In a recent paper in Science,Bruchez et al.1 provide new insights how host cells can fight virus infection.They show that an MHC class II transactivator(CIITA)—which normally operates as part of the interferon(IFN)-s...In a recent paper in Science,Bruchez et al.1 provide new insights how host cells can fight virus infection.They show that an MHC class II transactivator(CIITA)—which normally operates as part of the interferon(IFN)-stimulated immune response—is also involved in an antiviral response,beyond its well-known function of antigen presentation.展开更多
The here highlighted study by Garcia-Beltran et al.demonstrates that SARS-CoV-2 Omicron can largely escape the immune responses.Hence,while two doses of COVID-19 vaccines seem to be insufficient to provide protection ...The here highlighted study by Garcia-Beltran et al.demonstrates that SARS-CoV-2 Omicron can largely escape the immune responses.Hence,while two doses of COVID-19 vaccines seem to be insufficient to provide protection against Omicron,a third dose provides mature neutralizing antibodies to enhance the response.1 Since March 2020,when the World Health Organization(WHO;www.who.int)officially declared the COVID-19 pandemic caused by the SARS-CoV-2.展开更多
基金supported by the“Excellence Initiative—Research University”program at the Nicolaus Copernicus UniversityK.P.is supported by the subsidy from the Polish Ministry of Science and Higher Education for the research on the SARS-CoV-2 and a grant from the National Science Center UMO-2017/27/B/NZ6/02488C.S.v.B.is supported by grant GM103554 from the National Institutes of Health.
文摘In a recent paper in Science,Bruchez et al.1 provide new insights how host cells can fight virus infection.They show that an MHC class II transactivator(CIITA)—which normally operates as part of the interferon(IFN)-stimulated immune response—is also involved in an antiviral response,beyond its well-known function of antigen presentation.
基金This work is supported by the Bayerische Forschungsstiftung grant AZ-1453-20C(to G.M.P.)the Deutsche Forschungsgemeinschaft,grants PO 1851/4-1(to G.P.)subsidy from the Polish Ministry of Science and Higher Education for research on SARS-CoV-2 and a grant from the National Science Center(UMO-2017/27/B/NZ6/02488)and by EU-Horizon2020 ITN OrganoVir grant 812673(to K.P).Open Access funding enabled and organized by Project DEAL.
文摘The here highlighted study by Garcia-Beltran et al.demonstrates that SARS-CoV-2 Omicron can largely escape the immune responses.Hence,while two doses of COVID-19 vaccines seem to be insufficient to provide protection against Omicron,a third dose provides mature neutralizing antibodies to enhance the response.1 Since March 2020,when the World Health Organization(WHO;www.who.int)officially declared the COVID-19 pandemic caused by the SARS-CoV-2.
