatment strategies for patients with colorectal cancer due to histopathological similarities.AIM To retrospectively investigate the clinical outcome of patients with DA and it-PVA.METHODS All patients with DA and it-PVA diagnosed between 2000 and 2017 were included at two academic centers in the Netherlands.All patients with histopathologically-confirmed DA or it-PVA were eligible for inclusion.Clinical outcome was compared between DA and it-PVA per disease stage.In the subgroup of stage IV disease,survival after local treatment of oligometastases was compared with systemic therapy or supportive care.RESULTS In total,155 patients with DA and it-PVA were included.Patients with it-PVA more often presented with stage I disease,while DA was more often diagnosed at stage IV(P<0.001).Of all patients,79%were treated with curative intent.The median survival was 39 mo,and no difference in survival was found for patients with DA and it-PVA after stratification for disease stage.Seven(23%)of 31 patients with synchronous stage IV disease underwent resection of the primary tumor,combined with local treatment of oligometastases.Local treatment of metastases was associated with an overall survival of 37 mo,compared to 14 and 6 mo for systemic therapy and supportive care,respectively.CONCLUSION Survival of patients with DA and it-PVA is comparable per disease stage.These results suggest a potential benefit for local treatment strategies in selected patients with oligometastases,although additional prospective studies are needed.
文摘Sea asparagus is a newly emerging seawater-irrigated vegetable. Firstly, the economic value of sea asparagus was introduced, and then, someexploiting approaches of sea asparagus werefully reviewed. The exploiting approaches mainly include fresh vegetable, pickle, bio-salt, health-care products, animal feed, vegetable oil, bio-diesel and skin-care products.
文摘There are high expectations for Mobile Health to transform health into a sustainable and prevention-based system. Unfortunately it has not reached its scale of adoption many had hoped for, due to the existence of adoption barriers. More insight into these barriers fosters adoption of mHealth and the innovation it can bring to worldwide healthcare. This study investigates the main barriers in the adoption of mHealth, their underlying causes and their breakthrough possibilities. All the data are gathered from an international and multi-stakeholder point of view. First of all we tried to identify the main barriers by doing an international literature study. Second of all we asked Dutch mHealth Key Opinion Leaders (KOLs) to rank the barriers to importance. These KOLs were from different stakeholder groups;policy-makers, users and developers. At last we asked the KOLs in interviews for underlying causes and breakthrough opportunities of the barriers. Eventually twelve main adoption barriers emerged. According to literature and to the KOLs the most important barriers are “Integration and interoperability” and “Business case”. An underlying cause for the barrier “Integration and interoperability” might be the active closed power system of technology suppliers, which exists in the Netherlands. Furthermore there seems to be a difference in the importance of the barriers “Privacy and security” and “Conservative culture” when perceptions of Dutch KOLS and international literature are compared. Within the stakeholders-groups, the KOLs think differently about the importance of the barriers “Visionless development” and “Competing payment mechanism”. The Dutch healthcare insurers could take a more leading role in the fragmented landscape of mHealth in the Netherlands, by strategically funding new initiatives that use open standards and deliver better value for end-users. Other chances might lie in the international cooperation between countries to overcome certain barriers.
